Presentation
An invasive infection was present in 3 patients who died soon after the diagnosis at 12, 13, and 45 days. Physicians should be mindful of this potential risk after treatment with voriconazole. [ncbi.nlm.nih.gov]
Hematological
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Easy Bruising
Platelet Disorders – (usually a deficiency in platelets leading to easy bruising and excessive bleeding) Immune Thrombocytopenic Purpura (ITP) – A clinical syndrome where a decreased number of platelets causes bleeding, and easy bruising. [nhoh.com]
Patients may report a history of easy bruising and petechiae or epistaxis and gingival bleeding preceding the pregnancy. [www1.cgmh.org.tw]
Several of the most common are weakness, fatigue, shortness of breath, easy bruising and bleeding, frequent infections, enlarged lymph nodes, distended or painful abdomen (due to enlarged abdominal organs), bone or joint pain, fractures, unplanned weight [sharecare.com]
These conditions can result in low blood counts (anemia), low platelet counts (thrombocytopenia) and cause many symptoms, including shortness of breath, rapid heart rate, paleness, lack of energy and easy bruising. [mountsinai.org]
On the other hand, easy bruising, a symptom suggestive of a blood disorder, can be caused by conditions other than a blood disorder, especially disorders of the blood vessels or the use of various drugs such as aspirin. [merckmanuals.com]
Entire Body System
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Anemia
The anemia of chronic renal failure and of acquired immunodeficiency syndrome has responded to treatment with recombinant human erythropoietin. [ncbi.nlm.nih.gov]
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Fatigue
However, rapid onset may result in symptoms of dyspnea, weakness and fatigue, and palpitations, reflecting the lack of oxygen transport to the lungs and muscles. Many people can have moderate-to-severe anemia without these symptoms. [musculoskeletalkey.com]
(ABCB7): early-onset spinocerebellar syndrome in males, manifest primarily as delayed walking, ataxia evident in early childhood, dysmetria, and dysdiadochokinesis 1/1,000,000 Early onset, rare late onset Sickle cell anemia HBB Shortness of breath, fatigue [centogene.com]
Several of the most common are weakness, fatigue, shortness of breath, easy bruising and bleeding, frequent infections, enlarged lymph nodes, distended or painful abdomen (due to enlarged abdominal organs), bone or joint pain, fractures, unplanned weight [sharecare.com]
Liver, Gall & Pancreas
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Jaundice
Jaundice and anemia c. Laboratory test: osmotic fragility test, cryohemolysis or EMA test e. [annexpublishers.co]
[…] granuloma formation (pneumonia, lymphadenitis, liver abscess, osteomyelitis) 1:200,000 in US 1/111,000 in Israel Arabs 1/1,000,000 in Italy Early to late onset Hemolytic anemia G6PD, TPI1, CD59, KEL General pallor, tachycardia, tachypnea, hypotension, jaundice [centogene.com]
Hyperbilirubinemia and jaundice ineffective RBC formation and increased erythroblast destruction leads to excess bilirubin in the blood the waste product from breakdown of hemoglobin Neutropenia and thrombocytopenia decreased white cell count and decreased [quizlet.com]
• Jaundice. • Pica. • Infections. • Thrombocytopenia. • Drug history. Detailed work history 5. PHYSICAL EXAMINATION Pallor, jaundice, cyanosis. Abnormal bleeding. Infections. Bone tenderness (sternum) 6. [slideshare.net]
Management Canadian Medical Association Journal Hemophilia A GeneClinics Hemophilia B GeneClinics Obstetrical management of von Willebrand's disease 2000 OBG Management Platelet Disorders Jaundice and DIC in Pregnancy Medscape Platelet disorders March [perinatology.com]
Cardiovascular
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Tachycardia
[…] usually normal in people with anemia, but cardiac output increases with exercise more than it does in people without anemia.9 As the anemia becomes more severe, resting cardiac output increases and exercise tolerance progressively decreases until dyspnea, tachycardia [musculoskeletalkey.com]
[…] recurrent bacterial and fungal infections, granuloma formation (pneumonia, lymphadenitis, liver abscess, osteomyelitis) 1:200,000 in US 1/111,000 in Israel Arabs 1/1,000,000 in Italy Early to late onset Hemolytic anemia G6PD, TPI1, CD59, KEL General pallor, tachycardia [centogene.com]
Skin
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Petechiae
Petechiae were the most common skin manifestation (58.3%) followed by noninflammatory retiform purpura (33.3%) [Figure 1] and hematoma (16.6%). The average platelet count in patients with petechiae was 48,000/mm 3 (range, 40,000-74,000/mm 3 ). [idoj.in]
Patients may report a history of easy bruising and petechiae or epistaxis and gingival bleeding preceding the pregnancy. [www1.cgmh.org.tw]
F.cchymosis and petechiae observed most often in the soft palate area is a sign of an underlying bleeding disorder d igs. 12-N and 12-9). [clicktocurecancer.info]
Idiopathic thrombocytopenic purpura mostly occurs with an onset of petechiae and/or ecchymoses on the skin and mucous membranes. [emedicine.medscape.com]
Skin manifestations Petechiae (pinpoint red blood spots) Pinch purpura (blood spots as a result of stroking skin) Ecchymoses (flat bluish/purplish blood spots, larger than petechiae) Waxy induration of the skin Macroglossia (enlarged tongue) Skin signs [dermnetnz.org]
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Localized Scleroderma
The development of a serious hematologic disease, especially a lymphoproliferative process, may rarely be seen not only in patients with eosinophilic fasciitis but also in those with systemic or localized scleroderma. [ncbi.nlm.nih.gov]
Workup
[…] antiphospholipid antibodies panel test (lupus anticoagulant, moderate or high titer anticardiolipin antibodies, and/or anti-b2GP1 antibodies) on 2 separate occasions at least 12 weeks apart, in the setting of thrombosis or pregnancy complications. 27 A workup [revespcardiol.org]
Initial Diagnostic Workup of Acute Leukemia: Guideline From the College of American Pathologists and the American Society of Hematology. Arch Pathol Lab Med. 2017 Feb 22. [Medline]. [Full Text]. [medscape.com]
Treatment
LM may be a safe method of treatment of PMH in children in selected cases. [ncbi.nlm.nih.gov]
Prognosis
From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. [ncbi.nlm.nih.gov]
Scientific articles from MEDLINE for "Hematologic Diseases" - English - French - German - Spanish - Portuguese - Italian - Dutch All recent articles Therapy: by recall / by precision Diagnosis: by recall / by precision Etiology: by recall / by precision Prognosis [hon.ch]
Idiopathic pneumonia syndrome after HSCT IPS has a grave prognosis, and the requirement for mechanical ventilation confers a particularly poor prognosis. [clinicaladvisor.com]
Etiology
A systematic approach to these etiologies is important. [ncbi.nlm.nih.gov]
by recall / by precision Prognosis: by recall / by precision Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy Browse - New search Clinical Trials for "Hematologic Diseases" [hon.ch]
of unknown etiology, as in VVerlhof's disease), or it may occur secondary to some known etiologic factor responsible lor a reduc tion in the amount of functioning marrow and a resultant reduction in the number of circulating platelets. [clicktocurecancer.info]
Epidemiology
DESIGN AND METHODS: To define sources and clinical courses of HCV infection, an epidemiologic study was performed on 13 patients newly admitted over one year who showed transaminase elevation and anti-HCV seroconversion. [ncbi.nlm.nih.gov]
Consult HON's world-wide database of medical meetings Browse - New search Refine the search for "Hematologic Diseases" Subheadings: complications / diagnosis / embryology / epidemiology / etiology / metabolism / microbiology / surgery / therapy Broader [hon.ch]
The presence of Philadelphia chromosome does not confer poor prognosis in adult pre-B acute lymphoblastic leukaemia in the tyrosine kinase inhibitor era - a surveillance, epidemiology, and end results database analysis. [medscape.com]
Pathophysiology
Additionally, it is important for urologists to understand the underlying pathophysiology of hematologic disease to best serve the patients. [ncbi.nlm.nih.gov]
Research interests may include an area of applied genomics of disease of the hematological system, including but not limited to the following: molecular signaling of blood cells, bone marrow biology, and pathophysiology, molecular cytogenetics, genes [careers.insidehighered.com]
Pathophysiology of vitamin B 12 deficiency The pathophysiological mechanism by which H. pylori is related to the etiology of vitamin B 12 deficiency has not been fully clarified, and many questions remain. [intechopen.com]
Prevention
Our ability to treat and prevent these complications will improve as our understanding of these disease processes and their pathophysiology grows. [ncbi.nlm.nih.gov]
Blood diseases and disorders affect one or more parts of the blood and prevent your blood from doing its job. Many blood diseases and disorders are caused by genes. [hematologic.niddk.nih.gov]
Hematology is the branch of medicine concerned with the study of the prevention, cause, diagnosis, and treatment of diseases related to blood. Hematologic diseases are disorders which primarily affect the blood. [imedpub.com]
The Iron Disorders Institute provides information about iron disorders as well as preventions, publications, diet suggestions, and more. [nhoh.com]