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Gram Negative Bacterial Infection


Presentation

  • Presented at: ASM Microbe; June 16-20, 2016; Boston. Tsai L, et al.[healio.com]
  • The etiology, presentation, and surgical management are reviewed. Three abdominal aortic aneurysms were infected during urinary tract sepsis and one infection occurred with Salmonella septicemia.[ncbi.nlm.nih.gov]
  • Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals.[dtic.mil]
Rigor
  • Rigorous proof of this concept must await the development of confirmatory methodology.[ncbi.nlm.nih.gov]
Pleural Effusion
Abdominal Mass
  • The clinical triad of fever, abdominal pain, and a pulsatile abdominal mass led to a preoperative diagnosis in three of four patients.[ncbi.nlm.nih.gov]
Neglect
  • Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa. Lancet. 2012; 379: 2489-2499. Rolain JM. Food and human gut as reservoirs of transferable antibiotic resistance encoding genes.[jscimedcentral.com]

Workup

  • […] bacteria and assign scores to each as shown: Lactobacillus (score, 0-4) Bacteroides / Gardnerella (score, 0-4) Mobiluncus (score, 0-2) Total scores are calculated and interpreted as follows: 0-3: Normal 4-6: Intermediate bacterial count 7-10: BV See Workup[emedicine.com]
Creatinine Increased
  • Serum creatinine increases of at least 0.5 mg/dL during IV treatment occurred in fewer taking plazomicin (1 vs. 6 taking colistin). Full renal recovery occurred in the patient taking plazomicin, but only in three taking colistin.[mdedge.com]
Coxiella Burnetii
  • burnetii Q fever Thiotrichales Francisella tularensis Tularemia Vibrionaceae Vibrio cholerae Cholera Vibrio vulnificus Vibrio parahaemolyticus Vibrio alginolyticus Plesiomonas shigelloides Pseudomonadales Pseudomonas aeruginosa Pseudomonas infection[en.wikipedia.org]
Rickettsia Rickettsii
  • rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders Island spotted fever[en.wikipedia.org]
Rickettsia Conorii
  • conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders Island spotted fever Rickettsia africae African tick bite fever Rickettsia[en.wikipedia.org]
Rickettsia Akari
  • akari Rickettsialpox Orientia tsutsugamushi Scrub typhus Flea-borne Rickettsia felis Flea-borne spotted fever Anaplasmataceae Ehrlichiosis : Anaplasma phagocytophilum Human granulocytic anaplasmosis, Anaplasmosis Ehrlichia chaffeensis Human monocytotropic[en.wikipedia.org]
Bartonella Quintana
  • quintana Trench fever Either B. henselae or B. quintana Bacillary angiomatosis Bartonella bacilliformis Carrion's disease, Verruga peruana β Neisseriales M Neisseria meningitidis/meningococcus Meningococcal disease, Waterhouse–Friderichsen syndrome,[en.wikipedia.org]
Pleural Effusion

Treatment

  • Initial therapies consistent with MST could result in reduced in-hospital mortality, treatment failure rate, infection-related death, percentages of patients needing therapy adjustment, and daily hospitalization cost with increased successful treatment[ncbi.nlm.nih.gov]
  • Everyone, regardless of treatment group, could also receive meropenem or tigecycline if deemed necessary. Treatment lasted 7-14 days.[mdedge.com]
  • Patients also need the right dose, exposure and treatment duration. Jason A.[healio.com]

Prognosis

  • But for patients with MDR infection, adjustment relying on MST gained more benefit than non-MDR infection.Appropriate initial therapy significantly improved the prognosis of patients with gram-negative bacterial infections, but improvement was not that[ncbi.nlm.nih.gov]
  • What Is the Prognosis for a Person Infected With NDM-1 Producing Bacteria? The prognosis (outcome) for a person infected with NDM-1 is related to the patient's overall condition at the time of diagnosis and appropriate treatment.[emedicinehealth.com]
  • Prognosis Uncomplicated cases of bacterial vaginosis (BV) typically resolve after the standard antibiotic treatment. Mortality/Morbidity The prognosis for uncomplicated cases of bacterial vaginosis is generally excellent.[emedicine.com]
  • Prognosis In most patients, the prognosis is excellent. With appropriate therapy, complete recovery is usually attained. Patient Education Patients should be instructed about proper hygiene, which is a primary preventive measure.[emedicine.medscape.com]
  • Prognosis is frequently worse. Resistance to multiple antibiotic classes, including carbapenems, is growing and it compromises prophylaxis and treatment options.[link.springer.com]

Etiology

  • The etiology, presentation, and surgical management are reviewed. Three abdominal aortic aneurysms were infected during urinary tract sepsis and one infection occurred with Salmonella septicemia.[ncbi.nlm.nih.gov]
  • Overview Practice Essentials Bacterial vaginosis (BV), or nonspecific vaginitis, was named because bacteria are the etiologic agents and an associated inflammatory response is lacking.[emedicine.com]
  • Enterotoxigenic (ETEC): This is the most common etiology ( 50%) of traveler’s diarrhea. It is found mostly in tropical or developing countries.[clinicaladvisor.com]
  • H. pylori -- the once controversial but today widely recognized cause of peptic ulcers -- is also regarded as a possible culprit in the etiology of dementia.[holisticprimarycare.net]
  • Etiology of foot intertrigo in the District of Afyonkarahisar, Turkey: a bacteriologic and mycologic study. J Am Podiatr Med Assoc. 2008 Jan-Feb. 98(1):42-4. [Medline]. Devraj A, Siva Tez Pinnamaneni V, Biswal M, Ramachandran R, Jha V.[emedicine.medscape.com]

Epidemiology

  • Infection Control & Hospital Epidemiology ISSN: 0899-823X EISSN: 1559-6834 URL: /core/journals/infection-control-and-hospital-epidemiology[cambridge.org]
  • Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013;13(9):785–96. PubMed PubMedCentral CrossRef Google Scholar 98.[link.springer.com]
  • Presentation Details Downloads Welcome Professor Dilip Nathwani OBE, President, BSAC Watch Video Download Video The current global and UK epidemiology of GNB infections Professor Timothy Walsh, Professor of Medical Microbiology and Antibiotic Resistance[bsac.org.uk]
  • Lautenbach E, Synnestvedt M, Weiner MG, Bilker WB, Vo L et al. (2009) Epidemiology and impact of imipenem resistance in Acinetobacterbaumannii. Infect Control HospEpidemiol 30: 1186-1192.[omicsonline.org]
  • Acinetobacter baumannii : epidemiology, antimicrobial resistance, and treatment options. Clin Infect Dis. 2008; 46: 1254-1263. Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA.[jscimedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • Patient Education Educate patients regarding the basic pathophysiology, natural history, and risk factors of the bacterial vaginosis.[emedicine.com]
  • Pathophysiology Typically, the interweb space is colonized by polymicrobial flora.[emedicine.medscape.com]

Prevention

  • Thus we concluded that GM-CSF might play important roles in preventing Gram-negative bacterial infections in cirrhotic patients through maintaining immune system functions and homeostasis.[ncbi.nlm.nih.gov]
  • Resources Centers for Disease Control and Prevention IDSA—Infectious Diseases Society of America Canadian Resources Infection Prevention and Control Canada Public Health Agency of Canada References Antibiotic resistance threats in the United States, 2013[winchesterhospital.org]
  • Dr Jonathan Folb will guide you through what antibiotic-resistant Gram-negative bacteria are, what infections they cause and what junior doctors can do to treat and help prevent these kinds of infections.[learning.bmj.com]
  • Antibiotic Reduction Kit (ARK-Hospital) Programme Professor Martin Llewelyn, Reader in Infectious Diseases, Brighton and Sussex Medical School Watch Video Download Video Download Slides NDM, ESBL and KPC – the US experience Dr Lilian Abbo, Chief Infection Prevention[bsac.org.uk]
  • The seasonal trends reported may be used to inform infection prevention and should be considered in the design and evaluation of longitudinal quasi-experimental studies of infection prevention interventions.[journals.plos.org]

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