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Hepatic Vein Thrombosis

Hepatic Vein Obstruction


Presentation

  • We present a patient with paroxysmal nocturnal hemoglobinuria with diffuse hepatic central vein thrombosis who presented with encephalopathy and recovered from the hepatic manifestations with antihepatic coma measures alone.[ncbi.nlm.nih.gov]
Constitutional Symptom
  • We present a case of a previously healthy 43-year-old Canadian man presenting with constitutional symptoms and right upper quadrant abdominal pain.[ncbi.nlm.nih.gov]
Turkish
  • We report the case of a 26-year-old man with a chronic Budd-Chiari syndrome with ascites, caused by a hereditary Protein S deficiency, in a Turkish family with consanguinity.[ncbi.nlm.nih.gov]
Internal Bleeding
  • The criteria for ending the therapy were: i) the thrombus was completely dissolved; ii) the thrombus was consistent in two consecutive reviews; and iii) internal bleeding was observed or other complications occurred.[spandidos-publications.com]
Weakness
  • The major early complications after RT were general weakness and nausea. Five patients (10%) complained of having grade 1 general weakness, and 1 patient (2%) complained of having grade 2 general weakness.[e-roj.org]
Anorexia
  • There was no history of vomiting, bleeding, bruising, mental status changes, anorexia, weight loss, or jaundice. Physical examination showed that the liver was tender and palpable 5 cm below the xiphoid, with enlargement of the left lobe.[journals.lww.com]
Abdominal Pain
  • BACKGROUND/AIMS: Hepatic vein thrombosis is thought to be manifested by ascites, abdominal pain, and hepatomegaly, with a uniformly poor prognosis.[ncbi.nlm.nih.gov]
  • The syndrome classically presents with abdominal pain, fluid in the abdomen (ascites) and liver enlargement (hepatomegaly).The syndrome can present all of a sudden or gradually.[veindirectory.org]
Hepatomegaly
  • BACKGROUND/AIMS: Hepatic vein thrombosis is thought to be manifested by ascites, abdominal pain, and hepatomegaly, with a uniformly poor prognosis.[ncbi.nlm.nih.gov]
  • #4 I'm sure you've figured this out but clinically, you have no hepatomegaly with portal vein thrombosis vs hepatomegaly with hepatic vein thrombosis #5 I did a question on Uworld today on that same concept.....in case you haven't seen the question its[forums.studentdoctor.net]
Jaundice
  • We report a 24-year-old Japanese female hospitalized with jaundice and ascites. She exhibited hepatosplenomegaly, severe liver dysfunction, and slight polycythemia with an increase in serum levels of beta-thromboglobin and platelet factor 4.[ncbi.nlm.nih.gov]
  • Symptoms include: Abdominal swelling or stretching due to fluid in the abdomen Pain in the right upper abdomen Vomiting blood Yellowing of the skin (jaundice) Treatment varies, depending on the cause of the blockage.[nlm.nih.gov]
  • Symptoms Symptoms include: Abdominal swelling or stretching due to fluid in the abdomen Pain in the right upper abdomen Vomiting blood Yellowing of the skin (jaundice) Exams and Tests One of the signs is swelling of the abdomen from fluid buildup ( ascites[mountsinai.org]
  • Associated disorders usually include jaundice, haematemesis, leg oedema, oesophageal varices, thrombophlebitis of the inferior vena cava, and portal hypertension. Occurs in an acuta and an intermittent form. More common in males. Bibliography G.[whonamedit.com]
Skin Lesion
  • Recognition of the skin lesion could allow the prevention of major systemic complications.[ncbi.nlm.nih.gov]
Cutaneous Manifestation
  • This cutaneous manifestation of the anticardiolipin syndrome has not been described before, though its histological appearances resemble those of previously reported cutaneous complications, such as chronic ulceration, livedo reticularis and distal cutaneous[ncbi.nlm.nih.gov]

Workup

  • Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate.[books.google.com]
  • As mentioned earlier, another important feature of the laboratory workup is the detection of underlying prothrombotic factors. A thorough workup should be undertaken directed at exploring multiple prothrombotic risk factors.[journals.sagepub.com]
  • See Workup for more detail.[emedicine.medscape.com]
Entamoeba Histolytica
  • Abstract The most common extraintestinal complication of Entamoeba histolytica is amebic liver abscess (ALA).[ncbi.nlm.nih.gov]

Treatment

  • Both patients had a marked clinical and radiological improvement following the t-PA treatment and remain well over 2 years and 6 years after the treatment.[ncbi.nlm.nih.gov]
  • Symptoms include: Abdominal swelling or stretching due to fluid in the abdomen Pain in the right upper abdomen Vomiting blood Yellowing of the skin (jaundice) Treatment varies, depending on the cause of the blockage.[nlm.nih.gov]
  • […] the treatment was reliable.[spandidos-publications.com]

Prognosis

  • In asymptomatic patients, prognosis at 3 years seems to be good, and surgical therapy may not be required.[ncbi.nlm.nih.gov]
  • What is prognosis of patients with hepatic vein thrombosis? If the individual has minimal symptoms and the liver is functioning well, the majority of patients survive for at least 10 years after the diagnosis.[veindirectory.org]
  • Prognosis Factors associated with a good prognosis include younger age at diagnosis, absence or a small amount of ascites, and a low serum creatinine level.[patient.info]

Etiology

  • The etiology is often idiopathic but may involve conditions that increase thrombogenic tendencies. Oral contraceptives are known to increase the risk of a number of thrombotic conditions and have been associated with the Budd-Chiari syndrome.[ncbi.nlm.nih.gov]
  • It has multiple etiologies and a variety of clinical consequences.[unboundmedicine.com]
  • Though the mechanism was not documented in this patient, the hypercoagulability associated with inflammatory bowel disease may have played an etiologic role (1,2) .[journals.lww.com]

Epidemiology

  • Author information 1 Department of Medicine, McMaster University, Hamilton, Ontario, Canada. 2 Department of Radiology, McMaster University, Hamilton, Ontario, Canada. 3 Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton[ncbi.nlm.nih.gov]
  • Epidemiology The global prevalence of BCS is unknown but is estimated at 1 in 100,000. [ 3 ] The epidemiology and presentation tend to vary in different parts of the world.[patient.info]
  • Aims: To investigate the epidemiology, clinical presentation and survival in patients with BCS.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of this phenomenon involves two major aspects. Oral contraceptives are known to cause a hypercoagulation state as well as a direct effect on the blood vessels.[ncbi.nlm.nih.gov]
  • obliterative hepatocavopathy likely represents recanalized thrombosis, more commonly seen in developing countries Epidemiology Occurs in roughly 0.001% of the population Sites Occlusion may occur anywhere from hepatic venules to inferior vena cava Pathophysiology[pathologyoutlines.com]

Prevention

  • Recognition of the skin lesion could allow the prevention of major systemic complications.[ncbi.nlm.nih.gov]
  • Hepatic vein obstruction prevents blood from flowing out of the liver and back to the heart. This blockage can cause liver damage.[nlm.nih.gov]
  • When the hepatic vein is obstructed, blood flow from the liver to the heart is prevented. This situation is very dangerous as it can lead to the liver being damaged.[buddchiarisyndrome.org]

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