Hemiballismus is a hyperkinetic movement disorder most commonly arising after stroke and large-amplitude flinging movements of contralateral limb or limbs is pathognomonic for this condition. Spontaneous remission is frequent within several months, but D2 blockers, neuroleptics and surgery are used when necessary.
The hallmark of hemiballsimus is the development of large-amplitude, involuntary, irregular and violent movement of the limbs on one side of the body [1]. The proximal aspects of the arm and leg are most commonly affected, whereas facial involvement is seen in about 50% of cases [1]. These large-amplitude movements can cause severe exhaustion and dehydration, but also local injury and even death in extreme cases [7].
The diagnosis can be made during physical examination, as this hyperkinetic disorder is easily distinguished from other movement disorders. If stroke is presumed to be the cause, either CT or MRI of the endocranium may be performed to confirm the diagnosis.
The goal of treatment is to resolve the underlying cause [1], which may not be confirmed in all cases. Dopamine-2 receptor blockers and neuroleptics (haloperidol, perphenazine) are first-line pharmacologic agents used for patient in whom spontaneous remission of symptoms does not occur [1] [2]. Catecholamine-depleting agents such as reserpine and tetrabenazine, on the other hand, are used in more resistant cases, whereas surgery is considered to be the last resort of care [1]. Stereotactic pallidotomy may be performed in patients who suffer from persistent hemiballismus that is refractory to therapy [6].
The prognosis is generally good, as spontaneous improvement or remission occurs in many patients [2].
The most common cause of hemiballismus is stroke, while other notable conditions include nonketotic hyperglycemia and complications of advanced human immunodeficiency virus (HIV) infection [5].
Approximately 1% of individuals who suffer from acute stroke develop hemiballismus and symptoms appear around 4 days after the initial incident, but in a small fraction of patients, the onset may be within 24 hours [1].
Presumably, the conditions that induce this hyperkinetic disorder interfere with the basal ganglia and the pathogenesis is thought to involve abnormal neuronal signaling in the globus pallidus, most likely caused by focal lesions in the contralateral basal ganglia and the subthalamic nucleus [1] [3].
Fortunately, the disorder is self-limiting and can resolve either spontaneously or through the use of drugs, as prevention strategies can only be aimed at preventing its occurrence as a part of the underlying disease (maintaining general health through exercise and diet to reduce the risk of stroke, control of blood sugar and management of HIV by regular use of antiretroviral drugs).
Hemiballismus is a rare disorder of hyperkinetic movement characterized by involuntary, irregular and violent large-amplitude movements of contralateral limbs, most frequently the proximal aspects of the arm and leg [1]. Stroke is the most common cause, affecting approximately 1% of patients, and the mechanism of disease is thought to involve impairment of neuronal signaling in the basal ganglia, most notably in the area of globus pallidus, which is one of the most important regions that control body movement [2] [3]. The diagnosis is made based on clinical findings, while magnetic resonance imaging (MRI) or computed tomography (CT) of the brain may be performed to exclude stroke as the underlying cause. The prognosis is generally good, as spontaneous remission is observed within months, but because symptoms may sometimes be severe and even life-threatening for the patient (exhaustion, dehydration and injury), drugs such as dopamine-2 receptor blockers, neuroleptics and catecholamine-depleting agents are used in therapy [3]. If hemiballismus is refractory to therapy, pallidotomy may be performed [4] [5].
Hemiballismus is a rare condition of abnormal body movement most commonly encountered in patients after suffering from stroke. Involuntary, irregular and large-amplitude movements of either one or two limbs on the same side (for example left arm and/or left leg are affected) are main features of this disorder and the diagnosis should be made during physical examination. Treatment is sometimes not necessary, as the condition resolves on its own in many patients in a period of months, but some individuals experience extreme fatigue and can suffer from life-threatening trauma. For this reason, drugs that interfere with dopamine and other neurotransmitters that regulate body movement are given, most commonly haloperidol, perphenazine, reserpine and tetrabenazine. If symptoms persist despite therapy, surgical removal of globus pallidus, one of the most important structures involved in movement regulation, is recommended, as it is almost always damaged in these patients.