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Hematologic Neoplasm

Hematological Malignancy


Presentation

  • Originally presented on December 17, 2015 in Salt Lake City, Utah.[arup.utah.edu]
  • Factors associated with/or prognostic for CNS involvement is a high initial white blood cell count at presentation and a high LDH at presentation.[mdanderson.org]
  • The program content is structured as "How I Treat" presentations, which showcase each speaker's evidence-based treatment approaches.[hematology.org]
  • Case Study 3 History and presentation.[academic.oup.com]
  • Review 'tables concisely highlight the pertinent points in the text' 'the combination of flow cytometry, immunohistochemistry, and molecular techniques makes this book a powerful reference text' 'images are high quality and help illustrate the case' 'presents[amazon.com]
Fishing
  • Cryptic insertion of BCR at 9q34 in CML Wan TS et al, Leukemia 18: 161 – 2, 2004 D-FISH: 1R2G1F pattern S-FISH ES-FISH D-FISH 10. BTG 2013 Chimerism status by XY-FISH 11. BTG 2013 Chronic myeloid leukaemia post-BMT donor relapse 12.[slideshare.net]
  • Specific indications to perform PDGFRA, PDGFRB or FGFR1 analysis by fluorescent in situ hybridization (FISH) or by karyotyping have not been established as eosinophilia may be absent in a subset of cases and is therefore not a reliable indicator for laboratory[eposters.net]
  • In cytogenetics, the conventional karyotype is supplemented and partly replaced by the fluorescence in situ hybridization (FISH) technique.[books.google.com]
  • HEMC assessments include information from flow cytometry, morphology, chromosomal analysis, FISH and molecular testing.[n-of-one.com]
  • PMID 10459351 Detection of hyperdiploid karyotypes ( 50 chromosomes) in childhood acute lymphoblastic leukemia (ALL) using fluorescence in situ hybridization (FISH).[atlasgeneticsoncology.org]
Exposure to Benzene
  • The childhood peak in LL/ALL is well known 1, 2 and has been related to host susceptibility factors and response to antigens in early or prenatal life, 14 to exposure to electromagnetic fields, 15 or to exposure to benzene and other hydrocarbons from[bloodjournal.org]
Painter
  • Smith A, Crouch S, Lax S, Li J, Painter D, Howell D, et al. Lymphoma incidence, Survival and prevalence 2004–2014: sub-type analyses from the UK's Haematological Malignancy Research Network.[journals.plos.org]
Weight Gain
  • gain and edema, progressing to dyspnea, interstitial pulmonary infiltrates, pleural and/or pericardial effusions, unexplained fevers, and acute renal insufficiency.[accessmedicine.mhmedical.com]

Workup

  • Molecular testing is entrenched in the workup and management of hematological malignancies.[cancertherapyadvisor.com]
  • Elderly patients may also be considered by physicians to have poor prognoses (perhaps because of the frequent presence of comorbidities), and thus receive a suboptimal diagnostic workup.[bloodjournal.org]
  • […] the systemic circulation. [1] Clinically, the syndrome is characterized by rapid development of hyperuricemia,hyperkalemia, hyperphosphatemia, hypocalcemia, and acute kidney injury. [2, 3] (See Pathophysiology, Etiology, Prognosis, Presentation, and Workup[emedicine.medscape.com]

Treatment

  • S/A/R pos adversely affected response to treatment and progression to secondary mast cell leukemia (n 6) or acute myeloid leukemia (n 3) while on treatment ( P P 0.03).[ncbi.nlm.nih.gov]
  • We report a case of donor derived 20q11.2 deletion in a male patient who received an allogeneic HSCT from his HLA-identical sister for the treatment of his chronic lymphocytic leukemia.[ncbi.nlm.nih.gov]
  • The program content is structured as "How I Treat" presentations, which showcase each speaker's evidence-based treatment approaches.[hematology.org]
  • This commonly leads to a different approach in diagnosis and treatment of haematological malignancies.[omicsonline.org]
  • Studies in Newly Diagnosed Patients Novel agents have been incorporated in the treatment of multiple myeloma.[massgeneral.org]

Prognosis

  • These patients can receive adjuvant imatinib, which can improve complete remission rates despite carrying the worst prognosis of all types of lymphoblastic lymphoma.[cancertherapyadvisor.com]
  • On this end, translocation t(12;21), in fact, is associated with a better prognosis, as most often seen in younger kids. This is a table looking at the types of chromosomes and the prognosis that they portend.[mdanderson.org]
  • Disease prognosis relies on accurately classifying the eosinophilia.[eposters.net]
  • The current development of gene expression profiling is even more powerful in terms of subtyping the hematologic tumors, which may help guiding the treatment and predict the prognosis.[books.google.com]

Etiology

  • […] anatomy and histology blood blood supply cerebrospinal fluid chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology[ncbi.nlm.nih.gov]
  • Dexamethasone 10 mg IV twice a day should be started at the earliest sign of differentiation syndrome, even if other etiologies like sepsis or primary CHF are possible.[accessmedicine.mhmedical.com]
  • […] similar etiologies, and are more compatible with clinical classifications than the broad categories used by CRs.[bloodjournal.org]
  • Etiology Tumor lysis syndrome occurs most often in patients with acute leukemia with high white blood cell (WBC) counts and in those with high-grade lymphomas in response to aggressive treatment.[emedicine.medscape.com]
  • And the reason for this is to try to figure out the etiology of the cytopenia, whether it is due to underproduction, where the bone marrow is not producing good blood cells or whether it is due to increased peripheral destruction.[mdanderson.org]

Epidemiology

  • HAEMACARE classified HMs into groupings consistent with the latest World Health Organization classification and useful for epidemiologic and public health purposes.[ncbi.nlm.nih.gov]
  • […] options Subheadings: analysis anatomy and histology blood blood supply cerebrospinal fluid chemically induced chemistry classification complications congenital cytology diagnosis diagnostic imaging diet therapy drug therapy economics embryology enzymology epidemiology[ncbi.nlm.nih.gov]
  • Middleton, RJ Gavin, AT Reid, JS O’Reilly, D Accuracy of hospital discharge data for cancer registration and epidemiological research in Northern Ireland. Cancer Causes Control 2000 11 10 899 – 905 Google Scholar Crossref Medline[journals.sagepub.com]
  • Epidemiology Male predominance (71%), patients ranged in age from 14 to 69 (median 41.5 years). Prognosis Most of 1q triplication cases did not provide detailed information for the patients' survival.[atlasgeneticsoncology.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Rapid tumor cell turnover results in release of intracellular contents into the circulation. This release can inundate renal elimination and cellular buffering mechanisms, leading to numerous metabolic derangements.[emedicine.medscape.com]

Prevention

  • […] imaging diet therapy drug therapy economics embryology enzymology epidemiology ethnology etiology genetics history immunology metabolism microbiology mortality nursing organization and administration parasitology pathology physiology physiopathology prevention[ncbi.nlm.nih.gov]
  • Author information 1 Department of Preventive and Predictive Medicine, Unit of Analytical Epidemiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. milena.sant@istitutotumori.mi.it Abstract Changing definitions and classifications of[ncbi.nlm.nih.gov]
  • Medical oncologist Jane Churpek, MD, left, and gastroenterologist Sonia Kupfer, MD, are co-directors of the Comprehensive Cancer Risk and Prevention Clinic.[uchospitals.edu]
  • Stockholm, Sweden : European Centre for Disease Prevention and Control ; 2009. European Centre for Disease Prevention and Control/WHO Regional Office for Europe. View Abstract[bloodjournal.org]
  • […] and other material related to breast cancer, gastrointestinal cancer, hematologic malignancies, molecular oncology, lung cancer, genitourinary cancer, head and neck cancer, pediatric oncology, neurooncology, supportive care and quality of life issues, prevention[ghrnet.org]

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