Symptoma

Granulocytic Sarcoma

Myeloid sarcoma

Rarely it may present as intravascular tumor aggregates called granulocytic sarcoma which presents as intracranial hemorrhage. [ncbi.nlm.nih.gov]

  • Fatigue

    Case 363 was from a 70-year-old man who had weakness and fatigue. The BM revealed AML without increased eosinophils. Conventional cytogenetic studies showed 46,XY,t(2;4)(p11.2;q12[18]/46,XY[2]. [doi.org]

    Case 221 occurred in a 5-year-old boy who had pallor, fatigue, fever, and chest and joint pain in November 2006. CT scans showed multiple lytic bone lesions in the ribs, scapula, sternum, and skull. [academic.oup.com]

  • Hypothermia

    […] this TOC Section Managing antiphospholipid antibodies and antiphospholipid syndrome in children Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response Recurrent hypoglycemia and hypothermia [haematologica.org]

  • Hemoptysis

    (h) CD2 negative Click here to view Case 2 An 18-year-old male presented with gradually progressive cough and breathlessness for 1 month, associated with occasional hemoptysis. [jahjournal.org]

    Adarsh Vennepureddy, Gautam Valecha, Srujitha Murukutla, Shafinaz Hussein and Terenig Terjanian, Bronchial myeloid sarcoma with concurrent Aspergillus fumigatus infection in a patient presenting with hemoptysis, Expert Review of Hematology, 10.1586/17474086.2015.1044747 [doi.org]

  • Epigastric Pain

    The patient presented with acute epigastric pain because of splenic infarction due to a mass consisting of myeloblasts in the pancreatic tail. The patients underwent splenectomy and distal pancreatectomy. [ncbi.nlm.nih.gov]

    Case 129 involved a 25-year-old man who entered the hospital for an acute abdomen preceded by progressively increasing epigastric pain. [academic.oup.com]

  • Hematochezia

    His hematochezia responded rapidly to induction chemotherapy and the patient remained in complete remission after 3-month follow-up. [ncbi.nlm.nih.gov]

  • Gingival Overgrowth

    She was referred to a dentist for further evaluation, revealing generalized gingival overgrowth as well as periodontal, apical disease, and bleeding of the gums. [ncbi.nlm.nih.gov]

  • Murphy's Sign

    The right upper quadrant ultrasound showed a thickened gallbladder wall with cholelithiasis, a positive sonographic Murphy sign, and marked dilatation of the common bile duct, which was up to 17 mm in diameter. [ncbi.nlm.nih.gov]

  • Sciatica

    Intervertebral disc herniation can be an incidental finding and is not always the cause of sciatica. [ncbi.nlm.nih.gov]

It may present at any stage of AML and requires appropriate workup and treatment, though generally carries a poor prognosis. [ncbi.nlm.nih.gov]

MS share morphological features similar to non-Hodgkins lymphoma and both express certain markers, such as CD43 and CD45. [2] An inadequate workup may lead to confounding diagnosis. [pediatricneurosciences.com]

Presence of musculoskeletal complaints in leukemic patient should alert the attending trauma surgeon to carry out rigorous diagnostic workup for associated and underlying pathology. [joas.in]

As the initial presentation was consistent with pelvic malignancy, workup for gynecologic and urologic malignancy was done. Cervical and endometrial biopsies were negative for malignancy, and bladder wash was suspicious for malignant cells. [hematologyandoncology.net]

  • Ovarian Mass

    Here, we report the ninth case: a 27-year-old female who presented with an ovarian mass without any underlying hematologic disorder. [ncbi.nlm.nih.gov]

This form of myeloid sarcoma is distinguished by its highly successful treatment with imatinib (the recommended treatment for FIP1L1-PDGRGA fusion gene-induced eosinophilic leukemia) rather than more aggressive and toxic therapy. [en.wikipedia.org]

Development of a treatment plan for GS in poor responders involves a systemic leukemia plan as novel therapeutics have not been investigated for treatment GS per se, but used more widely for AML. [ncbi.nlm.nih.gov]

In spite of the fact that t(8;21) is considered to be associated with good prognosis, patients with GS and spinal cord compression had less favorable prognosis than other AML patients with t(8;21). [ncbi.nlm.nih.gov]

Further studies confirmed the etiology of the tumor. On control ultrasonography, a marked decrease in tumor size 15 days after treatment was revealed. [ncbi.nlm.nih.gov]

To define clinical characteristics, epidemiology, pathologic findings, treatment options and outcomes in MS. We conducted a retrospective review of 23 patients diagnosed with MS at our institute over a period of 13 years (2002-2015). [ncbi.nlm.nih.gov]

Summary Epidemiology The exact prevalence is unknown. Clinical description The clinical presentation depends on the site of involvement. [orpha.net]

Presentation and outcomes among patients with isolated myeloid sarcoma: a Surveillance, Epidemiology, and End Results database analysis [published online October 9, 2014 ]. Leuk Lymphoma. doi: 10.3109/10428194.2014.963080. [doi.org]

Presentation and outcomes among patients with isolated myeloid sarcoma: a Surveillance, Epidemiology, and End Results database analysis. Leuk Lymphoma 56(6): 1698–1703, DOI: Lazzarotto, D Candoni, A Filì, C et al. (2017). [jbsr.be]

(This is an excellent recent review of the clinical manifestations, epidemiology, and histopathology. It discusses and compares the histopathology and immunophenotypes of several types of LC. There are several clinical and histologic photographs.) [dermatologyadvisor.com]

Pathophysiology of MS remains poorly understood, however altered homing mechanisms for myeloid lineage blasts have been implicated. [doi.org]

An understanding of how extramedullary granulocytic sarcoma of the heart appears on MDCT may decrease or prevent delays in diagnosing this uncommon, although important, complication from AML. [ncbi.nlm.nih.gov]

The addition of immunohistochemical stains can assist in preventing such misdiagnoses and should be included in all atypical lymphoma/carcinoma cases. [doi.org]

In a review of 154 patients with MS, 47% were initially misdiag-nosed as soft tissue sarcomas, non-Hodgkin lympho-mas or malignant melanomas.10 In order to prevent misdiagnosis, histologic examination is obligatory. [journalofcasereport.com]

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