We present a rare case of acute epiglottitis in a fully vaccinated child due to nontypeable H. influenzae and discuss the clinical presentation and management. [ncbi.nlm.nih.gov]

• Splenomegaly

  He also had a history of chronic lymphatic leukaemia (CLL), haemolytic anaemia and splenomegaly, and was in partial remission following chemotherapy in 2008. He underwent arthroscopic washout of right TKR on admission. [ncbi.nlm.nih.gov]

• Progressive Hearing Loss

  His course was complicated by progressive hearing loss due to labyrinthitis ossificans. Placement of cochlear implant improved hearing thresholds. [ncbi.nlm.nih.gov]

• Joint Effusion

  Blood cultures revealed Gram-negative diplococci, which prompted an MRI that was significant for a hip joint effusion and femoral head bone marrow edema. The patient had no sick contacts and no significant past medical history other than ALL. [ncbi.nlm.nih.gov]

• Thigh Pain

  A 59-year-old woman was admitted to the intensive care unit after sudden onset of fever, chills, and right thigh pain. She received chemotherapy with fluorouracil, irinotecan, and bevacizumab for colon cancer 10 days prior to admission. [ncbi.nlm.nih.gov]

[…] presence of cellulitis Joint, lung, and sinus aspiration Transtracheal aspiration Tympanocentesis Pericardiocentesis Laparoscopy and tubal cultures in women: For suspected NTHi Culdocentesis and peritoneal fluid cultures in women: For suspected NTHi See Workup [emedicine.medscape.com]

• Lymphopenia

  Leukocytosis occurred in 7 cases and lymphopenia in 3; no cases presented with neutropenia. Four isolates were positive for beta-lactamase. Susceptibility data were unavailable in 5 case patients. [ncbi.nlm.nih.gov]

However, azithromycin treatment failures were reported in acute urethritis caused by H. influenzae strains considered susceptible to azithromycin. [ncbi.nlm.nih.gov]

Treatment and prognosis Mortality rates in patients with H. influenzae pneumonia have been reported as ranging around 10-42% Promoted articles (advertising) [radiopaedia.org]

Prognosis The sequelae following Hib meningitis may include deafness, convulsions and intellectual impairment. [patient.info]

We find a favorable prognosis for the majority of children who are treated for meningitis caused by H. influenzae type b. (N Engl J Med 1990; 323:1657–63.) [nejm.org]

The prognosis of uncomplicated Hib pneumonia and nonencapsulated H influenzae infections is usually good. [emedicine.medscape.com]

Tabs Content Clinical Overview Diagnosis Indications for Testing Identify etiologic agent in pneumonia, meningitis, cellulitis, septic arthritis Laboratory Testing CDC testing recommendations Rapid antigen detection tests are available – utility is questionable [arupconsult.com]

The authors suggest that this species should be taken into account as the etiologic agent of peritoneal dialysis-associated peritonitis. Targeted antimicrobial therapy should be based on local antibiotic resistance patterns. [ncbi.nlm.nih.gov]

KEYWORDS: Europe; bacteria; coccobacillus; epidemiology; invasive Haemophilus influenzae disease; invasive disease; invasive pathogen; serotype; surveillance; temporal trends; vaccine [ncbi.nlm.nih.gov]

Little information is available concerning the microbiological, clinical, and epidemiological significance of H. influenzae serotype e (HiE) [ 2, 7–15 ]. [academic.oup.com]

[…] settings where the test may be helpful Assessing a patient's immunological (IgG) response to Haemophilus influenzae type B (HIB) vaccine Assessing immunity against HIB Aiding in the evaluation of immunodeficiency Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]

In this article, the author reviews the clinical manifestations and pathophysiology of H influenzae infection, with emphasis on the key features useful for making a timely diagnosis. [medlink.com]

Pathophysiology The nomenclature ( Haemophilus is Greek for "blood loving") acknowledges the fact that H influenzae requires 2 erythrocyte factors for growth: X (hemin) and V (nicotinamide-adenine-dinucleotide). [emedicine.medscape.com]

Author information 1 Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; Department of Infection Control and Prevention, Osaka University Graduate School of Medicine, Osaka, Japan; Division of Infection Control and Prevention, Osaka [ncbi.nlm.nih.gov]

Prevention: Immunization of all infants prevents H. influenzae type b infection. Respiratory and hand hygiene prevent transmission. Recent Washington trends: 4 to 13 cases (due to all serotypes) are reported annually. [doh.wa.gov]

[…] by Hib vaccine very rare in children and infants life-threatening infection of the area of the throat that covers and protects the windpipe Meningitis prevented by Hib vaccine very rare in children and infants infection of the membranes that surround [childrenshospital.org]