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Harpagophytum Procumbens

Devil's Claw


Presentation

  • An IC (50) of 542 microg/mL was determined for the aqueous extract of H. procumbens, but 1012 microg/mL for that of H. zeyheri. 6'- O-Acetylacteoside (8), that is not present in H. zeyheri, inhibited the enzyme with an IC (50) of 47 microg/mL (70 microM[ncbi.nlm.nih.gov]
  • Considering both the antiinflammatory effects of H. procumbens in multiple tissues and the stability of harpagoside in artificial intestinal fluid, the aim of the present study was to explore the possible protective role of a microwave-assisted aqueous[ncbi.nlm.nih.gov]
  • Therefore, the present study was designed to investigate the influence of an external metabolic activation of a DC extract on the cytotoxicity and the release of proinflammatory cytokines.[ncbi.nlm.nih.gov]
  • Abstract The present study evaluates the effect of isolated fractions of Harpagophytum procumbens (devil's claw) on cyclooxygenase (COX-1 and COX-2) activities and NO production using a whole blood assay.[ncbi.nlm.nih.gov]
  • In the present study, we have, therefore, examined the effects of Harpagophytum procumbens secondary root aqueous extract (HPE) on isolated uterine muscle strips taken from pregnant and non-pregnant, young female rats.[journals.sfu.ca]
Disability
  • Assessments of pain and functional disability were made on a 10 cm horizontal visual analogue scale; severity of osteoarthritis was evaluated by Lequesne's index.[ncbi.nlm.nih.gov]
  • RESULTS: After four months, considerable improvements in osteoarthritis symptoms were seen in both groups, with no significant differences for pain, functional disability, or the Lequesne score.[ncbi.nlm.nih.gov]
Weight Loss
  • These results reinforce the promising potential of natural bioactives to be developed into functional foods with weight-loss and weight maintenance benefits.[ncbi.nlm.nih.gov]
  • Overweight patients with hip and knee OA should be encouraged to lose weight and maintain the weight loss. Walking aids can reduce pain in patients with hip and knee OA.[chiro.org]
Cough
  • In its local areas, and increasingly elsewhere, it has also been used for fever, blood diseases, blood purification, lower back pain and pain in pregnant women, coughs, diarrhoea, diabetes, bleeding gums, syphilis, gonorrhoea, gout and lumbago.[web.archive.org]
Bleeding Gums
  • In its local areas, and increasingly elsewhere, it has also been used for fever, blood diseases, blood purification, lower back pain and pain in pregnant women, coughs, diarrhoea, diabetes, bleeding gums, syphilis, gonorrhoea, gout and lumbago.[web.archive.org]
Skin Lesion
  • Externally it helps heal ulcers, boils, skin lesions and wounds (Neuwinger 2000; Powell 2001). There are some contradictions and warnings in the literature ( such as in Duke et al. 2002).[web.archive.org]
Excitement
  • These extra difficulties have made the journey extremely exciting. Evolution can be messy; genetic distinctions among plant species are not always made clear by their physical characteristics.[nybg.org]

Treatment

  • Clinical trials support Hp as a beneficial treatment for the alleviation of pain and improvement of mobility in a variety of musculoskeletal conditions.[ncbi.nlm.nih.gov]
  • Spontaneous pain showed a significant improvement during the course of the study and there was no difference in the efficacy of the two treatments.[ncbi.nlm.nih.gov]
  • Abstract Harpagophytum procumbens (Hp), commonly known as Devil's Claw has been used as a traditional treatment for a variety of illnesses for centuries.[ncbi.nlm.nih.gov]
  • To standardize the assessment of treatment effects, the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index (10 point scale) as well as the 10 cm VAS pain scale were used.[ncbi.nlm.nih.gov]
  • OBJECTIVE: To evaluate the efficacy and safety of Harpagophytum in the treatment of hip and knee osteoarthritis comparatively with the slow-acting drug for osteoarthritis, diacerhein.[ncbi.nlm.nih.gov]

Pathophysiology

  • OBJECTIVES: Extracts of the tubers of Harpagophytum procumbens (devil's claw, DC) inhibit different proinflammatory mediators important in the pathophysiology of osteoarthritis.[ncbi.nlm.nih.gov]

Prevention

  • The Hp prevented TNFα and IL-6 mRNA expression in human monocytes and cyclooxygenase-2 (COX-2) in RAW 264.7 cells.[ncbi.nlm.nih.gov]
  • […] microwave-assisted Harpagophytum aqueous extract in modulating the inflammatory, oxidative stress and immune response in an experimental model of inflammatory bowel diseases (IBD), thus suggesting a rational use of Harpagophytum in the management and prevention[ncbi.nlm.nih.gov]
  • Molecular targets of the antiinflammatory Harpagophytum procumbens (devil s claw): inhibition of TNF and COX-2 gene expression by preventing activation of AP-1. Phytother Res. 2012 Jun;26(6):806-11. dos: 10.1002/ptr.3636. Pub 201[herbetom.com]
  • This product is not intended to diagnose, treat, cure or prevent any disease. The actual color of liquid extract might be different from the color indicated on the image.[amazon.com]
  • Indications Dietary supplement Legal Disclaimer Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.[amazon.com]

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