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Griscelli Syndrome Type 1

GS1


Presentation

  • Case Presentation Eleven Years old Saudi boy, followed up at our clinic since the age of 2 months, for Partial Albinism since birth.[omicsonline.org]
  • Tezcan I, Sanal O, Ersoy F, Uckan D, Kiliç S, Metin A, Cetin M, Akin R, Oner C, Tuncer A (1999) Successful bone marrow transplantation in a case of Griscelli disease which presented in accelerated phase with neurological involvement.[link.springer.com]
  • Griscelli syndrome has to be distinguished from Chediak-Higashi syndrome and Elejalde disease, which can also present with silvery hair.[pigmentinternational.com]
  • Primary neurological presentation is rare.[casereports.in]
  • The melanosomes are present in the center of melanocytes but must be transported to the outer part of the cells and into other cells in order to provide the pigmentation.[mybiosource.com]
Physician
  • In-Depth Information The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers.[rarediseases.info.nih.gov]
  • J Lab Physicians [serial online] 2012 [cited 2019 May 14];4:129-30. Available from: Sir, Fever is associated with multitude etiologies and its diagnosis often requires number of investigations.[jlponline.org]
  • While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis griscelli for answers to personal questions.[pdfoftheworld.us]
  • Moreover, we need to educate the physician about different phenotypes of GS.[omicsonline.org]
  • While the OMIM sindrome de griscelli is open to the public, users seeking information about a sindrome de griscelli medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.[getpdffromjax.club]
Disability
  • […] graying [ more ] 0002216 Retinopathy Noninflammatory retina disease 0000488 Seizures Seizure 0001250 White hair 0011364 30%-79% of people have these symptoms Global developmental delay 0001263 Hyperlipidemia Elevated lipids in blood 0003077 Intellectual disability[rarediseases.info.nih.gov]
  • In addition to the silvery-gray sheen of the hair and the light-colored skin, GS type 1 patients present with delayed motor development, intellectual disability and hypotonia.[orpha.net]
  • Affected individual may have intellectual disability, seizures, and weak muscle tone (hypotonia) eye and vision abnormalities.[omicsonline.org]
  • Affected individuals typically have delayed development, intellectual disability, seizures, weak muscle tone (hypotonia), and eye and vision abnormalities.[ghr.nlm.nih.gov]
Movement Disorder
  • Showing of 23 80%-99% of people have these symptoms Abnormality of movement Movement disorder Unusual movement [ more ] 0100022 Ataxia 0001251 Diplopia Double vision 0000651 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290[rarediseases.info.nih.gov]
  • Movement disorders: official journal of the Movement Disorder Society. 2004;19(4):472–5.[ojrd.biomedcentral.com]
Hypopigmented Skin
  • Griscelli syndrome is an inherited condition characterized by unusually light (hypopigmented) skin and light silvery-gray hair starting in infancy.[ghr.nlm.nih.gov]
  • Griscelli syndrome is an inherited condition characterized by unusually light hypopigmented skin and light silvery-gray hair starting in infancy.[getpdffrommia.me]
  • The features of silvery hair, cerebellar atrophy, hypopigmented skin lesions, and absence of recurrent infections was suggestive of Elejalde Syndrome. Discussion ES is a rare syndrome, which was first described by Elejalde et al. [3].[symbiosisonlinepublishing.com]
  • Since then, a little over than 60 cases of Griscelli syndrome (GS) have been reported in the medical literature in association with primary neurologic manifestations, with immunologic abnormalities or with silvery gray hair and hypopigmented skin as the[scielo.br]
Diplopia
  • Affiliated tissues include skin, bone and bone marrow, and related phenotypes are nystagmus and diplopia Disease Ontology : 12 A Griscelli syndrome characterized by silvery gray sheen of the hair, hypopigmentation of the skin and neurological impairment[malacards.org]
  • Showing of 23 80%-99% of people have these symptoms Abnormality of movement Movement disorder Unusual movement [ more ] 0100022 Ataxia 0001251 Diplopia Double vision 0000651 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290[rarediseases.info.nih.gov]
  • The neurological deficits in Elejalde syndrome were reported as severe neurodevelopmental delay, seizures, hypotonia, and ophthalmological problems including nystagmus, diplopia, and retinal problems.[link.springer.com]
Muscle Hypotonia
  • These individuals are prone to have developmental delays, seizures, weak muscle (hypotonia), vision problems and intellectual problems. This results in the defect of the gene MY05A.[mybiosource.com]
Muscle Hypotonia
  • These individuals are prone to have developmental delays, seizures, weak muscle (hypotonia), vision problems and intellectual problems. This results in the defect of the gene MY05A.[mybiosource.com]
Cerebral Calcification
  • calcification Abnormal deposits of calcium in the brain 0002514 Percent of people who have these symptoms is not available through HPO Accumulation of melanosomes in melanocytes 0001008 Autosomal recessive inheritance 0000007 Hypopigmentation of the[rarediseases.info.nih.gov]
Opisthotonus
  • These pathways complement our catalog of research reagents for the study of Griscelli Syndrome, Type 1 including antibodies and ELISA kits against MYO5A, MYOSIN VA, DILUTE-OPISTHOTONUS, MYOVA.[novusbio.com]
Paresis
  • Polyglucosan body disease, adult form 263570 GCDH 19p13.2 Glutaricaciduria, type I 231670 GCSH 16q23.2 Glycine encephalopathy 605899 GDAP1 8q21.11 Charcot-Marie-Tooth disease, axonal, type 2K 607831 Charcot-Marie-Tooth disease, axonal, with vocal cord paresis[institutobernabeu.com]
Delayed Milestone
  • Child had delayed milestones with growth retardation. On examination, child had pallor, vitals were normal. Cutaneous examination showed hypopigmented macule on face with silvery brown hair all over the body [Figure 3].[ijtrichology.com]

Workup

  • Sepsis workup and CSF study including cytospin for malignant cells were negative. LDH was mildly elevated and serum ferritin, fibrinogen levels, triglycerides were normal ruling out possibility of hemo-phagocytosis [Table 1].[casereports.in]
  • The work up for all these disorders came to be negative and child was referred to our facility for further workup.[e-ijd.org]
Enlargement of the Spleen
  • They studied seven children from five Palestinian families of common ancestry who presented in infancy with poor weight gain, enlarged livers and spleens, and severe infections or deep-seated abscesses.[medpagetoday.com]
  • […] liver and spleen Jaundice Ataxia causing incoordination and a typical ataxic gait Tremor Epilepsy Peripheral neuropathy causing motor and sensory changes and weakness (if patient survives into adulthood) [ 7 ] Differential diagnosis Initially the condition[patient.info]
Human Herpesvirus 6
  • herpesvirus 6 or in other herpesviruses, enteroviruses, or retroviruses.[checkorphan.org]

Treatment

  • Treatment - Griscelli syndrome type 1 Treatment is aimed at the cause, if one can be found. Supportive therapy includes an anti-inflammatory, an antihistamine, and rest.[checkorphan.org]
  • However the prognosis of GS3 is good where no special treatment needed [ 17, 18 ]. GS3 patients have no need for treatment and as seen in the present case the patient has attained 11 year of age and doing well with no deficit or medical illness.[omicsonline.org]
  • […] photographs of normal and abnormal skin conditions including images of rare conditions, this easily accessible resource is essential for pediatricians, neonatologists, and dermatologists as well as other healthcare professionals involved in the diagnosis and treatment[books.google.com]
  • You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.[rarediseases.info.nih.gov]
  • Since prognosis, treatment options, and genetic counseling markedly differ among different types, molecular characterization has utmost importance in GS.[link.springer.com]

Prognosis

  • Prognosis - Griscelli syndrome type 1 Not supplied. Treatment - Griscelli syndrome type 1 Treatment is aimed at the cause, if one can be found. Supportive therapy includes an anti-inflammatory, an antihistamine, and rest.[checkorphan.org]
  • Since prognosis, treatment options, and genetic counseling markedly differ among different types, molecular characterization has utmost importance in GS [ 19 ].[omicsonline.org]
  • Prognosis If not treated by HSCT, the prognosis for long-term survival in GS type 2 is relatively poor, with many patients not surviving the first decade. The prognosis of GS type 1 is good.[orpha.net]
  • Prognosis depends on the severity of neurologic manifestations. Type 2 GS patients have mutations in RAB27A and hemophagocytic syndrome, with abnormal T-cell and macrophage activation. This type has a grave prognosis if untreated.[jddonline.com]

Etiology

  • Etiology Mutations in in RAB27A (15q), which codes for a small GTPase(hemophagocytic syndrome) Mutations in MYO5A, which codes for an actin-based molecular motor (neurological involvement) The RAB27A and MYO5A gene products interact with each other and[humpath.com]
  • Etiology GS type 1 is caused by a mutation in the myosin Va (MYO5A) gene located on chromosome 15q21 and likely corresponds to Elejalde disease. GS type 2 is caused by mutations in the RAB27A encoding gene.[orpha.net]
  • Available from: Sir, Fever is associated with multitude etiologies and its diagnosis often requires number of investigations. Of interest, are certain rare entities like Hemophagocytic Lymphohistiocytosis (HLH).[jlponline.org]
  • Fever is associated with multitude etiologies and its diagnosis often requires number of investigations.[pdffilesfromalexa.website]

Epidemiology

  • Relevant External Links for MLPH Genetic Association Database (GAD) MLPH Human Genome Epidemiology (HuGE) Navigator MLPH Atlas of Genetics and Cytogenetics in Oncology and Haematology: MLPH No data available for Genatlas for MLPH Gene Genome-wide association[genecards.org]
  • Summary Epidemiology To date, approximately 150 cases have been reported, predominantly in Turkish and Mediterranean populations. GS type 2 appears to be the most common of the three known types, while GS type 3 is the least common.[orpha.net]
  • ABSTRACT:Background: Microfocused ultrasound with visualization (MFU-V) has emerged ... more Skin Cancer Epidemiology and Sun Protection Behaviors Among Native American....[jddonline.com]
  • Epidemiology Sindrome de griscelli United States. Ann Biol Clin Paris.[pdffilesfromalexa.website]
Sex distribution
Age distribution

Pathophysiology

  • Under polarized light microscopy, the hairs appear monotonously white. [2] Pathophysiology [ edit ] In melanocytes, melanosomes ( vesicles containing the pigment melanin ) are transported on microtubules.[en.wikipedia.org]
  • Griscelli Syndrome: Background, Pathophysiology, Epidemiology Griscelli syndrome type 3characterized by hypomelanosis with no immunologic or neurologic manifestations, can be caused by mutation in the melanophilin MLPH; or MYO5A genes.[getpdffrommiara.website]
  • Spanish) Genre: Software Published (Last): 12 October 2004 Pages: 148 PDF File Size: 16.7 Mb ePub File Size: 11.57 Mb ISBN: 669-7-58946-625-9 Downloads: 24711 Price: Free* [ *Free Regsitration Required ] Uploader: Tegore Griscelli Syndrome: Background, Pathophysiology[worldpdfdatabase.club]
  • Pathophysiology Griscelli syndrome is caused grsicelli mutations in 1 of 3 genes. Large granules of melanin unevenly distributed in the hair shaft were observed. Griscelli syndrome – Wikipedia Clinical Synopsis Toggle Dropdown.[pdffilesofjennifer.online]

Prevention

  • Prevention - Griscelli syndrome type 1 Not supplied.[checkorphan.org]
  • The genetic mutation affects the transportation of melanosomes thus trapping them in the center of the melanocytes preventing the normal pigmentation of the eyes, hair and skin.[mybiosource.com]
  • Light microscopic examination gdiscelli scalp hair sindrome de griscelli as an aid in the diagnosis of paediatric disorders: Mutations in either Rab27a or Munc prevented the formation of this complex and sindrome de griscelli secretion.[pdffilesfromalexa.pro]
  • Management [ 4 ] Drug Allogenic bone marrow transplantation (BMT) from an HLA-matched sibling is the treatment of choice but does not prevent the neurological disorders.[patient.info]
  • As a result, these structures clump near the center of melanocytes, trapping melanin within these cells and preventing normal pigmentation of skin and hair.[ghr.nlm.nih.gov]

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