(hallux varus), a useful diagnostic sign when present Small great toenail Fifth-finger clinodactyly, secondary to a shortened middle phalanx Short feet Altered dermatoglyphics of the hands; when present, primarily involving distal placement of the axial [en.wikipedia.org]

Considering the molecular data, the phenotype in the present patient was defined as the severe end of hand-foot-genital and Guttmacher syndrome spectrum. [ncbi.nlm.nih.gov]

• Recurrent Urinary Tract Infection

  Vesicoureteral reflux, recurrent urinary tract infections, and chronic pyelonephritis are common; fertility is normal. Hand-foot-genital syndrome is inherited in an autosomal dominant manner. [en.wikipedia.org]

  Ureterovesical reflux, ectopic accessory ureteral orifice, and subsequent recurrent urinary tract infections are common features in both sexes. [link.springer.com]

  The proposita had presented with recurrent urinary tract infections due to bilateral vesicoureteral reflux at age 2 years. [genome.jp]

  Recurrent urinary tract infections and an inability to control the flow of urine (urinary incontinence) have been reported. About half of males with this disorder have the urethra opening on the underside of the penis (hypospadias). [ghr.nlm.nih.gov]

• Absent Nails

  We report on a girl with absent nails, short/absent distal phalanges of the second to fifth fingers and toes, short thumbs, absent halluces, and carpo-tarsal coalition who also had genitourinary malformations. [ncbi.nlm.nih.gov]

• Short Fifth Finger

  finger clinodactyly; Fifth finger brachydactyly; Carpal delayed ossification; Short first metacarpal; Hypoplastic middle phalanges; Pseudoepiphyses; [Feet]; Absent halluces; Short halluces; Medially deviated halluces; Brachydactyly (2nd-5th toes); Tarsal [genome.jp]

• Hand Deformity

  Upton’s practice is one of the world’s largest specializing in congenital hand deformities, vascular anomalies, and pediatric and adult microsurgery. [books.google.com]

• Chordee

  Urogenital abnormalities include abnormalities of the ureters and urethra and various degrees of incomplete Müllerian fusion in females and hypospadias of variable severity with or without chordee in males. [en.wikipedia.org]

  Affected males may have penile hypospadias of variable severity with or without chordee, short penis, or bifid scrotum. [link.springer.com]

  At least 3 affected males had penile hypospadias with chordee. A fourth, who had not been married, had a surgical operation on the genitalia at age 45, but the type of surgery was not known. [genome.jp]

  […] in heart wall separating two lower heart chambers 0001629 Percent of people who have these symptoms is not available through HPO Autosomal dominant inheritance 0000006 Bifid scrotum Cleft of scrotum 0000048 Brachydactyly Short fingers or toes 0001156 Chordee [rarediseases.info.nih.gov]

• Retrograde Ejaculation

  ejaculation (related to structural anomalies and weakness of the bladder sphincter muscle) [en.wikipedia.org]

  ejaculation (related to structural anomalies and weakness of the bladder sphincter muscle) References ^ a b Innis, Jeffrey W; Pagon, RA; Bird, TD; Dolan, CR; Stephens, K (2006). [howlingpixel.com]

• Cervical Incompetence

  His mother had a bicornuate uterus, cervical incompetence, and minor anomalies of her hands and feet. [ncbi.nlm.nih.gov]

[…] convalescent antibody levels) may be obtained Differentiating coxsackievirus-associated HFMD from EV-71–associated HFMD may have prognostic significance PCR and microarray technology are among the various ways of identifying the causative virus [3] See Workup [emedicine.medscape.com]

Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. [books.google.com]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

Treatment - Hand foot uterus syndrome There is no specific therapy that removes, cures, or repairs all effects of hand-foot-uterus syndrome. Management of HFU mainly involves the treatment of specific effects. [checkorphan.org]

Prognosis - Hand foot uterus syndrome Since HFU results in a variety of physical signs and symptoms, the prognosis for each affected individual varies. Most people with mild or moderate hand, genital, or foot abnormalities lead normal lives. [checkorphan.org]

What is the prognosis of hand, foot, and mouth disease? The prognosis for routine HFMD is excellent. A patient's symptoms are bothersome but not debilitating. [medicinenet.com]

Prognosis [ 1 ] This is generally excellent with a full recovery in the vast majority people. Symptoms tend to improve within 3-6 days, usually with full resolution of skin and mouth lesions within 7-10 days. [patient.info]

[…] extremeties (feet or hand) enchondroma benign feet/hand elevation of the periostiom of metaphysis of long bones near the knee in someone with Paget's, bone infarcts, radiation or familial retinoblastoma osteosarcoma (osteogenic sarcoma) malignant - poor prognosis [quizlet.com]

Most cases affect children younger than 10 years old. 3 Etiology and Pathophysiology HFMD is most commonly caused by members of the enterovirus genus, especially coxsackie viruses. [mhmedical.com]

Management There is no antiviral agent specific for the etiologic agents of HFMD. [emedicine.medscape.com]

[…] interstitial and granulonodulo alveolar pattern 324 Interstitialreticular pulmonary pattern 326 Disseminated interstitial pneumonitis 327 The miliary pattern of pneumonia 328 Short linear andor wedgeshaped densities 329 Pulmonary edema in infancy and childhood Etiology [books.google.com]

Molecular epidemiology of enterovirus 71 infection in the Western Pacific Region. Pediatr Int. 2004 Apr. 46(2):231-5. [Medline]. Singh S, Poh CL, Chow VT. [emedicine.medscape.com]

Epidemiology [ 1, 2 ] HFMD occurs worldwide, with a peak incidence in the summer and autumn in temperate climates. It is most common among infants and children aged younger than 10 years but can occur at any age. [patient.info]

Most cases affect children younger than 10 years old. 3 Etiology and Pathophysiology HFMD is most commonly caused by members of the enterovirus genus, especially coxsackie viruses. [mhmedical.com]

Pathophysiology Infection generally occurs via the fecal-oral route or via contact with skin lesions and oral secretions. Viremia develops, followed by invasion of the skin and mucous membranes. [emedicine.medscape.com]

The alanine tract elongation may prevent protein-protein interactions of the mutant HOXA13, thereby inducing a localized heterochrony in the sequence of distal limb and genitourinary development. [ncbi.nlm.nih.gov]

Many of the suggested prevention strategies or treatments for HFS are based on this theory. How can I prevent HFS? Unfortunately, there is nothing that is guaranteed to prevent HFS. [oncolink.org]

Prevention of HFMD Good personal hygiene is essential to prevent the spread of HFMD to others, both for those infected and their carers. [betterhealth.vic.gov.au]

Treatment and Prevention There is no known therapy or preventive measures that doctors know of at the present time. [feetfirstinc.com]