Presentation
An invasive infection was present in 3 patients who died soon after the diagnosis at 12, 13, and 45 days. Physicians should be mindful of this potential risk after treatment with voriconazole. [ncbi.nlm.nih.gov]
Hematological
- Hemophilia A
A*/genetics Hemophilia A*/metabolism Hemophilia A*/pathology Humans Mannose-Binding Lectins/genetics Mannose-Binding Lectins/metabolism Membrane Proteins/genetics Membrane Proteins/metabolism Vesicular Transport Proteins/genetics Vesicular Transport [ncbi.nlm.nih.gov]
In fact, some women may have “mild hemophilia,” though this is less common. Men have one X and one Y chromosome, so if their X chromosome has the defective gene, they will have hemophilia. [hematology.org]
Common blood disorders include anemia and bleeding disorders such as hemophilia. [hematologic.niddk.nih.gov]
Hemophilia, a condition in which the blood does not clot properly. Hemophilia is a genetic blood disease that is usually passed from mothers (who do not have symptoms of the disorder) to sons. [medstarcancer.org]
- Easy Bruising
Platelet Disorders – (usually a deficiency in platelets leading to easy bruising and excessive bleeding) Immune Thrombocytopenic Purpura (ITP) – A clinical syndrome where a decreased number of platelets causes bleeding, and easy bruising. [nhoh.com]
Several of the most common are weakness, fatigue, shortness of breath, easy bruising and bleeding, frequent infections, enlarged lymph nodes, distended or painful abdomen (due to enlarged abdominal organs), bone or joint pain, fractures, unplanned weight [sharecare.com]
These conditions can result in low blood counts (anemia), low platelet counts (thrombocytopenia) and cause many symptoms, including shortness of breath, rapid heart rate, paleness, lack of energy and easy bruising. [mountsinai.org]
On the other hand, easy bruising, a symptom suggestive of a blood disorder, can be caused by conditions other than a blood disorder, especially disorders of the blood vessels or the use of various drugs such as aspirin. [merckmanuals.com]
Entire Body System
- Anemia
The anemia of chronic renal failure and of acquired immunodeficiency syndrome has responded to treatment with recombinant human erythropoietin. [ncbi.nlm.nih.gov]
- Fatigue
(ABCB7): early-onset spinocerebellar syndrome in males, manifest primarily as delayed walking, ataxia evident in early childhood, dysmetria, and dysdiadochokinesis >1/1,000,000 Early onset, rare late onset Sickle cell anemia HBB Shortness of breath, fatigue [centogene.com]
Several of the most common are weakness, fatigue, shortness of breath, easy bruising and bleeding, frequent infections, enlarged lymph nodes, distended or painful abdomen (due to enlarged abdominal organs), bone or joint pain, fractures, unplanned weight [sharecare.com]
FPs must remain cognizant of the many diverse clinical presentations of patients with HFV/AIDS, including fatigue, weight loss, unexplained rashes, and hematologic disorders (TABLE 1 (6) and TABLE 2 (7)). [medical-dictionary.thefreedictionary.com]
- Hodgkin Lymphoma
Most frequent diagnoses were acute lymphoblastic leukemia (ALL) 18.2% (n = 438), anemia 15.9% (n = 383), non-Hodgkin's lymphoma (NHL) 15.7% (n = 378), immune thrombocytopenic purpura (ITP) 9.8% (n = 235) and Hodgkin's lymphoma (HL) 6.5% (n = 156). [ncbi.nlm.nih.gov]
(Korean J Med 78:557-563, 2010) Keywords: Multiple myeloma; Myelodysplastic syndrome; Hodgkin lymphoma; Chronic lymphocytic leukemia; Thalassemia [ekjm.org]
Patients with Hodgkin’s lymphoma (HL) were more likely to receive an autologous transplant. A flowchart for transplantation for a patient with AML appears in the image on the lower right. [labce.com]
Conditions Conditions treated by our hematologists include the following: Hodgkin's Lymphoma Leukemia, including acute and chronic leukemia Non-Hodgkin's Lymphoma Myeloma Myelodysplastic syndromes A variety of other bone marrow disorders, including blood [uwhealth.org]
An estimated 74,680 diagnoses will take place in the U.S. in 2018. 70 percent of people diagnosed with non-Hodgkin’s lymphoma live at least 5 years after being diagnosed. Hodgkin’s lymphoma is far rarer than non-Hodgkin’s lymphoma. [medicalnewstoday.com]
- Gaucher Disease
’s thrombasthenia Gaucher’s disease Mucopolysaccharidosis HSC transplants are most commonly used when the patient has a disease with a low probability of cure from other treatments (eg, chemotherapy or radiation therapy), or a disease that is incurable [labce.com]
This program is designed to raise your awareness of rare hematologic disorders (ie, Gaucher’s disease, paroxysmal nocturnal hemoglobinuria, thrombotic thrombocytopenic purpura, and immune thrombocytopenia) and improve your ability to provide accurate [gotoper.com]
Examples of enzyme disorders include Gaucher's disease and Fabry's disease. Blood Disorders Blood disorders are serious illnesses that require rigorous medical care. [medstarcancer.org]
This can be important in choosing the best treatment for your disease. [seattlecca.org]
The platelet count is usually not low enough to cause serious bleeding, but it should trigger an investigation as to why the spleen is enlarged, whether from cirrhosis of the liver and portal hypertension, Gaucher's disease, infection or lymphoma. [my.clevelandclinic.org]
- Infectious Mononucleosis
Mononucleosis Leukocytosis + Leukopenia + Leukostasis Pelger-Huet Anomaly Phagocyte Bactericidal Dysfunction + Methemoglobinemia Pancytopenia Polycythemia Pregnancy Complications, Hematologic Preleukemia Sulfhemoglobinemia Thrombophilia Activated Protein [ncbi.nlm.nih.gov]
Anti-I–specific antibodies are associated with infectious mononucleosis and with some lymphomas. [emedicine.medscape.com]
Cardiovascular
- Tachycardia
[…] usually normal in people with anemia, but cardiac output increases with exercise more than it does in people without anemia.9 As the anemia becomes more severe, resting cardiac output increases and exercise tolerance progressively decreases until dyspnea, tachycardia [musculoskeletalkey.com]
[…] recurrent bacterial and fungal infections, granuloma formation (pneumonia, lymphadenitis, liver abscess, osteomyelitis) 1:200,000 in US 1/111,000 in Israel Arabs 1/1,000,000 in Italy Early to late onset Hemolytic anemia G6PD, TPI1, CD59, KEL General pallor, tachycardia [centogene.com]
Liver, Gall & Pancreas
- Jaundice
Age of onset: >1 year Dyserythropoietic anemia COX4I2, C15orf41, KIF23, KLF1 Moderate to severe macrocytic anemia presenting occasionally in utero as severe anemia associated with hydrops fetalis but more commonly in neonates as hepatomegaly, early jaundice [centogene.com]
Jaundice and anemia c. Laboratory test: osmotic fragility test, cryohemolysis or EMA test e. [annexpublishers.co]
Management Canadian Medical Association Journal Hemophilia A GeneClinics Hemophilia B GeneClinics Obstetrical management of von Willebrand's disease 2000 OBG Management Platelet Disorders Jaundice and DIC in Pregnancy Medscape Platelet disorders March [perinatology.com]
• Jaundice. • Pica. • Infections. • Thrombocytopenia. • Drug history. Detailed work history 5. PHYSICAL EXAMINATION Pallor, jaundice, cyanosis. Abnormal bleeding. Infections. Bone tenderness (sternum) 6. [slideshare.net]
Hyperbilirubinemia and jaundice ineffective RBC formation and increased erythroblast destruction leads to excess bilirubin in the blood the waste product from breakdown of hemoglobin Neutropenia and thrombocytopenia decreased white cell count and decreased [quizlet.com]
- Protein S Deficiency
Coagulation Protein C Deficiency Protein S Deficiency Purpura, Thrombotic Thrombocytopenic Transfusion Reaction Transfusion-Related Acute Lung Injury [ncbi.nlm.nih.gov]
factor V; PCD, protein C deficiency; PSD, protein S deficiency; RVTE, recurrent venous thromboembolism; VTE, venous thromboembolism. [revespcardiol.org]
The diagnosis of a thrombosis or hemostasis disorder is based on evaluation of plasma clotting-factor proteins (factors) and platelets. Protein C or protein S deficiency and Factor V Leiden are examples of hypercoagulation disorders. [ssa.gov]
Skin
- Petechiae
Skin manifestations Petechiae (pinpoint red blood spots) Pinch purpura (blood spots as a result of stroking skin) Ecchymoses (flat bluish/purplish blood spots, larger than petechiae) Waxy induration of the skin Macroglossia (enlarged tongue) Skin signs [dermnetnz.org]
Just a few examples include the following: Blood clot (phlebitis), usually in a leg (most often causing swelling, redness, and/or warmth of the leg or shortness of breath) Petechiae (a fine pin-point red skin rash) caused by too few platelets Blood blisters [merckmanuals.com]
[…] effusions 12-18% in Cyprus/Sardinia high in Medditeranean Fetal to adult onset Thrombocytopenia ANKRD26, MASTL, CYCS, ETV6, GATA1, ITGB3, ITGA2B, GATA1, WAS External bleeding (nosebleeds, bleeding gums), bruising, particularly purpura in the forearms, petechia [centogene.com]
Workup
Initial Diagnostic Workup of Acute Leukemia: Guideline From the College of American Pathologists and the American Society of Hematology. Arch Pathol Lab Med. 2017 Feb 22. [Medline]. [Full Text]. [medscape.com]
[…] antiphospholipid antibodies panel test (lupus anticoagulant, moderate or high titer anticardiolipin antibodies, and/or anti-b2GP1 antibodies) on 2 separate occasions at least 12 weeks apart, in the setting of thrombosis or pregnancy complications. 27 A workup [revespcardiol.org]
Serum
- Neutropenia
We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. [ncbi.nlm.nih.gov]
These blood disorders include severe aplastic anaemia (SAA), thalassaemia, immune (idiopathic) thrombocytopenic purpura, congenital neutropenia, haemophilia, sickle-cell disease, iron deficiency anaemia and various other diseases. www.kinderblutkrankheiten.de [kinderkrebsinfo.de]
Neutropenia: White blood cells fight infections. Patients with neutropenia means do not have enough white blood cells. Thrombocytopenia: Platelets are cells that help with blood clot formation. [mdanderson.org]
[…] anemia Hairy cell leukemia Diamond-Blackfan syndrome Myelodysplasia Sickle cell disease Chronic myeloid leukemia Thalassemia Chronic lymphocytic leukemia Paroxysmal nocturnal hemoglobinuria Hodgkin’s disease Myelofibrosis Non-Hodgkin lymphoma Congenital neutropenia [labce.com]
Treatment
Definitive studies of the treatment of autoimmune thrombocytopenia and acute pulmonary disease and of the diagnosis and treatment of neuropsychiatric disease are not available. [ncbi.nlm.nih.gov]
Treatments for blood disorders are as varied as the disorders themselves. Some types of anemia, for example, can be controlled through diet and nutrition. Other blood disorders require more aggressive treatment. [arizonaoncology.com]
Prognosis
From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. [ncbi.nlm.nih.gov]
Scientific articles from MEDLINE for "Hematologic Diseases" - English - French - German - Spanish - Portuguese - Italian - Dutch All recent articles Therapy: by recall / by precision Diagnosis: by recall / by precision Etiology: by recall / by precision Prognosis [hon.ch]
Etiology
A systematic approach to these etiologies is important. [ncbi.nlm.nih.gov]
by recall / by precision Prognosis: by recall / by precision Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy Browse - New search Clinical Trials for "Hematologic Diseases" [hon.ch]
Thrombocytopenia Thrombocytopenic purpura may be idiopathic (i.e., of unknown etiology, as in VVerlhof's disease), or it may occur secondary to some known etiologic factor responsible lor a reduc tion in the amount of functioning marrow and a resultant [clicktocurecancer.info]
Epidemiology
Consult HON's world-wide database of medical meetings Browse - New search Refine the search for "Hematologic Diseases" Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy Broader [hon.ch]
DESIGN AND METHODS: To define sources and clinical courses of HCV infection, an epidemiologic study was performed on 13 patients newly admitted over one year who showed transaminase elevation and anti-HCV seroconversion. [ncbi.nlm.nih.gov]
The presence of Philadelphia chromosome does not confer poor prognosis in adult pre-B acute lymphoblastic leukaemia in the tyrosine kinase inhibitor era - a surveillance, epidemiology, and end results database analysis. [medscape.com]
Pathophysiology
Additionally, it is important for urologists to understand the underlying pathophysiology of hematologic disease to best serve the patients. [ncbi.nlm.nih.gov]
What you will learn about rare hematologic disorders: Strategies to improve your differential diagnosis skills Relevance of the pathophysiology and biology to the management of these disorders State-of-the-art treatment approaches and treatment-related [gotoper.com]
Research interests may include an area of applied genomics of disease of the hematological system, including but not limited to the following: molecular signaling of blood cells, bone marrow biology, and pathophysiology, molecular cytogenetics, genes [careers.insidehighered.com]
Prevention
Our ability to treat and prevent these complications will improve as our understanding of these disease processes and their pathophysiology grows. [ncbi.nlm.nih.gov]
Blood diseases and disorders affect one or more parts of the blood and prevent your blood from doing its job. Many blood diseases and disorders are caused by genes. [hematologic.niddk.nih.gov]
Cancer Research Georgetown Lombardi's world-renowned Research Faculty are discovering cancer risk factors, designing effective prevention strategies, and learning how to detect cancers earlier. [lombardi.georgetown.edu]
Hematology is the branch of medicine concerned with the study of the prevention, cause, diagnosis, and treatment of diseases related to blood. Hematologic diseases are disorders which primarily affect the blood. [imedpub.com]
These abnormal blood cells, or cancerous cells, prevent your blood from performing many of its functions, like fighting off infections or preventing serious bleeding. [hematology.org]