Presentation
Survival differed by disease group (P 0.01) and having fever at presentation (P 0.02). Conclusion: We found long-term OS to be impacted by disease type and status of fever at presentation. [jmedtropics.org]
Zelenetz, MD, PhD Memorial Sloan Kettering Cancer Center Recorded Presentations from the NCCN 2019 Annual Congress (September 27 – 28, 2019) will be available through the NCCN Continuing Education Portal. Save the Date! [nccn.org]
Originally presented on December 17, 2015 in Salt Lake City, Utah. [arup.utah.edu]
Factors associated with/or prognostic for CNS involvement is a high initial white blood cell count at presentation and a high LDH at presentation. [mdanderson.org]
Occasional residual follicles are present. Scattered plasma cells and a minor population of larger cells were typically present. (B) Breast epithelium was either absent or only focally present. [journals.sagepub.com]
Entire Body System
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Fatigue
Blood and Lymph Cancer Robert is a 12-year-old who has recently started feeling quite sick, suffering from constant headaches, fever, and fatigue. Robert has also been losing a lot of weight over the past few weeks as well. [study.com]
They are usually very, very aggressive and patients often present very sick to the hospital with symptoms such as: severe malaise and fatigue; high fevers; symptoms of anemia such as shortness of breath and severe fatigue; bone pain, as the leukemia is [mdanderson.org]
Several of the most common are weakness, fatigue, shortness of breath, easy bruising and bleeding, frequent infections, enlarged lymph nodes, distended or painful abdomen (due to enlarged abdominal organs), bone or joint pain, fractures, unplanned weight [sharecare.com]
At examination, the patient had moderate mucositis and appeared to be fatigued. The central venous catheter site was not inflamed. The patient was admitted to the hospital and was given a β-lactam plus an aminoglycoside antibiotic. [academic.oup.com]
Gastrointestinal
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Abdominal Pain
Anagrelide A prostaglandin synthetase inhibitor, specifically inhibits platelet production but occasionally causes mild anemia Myeloproliferative neoplasms Palpitations, CHF, noncardiac edema, diarrhea, abdominal pain, headache, bleeding, anemia In the [accessmedicine.mhmedical.com]
In view of the case patient's acute abdominal pain, metronidazole might be a good addition to broad-spectrum antibiotic therapy. [academic.oup.com]
A 34-year-old man presented with a 6-month history of abdominal pain. CT scan showed a 9-cm mesenteric abdominal mass. On laparotomy, an unresectable mesenteric tumor was found, consistent with Castleman's disease, plasma cell variant, localized. [medscape.com]
Neurologic
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Headache
Anagrelide A prostaglandin synthetase inhibitor, specifically inhibits platelet production but occasionally causes mild anemia Myeloproliferative neoplasms Palpitations, CHF, noncardiac edema, diarrhea, abdominal pain, headache, bleeding, anemia In the [accessmedicine.mhmedical.com]
Blood and Lymph Cancer Robert is a 12-year-old who has recently started feeling quite sick, suffering from constant headaches, fever, and fatigue. Robert has also been losing a lot of weight over the past few weeks as well. [study.com]
Of note, the SM compartment is often involved in MC mediator-related symptoms such as recurrent syncope, headache, flushing, gastro-intestinal tract symptoms and, in severe cases, life-threatening anaphylactic shock. [orpha.net]
The clinical signs of SIADH vary with the degree and rapidity of onset of hyponatremia, so that the patients can manifest nausea, anorexia, headache, fatigue, muscle cramps, lethargy, seizures, respiratory depression, coma [93]. [archivesofmedicine.com]
Other toxicities that are associated with CAR T cell therapy include neurotoxicity, which can include headaches, confusion, hallucinations, dysphasia, ataxia, apraxia, facial nerve palsy, tremor, dysmetria, global encephalopathy, and even seizures [57 [jhoonline.biomedcentral.com]
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Cognitive Impairment
NCT03087227 Recruiting 18 NO Healthy Volunteers NO Placebo Multiple locations in your area Cognitive Impairment Clinical Trial A pilot study to evaluate feasibility of enrollment of patients in an intervention to improve neurocognitive function in hematopoietic [patientwing.com]
Workup
Molecular testing is entrenched in the workup and management of hematological malignancies. [cancertherapyadvisor.com]
Elderly patients may also be considered by physicians to have poor prognoses (perhaps because of the frequent presence of comorbidities), and thus receive a suboptimal diagnostic workup. [bloodjournal.org]
[…] the systemic circulation. [1] Clinically, the syndrome is characterized by rapid development of hyperuricemia,hyperkalemia, hyperphosphatemia, hypocalcemia, and acute kidney injury. [2, 3] (See Pathophysiology, Etiology, Prognosis, Presentation, and Workup [emedicine.medscape.com]
The workup of the diagnosis includes the absence of BCR-ABL1 fusion and of rearrangements of PDGFRA, PDGFRB, and FGFR1. [basicmedicalkey.com]
X-Ray
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Pulmonary Infiltrate
infiltrates, pleural and/or pericardial effusions, unexplained fevers, and acute renal insufficiency. [accessmedicine.mhmedical.com]
Treatment
S/A/R pos adversely affected response to treatment and progression to secondary mast cell leukemia (n 6) or acute myeloid leukemia (n 3) while on treatment ( P P 0.03). [ncbi.nlm.nih.gov]
New molecular and cytogenetic methods have been connected to determination of diagnosis and treatment. [intechopen.com]
Food and Drug Administration (FDA) approved fostamatinib disodium hexahydrate (Tavalisse) for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment. [ascopost.com]
What is the best treatment for a 51-year-old woman with diffuse large B-cell lymphoma of the spleen who underwent splenectomy? There was no other localization of disease. [medscape.com]
Prognosis
Prognosis Currently the overall median survival of 24 months is reported. [orpha.net]
These patients can receive adjuvant imatinib, which can improve complete remission rates despite carrying the worst prognosis of all types of lymphoblastic lymphoma. [cancertherapyadvisor.com]
On this end, translocation t(12;21), in fact, is associated with a better prognosis, as most often seen in younger kids. This is a table looking at the types of chromosomes and the prognosis that they portend. [mdanderson.org]
The prognosis is variable and depends on which gene is mutated. [basicmedicalkey.com]
Etiology
[…] anatomy and histology blood blood supply cerebrospinal fluid chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology [ncbi.nlm.nih.gov]
Dexamethasone 10 mg IV twice a day should be started at the earliest sign of differentiation syndrome, even if other etiologies like sepsis or primary CHF are possible. [accessmedicine.mhmedical.com]
Etiology In the vast majority of cases, an acquired and activating mutation in KIT, mostly KITD816V, can be found in the abnormal MCs of the SM compartment as well as in the malignant cells of certain AHN types. [orpha.net]
There is no single known cause for blood diseases; the frequency of HM varies with geography, age and ethnicity, which suggests the involvement of various etiological factors (20). [spandidos-publications.com]
[…] similar etiologies, and are more compatible with clinical classifications than the broad categories used by CRs. [bloodjournal.org]
Epidemiology
HAEMACARE classified HMs into groupings consistent with the latest World Health Organization classification and useful for epidemiologic and public health purposes. [ncbi.nlm.nih.gov]
Middleton, RJ Gavin, AT Reid, JS O’Reilly, D Accuracy of hospital discharge data for cancer registration and epidemiological research in Northern Ireland. Cancer Causes Control 2000 11 10 899 – 905 Google Scholar Crossref Medline [journals.sagepub.com]
Summary Epidemiology Systemic mastocytosis with an associated hematologic neoplasm (SM-AHN) is suggested to represent between 10-40% of all cases of SM, for which the prevalence in Europe is estimated between 1/7,700 and 1/10,400. [orpha.net]
Pathophysiology
This conference brings together biochemists, geneticists, molecular biologists, and clinicians interested in the pathophysiology of leukemias and lymphomas, and the development of novel therapies for these diseases. [src.faseb.org]
In these chapters we provide a more detailed look at the pathophysiology, clinical features, and treatment of the major types of hematologic malignancy, which include some of the most common cancers of children and adults. [accessmedicine.mhmedical.com]
Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. [annualreviews.org]
This unique situation may be explained by the complex array of physiological and possibly pathophysiological cell functions of PR3 [56]. [hindawi.com]
Maier JD, Levine SN (2015) Hypercalcemia in the Intensive Care Unit: A Review of Pathophysiology, Diagnosis, and Modern Therapy. J Intensive Care Med 30: 235-252. [archivesofmedicine.com]
Prevention
Leukemia can also prevent the body from producing red blood cells as well. [study.com]
University Teaching Hospital, Jos, Nigeria 2 Department of Family Medicine, University of Jos/Jos University Teaching Hospital, Jos, Nigeria 3 Department of Histopathology, Jos University Teaching Hospital, Jos, Nigeria 4 Department of Medicine and Preventive [jmedtropics.org]
[…] imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology genetics history immunology metabolism microbiology mortality nursing organization and administration parasitology pathology physiology physiopathology prevention [ncbi.nlm.nih.gov]
The authors also pointed out that prevention efforts are less effective for hematologic malignancies than for other cancers. [mdedge.com]