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Grover's Disease


Presentation

  • ( 26159656 ) Tognetti L...Rubegni P 2015 13 Grover's Disease in a Liver Transplant Patient. ( 24648700 ) Moon HR...Moon KC 2014 14 Grover's Disease with Acrosyringeal Acantholysis: A Rare Histological Presentation of an Uncommon Disease. ( 25484405 )[malacards.org]
  • The prototypic presentation of Grover disease consists of a self-limited papulovesicular rash on the upper trunk of an older white male (Figure 1). The seasonal association of Grover disease is more controversial.[medical-dictionary.thefreedictionary.com]
Heart Disease
  • People who are chronically depressed have higher rates of heart disease and stroke. A new study has linked it to dementia. Your first challenge is to persuade your husband that he can benefit from medical help.[chicago.suntimes.com]
Eruptions
  • Recently, a patient whom I had treated 20 years ago for proved allergic contact dermatitis was referred to me at the age of 73 years with a peculiar papular eruption and chronic lymphatic leukemia.[jamanetwork.com]
  • More severe eruptions usually clear up after treatment for one to three months with Accutane or tetracycline.[en.wikipedia.org]
  • The skin eruptions, which are often unbearably itchy, can last for weeks or months. In some cases, the disease spontaneously resolves within a year. For some individuals, however, it persists indefinitely.[chicago.suntimes.com]
Papule
  • It is characterized by papules and papulovesicles with excoriations occurring on the chest, back, lower sternum, arms, and thighs. [4] The papules are most commonly found on the mid chest.[en.wikipedia.org]
  • Grover, contemporary U.S. dermatologist] A common itchy (pruritic) condition of sudden onset, characterized by a few or numerous smooth or warty papules, vesicles, eczematous plaques, or shiny translucent nodules.[medical-dictionary.thefreedictionary.com]
Dermatitis
  • Recently, a patient whom I had treated 20 years ago for proved allergic contact dermatitis was referred to me at the age of 73 years with a peculiar papular eruption and chronic lymphatic leukemia.[jamanetwork.com]
  • Grover disease has been found to coexist with numerous other dermatoses in 11% of cases (5); these include asteatotic eczema, allergic contact dermatitis, atopic dermatitis, irritant contact dermatitis, and psoriasis.[medical-dictionary.thefreedictionary.com]
  • One series of 300 patients with Grover's disease reported an association with other coexisting dermatoses including atopic dermatitis, contact dermatitis, and xerosis cutis.[en.wikipedia.org]
Freckles
  • […] dermatosis (Grover's disease). ( 15627107 ) Breuckmann F...Kreuter A 2005 37 Grover's disease (transient acantholytic dermatosis) associated with atopy. ( 15857481 ) Rosina P...Barba A 2005 38 Persistent acantholytic dermatosis and extensive lentiginous 'freckling[malacards.org]
Pruritus
  • The pruritus may be mild or severe and is aggravated by heat. Even though the condition is self-limiting, it may last months or years. Treatment The patient should be treated symptomatically. Heat and sweat-inducing activities should be avoided.[medical-dictionary.thefreedictionary.com]
Arthritis
  • Rheumatoid arthritis factor was 1:280. Bone marrow studies confirmed[jamanetwork.com]
  • Roach: I heard that letting vinegar touch your skin causes arthritis. Is there any danger in using vinegar as a cleaning agent? N.J.A.[eu.detroitnews.com]
Irritability
  • Vinegar is a mild acid that normally isn’t irritating to the skin. Email questions to ToYourGoodHealth@med.cornell.edu.[eu.detroitnews.com]
  • Grover disease has been found to coexist with numerous other dermatoses in 11% of cases (5); these include asteatotic eczema, allergic contact dermatitis, atopic dermatitis, irritant contact dermatitis, and psoriasis.[medical-dictionary.thefreedictionary.com]
  • Suspected triggers of disease activity include heat and sweating, sunlight, and adverse reaction to medications [5] : 24 as well as ionizing radiation, end-stage renal disease / hemodialysis, and mechanical irritation or prolonged bed rest.[en.wikipedia.org]

Workup

Staphylococcus Aureus
  • aureus: case report and review. ( 23013197 ) Bunce PA...Stanford DG 2013 16 Transient acantholytic dermatosis (Grover's disease) with an isolated eruption. ( 23783409 ) Motegi S...Ishikawa O 2013 17 Grover's disease in a peritoneal dialysis patient.[malacards.org]
Sarcoptes Scabiei
  • scabiei. ( 11385234 ) Kaddu S...Kerl H 2001 47 Grover's disease secondary to ribavirin. ( 10848771 ) Antunes I...MacEdo G 2000 48 Grover's disease associated with Waldenström's macroglobulinemia and neutrophilic dermatosis. ( 10877140 ) Roger M...Fur[malacards.org]

Treatment

  • The most recalcitrant cases may require systemic treatment with oral steroids, vitamin A analogs like isotretoin, or ultraviolet light treatment.[eu.detroitnews.com]
  • Early diagnosis and treatment can reduce distress and head off complications. Even with treatment, it can take weeks and even months for depression to loosen its grip. If your family can be supportive and understanding, it will be a big help.[chicago.suntimes.com]
  • More severe eruptions usually clear up after treatment for one to three months with Accutane or tetracycline.[en.wikipedia.org]
  • Treatment The patient should be treated symptomatically. Heat and sweat-inducing activities should be avoided. Retinoic acid may be helpful. Grover, Ralph W., U.S. dermatologist, 1920–. Grover disease - a pruritic papular eruption.[medical-dictionary.thefreedictionary.com]

Epidemiology

  • […] severe, PUVA phototherapy treatments, antifungal medication and cortisone injections are alternatives. [7] Some research has suggested a correlation of Grover's disease with mercury toxicity [8] in which case Dimercaptosuccinic acid might help. [9] Epidemiology[en.wikipedia.org]
Sex distribution
Age distribution

Prevention

  • The patient complained of severe itching, but he said it was not severe enough to prevent sleep. He had had a knee replacement operation in 1977 before the onset of his disease for degenerative and rheumatoid arthritis.[jamanetwork.com]

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