Symptoma

Hemolytic Disease of the Newborn with Kell Alloimmunization

Maternal Anti-Kell Alloimmunization

Weiner, Bernard Gonik, Caroline Crowther, and Stephen Robson present an evidence-based approach to the available management options, equipping you with the most appropriate strategy for each patient. [books.google.com]

Fortunately, this is a rare event with present obstetrical management. If present, ascites may create ventilatory embarrassment and paracentesis should be considered. [uichildrens.org]

Abstract Hemolytic disease of the fetus and newborn (HDFN) is the result of immune-mediated destruction of fetal or newborn red blood cells when such cells contain antigens that are not present in the maternal blood. [hw-f5-neoreviews.highwire.org]

  • Physician

    Written by practising physicians specializing in pediatric hematology, neonatology, immunology, pediatric infectious disease and transfusion medicine, this is an essential text for pediatric hematologists, NICU specialists, neonatologists and neonatal [books.google.com]

    Now, we contacted the attending physician due to the remarkable mixed-field reactions, which are usually a hint for recent blood transfusion. [pubs.sciepub.com]

    Exchange Transfusions: The need for and timing of exchange transfusions should be done in consultation with the attending physician. Criteria for exchange transfusion do not change because of phototherapy. [uichildrens.org]

    Management of Neonate affected by Erythroblastosis / Hemolytic disease of the Newborn Reinforcing earlier statement, there should be a coordinated effort between the referring Obstetrician or Family Physician and the Perinatal center team (Maternal Fetal [omicsonline.org]

  • Surgical Procedure

    An exchange transfusion is a sterile surgical procedure, with aseptic techniques a polyvinyl catheter is inserted into the umbilical vein and threaded into the inferior vena cava. [fruittyblog.blogspot.com]

  • First Trimester Pregnancy

    […] woman who is not Rh D-alloimmunized should receive anti-D immune globulin: at approximately 28 weeks of gestation, unless the father of the baby is also known to be Rh D negative; within 72 hours after the delivery of an Rh D-positive infant; after a first-trimester [womenshealthsection.com]

  • Hypertension

    Apply new evidence-based management options to treat genetic and constitutional factors leading to a high-risk pregnancy (such as diabetes, obesity, hypertension, and cardiac disease) through new and expanded coverage of these increasingly common presentations [books.google.com]

    As a result, portal hypertension occur, causing the liver to reduces its albumin production.  This in turn result in edema. [slideshare.net]

    Kelly T, Moore RM: Maternal medical diseases of fetal significance : seizure disorder, hypertension and isoimmunisation : In. Ballard, ed. Avery’s Disease of the Newborn ; Taeusch, 3rd edn 1998. Google Scholar 7. [link.springer.com]

    The infant did well until the age of seven days, when he was noticed to be hypertensive (BP 106/62 mm Hg). Antihypertensive treatment with hydrallazine was started. [annsaudimed.net]

    Subsequently, hepatic circulatory obstruction (portal hypertension) with placental edema interferes with placental perfusion and ascites develops.[ 5 ] Hepatomegaly, increased placental thickness, and polyhydramnios often precede the development of hydrops [perinatology.com]

  • Arthritis

    Previous medical history revealed that the patient had undergone surgery for septic arthritis 8 years ago, during which she received transfusion of one unit of group specific nonleukoreduced packed red blood cells (RBCs). [gjtmonline.com]

  • Excitement

    Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. [books.google.com]

    Well, tune in next post for the exciting adventures of Genealogy Quest! [kyrackramer.com]

    There are some exciting new medications being developed in the transplant world that I think may end up moving to these patients. [hematologyandoncology.net]

  • Seizure

    Kelly T, Moore RM: Maternal medical diseases of fetal significance : seizure disorder, hypertension and isoimmunisation : In. Ballard, ed. Avery’s Disease of the Newborn ; Taeusch, 3rd edn 1998. Google Scholar 7. [link.springer.com]

    Additional more serious symptoms include a shrill sounding cry, a bulging fontanel and possibly seizures. [fruittyblog.blogspot.com]

In the present case, the intervening laboratory staff prevented repetitive transfusion of an incompatible RBC unit even though the initial workup was misled by the negative DAT. [pubs.sciepub.com]

Fetal blood group was A-positive and was negative in workup for non-immune hydrops. Maternal serum indirect Coomb's test was positive, thus leading to a suspicion of the presence of non-anti-D antibodies. [jmedicalcasereports.biomedcentral.com]

PMID 7655573. a b c Hemolytic Disease of Newborn workup at eMedicine [ full citation needed ] a b c American Academy of Pediatrics Subcommittee on Hyperbilirubinemia. (2004). [en.wikipedia.org]

Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. [books.google.com]

Early recognition and antenatal management may help to improve the prognosis. [medcaretips.com]

The scenario is different in most of the developing countries such as India, where red cell transfusions are matched only for ABO and RhD. [8] Although the incidence of Kell alloimmunization is observed to be low, the prognosis is poor in such pregnancies [gjtmonline.com]

HISTORY Haemolytic disease of the newborn (HDN) has been known for centuries with its typical and poor prognosis. The first described by a French midwife who delivered twins in 1609. [slideshare.net]

2009) 2.2 PROGNOSIS The severity of this condition can vary. Some babies have no symptoms. In other cases, problems such as hydrops can cause the baby to die before, or shortly after birth. [fruittyblog.blogspot.com]

In the largest retrospective review on the etiology of hydrops [ 6 ] involving 598 patients, the cause of hydrops was established unclearly in 26.3% of cases, isoimmunisation in 4.5% of cases, and non-immune etiology in 69.2% of cases. [jmedicalcasereports.biomedcentral.com]

Although anti-RhD was once the major etiology of hemolytic disease of the fetus/newborn (HDFN), the widespread adoption of antenatal and postpartum Rhesus immune globulin has resulted in a marked decrease in the prevalence of alloimmunization to the RhD [scienceopen.com]

The etiology was cleared retrospectively, since the baby subsequently died. In a second fatal case presenting a hydropic stillborn, anti-c was implicated as provoking HDFN as other causes of non-immune hydrops could be excluded. [pubs.sciepub.com]

Treatment of hemolytic disease The goal of any therapy is to treat the etiology of the disease using the most effective but least invasive method. [dovepress.com]

Am J Hematol 87:525–528 CrossRef PubMed Google Scholar Bellini C, Hennekam RC, Fulcheri E, Rutigliani M, Morcaldi G, Boccardo F, Bonioli E (2009) Etiology of nonimmune hydrops featlis: a systematic review. [link.springer.com]

Abstract Introduction The objective of the analysis was to examine the epidemiological aspects of maternal alloimmunization and to determine the most common antibody specificities resulting in hemolytic disease of the newborn (HDN). [thieme-connect.de]

History / Epidemiology In 1609, a French midwife first described HDN, in a set of twins—one baby was markedly edematous and died soon after birth, the second baby developed jaundice and died several days later [ 1 ]. [omicsonline.org]

"Epidemiology of cerebral palsy". Seminars in Fetal and Neonatal Medicine. 11 (2): 117–25. doi : 10.1016/j.siny.2005.10.010. PMID 16338186. Lande, Lottie (1948). "Clinical signs and development of survivors of kernicterus due to Rh sensitization". [en.wikipedia.org]

Epidemiology of Rh haemolytic disease of the new-born in the United States. Journal of American Medical Association; 265 (24):3270-3274. Cohen, D. W. (2009). [fruittyblog.blogspot.com]

Nathan and Oski’s is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. [books.google.com]

Pathophysiology Hemolytic disease of the newborn (anti-Kell 1 is caused by a mis-match between the Kell antigens of the mother and fetus. About 91% of the population are Kell 1 negative and about 9% are Kell 1 positive. [wikidoc.org]

It includes a review of historical perspective, pathophysiology of RBC antigen iso-sensitization, hydrops fetalis, clinical presentation, and management of HDN. [omicsonline.org]

Pathophysiology of Hemolytic Disease of Newborn During first pregnancy, senstization of Rhnegative mother to Rh-positive red cells occurs as a result of symptomatic fetomaternal hemorrhage during pregnancy. [medcaretips.com]

[…] can occur following: incompatible blood transfusions previous fetal-maternal hemorrhage (ie ectopic pregnancy, abortion) procedures (amniocentesis, cerclage, D&C) sharing needles labour and delivery naturally occurring (ie Kell, Duffy) return to top Pathophysiology [sharinginhealth.ca]

PREVENTION Rh Immune Globulin (RhIG or Rhogam) • Alloimmunization in pregnant woman can be prevented by administration of Rh immune globulin (RhIG or Rhogam). • RhIG is a concentrate of IgG anti-D prepared from pooled human plasma of D-negative people [slideshare.net]

Anti-Kell 1 is becoming relatively more important as prevention of Rh disease is becoming more and more effective. [wikidoc.org]

It has been hypothesized that IgG anti-Kell 1 antibody injections would prevent sensitization to RBC surface Kell 1 antigens in a similar way that IgG anti-D antibodies ( Rho(D) Immune Globulin ) are used to prevent Rh disease, but the methods for IgG [ipfs.io]

Preventing rhesus disease Rhesus disease is uncommon these days because it can usually be prevented using injections of a medication called anti-D immunoglobulin. [nhs.uk]

This prevents adverse reactions for the mother if any of the baby’s placenta remains in the womb. [healthline.com]