Presentation
The neutrophils in the bronchoalveolar space present as a heterogeneous population with very few pre-/pro-Neu and three mature subsets. [frontiersin.org]
Entire Body System
- Sepsis
Early Expansion of Circulating Granulocytic Myeloid-derived Suppressor Cells Predicts Development of Nosocomial Infections in Patients with Sepsis. [frontiersin.org]
- Inflammation
J Inflamm (Lond) (2020) 17:33. doi: 10.1186/s12950-020-00263-3 CrossRef Full Text | Google Scholar 82. Nicolai L, Leunig A, Brambs S, Kaiser R, Joppich M, Hoffknecht M, et al. [frontiersin.org]
Workup
Serum
- Neutrophilia
Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19. Front Pharmacol (2020) 11:870. doi: 10.3389/fphar.2020.00870 PubMed Abstract | CrossRef Full Text | Google Scholar 97. [frontiersin.org]
Treatment
Further, the aforementioned Navarixin, together with other CXCR2 inhibitors, has been proposed as treatment for COVID-19 (95). [frontiersin.org]
Etiology
Clearly, much more work is necessary to comprehensively connect the transcriptionally described subpopulations to cellular functions as well as their role in etiologies and disease outcomes. [frontiersin.org]
Pathophysiology
Neutrophils in COVID-19 Pathophysiology of severe COVID-19 is marked by altered neutrophil abundance, phenotype and functionality. [frontiersin.org]
Prevention
Here, the HIF-NFκB axis represents an additional checkpoint to prevent unwanted effector functions. HIF-1α is expressed at low levels in circulating neutrophils, but upregulated in hypoxic conditions of inflamed tissue (34). [frontiersin.org]