Presentation
The clinical course of patients presenting with hyperthyroidism was determined. [indiana.pure.elsevier.com]
Hyperthyroidism duration positively correlated with thyroid peroxidase autoantibody (TPOAb) levels at presentation (r = 0.729, p = 0.002). [ncbi.nlm.nih.gov]
Entire Body System
- Goiter
Unlike the classical diffusely enlarged, lobular, bruit-associated goiter that is described with classical Graves disease the goiter is small, diffuse and often firm in these cases. [thetrp.net]
(plunging) (substernal) E04.9 ICD-10-CM Diagnosis Code E04.9 Nontoxic goiter, unspecified 2016 2017 2018 2019 Billable/Specific Code Applicable To Goiter NOS Nodular goiter (nontoxic) NOS lymphadenoid E06.3 Hashimoto's disease or thyroiditis E06.3 Hashitoxicosis [icd10data.com]
Over time the thyroid may enlarge, forming a painless goiter. Some people eventually develop hypothyroidism with accompanying weight gain, feeling tired, constipation, depression, and general pains. [wikivividly.com]
Diffuse nontoxic goiter is caused by an increased production of TSH from an enlarging thyroid gland, thus resulting in multi-nodular goiters. [hyperthyroidismsymptomsx.com]
- Thyroid Nodule
An MRI with and without contrast revealed “heterogeneous in intensity and multiple small nodules.” There was also a 1.2x1.4x1.5 cm nodule at the thyroid isthmus. [healio.com]
Topics covered include the following: thyroid synthesis and physiology; hyperthyroidism; hypothyroidism; thyroid nodules; goiter; differentiated thyroid cancer; subacute, silent, and postpartum thyroiditis; thyroid and pregnancy; thyroid and the elderly [books.google.com]
Thyroid Cancer –Development of malignant thyroid tissue or nodules. [hyperthyroidismsymptomsx.com]
nodule on an ultrasound can give an idea as to whether a nodule is malignant or benign. [naturalendocrinesolutions.com]
- Fever
The hallmark symptoms of a thyroid storm is a fever which can go as high as 40.5 - 41.1 C (105 - 106 F). [medhelp.org]
Case 33: Headache Case 34: Vision loss Case 35: Heartburn Case 36: Fatigue Case 37: Skin changes Case 38: Ankle pain Case 39: Shoulder pain Case 4: Vaginal bleeding Case 40: Dizziness Case 5: Nausea Case 6: Pelvic pain Case 7: Toddler with a cough and fever [amboss.com]
Exacerbations with sudden enlargement and tenderness of the thyroid gland and general features of inflammation (elevated C-reactive protein levels and erythrocyte sedimentation rate, rarely with fever) are very rare; they may be accompanied by the clinical [empendium.com]
[…] body, manifested by fever and sore throat); * Propylthiouracil (PTU) "can cause serious liver damage. [drllynch.com]
Gastrointestinal
- Abdominal Cramps
Frequent bowel movements, along with abdominal cramping, may also lead to reduced appetite. Visual distortion During hyperthyroid phase, certain patients may complain of eye irritation or blurred vision. [primehealthchannel.com]
Symptoms of overstimulation: Abdominal cramps, anxiety, changes in appetite, change in menstrual periods, chest pain, diarrhea, emotional instability, fatigue, fever, flushing, hair loss, headache, heart attack or failure, heat intolerance, hyperactivity [drllynch.com]
- Steatorrhea
Goiter Graying hair, premature graying Hair and nail changes, increased growth Hair loss Headaches Heartburn Heat Intolerance High systolic blood pressure Hyper brain, trouble concentrating or comprehending Hyperdefecation - up to 8 movements a day, steatorrhea [dailystrength.org]
- Chronic Diarrhea
However, endo blew off that test, " must be an error", saying I would have been in hospital or standing in middle,of road naked if my level was that high, in spite of fact I have lost almost 50 ponds since June, extreme insomnia, and chronic diarrhea, [medhelp.org]
Cardiovascular
- Tachycardia
The second patient The second patient was a 42-year-old female presenting with tachycardia and mood swings who was diagnosed with hyperthyroidism in February 2008. [schildkliertje.blogspot.com]
The second patient was a 42-year-old female presenting with tachycardia and mood swings who was diagnosed with hyperthyroidism in February 2008. [touchendocrinology.com]
There were no eye changes typical of Graves' and no peripheral manifestations aside from tachycardia and brisk deep tendon reflexes. [healio.com]
Case report: A 19-year-old boy manifested initially, at the age of 15 years, the typical clinical signs of hyperthyroidism (excessive sweating, heat intolerance, sleep disturbances firm goiter (II degree), tachycardia, palpitations, nervousness, excessive [endocrine-abstracts.org]
- Diastolic Hypertension
Subclinical hypothyroidism is characterized by abnormal lipid metabolism, cardiac dysfunction, diastolic hypertension conferring an elevated risk of atherosclerosis, and ischemic heart disease. [ncbi.nlm.nih.gov]
- Heart Rate Irregular
Symptoms of a thyroid storm are severe and complications include fever, dehydration, rapid heart rate, irregular heart beat, nausea, vomiting, diarrhea, weakness, confusion, disorientation, heart failure, death. [medhelp.org]
"TH elevates the heart rate to meet the increased oxygen needs" (Phillips). [drllynch.com]
Musculoskeletal
- Leg Pain
When I had my first post op appointment with my endo I told him a lot of my pains were gone, particularly the excruciating arm and leg pain, and he told me that the antibodies should be dying down. [thyroidboards.com]
Neurologic
- Hyperactivity
[…] thyroiditis disturbing the thyroid follicles, resulting in excess release of thyroid hormone. [2] Symptoms Major clinical signs include weight loss (often accompanied by an increased appetite ), anxiety, intolerance to heat, fatigue, hair loss, weakness, hyperactivity [ipfs.io]
[…] thyroiditis disturbing the thyroid follicles, resulting in excess release of thyroid hormone. [ 2 ] Symptoms Major clinical signs include weight loss (often accompanied by an increased appetite ), anxiety, intolerance to heat, fatigue, hair loss, weakness, hyperactivity [research.omicsgroup.org]
Hashimoto's thyroiditis disturbing the thyroid follicles, resulting in excess release of thyroid hormone.[2] Major clinical signs include weight loss (often accompanied by an increased appetite), anxiety, intolerance to heat, fatigue, hair loss, weakness, hyperactivity [en.wikipedia.org]
Hashimoto's thyroiditis disturbing the thyroid follicles, resulting in excess release of thyroid hormone. [2] Major clinical signs include weight loss (often accompanied by an increased appetite ), anxiety, intolerance to heat, fatigue, hair loss, weakness, hyperactivity [wikivividly.com]
These include: Anxiety And Nervousness Panic Disorder Mania Hyperactivity Weight Loss Weakness Heat Intolerance Menstrual Irregularities Irritability Difficulty Sleeping Trembling Or Jittery Rapid Heart Rate Or Palpitations Shortness Of Breath Lightheadedness [thyax.net]
- Excitement
Individuals suffering from this disorder may become excited and behave in an abnormal manner. Hyperactivity Patients tend to be abnormally active during the transient phase of hyperthyroidism. [primehealthchannel.com]
Workup
The patient underwent a thorough medical and neurological workup. Circulating thyroperoxidase antibodies were highly elevated but thyroid function was adequately maintained with L-thyroxine substitution. [jeffreydachmd.com]
Serum
- Thrombocytosis
(Korean J Med 69:S856-S860, 2005) Keywords: Thyrotoxicosis, Hü ; rthle cell tumor, Thrombocytosis [ekjm.org]
Treatment
This is an alternative treatment to thyroid removal (thyroidectomy and ablation), however, if the treatment fails, once given an ample trial, thyroid removal might be recommended as a follow up treatment." [medhelp.org]
In the few patients with a more severe presentation, methimazole treatment was required, and definitive hyperthyroidism resolution was delayed. [ncbi.nlm.nih.gov]
Prospective identification of the individual benefit/risk ratio would facilitate personalized treatment strategies when IFN-α treatment is planned. [wjgnet.com]
Prognosis
Prognosis Top The disease usually leads to permanent hypothyroidism, which requires a lifelong hormone replacement therapy (with adequate treatment, the disease causes no sequelae). [empendium.com]
If a papillary microcarcinoma is discovered incidentally in a surgically removed hyperthyroid gland, the prognosis is excellent. [frontiersin.org]
Pulmonary hypertension associated with sarcoidosis: mechanisms, haemodynamics and prognosis. Thorax 2006 ; 61 : 68 –74. ↵ Sulica R, Teirstein AS, Kakarla S, et al. [err.ersjournals.com]
Fukao A, Takamatsu J Recent Res Devel Endocrinol 3:369-376,2002 21 The relationship of psychological factors to the prognosis of hyperthyroidism in antithyroid drug-treated patients with Graves’ disease. [takamatsu.gr.jp]
Etiology
However, initial studies and the subsequent evolution of the patient, the diagnosis oriented toward a different etiology. Keywords : Hashitoxicosis; hyperthyroidism; hypothyroidism. [scielo.org.co]
Grave's disease and toxic nodular goitre are always considered as the prime etiologies in a patient with thyrotoxicosis. [ijcasereportsandimages.com]
Etiology Although there have been many theories for the etiology of Hashimoto's, no definitive causative agent has yet been identified. [med.ucla.edu]
Thyroid Res Pract 2013;10, Suppl S1:5-6 Introduction Whenever a patient presents with thyrotoxicosis, common etiologies considered are Grave's disease and toxic goiters. [thetrp.net]
Clinical Manifestations of Thyroiditis Subtypes Subtype Etiology Neck pain RAIU TSH T 4 Thyroid autoantibodies Chronic lymphocytic (Hashimoto's disease) Autoimmune No Variable Variable Variable Present Subacute granulomatous Viral Yes Decreased Decreased [aafp.org]
Epidemiology
EPIDEMIOLOGY Women are three to five times more likely to be affected than men. [aafp.org]
“[An epidemiological study on the relationship between selenium and thyroid function in areas with different iodine intake]” (article in Chinese). Zhonghua Yi Xue Za Zhi Vol. 83, No. 23 (2003): 2036–2039. [naturopathiccurrents.com]
Epidemiology Hashimoto's thyroiditis was first described by Japanese surgeon Dr. Hakaru Hashimoto in 1912 while he was practicing in Germany. It has become very common in the United States affecting about 5-10% of the population 5. [med.ucla.edu]
Pulmonary hypertension in advanced sarcoidosis: epidemiology and clinical characteristics. Eur Respir J 2005 ; 25 : 783 –788. ↵ Bourbonnais JM, Samavati L. Clinical predictors of pulmonary hypertension in sarcoidosis. [err.ersjournals.com]
Pathophysiology
GD and HT share similar pathophysiologic mechanisms but different clinical manifestations. The autoantibodies in GD and HT are different in these disorders; TRAb in GD and thyroid peroxidase antibody (TPOAb) in HT (2). [journals.aace.com]
Pathophysiology of Hashimoto’s Hashimoto’s thyroiditis is an autoimmune disease in which the thyroid gland is infiltrated by lymphocytes which attack and destroy the functioning thyroid cells called thyrocytes. [jeffreydachmd.com]
Prevention
Beginning proper treatment for Hashimoto’s disease, even in its earliest stages, can prevent further damage to the thyroid gland and possibly prevent full-blown hypothyroidism. [holtorfmed.com]
[…] thyrotoxic phase of autoimmune thyroiditis can not be confirmed with certainty, i.e. if a possibility of Graves' disease is suspected, then a short course of anti-thyroid drugs may be prescribed, while cautiously watching out with periodic testing, for preventing [thetrp.net]
[…] p If you can do anything to prevent it, don't have RAI done. I really, really regret it now. [forum.lowcarber.org]
Porphyrias Portal hypertension Postmortem skin changes Postpartum hemorrhage Postpartum period Poststreptococcal glomerulonephritis Precancerous skin lesions Pregnancy Pregnancy loss Prenatal and postnatal physiology Prenatal care Preterm labor and birth Preventive [amboss.com]