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Hepatic Histoplasmosis


Presentation

  • Of these patients, 43% presented with gastrointestinal rather than pulmonary symptoms. Thirty-one percent had gastrointestinal lesions, 10% had liver lesions, and 43% had both.[ncbi.nlm.nih.gov]
  • And for the first time, this edition now offers a free companion website providing the 680 full-color illustrations and figures in the book, for use in scientific presentations.[books.google.com]
  • Acute presentation was seen in two patients, one of them presented with septic shock and ARDS.[ispub.com]
  • The disseminated disease can present with rheumatological, dermatological, and GI involvement.[acgcasereports.gi.org]
  • Case Presentation A 60-year-old female patient presented to the medical outpatient department with a history of a cough for more than two months, intermittent fever, and dyspnea on exertion.[cureus.com]
Fever
  • , syphilis, cat-scratch fever).[hepatitiscentral.com]
  • Non-productive cough shortness of breathing, hemoptysis night fever with sweating muscle and joint pain weight loss malaise Severe disseminated or systemic infection: consolidated lungs hepatosplenomegaly, hepatic insufficiency high fever anaemia and[onlinebiologynotes.com]
  • Signs include dyspnea, abnormal lung sounds in about 50% of cats ( 50% of dogs), fever, lethargy, and severe diarrhea.[k2publishing.ca]
  • Clinical signs may be nonspecific but often include respiratory difficulty, fever, depression, anorexia, and weight loss.[msdvetmanual.com]
  • On examination, he reported having spikes of fever over the previous 48 hours prior to the GI bleeding.[acgcasereports.gi.org]
Weight Loss
  • Clinical signs may be nonspecific but often include respiratory difficulty, fever, depression, anorexia, and weight loss.[msdvetmanual.com]
  • Weight loss, anorexia, jaundice, vomiting, diarrhea, polyuria/polydipsia, abdominal effusion, and abdominal pain are typical signs of liver disease or injury.[k2publishing.ca]
  • Symptoms The most common symptoms for cats are lack of appetite, weight loss, and difficulty breathing.[petmd.com]
  • Abstract A 56-year-old man with persistently elevated liver enzyme levels, fatigue, lethargy and a 9.0 kg weight loss over six months underwent a percutaneous liver biopsy that demonstrated multiple granulomas.[ncbi.nlm.nih.gov]
  • loss over the same time period.[acgcasereports.gi.org]
Pathologist
  • […] and hepatologists interested in reviewing liver biopsies with pathologists[books.google.com]
  • This volume will also help surgical pathologists gain familiarity with other contributory laboratory tests that are available to help confirm diagnosis.[books.google.com]
  • Liver Pathology will be essential reading for every pathologist who evaluates liver pathology specimens. In addition it will be a valuable resource for pathology residents and fellows.[books.google.com]
  • Kradin is also an Associate Pathologist at Massachusetts General Hospital in the Immunopathology Unit. His techniques include tissue culture and immunocytochemistry, flow cytometry, Northern blotting and immunocytochemistry. Dr.[books.google.com]
Malaise
  • Acute primary histoplasmosis is a syndrome with fever, cough, myalgias, chest pain, and malaise of varying severity. Acute pneumonia (evident on physical examination and chest x-ray) sometimes develops.[msdmanuals.com]
  • Non-productive cough shortness of breathing, hemoptysis night fever with sweating muscle and joint pain weight loss malaise Severe disseminated or systemic infection: consolidated lungs hepatosplenomegaly, hepatic insufficiency high fever anaemia and[onlinebiologynotes.com]
  • […] include fever, headache, nonproductive cough, chills, pleuritic chest pain, weight loss, malaise, myalgias, and sweats.[aafp.org]
  • Fever, malaise, and other systemic symptoms are the usual presenting manifestations of an infective etiology; prolonged FUO is especially common in TB and fungal infections. The history is critical in establishing a drug etiology.[hepatitiscentral.com]
  • Symptoms include weight loss, night sweats, a mild fever, and a general feeling of illness (malaise). Most people recover without treatment within 2 to 6 months.[merckmanuals.com]
Chronic Fatigue Syndrome
  • Kradin has a number of clinical interests including Chronic Fatigue Syndrome, Interstitial Lung Disease, Multiple Chemical Sensitivity and Pulmonary Immunology. He also holds an Associate Professor position of Pathology at Harvard Medical School.[books.google.com]
Heart Murmur
  • murmurs, hyperbaric medicine, home prepared and raw diets, obesity, botulism, artificial pacing of the heart, cancer vaccines, and more.[books.google.com]

Workup

  • An initial workup by her primary care physician, including complete metabolic panel, liver function tests, complete blood count, upper endoscopy/colonoscopy, and abdominal computed tomography (CT) scan, was non-revealing.[acgcasereports.gi.org]

Treatment

  • Significant updates on bariatric surgery, Barrett's esophagus, endoscopic ultrasound, endosonography, treatment of liver disease, and much more keep you current on the latest advances.[books.google.com]
  • Enabling clinicians to formulate incisive diagnoses and appropriate treatment strategies, this book has been updated to reflect the advances that have been made in the last 10 years, providing didactic and reliable clinical guidance in hepatology from[books.google.com]
  • The internationally acclaimed "gold standard" offers unparalleled coverage of pathophysiology, diagnosis, and treatment of diseases affecting dogs and cats, as well as the latest information on the genome, clinical genomics, euthanasia, innocent heart[books.google.com]
  • Without treatment, this form is fatal in more than 90% of people. Even with treatment, death may occur rapidly in people with AIDS.[merckmanuals.com]
  • -If flucytosine is not given or treatment is interrupted, consider lengthening induction treatment at least 2 weeks.[drugs.com]

Prognosis

  • Patients with acute liver failure generally have a good prognosis if the disease is diagnosed early and treatment is started immediately. However, patients with chronic liver disease have a variable prognosis.[k2publishing.ca]
  • […] not reliable, the detection of the urine antigen for this fungus is one of the fastest and most sensitive methods: it finds 90% of patients with disseminated infection and 75% with acute pulmonary histoplasmosis. 5 With the appropriate therapy, the prognosis[revistanefrologia.com]
  • The overall prognosis is excellent. Proper disposal of human feces and careful animal husbandry are mandatory in the control of muscular sarcocystosis.[omicsonline.org]
  • The course and prognosis of histoplasmosis. Amer. J. Med. Seminar on Mycotic Infections. 27 & 28: 19. Google Scholar 3. Schwarz, J., Bingham, E. & Roubenoff, D. 1955. The communicability of experimentally induced histoplasmosis. Amer. J. clin.[link.springer.com]

Etiology

  • Etiology The causes of liver granulomas are legion.[hepatitiscentral.com]
  • MISCELLANEOUS CONDITIONS Sarcoidosis Sarcoidosis is a multisystem disease of unknown etiology. Noncaseating granulomas are characteristic of this process and can affect any organ of the body.[ctisus.com]
  • Ileocecal fistulizing disease has been reported, as has pseudotumor mimicking malignancy. 12,14 Endoscopic findings have the potential to mimic inflammatory bowel disease, and in the case of negative antigen testing, pathologic exclusion of infectious etiology[acgcasereports.gi.org]
  • Presence of miliary shadows in chest imaging is often attributed to tuberculosis without further etiological investigation in our country. Patients are started on empirical anti-tubercular therapy (ATT).[lungindia.com]
  • Etiology The risk of infection is mostly related to environmental exposure and underlying immune status. Living in endemic areas with contaminated soil increases the risk of exposure. Inoculum size plays a role.[emedicine.medscape.com]

Epidemiology

  • Surgical Pathology of the Gastrointestinal System: Bacterial, Fungal, Viral, and Parasitic Infections provides pertinent clinical, diagnostic, and epidemiologic information that will be valuable to the practicing surgical pathologist.[books.google.com]
  • Definition / general Infection is caused by inhalation of airborne spores of Histoplasma capsulatum, a dimorphic saprophytic fungus found in soil contaminated with bird or bat feces Epidemiology Highest incidence is in North America, particularly in the[pathologyoutlines.com]
  • The epidemiology of histoplasmosis: A review. Semin Respir Infect 2001;16:109-18. 5. Singhi MK, Gupta L, Kacchawa D, Gupta D. Disseminated primary cutaneous histoplasmosis successfully treated with itraconazole.[e-ijd.org]
  • Guided Medline Search For Recent Reviews Epidemiology Clinical Manifestations Pathogenesis Therapy Prevention[antimicrobe.org]
  • Case report and review of disseminated histoplasmosis in South-East Asia: clinical and epidemiological implications. Trop Med Int Health . 1996;1:35–42. 15. Walsh TJ, Gonzalez C, Lyman CA, Chanock SJ, Pizzo PA.[aafp.org]
Sex distribution
Age distribution

Pathophysiology

  • The internationally acclaimed "gold standard" offers unparalleled coverage of pathophysiology, diagnosis, and treatment of diseases affecting dogs and cats, as well as the latest information on the genome, clinical genomics, euthanasia, innocent heart[books.google.com]
  • Understanding the pathophysiology of feline hepatic lipidosis. J Comp Pathol 2015; 152:70. Plumb DC. Plumb s Veterinary Drug Handbook. 7ª ed. Iowa: Wiley-blackwell; 2011. Polyak SJ, Ferenci P, Pawlotsky JM.[revistas.ces.edu.co]
  • Pathophysiology Granuloma formation is incompletely understood. The lesions are regarded as a host attempt to protect against poorly soluble exogenous or endogenous irritants.[hepatitiscentral.com]
  • Prospective study of histoplasmosis in patients infected with human immunodeficiency virus: incidence, risk factors, and pathophysiology. Clin Infect Dis. 1997 Jun;24(6):1195-203. Wheat LJ, Chetchotisakd P, Williams B, Connolly P, Shutt K, Hajjeh R.[med.ucla.edu]
  • […] profound, can calcify Extrapulmonary findings: Liver and spleen calcifications, adrenals, oral ulcers, bone marrow Differentials: Sarcoidosis and tuberculosis Usual treatment: Itraconazole; amphotericin for severe or diffuse disease Prognosis: Excellent Pathophysiology[emedicine.medscape.com]

Prevention

  • Centers for Disease Control and Prevention (November 21, 2015 updated.) Histoplasmosis. Available online at . Accessed August 27, 2016. Centers for Disease Control and Prevention (February 13, 2014 updated.) Pneumocystis Pneumonia.[labtestsonline.it]
  • […] inoculating macroconidia of Histoplasma into the mouse Histopathological examination X-ray examination Treatment: Amphotericin B: Intravenous drug Itraconazole: oral drug ketoconazole Fluconazole Veroconazole Pasaconazole Supportive therapy and rest Prevention[onlinebiologynotes.com]
  • The maintenance phase is directed at preventing relapse.[hivinsite.ucsf.edu]
  • Patients with progressive hepatic sarcoidosis may benefit from corticosteroid therapy, though it remains unclear whether this prevents hepatic fibrosis; corticosteroids are not indicated for most patients with sarcoidosis and should be given only if TB[hepatitiscentral.com]

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