The diagnosis was established based on histopathologic findings long before the disease's characteristic clinical presentation appeared... [read.qxmd.com]

These atypical presentations of MF may be difficult to diagnose, requiring a high level of suspicion and careful clinicopathologic correlation. [scholars.northwestern.edu]

We report this peculiar SS presentation that clinically resembles GSS, but with histopathology that does not show the typical features of this condition. [miami.pure.elsevier.com]

Lymphocytes and giant cells are sometimes present into the walls of several medium and large vessels—granulomatous vasculitis (Fig. 60.6 ). [plasticsurgerykey.com]

None of these therapies, however, present sustained satisfactory results. [ncbi.nlm.nih.gov]

• Hodgkin Lymphoma

  Fluorescence in situ hybridization analysis did not reveal involvement of the JAK2 gene, located at chromosome band 9p24, and previously shown to be amplified in Hodgkin lymphoma and primary mediastinal diffuse large B-cell lymphoma. [ncbi.nlm.nih.gov]

  It has been reported in association with Hodgkin lymphoma. Morphologically, there is a dense granulomatous dermal atypical lymphocytic infiltrate, often associated with multinucleated giant cells. Destruction of elastic tissue is present. [tititudorancea.com]

  DISCUSSION Mycosis fungoides is a rare form of non-Hodgkin lymphoma, classified as cutaneous T-cell lymphoma[ 1, 2 ]. [wjgnet.com]

• Inflammation

  Granulomatous slack skin (GSS) is a rare disorder which is considered a slowly evolving T-cell lymphoma associated with granulomatous inflammation that mediates clastolysis. [ncbi.nlm.nih.gov]

  The biopsies were initially misinterpreted as xanthogranuloma or granulomatous inflammation. Histologically, the entire dermis and subcutis was infiltrated by non-necrotizing granulomas comprising mononuclear… CONTINUE READING [semanticscholar.org]

• Swelling

  We report a case occurring in a 29-year-old man, who had generalized, progressive skin lesions evolving to nodular swellings and folds in the flexural regions, and peripheral blood and marrow involvement. [ncbi.nlm.nih.gov]

  Abstract A 32-year-Old man presented with multiple subcutaneous swellings of 6 years' duration. A biopsy performed 6 years earlier, when the patient presented with papules and plaques, was I reported as tuberculoid Hansen's disease. [eprints.manipal.edu]

  […] microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling [icdlist.com]

  […] of the legs Abdominal pain and swelling; constipation Frequent urination When specific organs are affected, then the following symptoms may be observed: Non-painful swelling of lymph nodes in the neck, armpits, or groin There may be associated autoimmune [dovemed.com]

• Anemia

  It may include the following: Chemotherapy: This approach uses a combination of drugs to kill the cancerous cells and can be used in patients, for all stages of the condition There can be severe side effects including fatigue, nausea, hair loss, anemia [dovemed.com]

• Exertional Dyspnea

  The patient also developed a persistent cough and worsening exertional dyspnea five years after her diagnosis. [omicsonline.org]

  His renal function deteriorated gradually, and he complained of general fatigue and exertional dyspnea due to uremia in April 2012. [wjgnet.com]

• Skin Disease

  This article reviews its literature on the etiology, clinical findings, and treatment of Granulomatous Slack Skin Disease. [ncbi.nlm.nih.gov]

  Abstract Granulomatous slack skin disease - disease features and response to pentostatin. [publications.icr.ac.uk]

  […] of one case of generalized granulomatous slack skin. ( 16463692 ) Liu Z...Li J 2005 38 Granulomatous slack skin without evidence of a clonal T-cell proliferation. ( 14726855 ) Gadzia J...Kestenbaum T 2004 39 Granulomatous slack skin disease--disease [malacards.org]

  Granulomatous slack skin with systemic involvement and a fatal outcome in an adolescent. Clin Exp Dermatol 2014;39:653-654. Shah A, Safaya A. Granulomatous slack skin disease: a review, in comparison with mycosis fungoides. [journalofpathology.org]

• Skin Lesion

  Histopathologic examination of the skin lesion and inguinal lymph node demonstrated granulomatous infiltration with multinucleated giant cells. [ncbi.nlm.nih.gov]

  We report a case occurring in a 29-year-old man, who had generalized, progressive skin lesions evolving to nodular swellings and folds in the flexural regions, and peripheral blood and marrow involvement. [semanticscholar.org]

• Dermatitis

  Menu Close Presented by Cutis Past Issues Career For Authors Register or Login Full Menu Full Menu CME Diseases & Conditions Acne Actinic Keratosis Aesthetic Dermatology Atopic Dermatitis Autoimmune Diseases Contact Dermatitis Hair & Nails Melanoma Nonmelanoma [mdedge.com]

  […] network_name_str Anais brasileiros de dermatologia (Online) repository_id_str spelling Marshall's syndromeAtrophyCutis laxaElastic tissueMarshall´s syndrome is a form of acquired cutis laxa without systemic involvement, which is preceded by an inflammatory dermatitis [oasisbr.ibict.br]

  Spongiosis and eosinophils favour a benign diagnosis. actinic reticuloid (chronic actinic dermatitis): is a disease of the middle-aged, especially males. It is exquisitely photosensitive. [e-immunohistochemistry.info]

  -- 2005 (NCI Thesaurus) ALSO IN ENCYCLOPEDIA : Granulomatous Prostatitis Granulomatous Endometritis Granulomatous Dermatitis Granulomatous Granulomatosis with Polyangiitis (Wegener's) Granuloma of the Mouse Mammary Gland Granuloma Inguinale Granuloma [tititudorancea.com]

  Biopsy showed non-Hodgkin's lymphoma-associated granulomatous dermatitis. The patient was treated with poly-chemotherapy without clinical response. [australasiancancer.org]

• Suggestibility

  This report discusses clinically and histologically the differential diagnoses, namely granulomatous slack skin and granulomatous mycosis fungoides, and suggests that these 2 disorders are only variants in the broad spectrum of a single disease. [ncbi.nlm.nih.gov]

• Uremia

  His renal function deteriorated gradually, and he complained of general fatigue and exertional dyspnea due to uremia in April 2012. [wjgnet.com]

• Irritability

  Allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. Many skin problems, such as acne, also affect your appearance. [icdlist.com]

  […] subcutaneous telangiectasia, as observed in blepharochalasis. [6] Differential Diagnoses Amyloidosis Cavernous Sinus Thrombosis Cutis Laxa (Elastolysis) Localized cutis laxa Dacryoadenitis Dermatochalasis Floppy Eyelid Syndrome Hereditary Angioedema Irritant [emedicine.medscape.com]

  […] than the aqueous solution, can cause irritant or allergic dermatitis in sensitized individuals (35-58%), but its efficacy is similar. [e-ijd.org]

Further invasive workup such as additional lung biopsies or bronchoscopic studies was not pursued because the previous studies were unremarkable. [omicsonline.org]

Stable or progressive disease was observed in most patients despite various treatment modalities. [ncbi.nlm.nih.gov]

Recurring tumors have worse prognosis compared to tumors that do not recur Response to treatment: Tumors that respond to treatment have better prognosis compared to tumors that do not respond to treatment Progression of the condition makes the outcome [dovemed.com]

prognosis is usually excellent with appropriate therapy. [dovemed.com]

It is not life-threatening, however its association with other neoplasm changes the prognosis.44 Yamashita T, Abbade LP, Marques ME, Marques SA. [scielo.br]

Diffuse positivity with CD4 in the lymphoid cell infiltrate (immunoperoxidase, x100) DISCUSSION GSS is a rare entity with good prognosis, recognized as a variant of mycosis fungoides. [ncbi.nlm.nih.gov]

This article reviews its literature on the etiology, clinical findings, and treatment of Granulomatous Slack Skin Disease. [ncbi.nlm.nih.gov]

McKee's Pathology of the Skin is the most complete, in-depth resource on dermatopathology, covering etiology, pathogenesis, disease mechanisms, and recent genetic, molecular, and basic science data. Drs. J. [books.google.com]

The exact etiology of this condition is presently unknown. A chromosomal translocation involving t(3;9) (q12; p24) has been described. The rearrangement of T-beta cell receptor gene is seen in molecular analysis. [ijdvl.com]

(effective October 01, 2015) Signs and Symptoms Itchy, painful, peeling and reddened skin Ulcerated skin lesion s, which may become infected Diagnostic Exams Flow cytometry Immunophenotyping Peripheral blood smear Progression and Transformation None Epidemiology [seer.cancer.gov]

Data from cancer registries of the Surveillance, Epidemiology, and End Results (SEER) Program found the incidence of MF to be 0.64 per 100,000 person years, with a median age at diagnosis of 55 to 60 years. 1-3 The incidence of MF/Sezary syndrome (SS) [jddonline.com]

1814), because it resembles yaws (caused by Treponema), which is also called pian Later renamed as mycosis fungoides, due to its resemblence to mushrooms Also called cutaneous T cell lymphoma (not a good term since nonspecific as to histological type) Epidemiology [pathologyoutlines.com]

Epidemiology [ 3 ] CTCLs typically affect adults with a median age of 55-60 years; the annual incidence is about 0.5 per 100,000. [patient.info]

Despite the indolent behavior of granulomatous slack skin, its early recognition and continuous monitoring by a dermatologist becomes essential for its management and prevention of an unfavorable outcome. [ncbi.nlm.nih.gov]

The information presented here is not intended to diagnose, treat, cure or prevent any disease. Read disclaimer. [gulfdoctor.net]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

How can Granulomatous Slack Skin be Prevented? The cause of Granulomatous Slack Skin (GSS) is unknown, and hence, there are no known methods to prevent its occurrence. However, the following factors may be considered to reduce risk of GSS. [dovemed.com]