In a community based study of 113 PDS and PG patients followed for a median of 6 years, 1 patient went unilaterally blind while a second went bilaterally blind. [3] In the same study, 10% of PDS patients progressed to PG at 5 years, while 15% progressed [eyewiki.aao.org]

Heterochromia iridis-a case study. Explor Anim Med Res 2014;4(2):240–5. White D, Rabago-Smith M. Genotype–phenotype associations and human eye color. J Hum Gen 2011;56:5–7. Bhallil S, Benatyia A, El-Mahjoubi B, El-Abdouni O, Tahri H. [jamc.ayubmed.edu.pk]

P: The reason I’d prefer to address the shedding of pigment is the fear that even once pigment release has abated, the trabecular meshwork has been irreparably damaged, so that even in the absence of further pigment release, there is lifelong dysfunction [willsglaucoma.org]

Other factors which influence eye colour during a person’s lifetime include: Emotions: Intense emotions such as anger can alter the size of the pupil and thus influence colour as well. [mymed.com]