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Glycopyrrolate

Glycopyrronium Bromide


Presentation

  • Other pharmacologic interventions, based on the physiology of erections, are presented.[ncbi.nlm.nih.gov]
  • Methods of the present invention for orally administering glycopyrrolate compositions may also include the coadministration of adjuvants with the compositions of the present invention.[patents.google.com]
Intravenous Administration
  • OBJECTIVES: In this proof-of-principle study, the effectiveness and safety of transdermal administration of neostigmine/glycopyrrolate to elicit a bowel movement was compared to intravenous administration in patients with spinal cord injury.[ncbi.nlm.nih.gov]
  • Although the disposition of GLY after intravenous administration to Standardbred horses was similar to that in Thoroughbred horses, differences in some pharmacokinetic parameter estimates were evident.[doi.org]
  • Objectives In this proof-of-principle study, the effectiveness and safety of transdermal administration of neostigmine/glycopyrrolate to elicit a bowel movement was compared to intravenous administration in patients with spinal cord injury.[nature.com]
  • For intravenous administration, especially where there is a need for protection against bradycardia, the adult dose is 0.2 mg, or on a weight related basis, 4-5 μg/kg, and 5-10 μg/kg in children.[patents.google.com]
Delayed Gastric Emptying
  • gastric emptying, and prolong GI transit time. d Specific Drugs Drug Interaction Comments Amantadine Possible additive anticholinergic effects d Use concomitantly with caution d Antacids Possible decreased absorption of antimuscarinic d Administer oral[drugs.com]
Localized Hyperhidrosis
  • METHODS: Review of case notes in a series of 24 patients, nine with generalized and 15 with localized hyperhidrosis. RESULTS: Fifteen of 19 evaluable patients (79%) responded to oral glycopyrrolate.[ncbi.nlm.nih.gov]
  • Methods Review of case notes in a series of 24 patients, nine with generalized and 15 with localized hyperhidrosis. Results Fifteen of 19 evaluable patients (79%) responded to oral glycopyrrolate.[doi.org]
Bromhidrosis
  • Stamatis Gregoriou, Dimitrios Rigopoulos, Zoe Chiolou, Dafni Papafragkaki, Michalis Makris and George Kontochristopoulos , Treatment of bromhidrosis with a glycine‐soja sterocomplex topical product , Journal of Cosmetic Dermatology , 10 , 1 , (74-77)[doi.org]
Paresthesia
  • Not only were subjective complaints of tremor, palpitations, and paresthesias increased for metaproterenol, but the heart rate response was significantly elevated (p less than 0.05) compared with glycopyrrolate.[ncbi.nlm.nih.gov]

Treatment

  • OBJECTIVES: To report a retrospective analysis describing the treatment responses, doses and side-effects of oral glycopyrrolate in the treatment of idiopathic hyperhidrosis.[ncbi.nlm.nih.gov]

Etiology

  • A concept of the etiology of gastric and duodenal ulcer. Caldwell Lecture, 1955. Am. J. Roentgenol. 75 :219, 1956. Google Scholar 6. Code, C. F. The peptic ulcer problem. Am. J. Digest. Dis. 5 :288, 1960. CrossRef PubMed Google Scholar 7.[link.springer.com]
  • Chambers et al. presented two case reports and reviewed the etiology, diagnosis, course, and treatment of pregnant patients with myasthenia gravis and who were receiving either neostigmine or pyridostigmine. [5] Plauche presented three case reports and[anesthesiology.pubs.asahq.org]
  • The usual attempts should be made to determine the etiology of the arrhythmia, and the surgical or anesthetic manipulations necessary to correct parasympathetic imbalance should be performed.[globalrph.com]

Epidemiology

  • Merello M: Sialorrhoea and drooling in patients with Parkinson's disease: epidemiology and management. Drugs Aging 2008;25:1007-1019[medicine.uiowa.edu]
  • Eun Jung Park, Kyung Ream Han, Ho Choi, Do Wan Kim and Chan Kim , An Epidemiological Study of Hyperhidrosis Patients Visiting the Ajou University Hospital Hyperhidrosis Center in Korea , Journal of Korean Medical Science , 10.3346/jkms.2010.25.5.772 ,[doi.org]
  • A prospective epidemiologic registry of acyclovir use during pregnancy was established in 1984 and completed in April 1999. Western society has marketed sex via shallow superficiality.[althurayafoundation.org]
Sex distribution
Age distribution

Pathophysiology

  • Author information 1 a Health Sciences Department, Pulmonary Rehabilitation Unit, Fondazione Salvatore Maugeri, Scientific Institute of Milan-IRCCS , Università degli Studi di Milano , Milan , Italy. 2 b Department of Pathophysiology and Transplantation[ncbi.nlm.nih.gov]
  • Others have found that clozapine has α 1 - and α 2 -antagonist effects that contribute to sialorrhea. 7 , – 9 The pathophysiologic mechanism could be multifactorial, which would explain why CIS is difficult to target and treat.[ajhp.org]

Prevention

  • The authors recommend glycopyrrolate use to prevent CAS-induced bradycardia and hypotension.[ncbi.nlm.nih.gov]
  • Anticholinergic drugs do not prevent the liberation of acetylcholine, nor do they react wih acetylcholine. Pharmacokinetics IV Administration: onset of action 2-3 minutes; duration of action 30-60 minutes.[theapms.com]
  • […] acetylcholine – Potentially prevent bronchoconstriction . 25.[slideshare.net]

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