Although they are present in only 3% of cases, glomeruloid hemangiomas are strongly associated with POEMS syndrome and, when present, contribute to reaching an early diagnosis. The present paper reports on two cases of POEMS syndrome. [scielo.br]

The present paper reports on two cases of glomeruloid hemangiomas associated with POEMS syndrome, and includes a review of the literature. [scienceopen.com]

Arch Dermatol 114:1082–1083 CrossRef Google Scholar Cuckow P, Doyle D (1991) Renal cell carcinoma presenting in the skin. [link.springer.com]

• Splenomegaly

  Tomography of the chest and abdomen showed paratracheal, precarinal and subcarinal lymphadenopathy, a small bilateral pleural effusion, pericardial effusion, mild ascites, splenomegaly and small retroperitoneal lymph nodes. [scielo.br]

• Plethora

  The most common are diffuse cutaneous hyperpigmentation, acrocyanosis and plethora. [scielo.br]

• Galactorrhea

  […] investigators, the most frequent manifestations being diabetes mellitus and hypothyroidism. 10,11 Other endocrine abnormalities reported consist of alterations in the gonadal axis, alterations in the adrenal axis, hyperprolactinemia, gynecomastia or galactorrhea [scielo.br]

• Weight Loss

  TNF-α is associated with demyelinating peripheral neuropathy, hepatosplenomegaly, endocrine dysfunction, edema, weight loss, hypertriglyceridemia and diarrhea. [scielo.br]

• Hypertension

  […] sclerodermiform type on the hands and feet has also been reported in association with other symptoms such as Raynaud's phenomenon and sicca syndrome. 14 Leukonychia is a very rare manifestation that occurs simultaneously with finger clubbing in pulmonary hypertension [scielo.br]

• Skin Thickening

  Other manifestations include thickening of the skin (of the sclerodermiform type), hypertrichosis, necrotizing vasculitis, hyperhidrosis and leukonychia, in addition to calciphylaxis and cicatricial alopecia. [scielo.br]

• Alopecia

  The cicatricial alopecia was of the secondary type, since it developed in an area adjacent to an osteosclerotic lesion on the cranium. [scielo.br]

• Suggestibility

  We therefore suggest that every histopathology report of glomeruloid hemangioma be issued with an accompanying note recommending investigation for POEMS syndrome and Castleman's disease. [scielo.br]

  Study of a series suggesting a continuous spectrum of infantile myofibroblastic lesions. [link.springer.com]

• Paresthesia

  Neuropathy is characterized by being of the thick-fiber, sensorimotor type with a demyelinating pattern that initially manifests itself as a distal symmetric sensory alteration, with paresthesia and sensations of pins and needles and cold, followed by [scielo.br]

• Hyporeflexia

  Neurological examination revealed generalized deep hyporeflexia, with tonus and muscle strength preserved; superficial distal hypoesthesia in the feet and distal pallanesthesia in all four limbs. [scielo.br]

• Pericardial Effusion

  Tomography of the chest and abdomen showed paratracheal, precarinal and subcarinal lymphadenopathy, a small bilateral pleural effusion, pericardial effusion, mild ascites, splenomegaly and small retroperitoneal lymph nodes. [scielo.br]

• Hyperprolactinemia

  […] findings have also been reported by other investigators, the most frequent manifestations being diabetes mellitus and hypothyroidism. 10,11 Other endocrine abnormalities reported consist of alterations in the gonadal axis, alterations in the adrenal axis, hyperprolactinemia [scielo.br]

• Thrombocytosis

  IL-6 is related to plasma cell proliferation and monoclonal gammopathy, thrombocytosis, Castleman's disease, hemangiomas and microangiopathic glomerulopathy. 16 Serum IL-6 levels in 6 patients with active POEMS syndrome were shown to be higher than those [scielo.br]

The patient was referred to the National Cancer Institute (INCA) for treatment of the plasmacytic neoplasm. [scielo.br]

Am J Surg Pathol 22:683–697 CrossRef CAS PubMed Google Scholar Mentzel T, Schildhaus HU, Palmedo G, Büttner R, Kutzner H (2012a) Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast [link.springer.com]

Clinicopathological analysis of a series with good prognosis. [link.springer.com]

Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy. [link.springer.com]

Am J Surg Pathol 21:1083–1089 CrossRef CAS PubMed Google Scholar Navarro-Nunez L, Langan SA, Nash GB et al (2013) The physiological and pathophysiological roles of platelet CLEC-2. [link.springer.com]