The purpose of the present study was to determine HAdV types responsible for viremia in HSCT recipients at a large tertiary hospital in Poland. [ncbi.nlm.nih.gov]

The improvement in the global economic condition is likely to present massive opportunities to these companies in the years to come, states the research report. [prnewswire.com]

These cells are present at such low levels, however, that collection of enough stem cells to do a transplantation is very difficult, generally requiring 5 or more apheresis. [bloodline.net]

• Pain

  Most donors reporting pain received pain medications, usually acetaminophen or ibuprofen, with approximately 65% and 30% reporting some pain relief or complete pain relief, respectively. [dx.doi.org]

• Hodgkin Lymphoma

  CASE PRESENTATIONS: Three patients with Hodgkin's lymphoma relapsed following allogeneic transplant received nivolumab therapy at our institution. [ncbi.nlm.nih.gov]

  lymphoma Autologous transplantation is the standard of care for chemosensitive, relapsed Hodgkin lymphoma and primary refractory Hodgkin lymphoma. [41] Therapy for chemoresistant relapsed disease is under investigation, and some evidence suggests that [emedicine.medscape.com]

• Candidiasis

  Widely adopted fluconazole prophylaxis led to marked reduction of invasive candidiasis after HCT and improved survival 3. [f1000research.com]

  With the breakdown of the mucosa of the gastrointestinal (GI) tract because of GVHD and chemotherapy, candida colonisers can invade the tissues and cause invasive candidiasis. [omicsonline.org]

  Nicolatou-Galitis O, Dardoufas K, Markoulatos P et al (2001) Oral pseudomembranous candidiasis, herpes simplex virus-1 infection, and oral mucositis in head and neck cancer patients receiving radiotherapy and granulocyte-macrophage colony-stimulating [springerlink.com]

• Weight Loss

  It causes fever, rash, hepatitis with hyperbilirubinemia, vomiting, diarrhea, abdominal pain (which may progress to ileus), and weight loss. [merckmanuals.com]

  History A 23 year old white man with refractory Hodgkin's disease and a history of hematopoietic stem cell transplantation was admitted with nausea, vomiting, abdominal pain and weight loss. [thoracic.org]

  Severe weight loss in 3 months after allogeneic hematopoietic SCT was associated with an increased risk of subsequent non-relapse mortality. [ncc.go.jp]

  In addition, joint stiffness along with restricted range of motion, weight loss, nausea, difficulty swallowing, and diarrhea should be noted. [cancer.gov]

• Aspiration

  These cells can be ”collected” either by performing repeated bone marrow aspirations or by “mobilizing” HSCs into the circulation using special medications called cytokines (like GCSF, also called neupogen), and filtering them out of your blood using [cumc.columbia.edu]

  41.0 Bone marrow or hematopoietic stem cell transplant Note: To report donor source - see codes 00.91-00.93 Excludes: aspiration of bone marrow from donor (41.91) [icd9cm.chrisendres.com]

  For bone marrow stem cell harvest, 700 to 1500 mL (maximum 15 mL/kg) of marrow is aspirated from the donor’s posterior iliac crests; a local or general anesthetic is used. [merckmanuals.com]

  Bone marrow is generally aspirated from the posterior iliac crests while the donor is under either regional or general anesthesia. [emedicine.medscape.com]

• Abdominal Pain

  It causes fever, rash, hepatitis with hyperbilirubinemia, vomiting, diarrhea, abdominal pain (which may progress to ileus), and weight loss. [merckmanuals.com]

  History A 23 year old white man with refractory Hodgkin's disease and a history of hematopoietic stem cell transplantation was admitted with nausea, vomiting, abdominal pain and weight loss. [thoracic.org]

  A 41-year-old man with fever and abdominal pain after stem-cell transplantation. N Engl J Med 2014; 370:1637-46. PubMed Fathi AT, Chen YB. CD30: a new target for ALL? Leuk Lymphoma 2014; 55:478-9. [dfhcc.harvard.edu]

  This causes hematuria, frequency, abdominal pain and thrombocytopnea. Graft-versus-host disease (GVHD) is an inflammatory disease that is unique to allogeneic transplantation. [en.wikipedia.org]

• Skin Rash

  Potential side effects: Fever Chills Hives or other skin rashes Severe allergic reaction (rare) BCNU (Carmustine) What it does: Destroys cancer cells. How it is given: IV. [ucsfbenioffchildrens.org]

  Introduction Systemic juvenile idiopathic arthritis (sJIA) is characterized by arthritis associated with prominent systemic features such as fever, skin rash, serositis, lymphadenopathy, hepatosplenomegaly, and increased inflammatory markers. [bloodadvances.org]

  This is a poorly understood syndrome of fever, skin rash, pulmonary infiltrates, cough and shortness of breath occurring just prior to, or at the time of the rise in the white cell count. [cancertherapyadvisor.com]

  Symptoms assessed included allergy, anorexia, chills, fever, sweats, fatigue, headache, myalgia, nausea, vomiting, other flulike symptoms, local reactions, skin rash, pain, and infections. [dx.doi.org]

• Blurred Vision

  Potential side effects: Nausea, vomiting and diarrhea Lowers blood counts Hair loss Irritation and sores in the mouth and intestinal tract Damage to the liver Drowsiness blurred vision May sensitize the skin to sunlight Tacrolimus (FK506) What it does [ucsfbenioffchildrens.org]

• Suggestibility

  Two recent retrospective studies suggested better outcome following transplantation in patients older than age 40 years compared with chemotherapy because of the reduced NRM and preserved GVL effects. 46, 56 These studies suggest that in the context of [bloodjournal.org]

  We demonstrated high variability in sequences of detected HAdV types, and patients infected with the same HAdV types were not hospitalized at the same time, which suggests the low possibility of cross-infection. [ncbi.nlm.nih.gov]

  I am indebted to Myra Patterson for assistance with the preparation of the manuscript, to Melissa Hunter for assistance with the figures, and to Herbert Copelan for many helpful suggestions. Author Affiliations From the Arthur G. [nejm.org]

The laboratory workup showed hemoglobin of 11.1 g/dL; white blood cells, 7500/mL; platelets, 172,000/mL; free thyroxine (FT4), 4.80 ng/dL (normal, 0.5-1.51); free triiodothyronine (FT3), 17.7 pg/mL (normal, 2.5-3.9); thyrotropin (TSH), 0.015 mIU/mL (normal [ncbi.nlm.nih.gov]

Several retrospective studies addressed that question, but an independent impact of age was often absent. 45, 48 ⇓ ⇓ - 51 Those studies suggested no definite age limit, but they noted that the assessment of comorbidities was an essential part of the workup [bloodjournal.org]

Table 2 Transplant features ( n =30) Pretransplant workup was as appropriate to ensure adequate organ function and to establish disease status. [dx.doi.org]

• Cytopenia

  Immune cytopenias complicated Wiskott Aldrich syndrome and Hemophagocytic lymphohistiocytosis transplants. 29.4% (25/85) children underwent haploidentical transplant in our cohort with a survival of 70% in this group. [ncbi.nlm.nih.gov]

  Myelodysplastic syndrome (MDS) is divided into: early (refractory anemia [RA] or refractory anemia with ringed sideroblasts [RARS], refractory cytopenia with unilineage dysplasia [RCUD], refractory cytopenia with multilineage dysplasia [RCMD], MDS with [cibmtr.org]

  Include presence/absence of refractory cytopenias. [cms.gov]

• HLA-A2

  For example, the recipient’s HLA type is HLA-A2, B44 and DR8/9. Donor 1’s HLA type is HLA-A2, B51, B46 and DR8/9. Donor 2’s HLA type is HLA-A2/11, B44, B46 and DR8/9. In this case, donor 1 is preferred. 2.3.2. [intechopen.com]

  HLA-A2 positive patients were divided into low and high cytotoxic T lymphocytes (CTL) autoreactivity groups according to the cumulative frequencies of islet-specific CTLs at baseline. [frontiersin.org]

Key results The results of the RCT did not favor either of the two treatment arms with respect to overall survival. There was one death related to treatment in the transplantation group and none in the chemotherapy-only group. [cochrane.org]

The prolonged treatment process leads to a decline in physical functioning due to the side effects of medical treatment [ 25, 28 ]. [link.springer.com]

Treatment-related morbidity and mortality rates are lowest with autografts, with the major problem being tumor relapse. [emedicine.medscape.com]

Treatment may not be necessary for GVHD that affects the skin and mucous membranes; treatment of more extensive disease is similar to that of acute GVHD. [merckmanuals.com]

Nutritional status recovery and prognosis were significantly worse in patients who developed OM. [ncbi.nlm.nih.gov]

Pneumatosis intestinalis (PI), defined as intestinal intra- and extramural gas accumulation, is a rare radiographic finding in conditions of intestinal wall damage of varied etiology. [ncbi.nlm.nih.gov]

Coplin et al, evaluated the incidence, etiology and prognosis of strokes in patients after HSCT. [scielo.br]

Idiopathic pneumonia syndrome after hematopoietic cell transplantation: evidence of occult infectious etiologies. Blood 2015;125:3789–97. 74. Nakane T, Nakamae H, Kamoi H, et al. [mdedge.com]

[…] as preparative regimen elements, prior use of gemtuzumab ozogamicin (Mylotarg, which is used to treat acute myelogenous leukemia by targeting CD33 expressing cells and thus may be toxic to liver sinusoids) and pre-HSCT liver disease irrespective of etiology [clinicaladvisor.com]

[…] chronic complications of type 1 diabetes mellitus (DM)—the higher the C-peptide levels (an indirect measure of viable beta-cell function), the lower the incidence of microvascular complications of type 1 DM. 1 Since the establishment of the autoimmune etiology [doi.org]

Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation. J Infect Dis 1997;175:1459–66. 45. Ascioglu S, Rex JH, de Pauw B, et al. [mdedge.com]

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med. 2007; 147 :573–7. [ PubMed ] [ Google Scholar ] 19. [ncbi.nlm.nih.gov]

Knowles WA (2006) Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV). Adv Exp Med Biol 577: 19-45. [omicsonline.org]

Calculated incidence rates were compared with age-specific (crude) incidence rates in the general white population of leukemia, non-Hodgkin’s lymphoma, Hodgkin’s lymphoma and myeloma, obtained from the US Surveillance, Epidemiology, and End Results (SEER [doi.org]

In this paper, we focused on the definitions of graft failure / poor graft function and also we reviewed the current understanding of the pathophysiology, risk factors and treatment approaches for these entities. Copyright © 2018. [ncbi.nlm.nih.gov]

Review the pathophysiology of graft-versus-host disease, its presentation, and its prevention and management. [pedsinreview.aappublications.org]

Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which immune mechanisms appear to be an important component of the pathophysiology. [doi.org]

Pathophysiology of acute lung injury and the adult respiratory distress syndrome. Semin Respir Crit Care Med 2006;27:337-349. Cagle PT, Allen TC, Barrios R, Bedrossian C, Dishop MK. Color atlas and text of pulmonary pathology. 2nd ed. [thoracic.org]

The role of the newly approved drug, letermovir, for CMV prevention is highlighted in the context of current prevention strategies after allogeneic hematopoietic stem cell transplantation. [ncbi.nlm.nih.gov]

These can often be prevented by simple measures as frequent hand washing, vaccinations and appropriate donor screening. [omicsonline.org]

Larmouth. 5 Prevention of infection during hematopoietic stem cell transplantation. W. Larmouth and A.Galloway. 6 Bacterial, fungal, and parasitic infections in the transplant patient. G. Jones, J. Clark and A. [wiley.com]

This can be explained by changes in clinical practice associated with more effective prevention of severe acute and chronic GVHD. [f1000research.com]

In order to prevent rejection, most patients require chemotherapy and/or radiation therapy to weaken their own residual immune system enough to prevent it from rejecting the transplanted HSCs. This is called “conditioning” before transplantation. [primaryimmune.org]