The diagnosis was established based on histopathologic findings long before the disease's characteristic clinical presentation appeared... [read.qxmd.com]

These atypical presentations of MF may be difficult to diagnose, requiring a high level of suspicion and careful clinicopathologic correlation. [scholars.northwestern.edu]

We report this peculiar SS presentation that clinically resembles GSS, but with histopathology that does not show the typical features of this condition. [miami.pure.elsevier.com]

Lymphocytes and giant cells are sometimes present into the walls of several medium and large vessels—granulomatous vasculitis (Fig. 60.6 ). [plasticsurgerykey.com]

None of these therapies, however, present sustained satisfactory results. [ncbi.nlm.nih.gov]

• Weight Loss

  Systemic symptoms may include fever, weight loss, lymphadenopathy and hepatosplenomegaly. There may be haemophagocytosis. Episodic eruptions may be precipitated by insect bites. The condition overlaps with NK/T cell lymphoma, nasal type. [e-immunohistochemistry.info]

  Affected individuals may also experience weight loss, fevers, and joint pain (arthralgia). [rarediseases.org]

  In such cases, the general signs and symptoms of GSS may include: Unintentional weight loss; changes in appetite Fatigue and weakness, headache High temperatures and excessive night sweats (may be recurrent) Anemia (low red blood cell count) Low lymphocyte [dovemed.com]

• Crying

  Blepharochalasis: something to cry about. Journal of Cutaneous Pathology. 2017 Mar. Vol. 44, Issue 3: Ortiz-Perez S, Patel BC. Blepharochalasis Syndrome. StatPearls [Internet]. 2021 Jan; updated 2021 Feb 25. [Full Text]. Chinmayee J. T., Ramesh T. [emedicine.medscape.com]

• Aspiration

  Computerized tomography of the chest, abdomen and pelvis showed shotty pulmonary, mesenteric and retroperitoneal lymph nodes; however fine needle aspiration cytology/biopsy could not done as the patient did not give her consent. [ijdvl.com]

  Complete blood count, biochemistry, chest X-ray, fine-needle aspiration of the inguinal lymph node, and bone marrow biopsy were performed without alterations. [ncbi.nlm.nih.gov]

• Diarrhea

  […] neurological symptoms such as the following may be observed: Confusion Tinnitus (ringing in the ears) Hearing and visual impairment If the gastrointestinal (GI) tract is involved, then GI tract symptoms such as the following may be observed: Ulcers Diarrhea [dovemed.com]

• Hypertension

  We report a unique case of granulomatous lung involvement in a patient with granulomatous slack skin syndrome, complicated by pulmonary hypertension. [omicsonline.org]

• Cutis Laxa

  laxa Elastic tissue topic Atrophy Cutis laxa Elastic tissue description Marshall´s syndrome is a form of acquired cutis laxa without systemic involvement, which is preceded by an inflammatory dermatitis with a neutrophilic component. [oasisbr.ibict.br]

  A 39-year-old man had a two-year history of three indurated plaques that progressively underwent a cutis laxa-like transformation. Histopathologically a granulomatous, deep, dermal infiltrate was observed. [ncbi.nlm.nih.gov]

• Urticaria

  CME Diseases & Conditions Acne Actinic Keratosis Aesthetic Dermatology Atopic Dermatitis Autoimmune Diseases Contact Dermatitis Hair & Nails Melanoma Nonmelanoma Skin Cancer Pigmentation Disorders Psoriasis Psoriatic Arthritis Rare Diseases Rosacea Urticaria [mdedge.com]

• Blister

  Close morphological similarity of MF is seen with hydroa-like CTCL, an unusual pediatric malignancy with an impressive cutaneous rash characterized by edema, blisters, ulcers, crusts and scars, resembling hydroa vacciniforme. [e-ijd.org]

• Blepharoptosis

  OUTCOME OF LEVATOR REATTACHMENT SURGERY FOR BLEPHAROPTOSIS IN BLEPHAROCHALASIS. Journal of Evidence Based Medicine and Healthcare. 2016 Aug 01. Vol. 3, no. 69:3743 – 3747. Collin JR, Beard C, Stern WH, Schoengarth D. Blepharochalasis. [emedicine.medscape.com]

Further invasive workup such as additional lung biopsies or bronchoscopic studies was not pursued because the previous studies were unremarkable. [omicsonline.org]

• Lymphocytic Infiltrate

  In both cases the excised material confirmed the former diagnosis of GSS and revealed a very deep, muscular infiltrate of neoplastic lymphocytes. One year later, a new excision of GSS on the axillae was made. [ncbi.nlm.nih.gov]

Stable or progressive disease was observed in most patients despite various treatment modalities. [ncbi.nlm.nih.gov]

Recurring tumors have worse prognosis compared to tumors that do not recur Response to treatment: Tumors that respond to treatment have better prognosis compared to tumors that do not respond to treatment Progression of the condition makes the outcome [dovemed.com]

prognosis is usually excellent with appropriate therapy. [dovemed.com]

It is not life-threatening, however its association with other neoplasm changes the prognosis.44 Yamashita T, Abbade LP, Marques ME, Marques SA. [scielo.br]

Diffuse positivity with CD4 in the lymphoid cell infiltrate (immunoperoxidase, x100) DISCUSSION GSS is a rare entity with good prognosis, recognized as a variant of mycosis fungoides. [ncbi.nlm.nih.gov]

This article reviews its literature on the etiology, clinical findings, and treatment of Granulomatous Slack Skin Disease. [ncbi.nlm.nih.gov]

McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. [books.google.com]

The exact etiology of this condition is presently unknown. A chromosomal translocation involving t(3;9) (q12; p24) has been described. The rearrangement of T-beta cell receptor gene is seen in molecular analysis. [ijdvl.com]

(effective October 01, 2015) Signs and Symptoms Itchy, painful, peeling and reddened skin Ulcerated skin lesion s, which may become infected Diagnostic Exams Flow cytometry Immunophenotyping Peripheral blood smear Progression and Transformation None Epidemiology [seer.cancer.gov]

Data from cancer registries of the Surveillance, Epidemiology, and End Results (SEER) Program found the incidence of MF to be 0.64 per 100,000 person years, with a median age at diagnosis of 55 to 60 years. 1-3 The incidence of MF/Sezary syndrome (SS) [jddonline.com]

1814), because it resembles yaws (caused by Treponema), which is also called pian Later renamed as mycosis fungoides, due to its resemblence to mushrooms Also called cutaneous T cell lymphoma (not a good term since nonspecific as to histological type) Epidemiology [pathologyoutlines.com]

Epidemiology [ 3 ] CTCLs typically affect adults with a median age of 55-60 years; the annual incidence is about 0.5 per 100,000. [patient.info]

Despite the indolent behavior of granulomatous slack skin, its early recognition and continuous monitoring by a dermatologist becomes essential for its management and prevention of an unfavorable outcome. [ncbi.nlm.nih.gov]

The information presented here is not intended to diagnose, treat, cure or prevent any disease. Read disclaimer. [gulfdoctor.net]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

How can Granulomatous Slack Skin be Prevented? The cause of Granulomatous Slack Skin (GSS) is unknown, and hence, there are no known methods to prevent its occurrence. However, the following factors may be considered to reduce risk of GSS. [dovemed.com]