Rarely it may present as intravascular tumor aggregates called granulocytic sarcoma which presents as intracranial hemorrhage. [ncbi.nlm.nih.gov]

• Massive Splenomegaly

  Massive splenomegaly was present. There was no hepatomegaly. At the same time, routine hematological investigations done revealed hemoglobin of 9.1 g/dl. [mjdrdypu.org]

  Case 237 was from a 54-year-old man with a history of persistent eosinophilia who had massive splenomegaly. The peripheral blood smear showed mild neutrophilia and eosinophilia (7.0 × 10 9 /L) and rare circulating blasts. [doi.org]

  Notably, when the patient was 12 years old, she had undergone splenectomy for massive splenomegaly and thrombocytopenia associated with infectious mononucleosis. [academic.oup.com]

• Fatigue

  Case 363 was from a 70-year-old man who had weakness and fatigue. The BM revealed AML without increased eosinophils. Conventional cytogenetic studies showed 46,XY,t(2;4)(p11.2;q12[18]/46,XY[2]. [doi.org]

  Case 221 occurred in a 5-year-old boy who had pallor, fatigue, fever, and chest and joint pain in November 2006. CT scans showed multiple lytic bone lesions in the ribs, scapula, sternum, and skull. [academic.oup.com]

• Hemoptysis

  (h) CD2 negative Click here to view Case 2 An 18-year-old male presented with gradually progressive cough and breathlessness for 1 month, associated with occasional hemoptysis. [jahjournal.org]

  Adarsh Vennepureddy, Gautam Valecha, Srujitha Murukutla, Shafinaz Hussein and Terenig Terjanian, Bronchial myeloid sarcoma with concurrent Aspergillus fumigatus infection in a patient presenting with hemoptysis, Expert Review of Hematology, 10.1586/17474086.2015.1044747 [doi.org]

• Epigastric Pain

  The patient presented with acute epigastric pain because of splenic infarction due to a mass consisting of myeloblasts in the pancreatic tail. The patients underwent splenectomy and distal pancreatectomy. [ncbi.nlm.nih.gov]

  Case 129 involved a 25-year-old man who entered the hospital for an acute abdomen preceded by progressively increasing epigastric pain. [academic.oup.com]

• Cyanosis

  There was no icterus, cyanosis, clubbing, and/or lymphadenopathy. Massive splenomegaly was present. There was no hepatomegaly. At the same time, routine hematological investigations done revealed hemoglobin of 9.1 g/dl. [mjdrdypu.org]

• Murphy's Sign

  The right upper quadrant ultrasound showed a thickened gallbladder wall with cholelithiasis, a positive sonographic Murphy sign, and marked dilatation of the common bile duct, which was up to 17 mm in diameter. [ncbi.nlm.nih.gov]

• Papilledema

  On examination she could count fingers close to the face bilaterally with fundi showing papilledema in both eyes. She had Grade 5 power in both upper limbs, Grade 3 power in the right and Grade 1 in the left lower limb respectively. [pediatricneurosciences.com]

It may present at any stage of AML and requires appropriate workup and treatment, though generally carries a poor prognosis. [ncbi.nlm.nih.gov]

MS share morphological features similar to non-Hodgkins lymphoma and both express certain markers, such as CD43 and CD45. [2] An inadequate workup may lead to confounding diagnosis. [pediatricneurosciences.com]

Presence of musculoskeletal complaints in leukemic patient should alert the attending trauma surgeon to carry out rigorous diagnostic workup for associated and underlying pathology. [joas.in]

As the initial presentation was consistent with pelvic malignancy, workup for gynecologic and urologic malignancy was done. Cervical and endometrial biopsies were negative for malignancy, and bladder wash was suspicious for malignant cells. [hematologyandoncology.net]

• Periodic Lateralized Epileptiform Discharges

  Electroencephalography demonstrated periodic lateralized epileptiform discharges. Acyclovir was initiated for herpes simplex encephalitis, however, follow-up MRI showed extension of the lesion. [ncbi.nlm.nih.gov]

• Hypercellular Bone Marrow

  The bone marrow biopsy revealed mildly hypercellular bone marrow with trilinear hematopoiesis; no granulomas or tumors were seen. Acid-fast bacillus and silver fungus stains were negative. Iron stain revealed increased iron stores. [hematologyandoncology.net]

  Bone marrow biopsy findings Bone marrow biopsy results at the time of MS diagnosis were available in 87% ( n = 20) of patients. Majority of the bone marrow biopsy samples ( n = 15) were notable for evidence of either AML or MDS. [doi.org]

This form of myeloid sarcoma is distinguished by its highly successful treatment with imatinib (the recommended treatment for FIP1L1-PDGRGA fusion gene-induced eosinophilic leukemia) rather than more aggressive and toxic therapy. [en.wikipedia.org]

Development of a treatment plan for GS in poor responders involves a systemic leukemia plan as novel therapeutics have not been investigated for treatment GS per se, but used more widely for AML. [ncbi.nlm.nih.gov]

In spite of the fact that t(8;21) is considered to be associated with good prognosis, patients with GS and spinal cord compression had less favorable prognosis than other AML patients with t(8;21). [ncbi.nlm.nih.gov]

the occurrence of GS frequently is associated with acute transformation of the disease and therefore a poor prognosis. 6 The most common sites of involvement are bone, soft tissue, lymph nodes, and skin. [mdedge.com]

Further studies confirmed the etiology of the tumor. On control ultrasonography, a marked decrease in tumor size 15 days after treatment was revealed. [ncbi.nlm.nih.gov]

Summary Epidemiology The exact prevalence is unknown. Clinical description The clinical presentation depends on the site of involvement. [orpha.net]

To define clinical characteristics, epidemiology, pathologic findings, treatment options and outcomes in MS. We conducted a retrospective review of 23 patients diagnosed with MS at our institute over a period of 13 years (2002-2015). [ncbi.nlm.nih.gov]

Epidemiology [ edit ] References: [1] Most frequently develop in the setting of AML but can occur with CML and MDS. Incidence of 2.5-9.1% in AML. Most common locations: skin, soft tissue, bone, periosteum, lymph nodes. [en.wikibooks.org]

Presentation and outcomes among patients with isolated myeloid sarcoma: a Surveillance, Epidemiology, and End Results database analysis [published online October 9, 2014 ]. Leuk Lymphoma. doi: 10.3109/10428194.2014.963080. [doi.org]

Presentation and outcomes among patients with isolated myeloid sarcoma: a Surveillance, Epidemiology, and End Results database analysis. [jbsr.be]

Pathophysiology of MS remains poorly understood, however altered homing mechanisms for myeloid lineage blasts have been implicated. [doi.org]

An understanding of how extramedullary granulocytic sarcoma of the heart appears on MDCT may decrease or prevent delays in diagnosing this uncommon, although important, complication from AML. [ncbi.nlm.nih.gov]

The addition of immunohistochemical stains can assist in preventing such misdiagnoses and should be included in all atypical lymphoma/carcinoma cases. [doi.org]

[…] pepsi stomach/GI system osteoporosis-prevention well-balanced diet(calcium,vitas &mins) weight bearing exercise, Hormone replacement therapy,no smoking moderate drink hydrocele an accumulation of fluid in a saclike cavity esp. in scrotum. [cueflash.com]