Edit concept Question Editor Create issue ticket

Hantaan Virus


Presentation

  • We present two patients with Hantaan virus infection, admitted to the Department of Nephrology, Skopje, at the same time, with the same clinical presentation (chills, fever, abdominal pain, hemorrhages, nausea, headache, proteinuria, hematuria, oliguria[ncbi.nlm.nih.gov]
  • The suppression of HTNV-specific CD8( ) T cells in the present model appears to occur at the periphery. The present study also demonstrates that CD8( ) T cells contribute to the clearance of HTNV.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Modification of viral antigen in fusion to bioactive factor will be promising to confer efficient antigen presentation and improve the potency of DNA vaccine in mice.[ncbi.nlm.nih.gov]
  • Graves' disease (GD) is generally presented by thyrotoxicosis with hyperthyroidism, and it is an organ-specific autoimmune disease induced by thyroid-stimulating hormone receptor autoantibodies.[ncbi.nlm.nih.gov]
  • The purpose of the present study was to describe the tolerance and pharmacokinetics of an intravenously administered single ascending dose of AHM in Chinese healthy volunteers.[ncbi.nlm.nih.gov]
Weakness
  • Hantaviruses are weak IFN-alpha/beta inducers and have surprisingly been shown to activate IFN-alpha/beta-independent IFN-stimulated gene (ISG) expression.[ncbi.nlm.nih.gov]
  • Weak sequence homology has been noted between the Rice stripe virus 94 kDa protein and phlebovirus glycoproteins, and between tenuivirus nucleocapsid proteins and those of phleboviruses.[talk.ictvonline.org]
Nightmare
  • Abstract Rodent-borne disease surveillance was conducted at Nightmare Range (NM-R), near the demilitarized zone in northeast Gyeonggi Province, Republic of Korea, to identify hemorrhagic fever with renal syndrome (HFRS) risks for a mountainous high-elevation[ncbi.nlm.nih.gov]
Intravenous Administration
  • Serial blood samples were obtained after intravenous administration for up to 17 days. A one-compartment model was determined to best describe the disposition of AHM.[ncbi.nlm.nih.gov]
Military Personnel
  • These data are useful in the development of risk reduction strategies for the prevention of hantavirus infections among military personnel, especially during training or the event of hostilities, and civilian populations.[ncbi.nlm.nih.gov]
Suggestibility
  • The results suggested that the induction of apoptosis in HEPF by HTNV started at 6 hrs post infection (p.i.). Following the Cor treatment, however, the caspase-3 activity began to increase at 24 hrs p.i.[ncbi.nlm.nih.gov]
  • However, among diverse etiologies, viral infections have been suggested to trigger or to be involved in the pathogenesis of GD.[ncbi.nlm.nih.gov]
  • It is suggested that sICAM-1 was involved in the progression of HFRS.[ncbi.nlm.nih.gov]
  • However, there is no evidence suggesting the hantavirus infection of endothelial cells directly causes obvious cell damage or morphological alteration either in vivo or in vitro.[ncbi.nlm.nih.gov]
  • Phylogenetic analysis of the S and M segment sequences revealed that all of these isolates belong to the species HTNV, suggesting a spillover of HTNV from A. agrarius to Rattus rats.[ncbi.nlm.nih.gov]
Renal Injury
  • Abstract Hantaan virus (HTNV), the prototype member of the Hantavirus genus in the family Bunyaviridae, causes hemorrhagic fever with renal syndrome (HFRS), which is characterized by capillary leakage, hemorrhage, and renal injury, and is an important[ncbi.nlm.nih.gov]

Workup

Lymphocytic Infiltrate
  • In the second case, glomeruli were normal in general, with slight mesangial proliferation found in two out of twenty, but interstitial edema, lymphocyte infiltrations and tubular changes were noted.[ncbi.nlm.nih.gov]
HLA-A1
  • The CTL lines specific for amino acids 12 to 20 were restricted by HLA B51, and those specific for amino acids 421 to 429 were restricted by HLA A1.[ncbi.nlm.nih.gov]
HLA-A2
  • Two epitopes aa129-aa137 and aa131-aa139 restricted by HLA-A2 and B35, respectively, were selected to evaluate the epitope-specific CD8( ) T-cell response.[ncbi.nlm.nih.gov]

Treatment

  • These data support the use of a treatment regimen in which AHM is given only once intravenously.[ncbi.nlm.nih.gov]
  • Following the Cor treatment, however, the caspase-3 activity began to increase at 24 hrs p.i.[ncbi.nlm.nih.gov]
  • The patient is now without hemodialysis treatment, with polyuria, in the stable phase of chronic renal failure which is not improving.[ncbi.nlm.nih.gov]
  • The HTNV-stimulated permeability was reduced by treatment of HUVECs with Ang-1. The plasma Ang-1 level was lower in HFRS patients than in healthy persons.[ncbi.nlm.nih.gov]
  • In this study, we discuss the clinical significance of evaluating HFRS treatment outcomes using cytokine information.[ncbi.nlm.nih.gov]

Etiology

  • However, among diverse etiologies, viral infections have been suggested to trigger or to be involved in the pathogenesis of GD.[ncbi.nlm.nih.gov]
  • The etiologic agent of haemorrhagic fever with renal syndrome (HFRS), Hantaan virus, was first isolated in 1976. Since then numerous Hantaan-like viruses have been isolated and five serotypes of Hantavirus have been recognized.[ncbi.nlm.nih.gov]
  • Vascular endothelial cells are the main targets of Hantaan virus, the etiological agent of the severe form of HFRS. Hantaan virus can induce extensive damage of small blood vessels and capillaries.[ncbi.nlm.nih.gov]
  • Both factors may play an important role in the etiology of Hantaan virus infection in humans.[ncbi.nlm.nih.gov]
  • Abstract Hantaan virus A9 strain (HTNV A9) is an etiologic agent of hemorrhagic fever with renal syndrome in China.[ncbi.nlm.nih.gov]

Epidemiology

  • KEYWORDS: Hantaan virus; epidemiology; virus-host interaction [Indexed for MEDLINE] Free full text[ncbi.nlm.nih.gov]
  • In this study, a landscape epidemiologic approach, combined with geographic information system and remote sensing techniques, was applied to increase our understanding of HFRS due to Hantaan virus and its relationship with landscape elements in China.[ncbi.nlm.nih.gov]
  • Abstract To gain further insight into the molecular epidemiology of Hantaan virus (HTNV) in Guizhou, China, rodents were captured in this region in 2004 and 2005. In addition, serum samples were collected from four patients.[ncbi.nlm.nih.gov]
  • If the mite hypothesis is correct, then it will significantly alter current concepts about the epidemiology, prevention, and control of human hantavirus infection. The Author 2014.[ncbi.nlm.nih.gov]
  • We conclude that RT-LAMP assays could be useful for the rapid and direct detection of HTNV and SEOV clinically, and for the epidemiological investigation of HFRS. Copyright 2015 Elsevier B.V. All rights reserved.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology There is no ideal model to study hantavirus infection leading to hantavirus pulmonary syndrome.[statpearls.com]

Prevention

  • […] and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. 6 Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo[ncbi.nlm.nih.gov]
  • The neutralizing antibodies to the most widely distributed hantaviruses causing HFRS might be promising candidates for the development of an agent for prevention and treatment of HFRS in patients.[ncbi.nlm.nih.gov]
  • Similarly, passive transfer of the HCO2 Mab on Days 1 through 4 after infection prevented antigen deposition in hamster lungs and kidneys but passive transfer of the recombinant HCO2 Fab did not.[ncbi.nlm.nih.gov]
  • If the mite hypothesis is correct, then it will significantly alter current concepts about the epidemiology, prevention, and control of human hantavirus infection. The Author 2014.[ncbi.nlm.nih.gov]
  • Author information 1 Research Institute for Medicine of Nanjing Command, Nanjing 210002, China. 2 Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China. 3 Center for Infection & Immunity, School of Basic Medical Sciences, Zhejiang[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!