Presentation
We present a rare case of probable DRESS secondary to griseofulvin. © 2016 Wiley Periodicals, Inc. [ncbi.nlm.nih.gov]
Entire Body System
- Fatigue
There have also been reports of dizziness and fatigue. Women can experience problems with their monthly menstrual cycle if they have a reaction to this medication. [brighthub.com]
Nervous system disturbance: Blurred vision, dizziness, depression, nightmares, fatigue. Menstrual disturbance. Liver disturbance. Griseofulvin should not be taken in pregnancy as there is a slight risk of malformation of the fetus. [dermnetnz.org]
Side Effects of Griseofulvin Common side effects include: oral thrush nausea vomiting diarrhea headache fatigue dizziness insomnia mental confusion impairment of performance of routine activities This is not a complete list of griseofulvin side effects [rxwiki.com]
Other adverse reactions include headache, dizziness, fatigue, insomnia, photosensitivity, nausea, vomiting, confusion, leukopenia, proteinuria, oral candidiasis, nephrosis, gastrointestinal bleeding and diarrhea. [aocd.org]
- Acute Intermittent Porphyria
Griseofulvin may increase attacks of porphyria in patients with acute intermittent porphyria Proper Use of This Medicine Griseofulvin is best taken with or after meals, especially fatty ones (for example, whole milk or ice cream). [mold-survivor.com]
This may precipitate an attack of acute intermittent porphyria in susceptible patients. Pregnancy Due to possible teratogenic and abortifacient effects, use of griseofulvin during pregnancy is contraindicated. [pdr.net]
- Intravenous Administration
Furthermore, this analogue proved compatible with formulations suitable for both oral and intravenous administration. Finally, 2'-benzylamine analogue 10 was confirmed to induce G2/M cell cycle arrest in vitro. Copyright © 2017 Elsevier Masson SAS. [ncbi.nlm.nih.gov]
Gastrointestinal
- Nausea
Common side effects may include: nausea, vomiting, upset stomach, diarrhea; headache, tired feeling; sleep problems (insomnia); or itching, rash. This is not a complete list of side effects and others may occur. [rxlist.com]
Griseofulvin interacts with alcohol rather like disulfiram (Antabuse) and can cause severe nausea and vomiting. [dermnetnz.org]
Common side effects include flushing, nausea, vomiting, and diarrhea. Griseofulvin may cause dizziness. Do not drive or operate heavy machinery until you know how it affects you. [rxwiki.com]
- Abdominal Pain
New chapters cover common exanthems of childhood, acne, cardiac murmur evaluation, gastrointestinal parasites, gastroesophageal reflux disease, acute abdominal pain, diabetes, and vision and hearing abnormalities. [books.google.de]
Tell your doctor right away if any of these rare but very serious side effects occur: yellowing eyes / skin, stomach / abdominal pain, persistent nausea / vomiting, dark urine, signs of kidney problems (such as change in the amount of urine, frothy urine [webmd.com]
Tiredness and joint pains. Tell your doctor if you get any of the following side effects: reactions to the sun. [drugs.com]
Musculoskeletal
- Leg Pain
A previously healthy 5-year-old boy presented with tactile fever, rash on his legs and back, swelling of his toes and fingers, and leg pain. He was being treated at the time with griseofulvin for tinea capitis. [ncbi.nlm.nih.gov]
Skin
- Skin Rash
Skin rashes disappeared after discontinuation of griseofulvin and recurred on challenge with the drug. [ncbi.nlm.nih.gov]
[…] burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. [rxlist.com]
[…] pain, tingling, numbness in the hands or feet skin rash, redness, blistering, or peeling of skin sores or whites patches in the mouth unusually weak or tired yellowing of the eyes or skin Side effects that usually do not require medical attention (report [carefirst.staywellsolutionsonline.com]
- Eczema
Rosacea, Acne, Shingles: Common Adult Skin Diseases Learn to spot and treat skin conditions commonly found in adults such as acne, eczema, shingles, psoriasis, rosacea, hives, cold... [medicinenet.com]
For example, tinea corporis can be confused with eczema, tinea capitis can be confused with alopecia areata, and onychomycosis can be confused with dystrophic toe-nails from repeated low-level trauma. [aafp.org]
CUTANEOUS T-CELL LYMPHOMA Cutaneous T-cell lymphoma is a rare type of non-Hodgkin's lymphoma in which certain white blood cells called T-lymphocytes become cancerous and affect the skin. 1 Because CTCL can look like common skin diseases such as psoriasis, eczema [stockwatch.com]
- Cradle Cap
cap or other conditions caused by Trichophyton or Microsporum fungi. [druglib.com]
Neurologic
- Headache
Common side effects may include: nausea, vomiting, upset stomach, diarrhea; headache, tired feeling; sleep problems (insomnia); or itching, rash. This is not a complete list of side effects and others may occur. [rxlist.com]
Headache, GI symptoms, and rashes also may occur. griseofulvin Microbiology An oral antifungal with an affinity for skin, used to treat dermatophytoses–eg, Epidermophyton spp, Microsporum spp, Trichophyton spp Adverse effects Headache, N&V, diarrhea, [medical-dictionary.thefreedictionary.com]
All patients did, however, report mild, transient gastrointestinal discomfort during the first 2 days of therapy, and one patient mentioned a mild headache. These remitted after approximately 2 to 4 days. [ncbi.nlm.nih.gov]
Workup
However, on laboratory workup, complement levels are normal. Management of serum sickness-like reaction includes replacing the offending agent and providing symptomatic relief. [ncbi.nlm.nih.gov]
Treatment
However, the optimal treatment duration for its use in the treatment of tinea capitis caused by Microsporum species has not yet been determined. [ncbi.nlm.nih.gov]
Etiology
We studied 153 consecutive patients of tinea capitis for clinical patterns, causative dermatophytic species, clinico-etiological correlation, and response to griseofulvin. Culture and sensitivity were done on all patients. [ncbi.nlm.nih.gov]
Epidemiology
However, varying dosage schedules, changes in epidemiology, and rising drug resistance are factors that hamper treatment in some cases. [ncbi.nlm.nih.gov]
Epidemiology and treatment of tinea capitis: ketoconazole vs. griseofulvin. Pediatr Infect Dis J. 1987; 6(1):46–49. 11. Ginsburg CM, Gan VN, Petruska M. [aafp.org]
Over the past 30 years, the reported incidence of tinea capitis has increased significantly, as travel and migration have been associated with changes in epidemiology and in distribution of the species of fungi that are likely to cause tinea capitis [doi.org]
Prevention
Give with food to prevent GI distress. Store in closed containers away from light. Prevent further reinfection by cleaning disinfecting cage and cage articles. Clip nails to prevent secondary infections. [ratguide.com]
In conclusion, we postulate that DXA acid would be more effective to prevent liver damage induced by Gris. [ncbi.nlm.nih.gov]
(via antibiotic antifungal agent ) Application (s): antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals. [ebi.ac.uk]
Griseofulvin in Grisovin-FP concentrates in the skin and prevents the fungus from dividing but does not kill the fungus. [inhousepharmacy.vu]