Presentation
Musculoskeletal
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Arthralgia
Treatment is currently symptomatic and supportive. 0010318 Arthralgia Joint pain 0002829 Broad nasal tip Broad tip of nose Broad, upturned nose Increased breadth of nasal tip Increased breadth of tip of nose Increased width of nasal tip Increased width [rarediseases.info.nih.gov]
Neurologic
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Seizure
[…] treatment for GM1 gangliosidosis. [3] [4] Symptomatic treatment for some of the neurologic signs and symptoms is available, but does not significantly alter the progression of the condition. [4] [7] For example, anticonvulsants may initially control seizures [rarediseases.info.nih.gov]
Treatment
Last updated: 11/17/2015 There is currently no effective medical treatment for GM1 gangliosidosis. [3] [4] Symptomatic treatment for some of the neurologic signs and symptoms is available, but does not significantly alter the progression of the condition [rarediseases.info.nih.gov]
Prognosis
[…] has not yet advanced to human trials. [4] [7] Neurologic and orthopedic sequelae may prevent adequate physical activity, but affected individuals may benefit from physical and occupational therapy. [4] Last updated: 8/6/2012 The long-term outlook ( prognosis [rarediseases.info.nih.gov]
Prevention
[…] treatment due to its success in other lysosomal storage disorders. [4] Active research in the areas of enzyme replacement and gene therapy for the condition is ongoing but has not yet advanced to human trials. [4] [7] Neurologic and orthopedic sequelae may prevent [rarediseases.info.nih.gov]