Presentation
Presented at: ASM Microbe; June 16-20, 2016; Boston. Tsai L, et al. [healio.com]
Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]
Cloutier presented a modified intent-to-treat analysis comprising 388 of these. They were randomized to plazomicin 15 mg/kg every 25 hours or to IV meropenem 1 gram every 24 hours. [mdedge.com]
The etiology, presentation, and surgical management are reviewed. Three abdominal aortic aneurysms were infected during urinary tract sepsis and one infection occurred with Salmonella septicemia. [ncbi.nlm.nih.gov]
Entire Body System
- Fever
Tick-borne Rickettsia rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders [en.wikipedia.org]
Patients receiving norfloxacin developed first infectious fevers later than did those receiving placebo, had more rapid resolution of that fever after systemic antibiotic treatment, and spent less time febrile. [annals.org]
The clinical triad of fever, abdominal pain, and a pulsatile abdominal mass led to a preoperative diagnosis in three of four patients. [ncbi.nlm.nih.gov]
Typical symptoms include rapid onset of dyspnea, pleuritic chest pain, fever, cough (often bloody). Salmonella typhi/paratyphi These bacterium produce a spectrum of symptoms classically known as Typhoid Fever (Enteric Fever). [clinicaladvisor.com]
[…] infections, genital infections in women, and wound infections of the skin •Involved in a number of sinus and ear infections and in almost all periodontal infections •Also cause gynecological infections, brain abscesses, and abdominal infections •Causes Q fever [quizlet.com]
Respiratoric
- Pneumonia
Infection with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae in solid organ transplantation. Transpl Infect Dis. 2012;14(2):198–205. PubMed CrossRef Google Scholar 116. [link.springer.com]
Nosocomial sinusitis and bacteremia due to Escherichia coli, Klebsiella pneumoniae, Enterobacter species, or P. aeruginosa develop in hospitalized patients. [ncbi.nlm.nih.gov]
The risk of a drug-resistant K. pneumoniae HAI increased by 1.14 times (95%CI: 1.04-1.24) with each prior K. pneumoniae HAI, after adjusting for potential confounders and antibiotic use. [academiccommons.columbia.edu]
Most (about 80%) had a bloodstream infection; bacterial pneumonias were present in the remainder. Most infections (85%) were monomicrobial, with polymicrobial infections making up the balance. [mdedge.com]
Otitis ROD Hemorrhagic pneumoniae AEROBE DIPLOCOCCUS N gonorrheae N meningitidis --------------------- Nitrogen fixing bacteria ROD AEROBES Pyocyanin (blue-green pigment) Nosocomiel infections (aquired at a hospital) Burn patinets!!! [quizlet.com]
Gastrointestinal
- Nausea
[…] injury to the head Spinal abnormalities Spinal fluid shunt placement after brain surgery Urinary tract abnormalities Urinary tract infection Weakened immune system Symptoms usually come on quickly, and may include: Fever and chills Mental status changes Nausea [medlineplus.gov]
Nausea, vomiting, and anemia occurred in about 1% of each group. More patients taking plazomicin experienced a serum creatinine clearance increase of at least 0.5 mg/dL during treatment (7% vs. 4%). [mdedge.com]
[…] sleepiness inactivity poor feeding seizures sluggishness stiffness in the body and neck fever, sweats, and/or chills Symptoms of gram-negative meningitis in adults include: confusion high fever, sweats, and/or chills lack of interest in eating or drinking nausea [healthline.com]
Gastrointestinal symptoms can be present, including nausea, vomiting, diarrhea and abdominal pain. Pneumonic plague: Often is secondary to bubonic or septicemic plague, but can occur as a primary infection. [clinicaladvisor.com]
- Diarrhea
An incubation period of 3-4 days is followed by an initial secretory diarrhea, which subsequently leads to the classic presentation of grossly bloody diarrhea. This hallmark symptom is found in over 90% of cases. [clinicaladvisor.com]
Diarrhea and hypertension were the most common adverse events (about 2% in each group). Headache occurred in 3% of the meropenem patients and 1% of the plazomicin patients. Nausea, vomiting, and anemia occurred in about 1% of each group. [mdedge.com]
Musculoskeletal
- Fracture
They also do not fracture, become schmaltzy, or break. [info.achs.edu]
Workup
[…] bacteria and assign scores to each as shown: Lactobacillus (score, 0-4) Bacteroides / Gardnerella (score, 0-4) Mobiluncus (score, 0-2) Total scores are calculated and interpreted as follows: 0-3: Normal 4-6: Intermediate bacterial count 7-10: BV See Workup [emedicine.com]
Microbiology
- Pseudomonas
Mechanisms of antibiotic resistance in Pseudomonas aeruginosa. J R Soc Med 2002;95:22-22 Bonomo RA, Szabo D. Mechanisms or multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. [infectiousdiseaseadvisor.com]
学会等名 16th International Conference on Pseudomonas, Liverpool, UK, Sep 5-9, 2017 関連する報告書 [学会発表] Intranasal PcrV vaccination protects against acute pulmonary Pseudomonas aeruginosa infection 2017 著者名/発表者名 Naito Y, Hamaoka S, Kainuma A,Kato H, Ishii JK, [kaken.nii.ac.jp]
Gram-negative infections include those caused by Klebsiella, Acinetobacter, Pseudomonas aeruginosa, and E. coli., as well as many other less common bacteria. [cdc.gov]
Risk of otitis externa after swimming in recreational fresh water lakes containing Pseudomonas aeruginosa. BMJ 1995 ; 311 : 1407 – 1410. 21. Barben, J, Hafen, G, Schmid, J. [cambridge.org]
- Gram-Positive Bacteria
Tags: Gram-negative bacteria Gram-positive bacteria [medimoon.com]
As a result, Gram-negative bacteria are not destroyed by certain detergents which easily kill Gram-positive bacteria. [blog.eoscu.com]
Gram-negative bacteria have a thin membrane, which is nearly "bulletproof.” Gram-positive bacteria have a big, thick membrane. Image: Structure of Gram-positive cell wall. [info.achs.edu]
bacteria (8 species) but only in Staphylococcus aureus of four gram-positive species tested. [jb.asm.org]
Paralleling the developments in Gram-positive bacteria, infections caused by multidrug-resistant (MDR) Gramnegative bacilli have become a growing challenge. [ingentaconnect.com]
- Staphylococcus Aureus
Soon after development, researchers quickly identified Staphylococcus aureus strains resistant to methicillin, termed methicillin-resistant Staphylococcus aureus (MRSA). [news-medical.net]
aureus of four gram-positive species tested. [jb.asm.org]
aureus LLT 14.1 10021881 - Infections and infestations 10004040 Bacterial infection due to streptococcus, group G LLT 14.1 10021881 - Infections and infestations 10018657 Gram-negative bacterial infection NOS LLT [clinicaltrialsregister.eu]
Staphylococcus aureus. Vol. 409, Issue., p. 199. CrossRef Google Scholar Ramsay, KA Stockwell, RE Bell, SC and Kidd, TJ 2016. Infection in cystic fibrosis: impact of the environment and climate. [cambridge.org]
Soon after methicillin was introduced, strains of Staphylococcus aureus developed genes that made them resistant to methicillin and related drugs. These strains are called methicillin-resistant Staphylococcus aureus (MRSA). [merck.com]
- Streptococcus Pneumoniae
Disease: Version SOC Term Classification Code Term Level 14.1 10021881 - Infections and infestations 10042196 Streptococcus pneumoniae secondary bacterial infection of acute bronchitis LLT 14.1 10021881 - Infections and infestations 10053021 Gram-positive [clinicaltrialsregister.eu]
Some examples of gram-positive bacteria are mentioned below; Staphylococcus Albus Streptococcus pyogenes Streptococcus pneumonia Staphylococcus aureus Bacillus subtilis Lactobacillus bacillus anthracis Clostridium tetani Clostridium botulinum Actinomyces [medimoon.com]
Finally, and among other examples, Neisseria meningitidis with asymptomatic carriers of meningococcus in the nasopharynx, can cause respiratory infection along with other microorganisms such as Streptococcus pneumoniae. [wakopyrostar.com]
For example, Streptococcus pneumoniae ( S. pneumoniae ), which causes pneumonia, is a Gram-positive bacterium, but Escherichia coli ( E. coli ) and Vibrio cholerae, which causes cholera, are Gram-negative bacteria. [livescience.com]
An example of this phenomenon is Streptococcus pneumoniae. The LD50 cannot be determined as only a few cells of this bacterium are able to kill an entire test group. In contrast, the LD50 of Salmonella enterica is a clear demarcation of the LD100. [lecturio.com]
Treatment
Everyone, regardless of treatment group, could also receive meropenem or tigecycline if deemed necessary. Treatment lasted 7-14 days. [mdedge.com]
Initial therapies consistent with MST could result in reduced in-hospital mortality, treatment failure rate, infection-related death, percentages of patients needing therapy adjustment, and daily hospitalization cost with increased successful treatment [ncbi.nlm.nih.gov]
[…] do not need treatment BV occurring in pregnant women should be treated Treatment before cesarean delivery, total abdominal hysterectomy, or insertion of an IUD is also recommended Uncomplicated cases typically resolve after standard antibiotic treatment [emedicine.com]
Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. [drugs.com]
Prognosis
But for patients with MDR infection, adjustment relying on MST gained more benefit than non-MDR infection.Appropriate initial therapy significantly improved the prognosis of patients with gram-negative bacterial infections, but improvement was not that [ncbi.nlm.nih.gov]
What Is the Prognosis for a Person Infected With NDM-1 Producing Bacteria? The prognosis (outcome) for a person infected with NDM-1 is related to the patient's overall condition at the time of diagnosis and appropriate treatment. [emedicinehealth.com]
Prognosis Uncomplicated cases of bacterial vaginosis (BV) typically resolve after the standard antibiotic treatment. Mortality/Morbidity The prognosis for uncomplicated cases of bacterial vaginosis is generally excellent. [emedicine.com]
Prognosis In most patients, the prognosis is excellent. With appropriate therapy, complete recovery is usually attained. Patient Education Patients should be instructed about proper hygiene, which is a primary preventive measure. [emedicine.medscape.com]
Prognosis is frequently worse. Resistance to multiple antibiotic classes, including carbapenems, is growing and it compromises prophylaxis and treatment options. [link.springer.com]
Etiology
The etiology, presentation, and surgical management are reviewed. Three abdominal aortic aneurysms were infected during urinary tract sepsis and one infection occurred with Salmonella septicemia. [ncbi.nlm.nih.gov]
Overview Practice Essentials Bacterial vaginosis (BV), or nonspecific vaginitis, was named because bacteria are the etiologic agents and an associated inflammatory response is lacking. [emedicine.com]
Enterotoxigenic (ETEC): This is the most common etiology (~50%) of traveler’s diarrhea. It is found mostly in tropical or developing countries. [clinicaladvisor.com]
H. pylori -- the once controversial but today widely recognized cause of peptic ulcers -- is also regarded as a possible culprit in the etiology of dementia. [holisticprimarycare.net]
Etiology of foot intertrigo in the District of Afyonkarahisar, Turkey: a bacteriologic and mycologic study. J Am Podiatr Med Assoc. 2008 Jan-Feb. 98(1):42-4. [Medline]. Devraj A, Siva Tez Pinnamaneni V, Biswal M, Ramachandran R, Jha V. [emedicine.medscape.com]
Epidemiology
Infection Control & Hospital Epidemiology ISSN: 0899-823X EISSN: 1559-6834 URL: /core/journals/infection-control-and-hospital-epidemiology × [cambridge.org]
Assess the occurrence of resistance - epidemiology and basic mechanisms of resistance locally and globally. Identify and classify clinical infections associated with common Gram Negative Bacteria. [futurelearn.com]
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013;13(9):785–96. PubMed PubMedCentral CrossRef Google Scholar 98. [link.springer.com]
More About This Work Academic Units Epidemiology Thesis Advisors Larson, Elaine L. Degree Ph.D., Columbia University Published Here September 14, 2017 [academiccommons.columbia.edu]
Presentation Details Downloads Welcome Professor Dilip Nathwani OBE, President, BSAC Watch Video Download Video The current global and UK epidemiology of GNB infections Professor Timothy Walsh, Professor of Medical Microbiology and Antibiotic Resistance [bsac.org.uk]
Pathophysiology
Patient Education Educate patients regarding the basic pathophysiology, natural history, and risk factors of the bacterial vaginosis. [emedicine.com]
Pathophysiology Typically, the interweb space is colonized by polymicrobial flora. [emedicine.medscape.com]
Prevention
Guidelines for preventing healthcare-associated infections (Epic3) Use these national evidence-based guidelines for preventing healthcare-associated infections. [improvement.nhs.uk]
Resources Centers for Disease Control and Prevention https://www.cdc.gov IDSA—Infectious Diseases Society of America http://www.idsociety.org Canadian Resources Infection Prevention and Control Canada https://ipac-canada.org Public Health Agency of Canada [winchesterhospital.org]
Combination therapy as a tool to prevent emergence of bacterial resistance. Infection 1999;27:S24-S28 Boyer A, Doussau A, Thiebault R, et al. [infectiousdiseaseadvisor.com]
Thus we concluded that GM-CSF might play important roles in preventing Gram-negative bacterial infections in cirrhotic patients through maintaining immune system functions and homeostasis. [ncbi.nlm.nih.gov]
Dr Jonathan Folb will guide you through what antibiotic-resistant Gram-negative bacteria are, what infections they cause and what junior doctors can do to treat and help prevent these kinds of infections. [learning.bmj.com]