Call your doctor at once if you have easy bruising or unusual bleeding, such as a nosebleed, black or bloody tarry stools, or any bleeding that will not stop. [uwhealth.org]

Bleeding may be more likely in older adults, especially women over 60 years of age Stop using heparin and call your doctor at once if you have: skin changes where the medicine was injected; fever, chills, runny nose, or watery eyes; easy bruising, unusual [rxlist.com]

Salmon heparin activity was recovered in plasma samples expressed as antifactor Xa activity after intravenous administration. [ncbi.nlm.nih.gov]

The heparin-induced elevation of the plasma FFA was blocked by the intravenous administration of protamine sulfate 5 min prior to the heparin in 4 control subjects; however, the rise in the TfT 4 was not inhibited. [academic.oup.com]

In patients with STEMI, intravenous administration of up to 5000 U of unfractionated heparin was permitted before arrival at the catheterization laboratory. [nejm.org]

Musculoskeletal Frequency not reported: Significant bone demineralization, spontaneous bone fracture Postmarketing reports: Osteoporosis[Ref] Dermatologic Frequency not reported: Ecchymoses Postmarketing reports: Cutaneous necrosis, delayed transient alopecia [drugs.com]

[…] severe thrombocytopenia, usually after 5 days of heparin, with thrombo-embolic complications requiring discontinuation of treatment; • localised reactions at the injection site, rarely, necrosis; • allergic reactions, osteoporosis after prolonged use, alopecia [medicalguidelines.msf.org]

Rarely, LMWH therapy can cause alopecia. The extent of hair loss can vary greatly. All cases of LMWH-related alopecia have resolved upon cessation of therapy. LMWH Antidote The antidote for LMWH is Protamine sulphate. [rch.org.au]

Miscellaneous Osteoporosis following long-term administration of high doses of heparin, cutaneous necrosis after systemic administration, suppression of aldosterone synthesis, delayed transient alopecia, priapism and rebound hyperlipemia on discontinuation [rxlist.com]

Bleeding High blood potassium level (hyperkalaemia) Decrease in the number of platelets in the blood (thrombocytopenia) Breakdown of skin cells Thinning of the bones (osteoporosis) with long term use Hair loss (alopecia) may be experienced after prolonged [netdoctor.co.uk]

Skin necrosis manifests as sharply demarcated tender red or purple patches ( purpura ) which develop black centres and may lead to dry gangrene. A net-like or branching, retiform, pattern of purpura may also be seen. [dermnetnz.org]

Hematologic: conditions associated with increased bleeding tendencies such as hemophilia, some purpuras and thrombocytopenia. In patients with a history of heparin-induced thrombocytopenia (HIT), danaparoid and ancrod are considered alternatives. [rxmed.com]

Pancreas 1 1, 2 Not Yet Recruiting Treatment End Stage Renal Disease (ESRD) 1 1, 2 Recruiting Prevention Thoracic Surgery / Thromboprophylaxis 1 1, 2 Recruiting Prevention Urinary Tract Infections, Recurrent 1 1, 2 Recruiting Treatment Henoch-Schoenlein Purpura [drugbank.ca]

hemophilia, some vascular purpuras, thrombocytopenia); menstruation; hepatic disease with impaired hemostasis; severe hypertension; major surgery, especially involving the eye, brain, or spinal cord; continuous tube drainage of the stomach or small [drugs.com]

[…] anaphylactic shock Postmarketing reports: Chills, fever, urticaria, asthma, rhinitis, lacrimation, headache, nausea, vomiting, anaphylactoid reactions, shock, itching, burning[Ref] Local Frequency not reported: Erythematous nodules, infiltrated and sometimes eczema-like [drugs.com]

Se han descrito diversas lesiones cutáneas adversas, entre ellas urticaria, necrosis cutánea, eczema localizado en el punto de inyección o eczema diseminado. [medigraphic.com]

Often the first sign of bleeding may be epistaxis, hematuria or melena. Bleeding may be from any site and can be difficult to detect, i.e., retroperitoneal bleeds. Bleeding may also occur from surgical sites. [rxmed.com]

Minor hemorrhages were those that were confirmed to be overt and to have some clinically important feature, such as epistaxis, ecchymosis, hematoma, or macroscopic hematuria but that did not meet the criteria for major hemorrhage. [doi.org]

headaches of sudden onset sudden loss of coordination sudden shortness of breath for no apparent reason sudden slurred speech sudden vision changes unusual bleeding or bruising For Healthcare Professionals Applies to heparin: injectable kit, injectable [drugs.com]

increased, hyperkalemia, metabolic acidosis Postmarketing reports: Rebound hyperlipidemia[Ref] Musculoskeletal Frequency not reported: Significant bone demineralization, spontaneous bone fracture Postmarketing reports: Osteoporosis[Ref] Dermatologic [drugs.com]

[Ref] Cardiovascular Postmarketing reports: Hemorrhage, retroperitoneal hemorrhage[Ref] Hematologic Very common (10% or more): Thrombocytopenia (up to 30%) Frequency not reported: Plasma lipoprotein lipase increased Postmarketing reports: Heparin resistance [drugs.com]

[Ref] Cardiovascular Postmarketing reports: Hemorrhage, retroperitoneal hemorrhage[Ref] Hematologic Very common (10% or more): Thrombocytopenia (up to 30%) Frequency not reported: Plasma lipoprotein lipase increased Postmarketing reports: Heparin resistance [drugs.com]