In 2012, the European Association of Urology published a guideline on male hypogonadism that was developed by European genitourinary surgeons. 28 The levels of evidence were graded in accordance with a rating scheme adapted from the Oxford Centre for [cmaj.ca]

12y 20y Tendon reflexes increased in UE/LE increased in UE/LE increased in UE/LE Spacticity in UE and LE in UE and LE in UE and LE Babinski’s sign bilateral bilateral bilateral Ankle clonus - bilateral bilateral Urge incontinence (40y) Parkinsonism hypomimia [ojrd.biomedcentral.com]

Ankle clonus - bilateral bilateral Urge incontinence (40y) Parkinsonism hypomimia - - Hyperkinetic movements (dystonia/athetosis) focal dystonia upper limb intermittend ballistic athetotic movements intermittend ballistic athetotic movements Epilepsy [ojrd.biomedcentral.com]

[…] to walk, requiring wheelchair; 7: confined to the bed) [ 12 ]. [ojrd.biomedcentral.com]

ataxia 42 , since age 6 (including primary amenorrhoea) / n/Ø Mild Atrophy cerebellum IHG25353 1 B M BNS 6, gait ataxia 61 , since age 6 / / N Atrophy cerebellum 2 B M BNS 6, gait ataxia 57 , since age 6 / / N Atrophy cerebellum IHG25357 1 V M BNS 14 [academic.oup.com]

Subject II.1, family 1, presented with slightly delayed early motor development, generalized tonic-clonic seizures (years 1–2 of life) and undescended testes (surgery at age 7). He did not show ataxia symptoms until age 12. [ojrd.biomedcentral.com]