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Gliomatosis Cerebri


  • These pediatric cases underscore the limitations of relying solely on clinical presentation and neuroimaging and call to attention the essential role of neurosurgical intervention.[ncbi.nlm.nih.gov]
  • GC in children is rare and difficult to diagnose, often presenting with a variety of signs and symptoms that may mimic encephalitis.[ncbi.nlm.nih.gov]
  • This case describes a unique clinical presentation of gliomatosis cerebri in a pediatric patient.[ncbi.nlm.nih.gov]
  • The unique clinical presentation is discussed in light of this rare neoplasm of the central nervous system.[ncbi.nlm.nih.gov]
  • Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rochester between 1991 and 2008 were retrospectively[ncbi.nlm.nih.gov]
  • A 45-year-old female presented with gliomatosis cerebri manifesting as hemiballismus-like involuntary movement in the arm, motor weakness in the leg, and hypesthesia in her left side.[ncbi.nlm.nih.gov]
  • Allie’s Symptoms Voracious appetite/weight gain (hypothalamus obesity) Partial facial paralysis Seizures Headache Short-term memory loss Weakness and numbness in the limbs Trouble sleeping GC Registry The Children’s Brain Tumor Project launched the International[teamlittleowl.org]
  • Symptoms of gliomatosis cerebri depend on what parts of the brain are affected and include: Signs of raised pressure in the brain (seizures, nausea, vomiting, drowsiness, headaches) Personality and behavioral changes Localized symptoms (like weakness[nicklauschildrens.org]
  • […] can occur with supratentorial high grade gliomas, but do so less commonly than with low grade lesions localized symptoms – these tumours infiltrate normal structures as they grow and produce symptoms as a function of their location These can include: weakness[andrewinspires.com]
  • Initial examination revealed mild extensor weakness in the left upper and lower limb with mildly increased tone. Abbreviated mental test score was 6/10.[jneuro.com]
Progressive Dementia
  • A case of gliomatosis cerebri presenting as rapidly progressive dementia and Parkinson's disease like symptoms has been described in an 82-year-old woman. Before the advent of MRI, diagnosis was generally not established until autopsy.[en.wikipedia.org]
  • The following is a case report of a 14-year-old female who had a subtotal cortical resection of tumor and several years later developed a progressive dementia. At postmortem examination the diagnosis of gliomatosis cerebri was made.[ncbi.nlm.nih.gov]
  • Session Information Session Time: 1:45pm-3:15pm Location: Exhibit Hall C Objective : Report a case of rapidly progressive dementia and parkinsonism related to gliomatosis cerebri.[mdsabstracts.org]
Familial Adenomatous Polyposis
  • In 2% to 3.5% of cases they occur in multiplicity and then may be associated with genetic diseases, such as myotonic dystrophy Curschmann-Steinert, familial adenomatous polyposis (Gardner syndrome), and Rubinstein-Taybi syndrome.[ncbi.nlm.nih.gov]
  • Because of the improved survival seen with the use of temozolomide (TMZ) in malignant glioma, a rigorous systematic review of the published literature was performed to ascertain the benefit of TMZ in GC.[ncbi.nlm.nih.gov]
  • Symptoms of gliomatosis cerebri depend on what parts of the brain are affected and include: Signs of raised pressure in the brain (seizures, nausea, vomiting, drowsiness, headaches) Personality and behavioral changes Localized symptoms (like weakness[nicklauschildrens.org]
  • You know, “chemo brain,” issues with steroids, fatigue, nausea, etc. Could be MUCH worse. Now, coming to the fact that I might lose my hair…It doesn’t bother me.[braintumor.org]
  • So side effects, he has a shaved head and massive issues with nausea from the chemo. Otherwise - his problems have been with the continued detoriation of his right side where the largest tumor is pressing against the motor strip.[cancercompass.com]
Auditory Hallucination
  • The current patient had obsessive images, anxiety, auditory hallucinations and seizures following (possible) gliomatosis cerebri, with onset around 69 years of age.[ncbi.nlm.nih.gov]
  • Type 2: A 59-year-old woman presented with right hemiparesis and headache.[ncbi.nlm.nih.gov]
  • A 33-year-old woman with neurofibromatosis type 1 presented with progressive headache, diplopia, dysphagia, and a rightward instability.[ncbi.nlm.nih.gov]
  • The very few cases reported in children have presented with intractable epilepsy, corticospinal tract deficits, unilateral tremor, headaches, and developmental delay.[ncbi.nlm.nih.gov]
  • A 47-year-old woman presented with a 2-week history of worsening headache and progressive drowsiness.[ncbi.nlm.nih.gov]
  • Clinical signs vary and are non-specific, including changes in the mental state and headaches, followed by focal motor deficits and convulsive episodes [4].[ncbi.nlm.nih.gov]
Generalized Seizure
  • Both children had a preceding prolonged secondary generalized seizure 2-4 months before the evolution of epilepsia partialis continua, including recurrent clusters of left-sided myoclonic twitching and sensory impairment.[ncbi.nlm.nih.gov]
  • Case 5 A 12-year-old boy presented after experiencing the first instance of a generalized seizure.[ajnr.org]
Involuntary Movements
  • A 45-year-old female presented with gliomatosis cerebri manifesting as hemiballismus-like involuntary movement in the arm, motor weakness in the leg, and hypesthesia in her left side.[ncbi.nlm.nih.gov]


  • Spinal MRI is necessary for the complete neurological workup, even when the patients do not show spinal symptoms.[ncbi.nlm.nih.gov]
  • Here, we report the diagnostic workup of 2 patients with gliomatosis cerebri, discussing the clinical, radiologic, and pathologic findings.[ncbi.nlm.nih.gov]
  • She had an extensive workup for autoimmune (Anti-Ro/La, ANA, anti-dsDNA, anti-cardiolipin antibodies, RNP, RF), granulomatous (ANCA, ACE), infectious (encephalitis panel, VZV, HIV, Borrelia, Brucella, HTLV, Syphilis, Coccidiomycosis, Entamoeba, Mycobacterium[n.neurology.org]


  • The prognosis is poor and no definite treatment has proven effective for GC.[ncbi.nlm.nih.gov]
  • We identified all GC cases in the literature where there was enough information to ascertain a clear response to a specific chemoradiotherapeutic treatment.[ncbi.nlm.nih.gov]
  • Relief of intracranial hypertension allowed further treatment and a survival of 23 months. Relevant literature on the subject has been reviewed.[ncbi.nlm.nih.gov]
  • We also compared the overall survival according to treatment.[ncbi.nlm.nih.gov]
  • RESULTS: In all patients, treatment was well tolerated and MRI follow-up showed no tumour progression for at least six months.[ncbi.nlm.nih.gov]


  • Real-time expression values relative to these 23 gene features were used to build a prediction method able to distinguish patients with a good prognosis (those more likely to be responsive to therapy) from patients with a poor prognosis (those less likely[ncbi.nlm.nih.gov]
  • Prognosis was always very gloomy in the short term, with a median survival of less than a year.[ncbi.nlm.nih.gov]
  • KEYWORDS: Diffuse astrocytoma; Gliomatosis cerebri; IDH1 mutation; Molecular markers; Prognosis[ncbi.nlm.nih.gov]
  • Given the widespread nature of the disease, surgical treatment is not possible and has a poor overall prognosis. A pediatric patient presented with elevated intracranial pressure.[ncbi.nlm.nih.gov]
  • Gliomatosis cerebri is a rare glial tumor that carries a poor prognosis. Seen in both adults and children, gliomatosis cerebri appears to differ in these populations as with adult versus pediatric glioblastoma.[ncbi.nlm.nih.gov]


  • Conclusions: It is important to consider neoplastic etiologies in the differential of granulomatous processes, even when preliminary neoplastic evaluation is unremarkable. Disclosure: Dr. LaBuzetta has nothing to disclose. Dr.[n.neurology.org]


  • OBJECTIVE: We used the SEER (Surveillance Epidemiology and End Results) database (1999-2010) to analyze the clinical practice patterns and overall survival in patients with gliomatosis cerebri (GC), or glioma involving 3 or more lobes of the cerebrum.[ncbi.nlm.nih.gov]
  • Histology of Gliomatosis cerebri often low malignancy of cells because of the special growth pattern it is classified as WHO grade III Epidemiology of Gliomatosis cerebri usually in median and high adult age can also occur in children Symptoms of Gliomatosis[hirntumorhilfe.org]
  • Epidemiology Peak incidence is between 40 and 50 years. Both genders are equally affected. Localization The primary nosological characteristic of gliomatosis cerebri is its diffuse growth pattern.[prod.wiki.cns.org]
  • ., Parfrey, P.S. (2011) Sudden cardiac death in chronic kidney disease: epidemiology and prevention.[scindeks.ceon.rs]
  • Vialle , Meningiomas: estudo epidemiologic e anátomo-patológico de 304 casos , Arquivos de Neuro-Psiquiatria , 54 , 4 , (549) , (1996) .[dx.doi.org]
Sex distribution
Age distribution


  • Semin Dial , 12(2): 77 [ CR ] [ PM ] [ EČ ][ GS ] London, G.M. (2003) Cardiovascular disease in chronic renal failure: pathophysiologic aspects.[scindeks.ceon.rs]
  • Wass , Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? , Pituitary , 10.1007/s11102-007-0074-2 , 11 , 3 , (325-330) , (2007) .[dx.doi.org]


  • Analysis of preventability of malignancy-related maternal death from the nationwide registration system of maternal deaths in Japan.[dx.doi.org]
  • ., Sandberg, K.R. (2004) Chronic kidney disease and sudden death: strategies for prevention.[scindeks.ceon.rs]
  • One question I thought to ask: in all of your messages and postings about different treatments, you have never mentioned the so-called cytostatic drugs like Bevacizumab, which is an angiogenesis inhibitor i.e. it prevents the creation of blood supply[cancerforums.net]
  • Rainov , Predisposing conditions and risk factors for development of symptomatic meningioma in adults , Cancer Detection and Prevention , 10.1016/j.cdp.2005.07.002 , 29 , 5 , (440-447) , (2005) .[dx.doi.org]

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