Presentation
We describe a 53-year-old male thymoma patient who presented with respiratory symptoms caused by granulomatous lung disease and an opportunistic infection. [ncbi.nlm.nih.gov]
[…] diarrhea, and anal fissures before presenting to a physician. [journals.lww.com]
Other infectious diseases present in their patients were CMV, Pneumocystis jirovecii, infectious diarrhea, and tuberculosis. [kjim.org]
Immune System
- Cervical Lymphadenopathy
He had a bilateral malar rash, tender cervical lymphadenopathy, swelling of parotid and submandibular glands, and arthritis affecting the bilateral metacarpophalangeal joints of the hands. [jmedicalcasereports.biomedcentral.com]
Entire Body System
- Pain
Her cough was initially nonproductive, but she eventually developed blood-tinged green sputum, pleuritic chest pain, and persistent fevers and chills. This article appears in HSS Journal: Volume 2, Number 2. [hss.edu]
When granulomas form in the lungs, a person may experience coughing, wheezing or chest pain. Fatigue, night sweats, and weight loss are also common to the disease. Sarcoidosis has a variable course. [livestrong.com]
Pain in the hands, feet, or other bony areas due to the formation of cysts (an abnormal sac-like growth) in bones. Kidney stone formation. Enlarged liver. [webmd.com]
In the following months, the patient gradually developed severe activity related right hip pain. Six months post-revision, the patient developed erythema nodosum of the left leg and bilateral chorioretinitis and papilledema. [synapse.koreamed.org]
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- Pathologist
Pathologists will find this book tremendously helpful when faced with difficult cases of interstitial lung disease or lung granulomas. It should be part of every surgical pathologist's library. [books.google.com]
This review is aimed at surgical pathologists who encounter granulomas in lung specimens. [ncbi.nlm.nih.gov]
The ILD team at UT Southwestern includes pulmonologists, an ILD-trained nurse practitioner, a thoracic radiologist, and a pulmonary pathologist who meet weekly to discuss cases and reach agreement about the underlying ILD diagnosis. [utswmedicine.org]
- Falling
Treatments generally fall into two categories -- maintenance of good health practices and drug treatment. [webmd.com]
[…] tissue - slow growth in culture - PCR Difficult to kill They have no toxins or histolytic enzymes they inhibit phagosome-lysosome fusion and killing by macrophages they induce delayed hypersensitivity TUBERCULOSIS 5 Developed countries – considerable fall [slideplayer.com]
Subtypes Although there are almost 200 potential forms of ILD, the vast majority (95 percent) will fall into one of the following categories: Autoimmune disease – People with autoimmune disease like rheumatoid arthritis, scleroderma, systemic lupus erythematosis [utswmedicine.org]
- Malaise
[…] and main bronchi resulting from fibrosis -Steroids and immunosuppression -Common spontaneous remission -Overall good prognosis -Relapses occur Hypersensitivity pneumonitis (HP) -Acute: responds to steroids -Sx include cough, fever, chest tightness, malaise [brainscape.com]
[…] of presumed Crohn’s disease at age 16 years, on the basis of peri-anal fistula with compatible histopathological features and spontaneous healing without medical intervention, presented to our facility with a 10-day history of fever (39°C to 40°C), malaise [jmedicalcasereports.biomedcentral.com]
- Chronic Infection
Chronic granulomatous disease (CGD) is an inherited disorder in which certain immune system cells do not function properly. This leads to repeated and severe infections. [medlineplus.gov]
Prevention and Control of Infection. Acute respiratory infection can be fatal in patients with chronic airflow limitation. [medical-dictionary.thefreedictionary.com]
Respiratoric
- Pulmonary Disorder
Called also chronic obstructive pulmonary disease. Chronic airflow limitation has the highest morbidity rate of any significant chronic pulmonary disorder in the United States and is the second most common cause of hospital admissions. [medical-dictionary.thefreedictionary.com]
View Article Google Scholar Fairfax AJ, Haslam PL, Pavia D, Sheahan NF, Bateman JR, Agnew JE, Clarke SW, Turner-Warwick M: Pulmonary disorders associated with Sjögren’s syndrome. Q J Med. 1981, 50: 279-295. [jmedicalcasereports.biomedcentral.com]
- Persistent Cough
Most patients initially complain of a persistent dry cough, fatigue, and shortness of breath. Other symptoms may include: Tender reddish bumps or patches on the skin. Red and teary eyes or blurred vision. Swollen and painful joints. [webmd.com]
- Respiratory Distress
Having diagnosed Good's syndrome, we continued supportive ventilatory care and antibiotic treatment for acute respiratory distress syndrome. [kjim.org]
- Chronic Cough
ILD is typically associated with symptoms like chronic cough and shortness of breath. The clinical course of ILD varies widely. [utswmedicine.org]
Gastrointestinal
- Diarrhea
Up to 50% of patients present with diarrhea, abdominal pain, and failure to thrive. Pneumonia, abscesses, cellulitis, adenitis and osteomyelitis are common. [orpha.net]
Other infectious diseases present in their patients were CMV, Pneumocystis jirovecii, infectious diarrhea, and tuberculosis. [kjim.org]
CGD can cause many types of skin infections that are hard to treat, including: Blisters or sores on the face (impetigo) Eczema Growths filled with pus (abscesses) Pus-filled lumps in the skin (boils) CGD can also cause: Persistent diarrhea Swollen lymph [medlineplus.gov]
[…] the 1 reported case of a patient with Crohn disease who presented with pulmonary findings preceding the gastrointestinal manifestations, the patient had already developed classic gastrointestinal symptoms of Crohn disease, including abdominal pain, diarrhea [journals.lww.com]
- Failure to Thrive
Up to 50% of patients present with diarrhea, abdominal pain, and failure to thrive. Pneumonia, abscesses, cellulitis, adenitis and osteomyelitis are common. [orpha.net]
Cardiovascular
- Hypertension
Divided into two sections, the first part provides and update on general issues and introduces both interstitial lung disease and associated pulmonary hypertension. [books.google.com]
We consider that addressing coexisting conditions such as sleep apnea, gastroesophageal reflux, and pulmonary hypertension are important to your overall care. [utswmedicine.org]
microscopic Lung, interstitial fibrosis, Trichrome stain, microscopic Lung, sarcoidosis, radiograph Lung, diffuse alveolar damage, gross Lung, diffuse alveolar damage, microscopic Lung, honeycomb change, gross Lung, plexiform lesion with pulmonary hypertension [library.med.utah.edu]
Hepatic involvement and portal hypertension predict mortality in chronic granulomatous disease. Gastroenterology. 2008;134(4):1917-1926. DOI: 10.1053/j.gastro.2008.02.081 [ Links ] 30. [scielo.org.mx]
Liver, Gall & Pancreas
- Hepatosplenomegaly
A chest X-ray was clear and computed tomography (CT) revealed a small amount of pleural effusion in addition to lymphadenopathy in bilateral cervical, mediastinal and peritoneal areas, and hepatosplenomegaly. [jmedicalcasereports.biomedcentral.com]
Skin
- Eczema
CGD can cause many types of skin infections that are hard to treat, including: Blisters or sores on the face (impetigo) Eczema Growths filled with pus (abscesses) Pus-filled lumps in the skin (boils) CGD can also cause: Persistent diarrhea Swollen lymph [medlineplus.gov]
Neurologic
- Insomnia
Cancer Connect 4 days Cancer Survivorship: Insomnia and Sleep Disturbance Dr. Barrie Cassileth Chief of Integrative Medicine MSKCC. Mind body therapy, medication, exercise, CAM all play a role. [news.cancerconnect.com]
Workup
At that point, the patient was admitted to the hospital for further workup. [journals.lww.com]
Treatment
Outcome was favorable for all the patients, with either discontinuation or maintenance of anti-TNF-alpha treatment. [ncbi.nlm.nih.gov]
This treatment has been partially successful. [emedicine.medscape.com]
The disease is known to affect people of all age groups and while around 40% patients respond well to treatment, over 40% develop anatomical problems and long-term pulmonary complications. [buzzle.com]
Treatments generally fall into two categories -- maintenance of good health practices and drug treatment. [webmd.com]
Prognosis
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Prognosis The prognosis has greatly improved with the use of antibacterial and antifungal prophylaxis therapy, with most patients living well into adulthood. The documents contained in this web site are presented for information purposes only. [orpha.net]
[…] adenopathy most common finding -Upper and mid lung shows coarse reticular and cystic changes and volume loss, upward displacement of the hila and main bronchi resulting from fibrosis -Steroids and immunosuppression -Common spontaneous remission -Overall good prognosis [brainscape.com]
Patients with absent NADPH oxidase activity and poor prognosis have been recommended for early HSCT. [emedicine.medscape.com]
Determining the specific type of interstitial lung disease is essential in order to predict prognosis and outline appropriate therapies. [utswmedicine.org]
Etiology
Abstract Granulomatous lung diseases, such as sarcoidosis, hypersensitivity pneumonitis, Wegener's granulomatosis, and chronic beryllium disease, along with granulomatous diseases of known infectious etiologies, such as tuberculosis, are major causes [ncbi.nlm.nih.gov]
other autoimmune Hx for granulomatous lung disease -Travel: bakersfield associated w/ coccidiomycosis -Occupation: farms usually associated w/ fungi and/or hypersensitivity -Pigeons: hypersensitivity -Multisystem granulomatous disease w/ no known etiology [brainscape.com]
Unlike most pathology textbooks, diseases are grouped on the basis of pathologic findings rather than etiology, mirroring the actual practice of surgical pathology. [books.google.com]
Etiology Infection Atypical Mycobacteria Brucellosis (see Brucellosis, [[Brucellosis]]) Coccidioidomycosis (see Coccidioidomycosis, [[Coccidioidomycosis]]) Histoplasmosis (see Histoplasmosis, [[Histoplasmosis]]) Leishmaniasis (see Leishmaniasis, [[Leishmaniasis [mdnxs.com]
This project will also characterize the potential etiologic roles of reproducibly associated sarcoidosis risk variants by examining important smoking exposure and disease severity subgroups to determine whether disease risk depends on smoking history [grantome.com]
Epidemiology
This article reviews the epidemiologic, clinical, pathologic, and radiologic features of sarcoidosis, hypersensitivity pneumonitis, berylliosis, and the five entities traditionally classified as pulmonary angiitis and granulomatosis. [ncbi.nlm.nih.gov]
[…] largest cause of a death from a single pathogen TB kills twice as many adults as AIDS, malaria and other parasitic diseases combined > 80% of TB toll in developing countries is in the economically most productive age-group (15-60 years) TUBERCULOSIS - Epidemiology [slideplayer.com]
Summary Epidemiology The average worldwide birth prevalence is estimated at 1/ 217,000. Clinical description CGD can present at any age but is most commonly diagnosed before the age of 5 years. [orpha.net]
Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in France. Pediatr Infect Dis J. 2011;30(1):57-62. DOI: 10.1097/INF.0b013e3181f13b23 [ Links ] 20. [scielo.org.mx]
Pathophysiology
Chronic granulomatous disease: epidemiology, pathophysiology, and genetic basis of disease. J Pediatric Infect Dis Soc. 2018;7(Suppl 1):S2-S5. DOI: 10.1093/jpids/piy008 [ Links ] 3. Rawat A, Bhattad S, Singh S. Chronic granulomatous disease. [scielo.org.mx]
Prevention
Primary prevention of this disease relies on ventilation and good use practices. Secondary prevention of this disease requires education of both the general public and clinicians to allow for the early diagnosis of this disease. [ncbi.nlm.nih.gov]
الصفحة 158 - Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. [books.google.com]
Cancer Connect 3 days Overview of Melanoma Melanoma: Signs & Symptoms, Diagnosis, Screening, Prevention & Early Detection Cancer Connect 3 days Sunscreen May Reduce Risk of Melanoma Regular use of sunscreen may help prevent melanoma. [news.cancerconnect.com]
Prevention Since CGD is a hereditary disorder, it cannot currently be prevented. Patients and their families may benefit from genetic counseling. [medical-dictionary.thefreedictionary.com]
PDF: Lifeguard Lung This study found that lifeguards in the subject swimming pool developed granulomatous lung disease associated with endotoxin-containing respirable bioaerosols from water spray features, which ventilation system improvements did not prevent [paddockevacuator.com]