It is commonly seen in childhood but it can present in adults. Here we report a case of GRN in an adult patient with very unusual histopathological presentation. 1. [hindawi.com]

[…] with peak age of presentation 7–12 years. [ncbi.nlm.nih.gov]

• Tachycardia

  CASE REPORT: A noradrenalin secreting pheochromocytoma was found in 19-year-old girl with hyperhidrosis, granulosis rubra nasi and tachycardia. [read.qxmd.com]

  […] systemic diseases such as lupus erythematosus, lupus vulgaris and leishmaniasis important to consider other clinical manifestations because it has reported the case of a patient who presented with pheochromocytoma associated with granulosis rubra nasi tachycardia [medigoo.com]

  Case Report: A noradrenalin secreting pheochromocytoma was found in 19-year-old girl with hyperhidrosis, granulosis rubra nasi and tachycardia. [pubfacts.com]

  Heid describes a case of 19-year-old woman with hyperhidrosis, GRN, tachycardia and pheochromocytoma [12]. After surgical removal of pheochromocytoma was sweating involution and regression of the GRN. The lesions usually disappear during puberty. [odermatol.com]

• Hyperhidrosis

  Primary concerns of the patients are cosmetic and hyperhidrosis, which tend to worsen in summer. Association with primary palmoplantar hyperhidrosis, acrocyanosis, and poor peripheral circulation has been observed. [ijdvl.com]

  The condition is associated with anti-dsDNA antibodies, lacks hyperhidrosis, and is not confined to the nose. [avensonline.org]

  Persistent localized hyperhidrosis of central face is the main cause for this condition [6]. [hindawi.com]

  The eccrine glands produce and secrete sweat, a change in the rate of secretion is manifested through one hypohidrosis or hyperhidrosis. [medigoo.com]

  Granulosis rubra nasi could be a complication of hyperhidrosis. Find Full Text Links for this Article Trending Papers [read.qxmd.com]

• Sweating

  The authors believe that inflammation around sweat ducts are responsible for decreased sweating and hence, vesicle formation- findings in the late stage of GRN. [ncbi.nlm.nih.gov]

• Papule

  Lupus pernio, or chilblain lupus, consists of red or dusky purple papules and plaques not only on the nose, but also on the toes, fingers, and sometimes, elbows, knees and lower legs. [avensonline.org]

  Symptoms: Clinically, it is characterized by the presence of papules, micro-papules, pruritic with vesicles and occasional cysts, associated with diffuse erythema and persistent hyperhidrosis in nasal region, cheeks and chin. [medigoo.com]

  It is likely to represent a unique form of sweat retention with the occurrence of erythema, papules, and vesiculation as secondary changes. [ijdvl.com]

  Multiple skin-colored to erythematous papules over the alae (A) and dorsum (B) of the nose. [ncbi.nlm.nih.gov]

• Erythema

  This localized hyperhidrosis seems to be responsible for the secondary changes like erythema and erythematous papules. GRN usually disappeared spontaneously during puberty, but erythema and telangiectasia may persist. [avensonline.org]

  However, the onset of lesions is later (typically seen in middle-aged females) and the facial erythema characteristic of GRN does not occur. Persistent erythema of the central face is seen in both GRN and rosacea. [ijdvl.com]

  Beads of sweat seen on an erythematous base over the nose Shows erythema more prominently. [ncbi.nlm.nih.gov]

  Figure 2: Shows erythema more prominently. [idoj.in]

• Dermatitis

  Synonyms for granulosis rubra nasi are: a peculiar form of acne with changes in the sweat glands (Luithlen); perisyringitis chronica nasi (Jadassohn); dermatitis micropapulosa or granularis erythematosa hyperidrotica chronica nasi (infantum) (Jadassohn [jamanetwork.com]

  Clinical differential diagnoses include eccrine hidrocystoma and inflammatory or photosensitive dermatoses such as rosacea, perioral dermatitis, and lupus erythematosus. [ijdvl.com]

  In the case of perioral dermatitis there are small monomorphic papules, pustules, erythema, and scaling involving the perioral area and no hyperhidrosis. [journals.lww.com]

• Irritability

  Goldsmith had described rhino rrhea as an associated feature.[6] Eddowes had suggested that adenoids could be involved which can provide a source of irritation to the tip of the nose.[7] Heid et al. reported a case of granulosis rubra nasi associated [journals.lww.com]

  Goldsmith had described rhino rrhea as an associated feature. [6] Eddowes had suggested that adenoids could be involved which can provide a source of irritation to the tip of the nose. [7] Heid et al. reported a case of granulosis rubra nasi associated [idoj.in]

• Confusion

  The bilateral malar erythema “butterfly rash” of acute cutaneous lupus erythematosus (ACLE) is typical, and cannot be confused with GRN. [avensonline.org]

• Lymphocytic Infiltrate

  Telangiectasias are appreciable Figure 3 Histopathology section showing dilated blood vessels and eccrine ducts with surrounding lymphocytic infiltrate [H & E, 10X] Similar articles Granulosis Rubra Nasi Response to Topical Tacrolimus. [pubmed.ncbi.nlm.nih.gov]

  Telangiectasias are appreciable Figure 3: Histopathology section showing dilated blood vessels and eccrine ducts with surrounding lymphocytic infiltrate [H & E, 10X] DISCUSSION Our patient presented with granulosis rubra nasi, a rare disease. [journals.lww.com]

  Telangiectasias are appreciable Histopathology section showing dilated blood vessels and eccrine ducts with surrounding lymphocytic infiltrate [H & E, 10X] DISCUSSION Our patient presented with granulosis rubra nasi, a rare disease. [ncbi.nlm.nih.gov]

  Telangiectasias are appreciable Click here to view Figure 3: Histopathology section showing dilated blood vessels and eccrine ducts with surrounding lymphocytic infiltrate [H & E, 10X] Click here to view Our patient presented with granulosis rubra nasi [idoj.in]

Treatment: There is no local or systemic treatment effective, but can recommend the use of astringent lotions. The use of topical steroids low power are helpful to relieve symptoms. Consult your dermatology for more appropriate treatment options. [medigoo.com]

Treatment of granulosis rubra nasi with botulinum toxin type A. Dermatol Surg. 2009 Aug. 35(8):1298-9. [Medline]. Kurta AO, Glaser DA. Emerging Nonsurgical Treatments for Hyperhidrosis. Thorac Surg Clin. 2016 Nov. 26 (4):395-402. [Medline]. [emedicine.medscape.com]

Drying lotions like calamine can be tried.[3] Grazziotin et al. have recently described a treatment using botulinum toxin A that induced long-term remission in a patient with granulosis rubra nasi.[9] REFERENCES 1. [journals.lww.com]

Treatment of granulosis rubra nasi with botulinum toxin type A. Dermatol Surg. 2009;35:1298–9. [PubMed] [Google Scholar] Articles from Indian Dermatology Online Journal are provided here courtesy of Wolters Kluwer -- Medknow Publications [ncbi.nlm.nih.gov]

Prognosis The prognosis is excellent. Granulosis rubra nasi is primarily a cosmetic disorder. Patients have few physical complaints, and most occurrences resolve completely at puberty. [emedicine.medscape.com]

The epidermis, connective tissue and pilosebaceous apparatus are otherwise normal and no heterotopic apocrine glands are found.2,3 No preventive measures or complications are reported and the disease has an excellent prognosis with self resolution at [ncbi.nlm.nih.gov]

Bocian and Andrea Bettina and Rita Garc{\'i}a D{\'i}az and Amelia Laterza and Mart{\'i}n Pierini}, year={2003} } Granulosis Rubra Nasi is a rare childhood disease of unknown etiology. [semanticscholar.org]

The etiology of GRN is obscure, presentation uncommon, benign and chronic course. It occurs in childhood and spontaneous resolution in adolescence, but some cases may persist indefinitely and cysts presenting residual telangiectasias. [medigoo.com]

61 Heid E...Boivin S 8761763 1996 13 [Granulosis rubra nasi]. 61 Zuccati G...Staderini C 2279756 1990 14 [Granulosis rubra nasi: report of a new case]. 61 Raymond GP...Tetrault C 705963 1978 15 [Granulosis rubra nasi]. 61 PIATTI A 13670748 1959 16 [Etiology [malacards.org]

Discussion GRN is an inflammatory condition involving eccrine sweat glands of nose, cheeks and chin.1 This benign condition of unknown etiology and chronic course is extremely rare and the literature is dominated by case reports only. [ncbi.nlm.nih.gov]

Epidemiology Frequency Granulosis rubra nasi is rare, and the precise frequency is unknown. Significant underreporting may be a factor. Race No racial predilection has been described. Sex No sexual predilection has been described. [emedicine.medscape.com]

The term is sometimes used as a diagnostic title for hyperhidrosis of the nose. [2] Pathophysiology Pathogenesis is unknown. [emedicine.medscape.com]

Prevention No preventative measures are known. Maschkilleisson LN, Naradow LA. Jadassohns Granulosis rubra nasi. Derm Z. 1935. 71:79-84. Bolognia JL, Jorizzo JL, Rapini RP, eds. Dermatology. St. Louis, Mo: Mosby; 2003. Wenzel FG, Horn TD. [emedicine.medscape.com]

The epidermis, connective tissue and pilosebaceous apparatus are otherwise normal and no heterotopic apocrine glands are found.2,3 No preventive measures or complications are reported and the disease has an excellent prognosis with self resolution at [ncbi.nlm.nih.gov]