There are, however, a few reports of granulomatous muscle disease presenting with flexion contractures of the limbs. [ncbi.nlm.nih.gov]

We herein report on an unusual presentation of sarcoidosis in a 16-year-old adolescent. Case presentation A 16-year-old previously healthy Caucasian female presented with fatigue, nausea and weight loss of 10 kg over a three month period. [ped-rheum.biomedcentral.com]

• Lymphadenopathy

  She lacked clinical and physical findings of arthritis, weakness, rash, uveitis, fever, lymphadenopathy or respiratory symptoms. [ncbi.nlm.nih.gov]

  A chest radiograph was negative for lymphadenopathy or parenchymal changes. A contrasted CT scan of the chest, abdomen and pelvis also showed no lymphadenopathy or hepatosplenomegaly. [ped-rheum.biomedcentral.com]

  Leg Ulcers 300 LeggCalvéPerthes Disease 301 Leptomeningeal Lesions 302 Leukoplakia Oral Hairy Oral Hairy Cell Leukoplakia 303 Lichen Simplex Chronicus 304 Listeriosis 305 Liver Lesions Benign Often Confused with Malignancy 306 Lumbar Disk Syndrome 307 Lymphadenopathy [books.google.com]

• Dysphagia

  Three of the five patients with isolated GM had predominantly distal muscle involvement, and two had dysphagia. Corticosteroid treatment was followed by prolonged improvement in only one patient with sarcoidosis. [ncbi.nlm.nih.gov]

  Pharyngeal weakness causes dysphagia. Weakness may vary from week to week or month to month. Only a third have pain. There is no rash. [patient.info]

  Symmetrical proximal or distal muscle weakness is the rule in the clinical presentation and is sometimes associated with dysphagia. [link.springer.com]

  S 1976 35 Dysphagia due to granulomatous myositis of the cricopharyngeus muscle; physiological and cineradiographic studies prior to and following successful surgical therapy. ( 13912620 ) SIEGEL CI...MENDELOFF AI 1961 [malacards.org]

• Regurgitation

  […] s disease who discontinued infliximab: a case report and review of the literature Sanam Verma, Karen I Kroeker & Richard N Fedorak BMC Gastroenterology (2013) Recurrent mitral valve regurgitation with neutrophil infiltration in a patient with multiple [nature.com]

  MalloryWeiss Tear 314 Mastoiditis 315 Mediastinitis Acute 316 Melanocytic Nevi Moles 317 Melanonychia 318 Menieres Disease 319 Meningitis Chronic 320 Menopause 321 Metabolic Syndrome 322 Metatarsalgia 323 Microcytosis 324 Mild Cognitive Impairment 325 Mitral Regurgitation [books.google.com]

  Weakness of the muscles of the oropharynx and the esophagus may lead to dysphagia, nasal regurgitation, and/or aspiration. Esophageal involvement is more common in the elderly and increases the chance of aspiration pneumonia. Cardiac. [ahcmedia.com]

• Vascular Disease

  Vascular disease. Infective process. ?Motor neuron disease. Myopathic: Inflammatory: Polymyositis. Inclusion body myositis. Dermatomyositis. Duchenne muscular dystrophy. Becker muscular dystrophy. Limb-girdle muscular dystrophy. Myotonic dystrophy. [librepathology.org]

• Osteoporosis

  […] and Ito 351 Nodules Painful 352 Nystagmus Monocular 353 Ocular Foreign Body 354 Ophthalmoplegia1 355 Optic Atrophy 356 Oral Mucosa Pigmented Lesions 357 Oral Ulcers Acute 358 Orbital Lesions Cystic 359 Orofacial Pain 360 OsgoodSchlatter Disease 361 Osteoporosis [books.google.com]

  Complications of steroid therapy - eg, osteoporosis, myopathy. Prognosis [ 15 ] The prognosis of the idiopathic inflammatory myopathies is very variable. An associated malignancy indicates a poor prognosis for recovery and increases mortality. [patient.info]

  The only other supported dx is osteoporosis. I am still on 5 mg of prednisone, and became even weaker during a recent attempt to taper. I am a formerly athletic, health and weight conscious, 59 yr old female, homebound, now barely ambulatory. [myositis.org]

  It is also recommended that patients start prophylactic calcium (1000-1500 mg/day), vitamin D (400-800 IU daily), and a proton pump inhibitor (PPI) for GI prophylaxis even though the PPI can predispose a patient to osteoporosis. [ahcmedia.com]

• Eruptions

  Peritoneal Carcinomatosis 383 Peritonitis Secondary 384 Periumbilical Swelling 385 Photodermatoses 386 Pinworms 387 Pityriasis Alba 388 Pleural Effusions 389 Pneumonia Bacterial 390 Pneumonia Recurrent 391 Polyarteritis Nodosa 392 Polymorphous Light Eruption [books.google.com]

  Hydroxyurea-induced dermatomyositis-like eruption. Br J Dermatol 1995; 133:455–459. CrossRef PubMed CAS Google Scholar Sibilia J, Sordet C, Goetz J. «Les autoanticorps dans les myopathies inflammatoires» in LFB éd.. [link.springer.com]

  Heliotrop rash is a term for a violaceous eruption in the upper eyelids, often accompanied by eyelid swelling. Shawl sign or V sign is a diffuse photosensitive, erythematous rash over the upper chest and neck in a V-shaped distribution. [ahcmedia.com]

In extensive diagnostic workup underlying primary granulomas forming diseases were excluded and corticoid therapy was initiated, but without clinical effect. [ncbi.nlm.nih.gov]

Conclusions Sarcoidosis should be considered in patients presenting with symptomatic hypercalcemia with no apparent causes and negative routine workup. [ped-rheum.biomedcentral.com]

• Colitis

  Granulomatous myositis and myopathy associated with Crohn's colitis. N Engl J Med 1976; 295 : 818–819. 5. Jain, S, Gottlob, I. Orbital myositis associated with ulcerative colitis. Am J Gastroenterol 2001; 96 : 3442–3444. [nature.com]

  […] granulomatous myositis. ( 29502295 ) Alvarado-Rybak M....Soto-Azat C. 2018 3 Extranodal NK/T-cell Lymphoma Mimicking Granulomatous Myositis: A Case Report. ( 30146568 ) Kawaguchi N...Nakashima I 2018 4 Non-granulomatous myositis in a patient with ulcerative colitis [malacards.org]

  Granulomatous myositis and myopathy associated with crohn's colitis. N Engl J Med. 1976 Oct 7;295(15):818–819. [PubMed] [Google Scholar] Pascuzzi RM, Roos KL, Phillips LH., 2nd Granulomatous inflammatory myopathy associated with myasthenia gravis. [ncbi.nlm.nih.gov]

  Immune Thrombocytopenic Purpura 277 Impotence 278 Incontinence Fecal 279 Infertility Male 280 Influenza 281 Interstitial Cystitis 282 Intracranial Lesion 283 Irritable Bowel Syndrome 284 Ischemic Colitis Nonocclusive 285 Jaundice 286 Jaundice in the Adult [books.google.com]

  […] amyotrophic lateral sclerosis ALS 全身性強皮症 Systemic Scleroderma SSc 皮膚筋炎 Dermatomyositis DM 多発性筋炎 polymyositis PM 特発性血小板減少性紫斑病 Idiopathic Thrombocytopenic Purpura ITP 結節性多発動脈炎 Polyarteritis nodosa PN 顕微鏡的多発血管炎 Microscopic PolyAngitis MPA 潰瘍性大腸炎 Ulcerative colitis [nanbyou-soudan.jp]

Steroids are the first line of treatment. It is unfortunate that you did not improve with this. In your case, other immune suppression treatments would be alternative treatment options. These include: 1. Methotrexate, 2. Azathioprine, 3. [healthmagic.gq]

There are a number of over the counter treatment options available to help you get rid of Inclusion Body Myositis but only a doctor can help you recommend a suitable treatment or an appropriate medication which can help you get rid of this disorder. [inclusionbody.wordpress.com]

Corticosteroid treatment was followed by prolonged improvement in only one patient with sarcoidosis. [ncbi.nlm.nih.gov]

Prognosis [ 15 ] The prognosis of the idiopathic inflammatory myopathies is very variable. An associated malignancy indicates a poor prognosis for recovery and increases mortality. [patient.info]

Involvement of respiratory muscles in these patients is associated with a poor prognosis. Esophagus. [ahcmedia.com]

Long-term prognosis of patients with juvenile dermatomyositis initially treated with intravenous methylprednisolone pulse therapy. Clin Exp Rheumatol. 1999 Sep-Oct. 17(5):621-4. [Medline]. [emedicine.medscape.com]

Patients with myositis are diagnosed at an earlier age and have a worse prognosis. Myositis, muscle atrophy, microtubular inclusion, and mononuclear cell infiltrates are found at histology [ 2 ]. [ajronline.org]

This type of lesion is compatible with a parasitic etiology. In fact, some muscle fibers were spotted with Sarcocystis spp. cysts within their cytoplasm, but those were not associated with the lesions. [cresa.cat]

Our case underscores the importance of considering sarcoidosis or granulomatous myositis in patients who present with hypercalcemia of unclear etiology and reinforces the need for tissue diagnosis and exclusion of other causes. [ped-rheum.biomedcentral.com]

“Inflammatory Muscle Disease: Etiology and pathogenesis, in Rheumatology”. 2003. pp. 1523-1536. Nirmalananthan, N, Holton, J.L, Hanna, M.G. “Is it really myositis? A consideration of the differential diagnosis”. [rheumatologyadvisor.com]

Recurrent scratching of skin is believed to play a role in the etiology of these lesions. [ahcmedia.com]

Granulomatous myositis General Etiology: [34] Sarcoidosis Idiopathic Infectious ( Tuberculosis, Syphillis, Brucellosis Foreign-body reaction Thymoma - myasthenia gravis Lymphoma - paraneoplastic Primary biliary cirrhosis Sarcoidosis ( H&E ) Granulomatous [librepathology.org]

Endomysium - histological slide Epidemiology The condition affects people with African or Caribbean ancestry at almost double the rate that it affects Caucasians. [kenhub.com]

Epidemiology Polymyositis tends to present between 30 and 60 years of age with a smaller peak at about 15 years of age. Dermatomyositis can occur in people of any age. [patient.info]

Idiopathic inflammatory myopathies: epidemiology, classification, and diagnostic criteria. Rheum Dis Clin North Am 2002; 28:723–741. CrossRef PubMed Google Scholar Cherin P, Marie I. [link.springer.com]

Epidemiology The idiopathic inflammatory myopathies are rare disorders. The overall annual incidence is approximately 1 in 100,000. [ahcmedia.com]

Moreover, further evidence is warranted that titin and, particularly, ryanodine receptor antibodies may co-occur or be pathophysiologically involved in myasthenia-myositis cases. [ncbi.nlm.nih.gov]

Pathophysiology On muscle biopsy, the muscle cells show small rimmed vacuoles, and no evidence of inflammation. This separates it from the inflammatory myopathies such as polymyositis and dermatomyositis. [kenhub.com]

These organized collections of immune cells have important pathophysiologic action including cytokine production leading to inflammation as well as enzymatic conversion of cholecalciferol to calcitriol via 1-α hydroxylase. [ped-rheum.biomedcentral.com]

It appears increasingly that myositis-specific autoantibodies play a specific role in the pathophysiology of the idiopathic inflammatory myopathies. [ahcmedia.com]

Rapidly find the answers you need with separate sections on diseases and disorders, differential diagnosis, clinical algorithms, laboratory results, and clinical preventive services, plus an at-a-glance format that uses cross-references, outlines, bullets [books.google.com]

As we all know this disorder is caused by serious autoimmune disturbances therefore it cannot be prevented without any special treatment that hits the right target and act against the symptoms of this disease. [inclusionbody.wordpress.com]

These include physical therapy and rehabilitation, prophylactic measures to prevent aspiration, avoiding decubitus ulcers and DVTs in bedridden patients, and educating patients with dermatomyositis to avoid UV light and sun exposure. 24 Successful management [ahcmedia.com]