Presentation
Gliosarcoma is a rare variant of glioblastoma, and this is the first documented case presenting as a primary neoplasm of the optic nerve. [ncbi.nlm.nih.gov]
Entire Body System
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Fatigue
He experienced the following treatment-related, reversible toxicities with ANP: fatigue, xerostomia and urinary frequency (grade 1), diarrhea, incontinence and urine color change (grade 2), and grade 4 hypernatremia. [ncbi.nlm.nih.gov]
Patients With Newly Diagnosed Glioblastoma Multiforme 273 NCT01648348 Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme 242 NCT01781468 Armodafinil in Reducing Cancer-Related Fatigue [virtualtrials.com]
My doctors are wonderful and I have had minimal side effects from the treatment ( mainly just fatigue) It sounds like your doctors have you on the right track. Please let me know if you have any questions. [cancercompass.com]
(holy cow,,, talk about Fatigue at the end.... Not to mention erratic dysfunctional sleep because of the 16 mg of steroids to deal with inflammation etc). My last treatment was this past Friday, Feb 3, YEAH!!! [steadyhealth.com]
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Fishing
Three cases of primary gliosarcoma (GS) were studied by immunohistochemical, ultrastructural and fluorescence in situ hybridization (FISH) methods. All tumors occurred in the supratentorial regions of the body. [ncbi.nlm.nih.gov]
Carnitine is made in muscle and liver tissue and is found in certain foods, such as meat, poultry, fish, and some dairy products. It is used by many cells in the body to make energy from fat. [cancer.gov]
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Wound Infection
Postoperative radiation had to be interrupted because of a wound infection necessitating explantation of the infected bone flap and implantation of a titanium mesh. [ncbi.nlm.nih.gov]
Gastrointestinal
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Nausea
A 57-year-old man experienced a month history of headache, nausea and vomiting. Worse yet, the headache has become more severe for the past 6 days. [ncbi.nlm.nih.gov]
The most common signs and symptoms include recurring headaches, nausea, vomiting, unsteadiness, incoordination, vision loss, cognitive problems, speech defects, changes in behavior, personality issues & seizures. [xpertdox.com]
Case Description: We present a 45-year-old female admitted to our center with progressive headache since 1 month ago concomitant with nausea and emesis and generalized weakness. [surgicalneurologyint.com]
There are many side effects to chemo treatments, and can include nausea, vomiting, and dizziness. There is some research to indicate the disease is caused by exposure to radiation. [wisegeekhealth.com]
Jaw & Teeth
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Xerostomia
He experienced the following treatment-related, reversible toxicities with ANP: fatigue, xerostomia and urinary frequency (grade 1), diarrhea, incontinence and urine color change (grade 2), and grade 4 hypernatremia. [ncbi.nlm.nih.gov]
Eyes
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Corneal Opacity
No funduscopic examination was possible because of a corneal opacity. [ncbi.nlm.nih.gov]
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Anisocoria
A 55-year-old female presented with a unique case of gliosarcoma with a huge cystic component manifesting as loss of consciousness, left-sided hemiparesis, and anisocoria. [ncbi.nlm.nih.gov]
Neurologic
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Headache
A 28-year-old male patient experienced intermittent headache, vomiting, and gait disorders for 3 months. [ncbi.nlm.nih.gov]
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Tonic-Clonic Seizure
A 51-year-old right-handed woman initially presented with generalized tonic-clonic seizures. MRI showed abnormal signal hyperintensity of the right temporal lobe that was thought to be consistent with ischemic stroke. [ncbi.nlm.nih.gov]
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Altered Mental Status
A 57-year-old man presented with altered mental status and was found to have a large right frontal mass. [ncbi.nlm.nih.gov]
Here we report the case of a 34 year old male who initially presented with altered mental status and seizures. [arcjournals.org]
Workup
A pulmonary workup revealed lung lesions that were biopsied and found to be gliosarcoma. [ncbi.nlm.nih.gov]
GS shows a predilection for a superficial location and dural invasion and thus may not be considered in the initial workup of parenchymal masses. 8 There were 2 cases of primary GS of the posterior cranial fossa in patients older than 60 years of age [journals.lww.com]
X-Ray
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Mediastinal Mass
Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass. [ncbi.nlm.nih.gov]
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Posterior Mediastinal Mass
Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass. [ncbi.nlm.nih.gov]
Treatment
Serial magnetic resonance imaging (MRI) revealed good treatment response, demonstrated by central necrosis and tumor shrinkage. [ncbi.nlm.nih.gov]
Prognosis
Our study adds further evidence to support GSM as a unique clinical entity with a likely worse prognosis than GBM. [ncbi.nlm.nih.gov]
Etiology
To gain a comprehensive view of the genomic alterations in GS and to understand the molecular etiology of GS, we applied whole-exome sequencing analyses for 28 GS cases (6 blood-matched fresh-frozen tissues for the discovery set, 22 formalin-fixed paraffin-embedded [ncbi.nlm.nih.gov]
The etiology of gliosarcoma remains speculative although it is recognized that gliomas can induce sarcomatous transformation in the supporting mesenchymal elements (2) and irradiation of the central nervous system can induce malignant transformation of [path.upmc.edu]
Etiology: It is thought that the sarcomatous changes may arise from fibroblasts of the blood vessels. Gross: The glioblastoma part of the tumor forms heterogeneous infiltrative areas with hemorrhage and necrosis. [aboutcancer.com]
Epidemiology
Although most gliomas rarely show metastases outside the cerebrum, gliosarcomas have a propensity to do so, most commonly spreading through the blood to the lungs, and also liver and lymph nodes.Gliosarcomas have an epidemiology similar to that of glioblastomas [en.wikipedia.org]
They share similarities with glioblastomas as far as clinico-epidemiological and prognostic factors are concerned. They are commonly cortically-surfacing lesions occurring mostly in the supratentorial compartment. [ncbi.nlm.nih.gov]
Due to its rarity, the pathogenesis, epidemiology and optimal therapy of GS have been based on small retrospective cohort studies, with treatment presently utilizing regimens established for other high-grade gliomas, including combination of resection [mdanderson.elsevierpure.com]
Pathophysiology
The case presented herein illustrates this through identification of a patient with type I Turcot syndrome, a Lynch syndrome variant, with confirmatory germline genetic testing and establishment of the molecular pathophysiologic explanation (i.e, microsatellite [arcjournals.org]
Prevention
Awareness of the phenomenon of melanocytic differentiation within primary neuroepithelial and glial neoplasms is important to prevent the misdiagnosis of these tumors such as metastatic melanoma or primary melanocytic neoplasms of the CNS. [ncbi.nlm.nih.gov]
Scientists are carrying out various researches and tests to find out whether it can be prevented. One can take certain preventive measures to keep the radiation-induced form of the disorder from occurring. [hxbenefit.com]
Symptoms - Gliosarcoma * Headache * Vomiting * Unsteadiness * Vision problems * Cognitive problems Causes - Gliosarcoma * Overeating * Regurgitation * Excessive alcohol * Hangover * Pregnancy Prevention - Gliosarcoma Not supplied. [checkorphan.org]