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Haldol


Presentation

  • This work shows that high levels of the glucuronidated form of haloperidol are present in patient urine samples.[ncbi.nlm.nih.gov]
  • When it is administered as an intramuscular depot injection in sesame oil, esterases present in the blood and tissues hydrolyse haloperidol decanoate to provide a slow release of the active neuroleptic haloperidol from the depot into the systemic circulation[myvmc.com]
  • Contraindications: Haloperidol should not be used in cases where other drug, especially sedatives are present.[mstcparamedic.pbworks.com]
  • Pearls , Pharm , Psych , tox 12 November, 2015 0 A 24yo M with hx schizophrenia presents to the ED agitated, threatening staff and making gestures of self-harm. You are unable to verbally deescalate him and go to order some sedative medication.[sinaiem.org]
  • Migraine Headaches Nausea Restlessness Drug: Haloperidol Drug: Metoclopramide 10mg Drug: Diphenhydramine Phase 4 Detailed Description: Investigators conducted a prospective, double-blind, randomized controlled trial in migraine patients who presented[clinicaltrials.gov]
Streptococcal Infection
  • Rheumatic Fever Rheumatic fever is a disease that sometimes occurs after a group A streptococcal infection of the throat. Symptoms and signs...[medicinenet.com]
Impaired Balance
  • If over sixty be careful when standing up because blood pressure may be lowered enough to impair balance. Do not use if: you had negative reactions to this drug in the pass. if you have Parkinson's disease. if you are taking lithium.[psyweb.com]
Sneezing
  • Generally accepted uses not FDA approved include, adjuvant for in chronic pain, control vomiting from chemotherapy, ease refractory sneezing, control refractory hiccups, lessen delirium from LSD flashbacks, lessen delirium from phencyclidine intoxication[psyweb.com]
Vomiting
  • Secondary outcomes included the number of vomiting episodes and side effects over time.[ncbi.nlm.nih.gov]
  • The vomiting centre is responsible for causing feelings of sickness (nausea) and for the vomiting reflex.[netdoctor.co.uk]
  • Haldol is used in the treatment of icu agitation; psychosis; dementia ; nausea/vomiting ; mania (and more ), and belongs to the drug class miscellaneous antipsychotic agents. Risk cannot be ruled out during pregnancy.[drugs.com]
  • […] after surgery in those who are at moderate to high risk, when other medicines do not work or have unacceptable side effects; with other medicines, for treatment of nausea and vomiting after surgery when other medicines do not work or have unacceptable[ema.europa.eu]
Nausea
  • OBJECTIVES: To determine any difference in the effectiveness of ABH gel compared with placebo in cancer patients with nausea.[ncbi.nlm.nih.gov]
  • Haloperidol controls nausea and vomiting by blocking dopamine receptors found in the CTZ. This stops the CTZ from sending the messages to the vomiting centre that would otherwise cause nausea and vomiting.[netdoctor.co.uk]
  • Haldol is used in the treatment of icu agitation; psychosis; dementia ; nausea/vomiting ; mania (and more ), and belongs to the drug class miscellaneous antipsychotic agents. Risk cannot be ruled out during pregnancy.[drugs.com]
  • Migraine Headaches Nausea Restlessness Drug: Haloperidol Drug: Metoclopramide 10mg Drug: Diphenhydramine Phase 4 Detailed Description: Investigators conducted a prospective, double-blind, randomized controlled trial in migraine patients who presented[clinicaltrials.gov]
Difficulty Opening the Mouth
  • opening the mouth uncontrollable muscle spasms affecting the eyes, head, neck and body feeling agitated, confused or depressed Serious mental health problem, such as believing things that are not true (delusions) or seeing, feeling, hearing or smelling[news-medical.net]
Orthostatic Hypotension
  • Orthostatic hypotension causes patients to become dizzy upon arising from a lying or sitting position because of a drop in blood pressure.[medicinenet.com]
  • Orthostatic hypotension may been seen in conjunction with this med, for this reason care should be given when administering this med to patient's taking anticoagulants.[mstcparamedic.pbworks.com]
  • hypotension reported, which may lead to falls and, consequently, fractures or other fall-related injuries; assess risk of falls when initiating treatment and recurrently for patients receiving repeated doses, particularly the elderly, with diseases,[reference.medscape.com]
Motor Restlessness
  • These include dystonia (continuous, often painful muscle spasms and contractions) and akathisia (motor restlessness). These reactions can be treated with anticholinergics like benzotropine or diphenhydramine.[epmonthly.com]
  • Other adverse neuromuscular reactions have been reported less frequently, but are often more severe, and include feelings of motor restlessness (i.e., akathisia), tardive dystonia , and dystonic reactions (e.g., hyperreflexia, opisthotonos, oculogyric[endoflifecare.tripod.com]
Joint Stiffness
  • stiffness breakdown of muscle tissue (rhabdomyolysis) lack of normal facial expressions that sometimes looks like a mask redness, burning or pain at the site Haldol is given including collection of pus at the site vision problems such as blurred vision[news-medical.net]
Blurred Vision
  • Adverse reactions due to haloperidol intoxication include drowsiness, blurred vision, extrapyramidal effects, tardive dyskinesia, tachycardia, hypotension and muscular rigidity.[ncbi.nlm.nih.gov]
  • See physician if severe: Lethargy / sleepiness,dry mouth, blurred vision, constipation, or weight gain. See physician NOW: Reduced urinary output.[psyweb.com]
  • Additional information Common side effects of Haldol include dry mouth, blurred vision, diarrhea, loss of appetite, agitation, heartburn, nausea, and headaches.[huntingtonsdiseasenews.com]
  • . • It may cause drowsiness, dizziness or blurred vision, do not drive a car or operate machinery while taking this medication. • Avoid exposure to sunlight; otherwise it may cause sunburn easily. • Avoid becoming overheated; otherwise heatstroke may[medindia.net]
  • Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More Common Blurred vision changes in menstrual period constipation dryness of the mouth swelling or pain[drugs.com]
Agitation
  • Even within a unique setting with high-powered and board-spectrum therapeutic tools, acute agitation can pose a serious problem.[ncbi.nlm.nih.gov]
  • […] sort of agitation.[nrsng.com]
  • It is the drug of choice in hospice for the treatment of terminal agitation and delirium. Haldol ( also known as haloperidol ) is an antipsychotic medication. In hospice, it is used to treat terminal delirium, severe agitation in end-stage dementia.[crossroadshospice.com]
  • A fourth study reviewed several previously research studies that had been conducted on the use of medications to treat agitation in dementia.[verywellhealth.com]
Seizure
  • . • Caution should be exercised in patients with history of blood disease porphyria, decrease in white blood cells, electrolyte disturbances, high or low blood pressure, dementia, Alzheimer’s disease, seizures, abnormal electroencephalogram (EEG), thyroid[medindia.net]
  • Acute alcohol ingestion: additive hypotension Patient monitoring Monitor CNS status closely, especially for seizures and neuroleptic malignant syndrome (shown by extrapyramidal symptoms, hyperthermia, and autonomic disturbances).[medical-dictionary.thefreedictionary.com]
  • […] risk (decrease seizure threshold) when combined with haloperidol such as: bupropion , isoniazid (INH), phenothiazines (e.g., chlorpromazine , fluphenazine , thioridazine ), theophylline , tramadol , or tricyclic antidepressants (e.g., amitriptyline ,[medicinenet.com]
Akathisia
  • Treatment of Akathisia Akathisia refers to an uncomfortable sense of internal restlessness, accompanied by constant movement of the legs or pacing back and forth.[livestrong.com]
  • Haloperidol ( Symptoms or Effects ) Common: Akathisia, akinesia,lethargy / sleepiness, low blood pressure, dry mouth, blurred vision, constipation, weight gain, difficulty urinating, or stiffness ( Acute dystonia ).[psyweb.com]
  • Akathisia usually occurred within 6 hours of administration and may be indistinguishable from psychotic agitation. [ Ref ] Very common (10% or more): Extrapyramidal disorder (up to 34%), hyperkinesia (up to 13%), headache (up to 12%) Common (1% to 10%[drugs.com]
Stupor
  • , indigestion, involuntary movements, irregular menstrual periods, irregular pulse, lack of muscular coordination, liver problems, loss of appetite, muscle spasms, nausea, Parkinson-like symptoms, persistent abnormal erections, physical rigidity and stupor[healthyplace.com]
  • Although most patients recover fully, delirium may progress to stupor, coma, seizures, and death, particularly if untreated.[endoflifecare.tripod.com]
  • A high value (greater than 50 ng/mL) for the test may indicate haloperidol toxicity, which is marked by: Vomiting Elevated blood pressure Loss of consciousness Seizures Stupor Nausea Anxiety A low value (less than 3 ng/mL) for the test may indicate more[dovemed.com]
Cognitive Disorder
  • disorder Documented Side Effects of Haldol: Source: Physicians Desk Reference , National Institutes of Health’s Medline Plus , and/or the drug label.[cchrint.org]

Workup

  • We perform a delirium workup while we start Ms. B on olanzapine, 5 mg/d orally and 5 mg intramuscular (IM) every 8 hours as needed. Ms.[mdedge.com]
  • Case 2 A 28-year-old man also with recurrent CHS and multiple ED visits and nondiagnostic workups came to the ED requesting admission to the hospital. This patient also had no other history of psychiatric disorder.[journals.lww.com]

Treatment

  • RESULTS: The mean change in nausea score from baseline to 60 minutes after treatment in the ABH gel group was 1.7 2.05 and 0.9 2.45 for the placebo group (P 0.42).[ncbi.nlm.nih.gov]
  • In adults, for: treatment of schizophrenia and schizoaffective disorder; acute treatment of delirium when non-pharmacological treatments (treatments that do not involve medicines) have not worked; treatment of moderate to severe manic episodes associated[ema.europa.eu]
  • According to "Kaplan and Sadock's Textbook of Psychiatry," there is no effective treatment.[livestrong.com]
  • […] problems for which specific treatments are available.[healthyplace.com]

Prognosis

  • We additionally adjusted for number of days from admission to the day before index date, as a longer hospital stay is associated with a worse prognosis. 29 30 Statistical analyses We compared the baseline characteristics of the patients who initiated[bmj.com]

Etiology

  • Regardless of the etiology, all types of delirium share a set of common symptoms that include: Disturbances of consciousness and attention Changes in cognition such as memory deficit, language disturbance, or disorientation Perceptual disturbances not[mdedge.com]
  • The choice of somatic intervention will depend on the specific features of the patients clinical condition, the underlying etiology of the delirium, and any associated comorbid conditions.[endoflifecare.tripod.com]
  • Both samples did not significantly differ in respect to age, cancer diagnoses or etiologies. The MDAS scores at baseline were higher in HAL treated subjects (20.2) compared to RIS treated subjects (17.7).[scielo.isciii.es]

Epidemiology

  • Although no clear association with the administration of antipsychotics and human breast tumours has been demonstrated in clinical and epidemiological studies, caution is recommended in patients with relevant medical history.[medicines.org.uk]
  • Although an increase in mammary neoplasms has been found in rodents following long-term administration of prolactin-stimulating antipsychotic agents, no clinical or epidemiologic studies conducted to date have shown an association between long-term administration[endoflifecare.tripod.com]
  • Epidemiology Although widely used as an antipsychotic, acute poisoning with haloperidol is rare. Adverse effects Extrapyramidal effects such as acute dystonia, Parkinsonian rigidity, tremor, and akathisia.[inchem.org]
Sex distribution
Age distribution

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Optimizing dosage Monitoring compliance Assessing toxicity Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory[mayomedicallaboratories.com]
  • Cannabinoid hyperemesis and compulsive bathing: a case series and paradoxical pathophysiological explanation. J Am Board Fam Med. 2010;23:90–93. 13. Morris R, Fisher M. Cannabinoid hyperemesis syndrome : a specific cause of cyclical vomiting .[journals.lww.com]

Prevention

  • The CMI and the CMI Search are not intended to be used by consumers to diagnose, treat, cure or prevent any disease or for any therapeutic purpose.[mydr.com.au]
  • […] levodopa; Medicines used to treat epilepsy (such as carbamazapine, phenobarbital); Medicines used to slow or prevent blood clotting (anticoagulants).[myvmc.com]
  • The use of agents given via inappropriate routes may delay or prevent the use of more effective interventions.[aafp.org]
  • […] levodopa (Levodopa) medicines used to treat epilepsy (such as carbamazapine, phenobarbital) medicines used to slow or prevent blood clotting (anticoagulants).[nps.org.au]

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