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Haemophilus Influenzae


Presentation

  • We present a rare case of acute epiglottitis in a fully vaccinated child due to nontypeable H. influenzae and discuss the clinical presentation and management.[ncbi.nlm.nih.gov]
Camping
  • By September 2013, war between Sudan and South Sudan resulted in 70,000 Sudanese refugees and high pneumonia incidence among the 20,000 refugees in Yida camp, South Sudan.[ncbi.nlm.nih.gov]
Splenomegaly
  • He also had a history of chronic lymphatic leukaemia (CLL), haemolytic anaemia and splenomegaly, and was in partial remission following chemotherapy in 2008. He underwent arthroscopic washout of right TKR on admission.[ncbi.nlm.nih.gov]
Hypotension
  • On physical examination she was tachycardic, hypotensive and had fundic tenderness to palpation. Imaging showed uterine leiomyomas and no IUD. Blood cultures grew a non-typable H. influenzae. Endometrial biopsy demonstrated acute endometritis.[ncbi.nlm.nih.gov]
Progressive Hearing Loss
  • His course was complicated by progressive hearing loss due to labyrinthitis ossificans. Placement of cochlear implant improved hearing thresholds.[ncbi.nlm.nih.gov]
Hip Pain
  • A 7-year-old boy with a history of recurrent acute lymphoblastic leukemia (ALL), in remission, presented to primary care clinic after 2 days of progressive right hip pain with weight-bearing activities.[ncbi.nlm.nih.gov]
Joint Effusion
  • Blood cultures revealed Gram-negative diplococci, which prompted an MRI that was significant for a hip joint effusion and femoral head bone marrow edema. The patient had no sick contacts and no significant past medical history other than ALL.[ncbi.nlm.nih.gov]
Thigh Pain
  • A 59-year-old woman was admitted to the intensive care unit after sudden onset of fever, chills, and right thigh pain. She received chemotherapy with fluorouracil, irinotecan, and bevacizumab for colon cancer 10 days prior to admission.[ncbi.nlm.nih.gov]
Recurrent Rhinitis
Brudzinsky Sign
  • She was irritable and the Brudzinski's sign was positive. The cerebrospinal fluid (CSF) analysis showed pleocytosis and high protein level.[ncbi.nlm.nih.gov]

Workup

  • […] presence of cellulitis Joint, lung, and sinus aspiration Transtracheal aspiration Tympanocentesis Pericardiocentesis Laparoscopy and tubal cultures in women: For suspected NTHi Culdocentesis and peritoneal fluid cultures in women: For suspected NTHi See Workup[emedicine.medscape.com]
Chlamydia Trachomatis
  • METHODS: In this retrospective study, we enrolled 68 men with H. influenzae-positive urethritis, including coinfections with Neisseria gonorrhoeae, Chlamydia trachomatis, and/or genital mycoplasmas: 2, 3, 20, and 43 treated with ceftriaxone, levofloxacin[ncbi.nlm.nih.gov]

Treatment

Prognosis

  • Treatment and prognosis Mortality rates in patients with H. influenzae pneumonia have been reported as ranging around 10-42% Promoted articles (advertising)[radiopaedia.org]
  • Prognosis The sequelae following Hib meningitis may include deafness, convulsions and intellectual impairment.[patient.info]
  • We find a favorable prognosis for the majority of children who are treated for meningitis caused by H. influenzae type b. (N Engl J Med 1990; 323:1657–63.)[nejm.org]
  • The prognosis of uncomplicated Hib pneumonia and nonencapsulated H influenzae infections is usually good.[emedicine.medscape.com]

Etiology

  • The authors suggest that this species should be taken into account as the etiologic agent of peritoneal dialysis-associated peritonitis. Targeted antimicrobial therapy should be based on local antibiotic resistance patterns.[ncbi.nlm.nih.gov]
  • Tabs Content Clinical Overview Diagnosis Indications for Testing Identify etiologic agent in pneumonia , meningitis , cellulitis , septic arthritis Laboratory Testing CDC testing recommendations Rapid antigen detection tests are available – utility is[arupconsult.com]

Epidemiology

  • Seven epidemiologically unrelated cases of invasive Haemophilus influenzae type a (Hia) disease were identified in First Nations communities of Northwestern Ontario, Canada, in 2004-2008. In all cases, Hia was isolated from blood.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • […] settings where the test may be helpful Assessing a patient's immunological (IgG) response to Haemophilus influenzae type B (HIB) vaccine Assessing immunity against HIB Aiding in the evaluation of immunodeficiency Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]
  • In this article, the author reviews the clinical manifestations and pathophysiology of H influenzae infection, with emphasis on the key features useful for making a timely diagnosis.[medlink.com]
  • Pathophysiology The nomenclature ( Haemophilus is Greek for "blood loving") acknowledges the fact that H influenzae requires 2 erythrocyte factors for growth: X (hemin) and V (nicotinamide-adenine-dinucleotide).[emedicine.medscape.com]

Prevention

  • There remains a need to develop improved vaccines for prevention of NTHi disease, which could be achieved by combining protein D with other antigens.[ncbi.nlm.nih.gov]
  • Vaccines are the only public health tool available to prevent the vast majority of Hib disease.[web.archive.org]

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