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2.1
Haemophilus Influenzae Infection
Hemophilus Influenza Infection

Presentation

Presents important “take home concepts within each chapter to help you recall clinical pearls. Includes the most need-to-know basic science, focusing on providing clear implications for patient care. [books.google.de]

The case involves a 37-year-old man with underlying illnesses, who has presented with fever, productive cough, runny nose and shortness of breath since August 2. [info.gov.hk]

Two cases presented with bacteraemia, and one case presented with meningitis. [hps.scot.nhs.uk]

This diagnosis should still be considered when a person presents with fever and signs of upper respiratory obstruction resembling croup. [www2.health.vic.gov.au]

Hib, for example may present as epiglottitis (severe swelling in the throat) or pneumonia. [immune.org.nz]

Entire Body System

  • Recurrent Infection

    including the recurrent infection described herein. [hoajonline.com]

    Biofilm formation by H. influenzae in the middle ear and the airways of cystic fibrosis patients is important for the pathogenesis of infection, particularly chronic and recurrent infections that characterize these clinical settings. [jcm.asm.org]

    What host factors protect against this infection? Recurrence is a characteristic feature of infection with nontypeable H. influenzae. [infectiousdiseaseadvisor.com]

  • Recurrent Otitis Media

    It can be a common cause of recurrent otitis media. Treatment and Chemoprophylaxis For guidelines on treatment and chemoprophylaxis for invasive Hib disease, see the Red Book External. [cdc.gov]

    Nasopharyngeal colonization by H. influenzae early in life is associated with the otitis-prone condition. The most common cause of recurrent otitis media is nontypeable H. influenzae (25). [jcm.asm.org]

    Recurrent and chronic otitis media causes prolonged middle ear effusions, which leads to conductive hearing loss. [infectiousdiseaseadvisor.com]

  • Chronic Infection

    H flu infections can spread by direct contact, respiratory droplets, and body fluids. How long does haemophilus influenzae last? These tend to be acute, not chronic infections. [drgreene.com]

    Studies into the nature of this biofilm structure and proteins will help develop strategies to fight chronic infections. [emedicine.medscape.com]

Respiratoric

  • Common Cold

    Types of Haemophilus influenzae Otitis media middle ear infection may develop after a child has a common cold caused by a virus Conjunctivitis inflammation of the membrane that lines the inside of the eye and also a thin membrane that covers the actual [childrenshospital.org]

    The patient had a two-day history of common cold-like symptoms and was taken to the emergency room as a cardiopulmonary arrest. [dovepress.com]

    May develop after a child has a common cold caused by a virus. [chop.edu]

    Below are the most common symptoms. Middle ear infection (otitis media) This may occur after a child has a common cold caused by a virus. [cedars-sinai.org]

  • Respiratory Disorders

    Many but not all have some associated predisposing conditions, including immunosuppression, HIV infection, or a respiratory disorder. Nontypeable strains that cause invasive infection are genetically diverse. [jcm.asm.org]

Psychiatrical

  • Suggestibility

    [PMID:8092913] Comment: Series from pre-HAART era in pts with advanced HIV suggesting that these pts are at risk of recurrent bacterial bronchitis. [hopkinsguides.com]

    Contrary to what the name Haemophilus influenzae suggests, the bacterium does not cause influenza. Clinical features Hib infection usually affects children aged below five years. The risk of infection among older children is relatively low. [chp.gov.hk]

    Maurice Sievers, Carla Nachu, George Lefebvre, and Jerry Short for their suggestions on conducting the study; to Yolanda Nashio, Eugenia Keller, Marna Clendon, Frances Carrizosa, and Lakota Kruse for help in gathering data; and especially to all the volunteer [nejm.org]

    Selected studies suggest an increasing incidence of invasive H. influenzae infection, particularly by nontypeable strains. [jcm.asm.org]

Neurologic

  • Confusion

    When the membranes covering the brain are infected, there will be fever, headache and stiff neck, coupled with decreased appetite, nausea, vomiting, fear of bright light, confusion and sleepiness. [chp.gov.hk]

    In older children and adults symptoms of meningitis include: headache fever vomiting neck stiffness and joint pains drowsiness or confusion discomfort on looking at bright lights. [dhhs.tas.gov.au]

    Older children and adults In older children and adults, symptoms of meningitis include: headache fever vomiting stiff neck or back joint pains drowsiness (excessive sleepiness) or confusion photophobia (discomfort when looking at light). [sahealth.sa.gov.au]

Workup

[…] presence of cellulitis Joint, lung, and sinus aspiration Transtracheal aspiration Tympanocentesis Pericardiocentesis Laparoscopy and tubal cultures in women: For suspected NTHi Culdocentesis and peritoneal fluid cultures in women: For suspected NTHi See Workup [emedicine.medscape.com]

Microbiology

  • Streptococcus Pneumoniae

    pneumoniae and Haemophilus influenzae type b were grown on culture Source: From the Immunization Action Coalition Infant with severe vasculitis with disseminated intravascular coagulation (DIC) with gangrene of the hand secondary to Haemophilus influenzae [cdc.gov]

    Other bacteria such as Streptococcus pneumoniae can also cause epiglottitis. Infection leads to inflammation and swelling of the epiglottis. This causes swelling of the epiglottis that may obstruct breathing. [news-medical.net]

    Bacterial vaccines and serotype replacement: lessons from Haemophilus influenzae and prospects for Streptococcus pneumoniae. Emerg Infect Dis 5, 336 –345. [CrossRef] [Google Scholar] Martinez, M. A., Ovalle, A., Ulloa, M. T. & Vidal, R. [jmm.microbiologyresearch.org]

    Antibiotic susceptibility in Streptococcus pneumoniae, Haemophilus influenzae and Streptococcus pyogenes in Pakistan: a review of results from the Survey of Antibiotic Resistance (SOAR) 2002-15. J Antimicrob Chemother. 2016 May. 71 Suppl 1:i103-9. [emedicine.medscape.com]

  • Staphylococcus Aureus

    aureus Source: PHIL Photo ID# 1047 Blood agar plate culture of Haemophilus influenzae Source: PHIL Photo ID# 1616 Cerebrospinal fluid culture positive for Haemophilus influenzae type b (Gram stain). [cdc.gov]

    Other previously rare bacterial causes of epiglottitis may now be more likely diagnoses, particularly streptococci and Staphylococcus aureus. Immunosuppressed individuals of any age remain at risk from Hib infection. [www2.health.vic.gov.au]

    (iii) Infections in cystic fibrosis.Colonization and infection by Pseudomonas aeruginosa in patients with cystic fibrosis are often preceded by infection with nontypeable H. influenzae or Staphylococcus aureus early in the course of the disease. [jcm.asm.org]

    Empiric therapy for preseptal cellulitis should cover not only Hib but also S pneumoniae, Staphylococcus aureus, and group A beta-hemolytic streptococci. [emedicine.medscape.com]

    In the case of H. influenzae type b, the onset may be more insidious compared to the pneumococcus and Staphylococcus aureus. Bacteremia without localized disease. [infectiousdiseaseadvisor.com]

  • Pseudomonas

    Escherichia coli [E. coli] as the cause of diseases classified elsewhere B96.3 Hemophilus influenzae [H. influenzae] as the cause of diseases classified elsewhere B96.4 Proteus (mirabilis) (morganii) as the cause of diseases classified elsewhere B96.5 Pseudomonas [icd10data.com]

    (iii) Infections in cystic fibrosis.Colonization and infection by Pseudomonas aeruginosa in patients with cystic fibrosis are often preceded by infection with nontypeable H. influenzae or Staphylococcus aureus early in the course of the disease. [jcm.asm.org]

    Most common pathogens in 18 episodes of bacterial bronchitis were H. influenzae and Streptococcus pneumoniae (5 episodes each) and Pseudomonas aeruginosa (4 episodes). [hopkinsguides.com]

Treatment

Antibiotics and supportive care These are the mainstays of treatment. [emedicine.medscape.com]

Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. [webmd.com]

Blood tests What is the treatment for H. influenzae infections? Treatment for H. influenzae greatly depends on which area of the body is infected. [stanfordchildrens.org]

Uses extensive color-coded algorithms to facilitate quick diagnosis, management, and treatment decisions. Organizes material to parallel your clinical decision making process. [books.google.de]

Prognosis

Treatment and prognosis Mortality rates in patients with H. influenzae pneumonia have been reported as ranging around 10-42% Promoted articles (advertising) [radiopaedia.org]

Outlook / Prognosis What can I expect if my child has a Haemophilus influenzae disease? The outlook (prognosis) for H. influenzae infections depends on the type and severity of your child’s condition. [my.clevelandclinic.org]

Prognosis The sequelae following Hib meningitis may include deafness, convulsions and intellectual impairment. [patient.info]

Moreover, there seemed to be a better prognosis than that previously described for C. jejuni-related Guillain–Barré syndrome patients (Rees et al., 1995a; Visser et al., 1995; Jacobs et al., 1996). [academic.oup.com]

The prognosis of uncomplicated Hib pneumonia and nonencapsulated H influenzae infections is usually good. [emedicine.medscape.com]

Etiology

S. pneumoniae and H. influenzae are the most frequent pathogens responsible for respiratory tract infections etiology. [ibn.idsi.md]

A consistent chapter format enables you to rapidly and effortlessly locate the most current protocols on manifestations, etiologies, triggers, approaches to treatment, complications, and preventative strategies. [books.google.de]

The gold standard for an etiologic diagnosis, culture of middle ear fluid, requires tympanocentesis, which is an invasive procedure and is thus not routinely performed. [jcm.asm.org]

Etiologic Agent H. influenzae is a pleomorphic gram-negative coccobacillus. H. influenzae may be either encapsulated (typeable) or unencapsulated (nontypeable). [cdc.gov]

Vishniakova LA, Putov NV (1990) The etiology of acute pneumonia. Ter Arkh 62: 15-18. Sinopalnikov A, Romanov AG (2006) An infectious exacerbation of chronic obstructive pulmonary disease. Pulmonology 1. [omicsonline.org]

Epidemiology

Please refer any child care exposures as soon as possible to Epidemiology & Assessment at 714-834-8180 for follow-up. [cms.ocgov.com]

Date: 1998 University: Göteborgs universitet/University of Gothenburg Institution: Department of Otolaryngology Avdelningen för öron-, näs- och halssjukdomar Date of Defence: 1998-04-17 Publication type: Doctoral thesis Keywords: Haemophilus influenzae epidemiology [gupea.ub.gu.se]

Additionally, these studies demonstrated similar epidemiologic distributions as historically documented with Hib, with 22 of 23 reported Hia cases occurring in patients less than 5 years old. [journals.lww.com]

An epidemiologic study with special reference to day-care centers. JAMA 1984; 252(18):2581-2584. Shapiro ED, Ward JI. The epidemiology and prevention of disease caused by Haemophilus influenzae type b. Epidemiol Rev 1991; 13:113-142.Tsang R. [ecdc.europa.eu]

INTRODUCTION The epidemiology and clinical manifestations of Haemophilus influenzae infections have undergone dramatic changes in the last 2 decades. [jcm.asm.org]

Pathophysiology

The similarities between Guillain–Barré syndrome subsequent to H. influenzae and C. jejuni infections may reflect the same pathophysiology. [academic.oup.com]

Pathophysiology The nomenclature ( Haemophilus is Greek for "blood loving") acknowledges the fact that H influenzae requires 2 erythrocyte factors for growth: X (hemin) and V (nicotinamide-adenine-dinucleotide). [emedicine.medscape.com]

We filtered for pathogenic and likely pathogenic variation with no conflicting evidence and criteria provided by at least one submitter and checked our alignment for known variations that could potentially relate to Y. pestis and H. influenzae pathophysiology [genomebiology.biomedcentral.com]

Prevention

Corticosteroids may help prevent brain damage. Epiglottitis must also be treated as soon as possible. People may need help breathing. [merckmanuals.com]

[…] by Hib vaccine very rare in children and infants life-threatening infection of the area of the throat that covers and protects the windpipe Meningitis prevented by Hib vaccine very rare in children and infants infection of the membranes that surround [childrenshospital.org]

How can haemophilus influenzae be prevented? The Hib vaccine can prevent most serious cases of H flu disease. Those in close contact with people with serious H flu disease should receive preventive antibiotics. [drgreene.com]

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