We present a case of H. parainfluenzae complicating pregnancy in the second trimester. Predisposing factors for infection with Haemophilus species and Australasian data on invasive neonatal Haemophilus infections are presented. [ncbi.nlm.nih.gov]

Nuchal rigidity was not present. Kernig and Brudzinski signs were negative. [journals.sagepub.com]

Five substitutions were present in all the strains [S385T, I442F, V511A, N526K and V562I], while three additional changes [K276N, A307N and V329I] were only present in HUB12435, HUB12445 and HUB12640. [nature.com]

• Chills

  All presented with fever, chills and malaise of less than two weeks' duration. Mitral valve involvement led to congestive heart failure in two of three cases. [ncbi.nlm.nih.gov]

  His complaint of neck pain associated with intermittent fever and chills was initially concerning for meningitis; therefore, after obtaining a cranial computed tomography (CT) scan, a lumbar puncture was performed. [journals.sagepub.com]

  […] in Spain, with no previous pathologies of interest nor recent trips, that was seen at our centre presenting a 4-day history consisting of colic-like abdominal pain, vomiting and diarrhoea with no pathological products, accompanied by a high fever and chills [elsevier.es]

  […] u enzae, Streptococcus intermedius and Streptococcus anginosus represent a part of normal oropharyngeal flora and may cause abscesses or sepsis under certain circumstances. (1-4) Case report A 78-year-old woman presented with high fever up to 41 °C, chills [signavitae.com]

• Intravenous Drugs

  We present a case of a 42-year-old intravenous drug abuser with H. parainfluenzae mitral prosthetic valve endocarditis. [ncbi.nlm.nih.gov]

  @article{d1a1b1121fb149789aa56ec88a494723, title = "Polymicrobial endocarditis with Haemophilus parainfluenzae in an intravenous drug user whose transesophageal echocardiogram appeared normal", author = "Atul Patel and Asirvatham, {Samuel J} and Cherian [mayoclinic.pure.elsevier.com]

  It has also been found to be a common cause of soft-tissue infections and endocarditis in drug users. This association may arise from the habit of intravenous drug abusers to lick their needles for good luck. [emedicine.medscape.com]

  He denied having any history of intravenous drug abuse, any recent dental work, and did not have any body piercings. [journals.sagepub.com]

• Swelling

  Abstract Septic arthritis of the acromioclavicular (AC) joint is a rare entity with symptoms that include erythema, swelling, and tenderness over the AC joint, fever, and limitation of shoulder motion with pain. [ncbi.nlm.nih.gov]

  An otherwise healthy 12-year-old boy was seen in our Emergency Department with swelling and pain in his right knee along with limp for the past day. There was no history of trauma or fever. [elsevier.es]

  She denied having any rashes, lower extremity swelling, or dyspnoea, and she was without additional gastrointestinal or genitourinary complaints. The patient had no past medical history. [emjreviews.com]

  They are gram-negative or gram-variable pleomorphic rods with bulbous swelling of both ends that are characteristically grouped in chains, clusters, or rosettes. [emedicine.medscape.com]

• Malaise

  All presented with fever, chills and malaise of less than two weeks' duration. Mitral valve involvement led to congestive heart failure in two of three cases. [ncbi.nlm.nih.gov]

  Case report A 41 year old woman presented to her GP with a 10 day history of pyrexia, cough with purulent sputum, and general malaise. [thorax.bmj.com]

  He also reported having extreme fatigue and malaise for a few weeks prior to admission. He denied having any history of intravenous drug abuse, any recent dental work, and did not have any body piercings. [journals.sagepub.com]

  […] endocarditis was acute: she was retrospectively questioned for any potential symptoms that would prove a mild, subacute disease form (one that would also be consistent with the vegetations' size), but she did not recall any symptoms apart from ill-defined malaise [jmedicalcasereports.biomedcentral.com]

• Fatigue

  He also reported having extreme fatigue and malaise for a few weeks prior to admission. He denied having any history of intravenous drug abuse, any recent dental work, and did not have any body piercings. [journals.sagepub.com]

  “Fatigue” was self reported as being unable to go any further. Susceptibility to “fatigue” was associated with a short walk on a flat surface, or with stair walk to the first or second floors. [bmcinfectdis.biomedcentral.com]

  More recent research on infective endocarditis has been performed on a difficult clinical case of a pregnant patient who presented with a 104 degree fever, severe headaches, and fatigue. [microbewiki.kenyon.edu]

• Pharyngitis

  Three patients had pneumonia, while the others had epiglottitis with meningitis, pharyngitis, arthritis, and endocarditis, respectively. Nonendocarditic manifestations of adult H parainfluenzae infection were reported in four other cases. [jamanetwork.com]

  CONCLUSION: The multiplex PCR assays were very rapid, reliable and feasible methods for detection of H.influenzae and H.parainfluenzae in pharyngeal swab specimens which were compared to conventional isolation and culture methods. 95.5% of H.influenzae [pubag.nal.usda.gov]

• Regurgitation

  Echocardiography showed bi-leaflet mitral valve prolapse and severe mitral regurgitation. A small vegetation was seen at the flail anterior valve leaflet. [ncbi.nlm.nih.gov]

  Figure 1: A repeat transthoracic echocardiogram revealing severe mitral regurgitation in the parasternal long-axis view (A) and an apical four-chamber view (B). Cardiothoracic surgery was considered. [emjreviews.com]

  In our patient, while TTE showed only mitral valve regurgitation, TEE revealed mitral valve perforation and vegetation. [journals.sagepub.com]

  Symptoms associated with infective endocarditis include presence of a new regurgitant murmur and feverFootnote 7. The mortality rate of Haemophilus-associated endocarditis is approximately 4-5%Footnote 8,Footnote 9. [canada.ca]

  […] a modern mortality risk closer to 10%-15%. [6] The morbidity of IE caused by the HACEK group is similar to that of other types of endocarditis and includes embolization, local extension into the perivalvular area, congestive heart failure (CHF), and regurgitant [emedicine.medscape.com]

• Recent Dental Work

  He denied having any history of intravenous drug abuse, any recent dental work, and did not have any body piercings. [journals.sagepub.com]

• Systolic Murmur

  Her blood pressure was 110/80 mm Hg, pulse 106/minute, and at the cardiac apex a discreet systolic murmur could be heard. No further particular events to report from her history. [signavitae.com]

  Initially, the systolic murmur heard on exam was not the focus of the diagnostic workup given that his symptoms were highly suggestive of meningitis. Mitral valve perforation and vegetation were eventually discovered via TEE. [journals.sagepub.com]

• Erythema

  Abstract Septic arthritis of the acromioclavicular (AC) joint is a rare entity with symptoms that include erythema, swelling, and tenderness over the AC joint, fever, and limitation of shoulder motion with pain. [ncbi.nlm.nih.gov]

• Neck Pain

  A 74-year-old man presented with neck pain and subsequently developed incomplete quadriparesis. A cervical epidural abscess and vertebral osteomyelitis were detected by radiologic studies. [ncbi.nlm.nih.gov]

  His complaint of neck pain associated with intermittent fever and chills was initially concerning for meningitis; therefore, after obtaining a cranial computed tomography (CT) scan, a lumbar puncture was performed. [journals.sagepub.com]

  ESR 39 mm/h Percutaneous aspiration biopsy Blood cultures (-) Ceftriaxone Percutaneous aspiration Cure/12 2(6/1991) Auten GM 74/M Vertebral Tooth abscess 2 weeks before NR Neck pain NR Abscess culture Blood cultures (-) Vancomycin + tobramycin + aztreonam [jbji.net]

• Suggestibility

  These results suggest that the infection of HP in the tonsil may be involved in the etiology of IgAN. [ncbi.nlm.nih.gov]

  Whilst he was admitted, he underwent an abdominal CAT scan that reported the presence of findings suggestive of infectious or inflammatory non-specific colitis, affecting segments of the ascending colon. [elsevier.es]

• Headache

  A 51-year-old man with a history of injection drug use presented to the emergency roomwith fevers, chills and headaches. [ncbi.nlm.nih.gov]

  He described the headaches as bilateral frontal headaches, which were not consistent with his typical migraines. He also reported having extreme fatigue and malaise for a few weeks prior to admission. [journals.sagepub.com]

  She presented with 1 week of fever, headache, and neck stiffness; she described the headache as “excruciating.” Additional symptoms included nausea, anorexia, and an intermittent aching sensation across her precordium that worsened on inspiration. [emjreviews.com]

  This 19-year-old woman was hospitalized in January 1986 for fever, headaches, and vomiting. Her family reported a history of nondocumented bacterial meningitis that occurred when she was 4 years of age. Report of a Case. [jamanetwork.com]

• Stroke

  […] particular type of endocarditis may share similar characteristics. 1 - 7 Patients with endocarditis due to H parainfluenzae, and other HACEK organisms, tend to be of younger age, 1 - 4 and a large majority of patients suffer from embolic phenomena, such as stroke [journals.sagepub.com]

  J Bone Jt Infect 2:104–106. https://doi.org/10.7150/jbji.17387 Article PubMed PubMed Central Google Scholar Machado-Viana J, Auxiliadora-Martins M, Basile-Filho A, Menegueti MG, Gaspar GG, Nicolini EA (2016) Ischemic stroke and septic shock after subacute [link.springer.com]

  […] antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke [emedicine.medscape.com]

• Frontal Headache

  He described the headaches as bilateral frontal headaches, which were not consistent with his typical migraines. He also reported having extreme fatigue and malaise for a few weeks prior to admission. [journals.sagepub.com]

• Brudzinsky Sign

  Kernig and Brudzinski signs were negative. [journals.sagepub.com]

Initially, the systolic murmur heard on exam was not the focus of the diagnostic workup given that his symptoms were highly suggestive of meningitis. Mitral valve perforation and vegetation were eventually discovered via TEE. [journals.sagepub.com]

This report is unique in that it documents successful treatment with a cephalosporin and what is, to our knowledge, the third reported case of a beta-lactamase producing H. parainfluenzae causing endocarditis. [ncbi.nlm.nih.gov]

In a series of 57 cases of A actinomycetemcomitans endocarditis, poor dentition (46%) and abnormal cardiac valves (60%) were found to be predisposing factors. [12] Prognosis The prognosis is quite variable, depending on many factors, such as delay in [emedicine.medscape.com]

Although the facts suggest that this case of urethritis may have been caused by H. parainfluenzae, a possible etiologic role of other microorganisms is not ruled out. [ncbi.nlm.nih.gov]

Overall, these organisms are the leading cause of exacerbations of chronic bronchitis, and the second most common etiology of acute otitis media and sinusitis. [encyclopedia2.thefreedictionary.com]

Establishing diagnosis of Haemophilus parainfluenzae as etiology of culture-negative endocarditis using DNA sequence analysis on tissue specimen. Am J Med. 2011 ;124: e9 - e10. Google Scholar | Crossref | Medline | ISI 9. Brouqui, P, Raoult, D. [journals.sagepub.com]

Abstract This study was undertaken to characterize serial Haemophilus parainfluenzae strains from epidemiologically unrelated chronic obstructive pulmonary disease (COPD) patients and from healthy carriers. [ncbi.nlm.nih.gov]

A. et al.: Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: crosssectional surveys in a population with high rates of pneumococcal disease. BMC Infect. Dis. 10, 2010. 31. [content.sciendo.com]

A. et al.: Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults: crosssectional surveys in a population with high rates of pneumococcal disease. BMC Infect. Dis. 10, 2010.Google Scholar 31. [degruyter.com]

Pathophysiology When introduced into healthy tissue, the HACEK group organisms have the potential for abscess formation and invasive disease. [emedicine.medscape.com]

The human microbiota has multidirectional effects on the host’s health and changes in its composition may have important consequences for human pathophysiology and disease development [5, 7, 8, 34]. [bmcinfectdis.biomedcentral.com]

We report a rare case of tricuspid valve and pacemaker endocarditis caused by this organism and explore factors related to etiopathogenesis, prevention, and treatment. [ncbi.nlm.nih.gov]

2017/1/2/49/217799 Introduction Pyogenic liver abscess (PLA) is an uncommon clinical entity, which requires prompt diagnosis and treatment to prevent unwanted outcomes. [ljmsonline.com]

To prevent a further infection in that critical situation, we treated the patient with fleroxacin, although the susceptibility profile of the isolated strain indicated no resistance to any of the tested agents, including amoxicillin-clavulanic acid, aminopenicillin [jcm.asm.org]