The clinical presentation of Good's syndrome (GS) starts during adulthood, most commonly in the 4th or 5th decade of life, with a mean survival rate of 14 years and overall mortality rates of 45-57% according to most recent reports [1] [2]. Recurrent infections due to bacterial, viral and fungal pathogens are the most important manifestation of Good's syndrome, arising due to extensive hypogammaglobulinemia and lymphopenia of varying severity [3] [4]. Most notable examples are infections of the sinuses and the respiratory tract by encapsulated bacteria (haemophilus influenzae and streptococcus pneumoniae, as well as klebsiella pneumoniae and pseudomonas aeruginosa) and fungi (pneumocystis jirovecii), cutaneous and urinary tract infections, but also diarrheas caused by giardia lamblia, campylobacter jejuni, cytomegalovirus (CMV) and salmonella spp. [5] [6] [7]. Moreover, CMV retinitis, mucocutaneous candidiasis, herpes simplex virus (HSV) and human herpesvirus 8 (HHV-8) infections have been described [1]. In rare cases, central nervous system (CNS) infection may be seen [7]. Sinorespiratory infections manifest with a cough, nasal discharge, fever, and headaches, while diarrhea, abdominal pain, cramping and weight loss are typical signs of gastrointestinal infection. The second cardinal feature of Good's syndrome is the presence of a thymoma, and up to 42% of patients have a confirmed diagnosis prior to the onset of infections [3]. In addition, thymomas are associated with a number of autoimmune disorders, and up to 50% of patients present with signs and symptoms of myasthenia gravis, whereas pemphigus, sjögren syndrome, pure red cell aplasia (PRCA) and systemic lupus erythematosus (SLE) have all been identified in patients suffering from this type of immunodeficiency [4]. In up to 10% of patients, hypogammaglobulinemia may be quite severe even after successful removal of thymomas and is the main cause of mortality in this patient group [3].

• Pain

  If you don’t give the inflamed tissue a break, you’ll likely just make the pain worse. “If your pain is moderate to severe at the beginning of a run, then don’t even start,” Conlon says. [outsideonline.com]

  Care should be taken to avoid manipulation in the recently injured foot and should only be considered once the acute pain and swelling have partially subsided. [journals.lww.com]

  The pain resolves to a reasonable level, and the moment you get back to the problematic activities, the pain skyrockets right back to where it started. [t-nation.com]

  Jones if you experience: Pain that lasts longer than a few weeks Sudden, severe pain Pain that starts after an injury Weakness or numbness in your leg There’s no need to suffer with the pain of piriformis syndrome when treatment can bring you significant [southeasttexasspine.com]

  It's also possible for the pain to disappear even while the swelling continues. The pain of Tietze syndrome sometimes extends to the neck, arms, and shoulders. The pain can be mild or severe, dull or sharp. [webmd.com]

• Collapse

  […] neurographic scan to be located. ( TNG : " All Good Things... ") According to the script's pronunciation guide, this syndrome's name was pronounced as "ear-uh-MAHD-ik". [1] It is unknown whether or not Picard's condition remained the same following the collapse [memory-alpha.wikia.com]

  Gas exchange, the process of trading carbon dioxide for oxygen, is reduced in areas of collapsed lung, resulting in low oxygen levels. [jamanetwork.com]

  Introduction John Stevens could taste it – he was tantalizingly close to a deal with Anna King after nine grueling months of off-again, on-again negotiations. [1] At times it looked as though the deal was going to collapse, but somehow he had kept it [mediate.com]

  Chambers FRCS, Director of the Emergency Department, Dunedin Hospital, NZ, states, "Fear of sudden collapse and death shortly after extrication is rather over-emphasised and this happens very rarely. [medenosrce.net]

• Epilepsy

  If you would like to know more about epilepsy in general, please contact Epilepsy Action. [epilepsy.org.uk]

  What is epilepsy with myoclonic-atonic seizures (myoclonic-astatic epilepsy or Doose Syndrome)? Epilepsy with myoclonic-atonic seizures (EMAS), typically known as myoclonic-astatic epilepsy or Doose Syndrome, was first described by Dr. [epilepsy.com]

• Severe Pain

  Jones if you experience: Pain that lasts longer than a few weeks Sudden, severe pain Pain that starts after an injury Weakness or numbness in your leg There’s no need to suffer with the pain of piriformis syndrome when treatment can bring you significant [southeasttexasspine.com]

  The main symptoms are chest pain and shortness of breath. [health.harvard.edu]

  It is often detected by severe pain on the passive stretching of an injured muscle group. If diagnosed early, treatment can begin before rhabdomyolysis occurs. [medenosrce.net]

• Surgical Procedure

  Depending on your situation, surgical procedures to treat dumping syndrome may include reconstructing the pylorus or surgery to reverse gastric bypass surgery. [mayoclinic.org]

  But some patients say this surgical procedure ruined their lives. In Michael Jackson’s wrongful death suit, one of his doctors testified that Jackson’s insomnia could have been a result of empty nose syndrome. [buzzfeed.com]

• Fear

  Characteristics of good girl syndrome are fear of disappointing others, fear of speaking out for fear of hurting others, must always excel, avoid conflict, obey rules, and also find it difficult to refuse. [voi.id]

  As is the case with any kind of fear, the only way out is through. You can’t get rid of fear, but you can build confidence and courage to move forward despite your fears. [nickwignall.com]

  They don’t like to stand up for themselves for fear of the reactions that they might encounter. [teensavers.com]

  The aspects of fear include: fear of evaluation, fear of not continuing success and fear of not being as capable as others. [6] In her 1985 paper, Clance explained that impostor phenomenon can be distinguished by the following six dimensions: [2] The [en.wikipedia.org]

  […] won't stop me again Good, brave I'm into it all Hope I can make it Hope fear won't stop me again Colaboração e revisão: [cifraclub.com.br]

• Behavior Disorder

  This problem is a psychological disorder. It may be mistaken for vomiting or other digestive problems. Behavioral therapy will help you to notice the pattern and work to correct it. [hopkinsmedicine.org]

• Headache

  Sinorespiratory infections manifest with a cough, nasal discharge, fever, and headaches, while diarrhea, abdominal pain, cramping and weight loss are typical signs of gastrointestinal infection. [symptoma.com]

  These areas may develop: pain, typically achey, which may be constant or it may come and go numbness, weakness, or tingling (may be worse overnight) loss of control of fine motor movements There may also be a headache at the back of the head or top of [goodhealthcentre.co.uk]

  Side effects of these medications include dizziness, tiredness and headaches. Medicines for aiding sleep If restless legs syndrome is badly disrupting your sleep, a short-term course of medicine may be recommended to help you sleep. [nhs.uk]

  There is no renal such care in serum headache and testosterone medicine between certificate opinions before development. [guistcreek.com]

  Josh Axe, an expert in leaky gut syndrome and autoimmune diseases, states that this autoimmune reaction leads to inflammation throughout your system causing symptoms such as bloating, food sensitivities, thyroid conditions, fatigue, joint pain, headaches [themoderngladiator.com]

• Agitation

  With each follow-up appointment, he becomes increasingly agitated. He says this routine surgery resulted in empty nose syndrome and ruined his life. You’ve heard of the condition, but you also know some doctors are skeptical of it. [buzzfeed.com]

• Aphasia

  However, 1 week after admission, motor aphasia and mild right hemiparesis reappeared. MRI showed that the lesion involving the left cingulate gyrus expanded in size, and revealed an abnormal signal intensity lesion in the left corona radiata. [ncbi.nlm.nih.gov]

Despite the fact that less than 200 patients have been diagnosed with GS so far [4], an early diagnosis must be achieved in order to reduce the risk of adverse events and prevent more serious infections that can be life-threatening [3]. For this reason, a detailed patient history (including assessment of age) must be obtained in order to identify the recent development of symptoms that may suggest recurrent infections, but laboratory studies are essential during diagnostic workup. A complete blood count (CBC) is mandatory and should be obtained right away, with anemia, leukopenia (either granulocytopenia or lymphopenia) and/or thrombocytopenia being frequently observed [7]. Furthermore, a thorough immunological workup composed of CD4+/CD8+ T cell and B cell counts and a quantitative immunoglobulin assessment will confirm lymphopenia and hypogammaglobulinemia [3]. Because many patients suffer from additional immunological diseases, detection of anti-acetylcholine receptor (AChR) antibodies, anti-Ro/SSA and anti-La/SSB, as well as antinuclear antibodies (ANA) for myasthenia gravis, sjögren syndrome and SLE, respectively, should be performed. Bone marrow aspiration, as a last resort, can reveal markedly reduced hematopoiesis [6]. On the other hand, the presence of recurrent infections should raise valid suspicion toward disorders of the thymus, and imaging studies, mainly in the form of computed tomography (CT), but also biopsy, are necessary to identify thymoma as an accompanying feature and thus confirm the diagnosis.

• Anterior Mediastinal Mass

  Imaging and laboratory studies revealed a large anterior mediastinal mass and panhypoimmunoglobulinemia, respectively. A biopsy was consistent with thymoma, and a diagnosis of Good's syndrome was established. [ncbi.nlm.nih.gov]

  Chest CAT disclosed a left sided infiltrate with a loculated pleural effusion(Figure 1,A), as well as an anterior mediastinal mass(Figure 1,B). [shmabstracts.com]

  MANAGEMENT OF GOOD’S SYNDROME An anterior mediastinal mass is noted on a postero-anterior chest x ray in 80% of patients with thymoma.63 Lateral x ray views may delineate the outline of the mass. [jcp.bmj.com]

• Anergy

  There was cutaneous anergy to intra dermal antigen challenge.Flow cytometry revealed reduced mature circulating B cells,reduced CD4 count and reversal of CD4:CD8 ratio.Bone marrow biopsy showed reduced pre-B cell lineage.Patient has remained stable on [neurology.org]

  The main abnormalities are an increase in circulating naive T cells, cutaneous T-cell anergy, TCR hyporesponsiveness in vitro as well as a numerical and functional impairment of regulatory T cells. [dl.begellhouse.com]

  This patient showed cutaneous anergy, even though he had normal numbers of peripheral blood total lymphocytes as well as CD4 + and CD8 + T cells. [jimmunol.org]

  Studies of cell mediated immunity in Good’s syndrome emphasised that T cell defects, as manifested by cutaneous anergy to two or more test antigens,32,33 or delayed rejection of skin allografts,28,34 were common features of this condition. [jcp.bmj.com]

We carry out obligatory diagnostics before the program, before starting treatment, a month after, and 3 months after treatment. [en.goodcells.com]

Early and aggressive treatment of patients with PG should be the norm, always considering surgery in severe cases and/or in those failing conservative treatment. [journals.lww.com]

Borderline Personality Disorder (BPD) in men is often misdiagnosed and typically leads to either no treatment or the wrong treatment. This is the first book to address this under-recognized problem. [books.google.de]

Its treatment consists of the surgical removal of the tumor and immunosuppressive drugs. [elsevier.es]

General consensus was that GS has a worse prognosis than other humoral immunodeficiencies. In this study, physicians of GS patients completed two questionnaires with a two year interval with data on 47 patients, 499 patient years in total. [helda.helsinki.fi]

This rare condition should not be misdiagnosed, as the prognosis is determined by infectious and autoimmune complications, which could be prevented. [ncbi.nlm.nih.gov]

Good’s syndrome shares many features with CVID, but unlike the latter and the more serious XLA, it carries a much worse prognosis. [link.springer.com]

[…] vs Host Disease/diagnosis|Humans|Immunologic Deficiency Syndromes/complications/immunology/microbiology|Incidence|Lichen Planus, Oral/diagnosis/etiology|Male|Middle Aged|Opportunistic Infections/diagnosis/etiology|Red-Cell Aplasia, Pure/diagnosis/etiology [drci-chu-clermontferrand.fr]

The etiologic relationship between thymoma and acquired hypogammaglobulinemia remains unclear. Thymectomy is generally ineffective in improving immunologic deficiencies and coexisting conditions in patients with acquired hypogammaglobulinemia. [ncbi.nlm.nih.gov]

Altered Autonomic Nervous System Activity As A Potential Etiological Factor of Premenstrual Syndrome and Premenstrual Dysphoric Disorder. Biopsychosocial Medicine, 1(24). Muninjaya, A. A. G. (2004). Manajemen kesehatan. [jurnal.ugm.ac.id]

"The significance of certain pulmonary lesions in relation to the etiology of influenza". Am J Med Sci. 158 (6): 863–870. doi : 10.1097/00000441-191911000-00012. ^ Salama AD, Levy JB, Lightstone L, Pusey CD (September 2001). "Goodpasture's disease". [en.wikipedia.org]

Results on epidemiology, disease characteristics, and outcome are presented. Mean age at diagnosis was 60 years and median follow-up from onset of symptoms was 9 years. [helda.helsinki.fi]

Correspondence Published: 17 April 2021 Epidemiology Leukemia volume 35, pages 1817–1819 (2021)Cite this article 200 Accesses 1 Citations Metrics details Subjects This is a preview of subscription content, access via your institution Access options Subscribe [nature.com]

Journal Journal ID (nlm-ta): Pan Afr Med J Journal ID (iso-abbrev): Pan Afr Med J Journal ID (publisher-id): PAMJ Title: The Pan African Medical Journal Publisher: The African Field Epidemiology Network ISSN (Electronic): 1937-8688 Publication date (Electronic [scienceopen.com]

Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. [medworm.com]

[…] study reported a decreased GBS incidence following administration of tetanus toxoid containing vaccinations when compared with the baseline population [54] An epidemiologic study failed to show any conclusive epidemiologic association between GBS and [emedicine.medscape.com]

CRUSH PATHOPHYSIOLOGY Our patient had many injuries. I do not intend examining all of these, but will highlight Crush Injury with references to Compartment Syndrome and Rhabdomyolysis. [medenosrce.net]

Pathophysiology [ edit ] GPS causes the abnormal production of anti-GBM antibodies, by the plasma cells of the blood. [6] The anti-GBM antibodies attack the alveoli and glomeruli basement membranes. [6] These antibodies bind their reactive epitopes to [en.wikipedia.org]

Pathophysiology Anti-GBM disease is an autoimmune disorder characterized by autoantibodies directed against the glomerular/alveolar basement membrane. [emedicine.medscape.com]

Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 122. Mayer EA. [mountsinai.org]

Polycystic ovary syndrome (PCOS) is not a simple pathophysiologic process for which one treatment addresses all manifestations. [aafp.org]

How can we prevent “good child syndrome”? To prevent children from developing “good child syndrome” is important that parents respect their child’s opinions and intentions. Please try to let your child do things at his/her own pace. [gymboglobal.jp]

This rare condition should not be misdiagnosed, as the prognosis is determined by infectious and autoimmune complications, which could be prevented. [ncbi.nlm.nih.gov]

Scantlebury says this exercise increases the strength and endurance of the muscles in the hand, which can alleviate symptoms and prevent functional deficits. [wellandgood.com]

1. Kelleher P, Misbah SA. What is Good’s syndrome? Immunological abnormalities in patients with thymoma. J Clin Pathol. 2003;56(1):12-16.
2. Jansen A, van Deuren M, Miller J, et al. Prognosis of Good syndrome: mortality and morbidity of thymoma associated immunodeficiency in perspective. Clin Immunol. 2016;171:12-17.
3. Tachdjian R, Keller JJ, Pfeffer M. A Bad Case of Good’s Syndrome. Infect Dis Ther. 2014;3(2):333-337.
4. Malphettes M, Gérard L, Galicier L, et al. Good syndrome: an adult-onset immunodeficiency remarkable for its high incidence of invasive infections and autoimmune complications. Clin Infect Dis. 2015;61(2):e13-19.
5. Sun X, Shi J, Wang M, Xu K, Xiao Y. Good’s Syndrome Patients Hospitalized for Infections: A Single-Center Retrospective Study. Callens. S, ed. Medicine (Baltimore). 2015;94(47):e2090.
6. Agarwal S, Cunningham-Rundles C. Thymoma and immunodeficiency (Good syndrome): a report of 2 unusual cases and review of the literature. Ann Allergy Asthma Immunol. 2007;98(2):185-190.
7. Ueno S, Sekimoto-Tsuboi S, Ishiguro Y, et al. Good’s syndrome with opportunistic infection of the central nervous system: a case report. BMC Neurol. 2015;15:150.