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Hemoglobinemia

Haemoglobinaemia


Presentation

  • A case of an intracranial hematoma in a neonate causing the release of free hemoglobin into the plasma is presented. No previous such case has been described.[ncbi.nlm.nih.gov]
  • MD Original Articles: PDF Only Abstract Four heroin-overdosed patients presented with coma, elevated serum enzymes (creatine phosphokinase (CPK) and serum glutamic oxaloacetic transaminase (SGOT)), and increased levels of plasma free hemoglobin.[journals.lww.com]
  • Subsequently, this volume was assembled from key papers presented at the Symposium. Additionally, invited man uscripts from leaders in specific areas were solicited to provide additional range to the topics covered.[books.google.ro]
  • For easy reference, information is provided by clinical presentation and abnormalities, and includes hundreds of tables, boxes, key points, and algorithms.[books.google.com]
  • See Clues on the Skin: Acute Poisonings , a Critical Images slideshow, to help diagnose patients based on their dermatologic presentations.[emedicine.medscape.com]
Asymptomatic
  • The induction of hemoglobinemia was asymptomatic. Coagulation studies showed no significant alteration in prothrombin time, partial thromboplastin time, thrombin time, clottable fibrinogen, or WBC. Fibrin degradation products were not found.[ncbi.nlm.nih.gov]
  • Patients with Hb M appear cyanotic but are otherwise generally asymptomatic.[emedicine.medscape.com]
  • […] therapy congenital — avoid precipitants cessation of precipitants methylene blue (1-2mg/kg over 5 minutes) provides an artificial electron acceptor to facilitate the reduction of MetHb via the NADPH-dependent pathway; give if: — symptomatic — consider if asymptomatic[lifeinthefastlane.com]

Workup

  • (See Workup.) The most important aspects of the management of methemoglobinemia are recognition of the condition and prompt initiation of treatment, when indicated.[emedicine.medscape.com]

Treatment

  • We found that erythrocytes from PNH patients on long term treatment with eculizumab were twice as vulnerable as normal erythrocytes to lysis induced by complement activated serum.[ncbi.nlm.nih.gov]
  • Alternative treatments include hyperbaric oxygen therapy and exchange transfusions. In most cases of mild acquired methemoglobinemia, no treatment is required, other than avoiding the medicine or chemical that caused the problem.[checkorphan.org]
  • 545 Dialysis ultrafiltration and hemofiltration 555 Use of drugs in uremia and dialysis 567 Donor and recipient selection in renal transplantation 587 Immunosuppression and treatment of rejection in renal transplantation 595 XIII 606 Renal tubular and[books.google.com]
  • The indication for treatment with anti-D IGIV was provided for all 15 patients.[bloodjournal.org]
  • Alternative treatments include hyperbaric oxygen therapy , red blood cell transfusion and exchange transfusions . In most cases of mild acquired MetHb, no treatment is needed. But you should avoid the medicine or chemical that caused the problem.[medlineplus.gov]

Prognosis

  • Indeed, few other symptoms indicate so serious a disturbance of body processes or carry so grave a prognosis.[nejm.org]
  • Prognosis - Hemoglobinemia People with Type 1 methemoglobinemia and hemoglobin M disease usually do well. Type 2 methemoglobinemia is much more serious, and usually causes death within the first few years of life.[checkorphan.org]
  • Prognosis The prognosis of mild cases of methemoglobinemia is very favorable. In severe cases, the prognosis is determined by the degree of anoxic end-organ damage.[emedicine.medscape.com]
  • Genetic Disease (List, Symptoms, Causes, Treatments, Prognosis) The definition of a genetic disease is a disorder or condition caused by abnormalities in a person's genome. Some types of...[medicinenet.com]

Etiology

  • The relationship between hemoglobinemia and the occurrence of acute renal failure in this neonate is discussed, with comments on the possible etiological role of the hemoglobinemia.[ncbi.nlm.nih.gov]
  • The presence of anemia and cyanosis despite oxygen treatment results from both of these effects. [4, 5 ] (See Pathophysiology and Etiology.) Methemoglobinemia occurs when red blood cells (RBCs) contain methemoglobin at levels higher than 1%.[emedicine.medscape.com]
  • Abstract Paroxysmal Nocturnal Hemoglobinuria (PNH) (1,2) is a rare disorder of unknown etiology characterized by an intracorpuscular defect that renders erythrocytes more susceptible to hemolysis in an acid medium.[annals.org]

Epidemiology

  • He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education.[lifeinthefastlane.com]
  • Part 2: Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context. ‎ Pagina 136 - ... calories by exercising. Cutting down on calories, especially calories from fat, is key to losing weight.[books.google.it]
  • Indigo carmine Resorcinol Metoclopramide [ 50 ] Antibiotics – Sulfonamides, nitrofurans, and para-aminosalicylic acid Industrial/household agents – Aniline dyes, nitrobenzene, naphthalene (moth balls), aminophenol, and nitroethane (nail polish remover) Epidemiology[emedicine.medscape.com]
  • Footnotes Reprints: Ann Reed Gaines, Office of Biostatistics and Epidemiology, HFM-220, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852; e-mail: gaines{at}cber.fda.gov .[bloodjournal.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology RBCs contain hemoglobin, which has a quaternary structure. Each hemoglobin molecule is composed of 4 polypeptide chains.[emedicine.medscape.com]

Prevention

  • Hyperventilation with warmed and humidified air or oxygen does not prevent hemolysis. Hemoglobinemia does not occur if alkalosis is prevented by hyperventilation with air-CO 2 mixtures.[jpet.aspetjournals.org]
  • Eculizumab is used to prevent the breakdown of red blood cells in people with paroxysmal nocturnal hemoglobinemia (PNH).[diki.pl]
  • Prevention - Hemoglobinemia Genetic counseling is recommended for couples with a family history of methemoglobinemia who are considering having children. Diagnosis - Hemoglobinemia Methemoglobinemia can be diagnosed with a blood test.[checkorphan.org]
  • It occurs in some people after they are exposed to certain chemicals and medicines, including: Anesthetics such as benzocaine Nitrobenzene Certain antibiotics (including dapsone and chloroquine) Nitrites (used as additives to prevent meat from spoiling[medlineplus.gov]
  • Patients who develop methemoglobinemia secondary to environmental exposure require a meticulous workup to prevent reexposure to the offending agent. All workplace or household members should be evaluated.[emedicine.medscape.com]

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