Presentation
If you are looking for ASRM Scientific Congress Presenter Guidelines, please go to the Congress Website Presenter Resources [asrm.org]
Individuals with habitual abortion presented with an abnormal expression of IL-1beta and IL-6 mRNA in endometrium, during the mid-secretory phase. [ncbi.nlm.nih.gov]
Workup
The authors also conclude, "that hysteroscopy should be a part of the diagnostic workup of infertile women complaining of unexplained recurrent miscarriage." [en.wikipedia.org]
Most patients with a history of recurrent miscarriage do not benefit from an extensive infection workup. For related information, see the following Medscape Reference articles. [emedicine.medscape.com]
It is of utmost importance that the laboratory has its interest invested in infertility workups. [fertilitysolution.com]
Treatment
Antibiotic treatment seems to be associated with an improved reproductive outcome. [ncbi.nlm.nih.gov]
Like treatment timing and duration, there was great heterogeneity in the mode of treatment administration. The majority of trials administered intervention intravenously, although some also administered treatment intramuscularly and subcutaneously. [doi.org]
One study found that in many women with chronic endometritis, "fertility was restored after appropriate antibiotic treatment."There are currently no treatments for women with unexplained recurrent pregnancy loss. [en.wikipedia.org]
Prognosis
Management – Unexplained RM Good prognosis for future pregnancy outcome 75% chance of a eventual live birth in subsequent pregnancy However, prognosis worsens with: Increasing maternal age Number of previous miscarriages Maternal age and number [slideshare.net]
* Disease is ‘‘any deviation from or interruption of the normal structure or function of any part, organ, or system of the body as manifested by characteristic symptoms and signs; the etiology, pathology, and prognosis may be known or unknown.’’ [web.archive.org]
In all patients, genetic variants associated with low plasma mannose binding lectin or thrombophilia affect the prognosis negatively. [forskning.ku.dk]
What is the prognosis for H. pylori infections? What if it is not treated? Many infections are mild and produce few, if any, symptoms. The prognosis of these infections is excellent. [medicinenet.com]
The definition of recurrent miscarriage must be made on the basis of prognosis for future pregnancies, and patients who have had two or more miscarriages probably should be evaluated. [nccrm.com]
Etiology
If patients are evaluated with an etiology in mind, a comprehensive study and management can be planned that will save time and expense. [ncbi.nlm.nih.gov]
Epidemiology
Epidemiological, immunogenetic and immunological studies support the hypothesis that aberrant maternal H-Y immune responses have a pathogenic role in SRM. [ncbi.nlm.nih.gov]
Regarding epidemiology it should be noted that the incidence of clinical abortion in the general population is 12-15%. [creafampuebla.com]
Epidemiology varies depending on the age of the mother. A mother under age 30, has only 25% chances to have another abortion. On the other hand, being older than 40 increases the rate up to 50-60%. [invitra.com]
Werler, Induced Abortions and the Risk of Preeclampsia Among Nulliparous Women, American Journal of Epidemiology, 182, 8, (663), (2015). [doi.org]
A study of epidemiology and fetal effects of human parvovirus B19 surg Gynecol Obstet. 1988;163(3):243-50. cohen BJ. Dtection of parvovirus B19 specific IgM by antibody capture radio immunosassay. Journal virol Metods. 1997;66(1):1-4. Djuki s. [jri.ir]
Pathophysiology
If the vascular hypothesis for the pathophysiology of miscarriage is accepted ( Hustin and Jauniaux 1997 ), bed rest may improve pressure variation and flow changes, and therefore improve the outcome. [clinicalgate.com]
H. (2011) Obstetric antiphospholipid syndrome: an update on pathophysiology and management. Semin Reprod Med, 29, 522–539. doi: 10.1055/s-0031-1293206. Schist, D. J., & Hill, J. A. (2002) Recurrent Pregnancy Loss. [zmj.zsmu.edu.ua]
Implications for research Effective treatment of an alleged alloimmune cause of recurrent miscarriage awaits more complete knowledge of the underlying pathophysiology. [doi.org]
None of the women with thyroid autoantibodies had clinically evident thyroid disease, and the increase in pregnancy loss was not due to changes in thyroid hormone levels or APLA. [10] The pathophysiology involved in this phenomenon is unclear and probably [emedicine.medscape.com]
Prevention
How else can a woman try to prevent recurrent pregnancy loss? Q. What is a miscarriage? A. A miscarriage is a pregnancy loss before five months gestation. Back to Top Q. How common is miscarriage? A. [web.archive.org]
Abstract In order to investigate the possible role of suppressor cells in paternal leukocyte immunization to prevent recurrent miscarriages, peripheral blood lymphocytes from habitually aborting women before and after immunization were assessed. [ncbi.nlm.nih.gov]
Progestogen for preventing miscarriage. Cochrane Database Syst Rev 2008;2:CD003511. 102. Oates-Whitehead RM, Haas DM, Carrier JA. Progestogen for preventing miscarriage. Cochrane Database Syst Rev 2003;4:CD003511. 103. Daya S. [doi.org]