Oct-2005 Present study KP659221 B5 A1896 Full Alaska 25-Jan-2005 Present study KP659222 B5 A1896 Partial 153–881; 1839–3215 Alaska 12-May-2003 Present study KP659223 B5 A1896 Full Alaska 15-Sep-2003 Present study KP659224 B5 A1896 Full Alaska 10-Dec- [doi.org]

ReleaseID=847055" type=" "] Read the press release[/spotlight-link] [spotlight-link icon="presentation" href="https://www.alnylam.com/web/assets/ALNY-Conjugates-HBVprogram-TIDES-May2014.pdf" type="(1.8 MB PDF)"] View our presentation [/spotlight-link] [alnylam.com]

The following is a case report detailing a patient presenting with all three of the above presentations who is cytoplasmic antineutrophil cytoplasmic antibody-positive and a chronic carrier of hepatitis B. [ncbi.nlm.nih.gov]

• Pain

  CASE REPORT A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifested as jaundice associated with hyperbilirubinemia, elevated transaminases, and coagulopathy. [ncbi.nlm.nih.gov]

  Flaviviruses: Infection with DENV produces a debilitating, painful and at times life threatening disease. [umassmed.edu]

• Asymptomatic

  METHODS: Serum was collected from 41 chronic hepatitis B and 55 HBV-ACLF patients in addition to 30 chronic asymptomatic HBV carriers as controls. The miRNAs expressions were measured by real-time quantitative PCR (q-PCR). [ncbi.nlm.nih.gov]

  It is usually asymptomatic but can cause chronic subclinical disease in later childhood or adulthood. Symptomatic infection causes jaundice, lethargy, failure to thrive, abdominal distention, and clay-colored stools. Diagnosis is by serology. [msdmanuals.com]

• Anorexia

  Tabs Content Clinical Overview Diagnosis Indications for Testing New onset of jaundice, anorexia, or dark urine Known exposure to hepatitis Suspicion of chronic hepatitis (elevated liver enzymes) Initial screening for acute hepatitis indicates HBV infection [arupconsult.com]

  CHARACTERISTICS: Partially double-stranded DNA, 42-47 nm diameter, enveloped, Hepadnaviridae; lipoprotein coat contains the HBsAg SECTION II - HEALTH HAZARD PATHOGENICITY: Two major forms: asymptomatic infection and symptomatic hepatitis; onset is insidious with anorexia [msdsonline.com]

  The signs and symptoms of acute symptomatic hepatitis B may include fever, chills, fatigue, myalgias, anorexia, nausea, vomiting, jaundice, and right upper quadrant pain or discomfort. [clinicaladvisor.com]

  Persons with chronic HBV infection may be asymptomatic or may suffer from symptoms such as fatigue, anorexia, nausea, abdominal discomfort and liver dysfunction. [canada.ca]

  Symptomatic treatment of the nausea, anorexia, vomiting, and other symptoms may be indicated. Many agents have been evaluated for the treatment of chronic hepatitis B. Most have been found to be ineffective or too toxic at effective doses. [clinchem.aaccjnls.org]

• Nausea

  A 58-year-old female lymphoma patient was admitted to our hospital for asthenia, nausea, vomiting, and abnormal liver function lasting over 1 week and diagnosed as acute hepatitis B. [ncbi.nlm.nih.gov]

  Over time, as the virus causes increasing damage to the liver, the following symptoms may appear: fatigue nausea dark urine muscle soreness vomiting loss of appetite stomach pain jaundice [childrenshospital.org]

  When they occur, symptoms can be mistaken for the flu (nausea and vomiting, malaise, loss of appetite and abdominal pain). Some people with hepatitis B also experience jaundice, a yellowing of the eyes or skin. [ashasexualhealth.org]

  A safe and effective vaccine… Read More vaccine In infectious disease: Hepatitis B vaccine Hepatitis B virus (HBV) produces an illness characterized by jaundice, poor appetite, malaise, and nausea. Chronic liver disease may follow the infection. [britannica.com]

  Not all people newly infected with HBV have symptoms, but for those that do, symptoms can include fatigue, poor appetite, stomach pain, nausea, and jaundice. For many people, hepatitis B is a short-term illness. [cdc.gov]

• Vomiting

  A 58-year-old female lymphoma patient was admitted to our hospital for asthenia, nausea, vomiting, and abnormal liver function lasting over 1 week and diagnosed as acute hepatitis B. [ncbi.nlm.nih.gov]

  Over time, as the virus causes increasing damage to the liver, the following symptoms may appear: fatigue nausea dark urine muscle soreness vomiting loss of appetite stomach pain jaundice [childrenshospital.org]

  When they occur, symptoms can be mistaken for the flu (nausea and vomiting, malaise, loss of appetite and abdominal pain). Some people with hepatitis B also experience jaundice, a yellowing of the eyes or skin. [ashasexualhealth.org]

  If a patient has had a large amount of vomiting or has not been able to take in liquids, blood electrolytes may also be checked to ensure that the patient's blood chemistry is in balance. [emedicinehealth.com]

• Loss of Appetite

  The prevalence rates of prodromal fever, fatigue, loss of appetite, and jaundice were 25.6%, 85.6%, 83.8%, and 92.8%, respectively. [ncbi.nlm.nih.gov]

  Over time, as the virus causes increasing damage to the liver, the following symptoms may appear: fatigue nausea dark urine muscle soreness vomiting loss of appetite stomach pain jaundice [childrenshospital.org]

  When they occur, symptoms can be mistaken for the flu (nausea and vomiting, malaise, loss of appetite and abdominal pain). Some people with hepatitis B also experience jaundice, a yellowing of the eyes or skin. [ashasexualhealth.org]

  Symptoms include: Achy muscles or joints Stomach pain Loss of appetite Mild fever Loose stool ( diarrhea ) Lack of energy Constipation Yellowing of skin or whites of the eyes Being sick to your stomach Brown urine Cleveland Clinic News & More Cleveland [my.clevelandclinic.org]

• Jaundice

  They develop jaundice, lethargy, failure to thrive, abdominal distention, and clay-colored stools. [msdmanuals.com]

  CASE REPORT A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifested as jaundice associated with hyperbilirubinemia, elevated transaminases, and coagulopathy. [ncbi.nlm.nih.gov]

  Tabs Content Clinical Overview Diagnosis Indications for Testing New onset of jaundice, anorexia, or dark urine Known exposure to hepatitis Suspicion of chronic hepatitis (elevated liver enzymes) Initial screening for acute hepatitis indicates HBV infection [arupconsult.com]

• Arthralgia

  Hepadnaviridae; lipoprotein coat contains the HBsAg SECTION II - HEALTH HAZARD PATHOGENICITY: Two major forms: asymptomatic infection and symptomatic hepatitis; onset is insidious with anorexia, vague abdominal discomfort, nausea and vomiting, sometimes arthralgias [msdsonline.com]

  Extrahepatic infection can cause arthralgias, arthritis, macular rashes, thrombocytopenia or papular acrodermatitis (Gianotti-Crosti syndrome) (10). Historical Information In the 1940s Dr. [austincc.edu]

  Among the 24 patients with arthralgia, 4 had polyarthritis at disease onset. Among the 6 patients with skin manifestations, 1 had urticarial vasculitis and the others had infiltrated purpura, with bullae in 1 patient. [journals.lww.com]

  PAN include the following: Cardiovascular (eg, hypertension [sometimes severe], pericarditis, heart failure) Renal (eg, hematuria, proteinuria, renal insufficiency) Gastrointestinal (GI) (eg, abdominal pain, mesenteric vasculitis) Musculoskeletal (eg, arthralgias [emedicine.medscape.com]

• Urticaria

  Although urticaria and arthritis are uncommon in children, other immune complex phenomena, particularly glomerulonephritis and papular acrodermatitis are relatively common. Recovery normally takes 6 to 12 weeks after the onset of illness. [virology-online.com]

  The usual response to HBV infection is the development of jaundice preceded by systemic manifestations, such as arthralgia, urticaria, migraine, and followed by dramatic increases of transaminases, which constitute the normal immune reaction to clear [journals.lww.com]

• Pruritus

  After initiating anti-TB treatment, they suffered from liver injury with different symptoms including fatigue, nausea, anorexia, vomiting, abdominal distention, pruritus, dark urine and jaundice and were therefore transported to our hospital. [bmcinfectdis.biomedcentral.com]

• Headache

  A 33-year-old Nepalese man presented to our hospital with headache, swelling of his body, paraplegia, and back pain that developed over a period of 10 days. Laboratory studies showed proteinuria and elevated levels of serum urea and creatinine. [ncbi.nlm.nih.gov]

  Symptoms may include: Fatigue Mild fever Headache Loss of appetite, nausea and sometimes vomiting Stomach pain Diarrhea or constipation Muscle aches and joint pain Skin rash Yellowish eyes and skin (jaundice) that usually appears after other symptoms [smartsexresource.com]

  Dialysis Disequilibrium Syndrome: • It is a common neurologic complication seen in dialysis patients that is characterized by weakness, dizziness, headache, and in severe cases, mental status changes. [omicsonline.org]

  Symptoms include: Fatigue Fever Headaches Jaundice (yellowish skin and eyes) Weight loss Decreased appetite Nausea and vomiting Bad breath and bitter taste in the mouth Dark brown urine Pale coloured bowel motions Pain in the right side of the abdomen [southerncross.co.nz]

  Side effects have been mild, with headache, nausea, fatigue, and slight increase of serum amylase noted. The lack of toxicity with lamivudine favors its long-term administration. [clinchem.aaccjnls.org]

• Irritability

  Hepatitis B is irritation and swelling (inflammation) of the liver due to infection with the hepatitis B virus (HBV). Other types of viral hepatitis include hepatitis A, hepatitis C, and hepatitis D. Hepatitis B infection is caused by the HBV. [medlineplus.gov]

  Individuals with dehydration may notice these symptoms: Extreme weakness Confusion or trouble concentrating Headache Lack of urination Irritability Symptoms of liver damage may include the following: Fluid retention causing swelling of the belly ( ascites [emedicinehealth.com]

• Treponema Pallidum

  BACKGROUND: Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs). [ncbi.nlm.nih.gov]

  pallidum (secondary syphilis) Sepsis Rickettsia typhi (typhus fever) Granulomatous disease Mycobacterium tuberculosis Sarcoidosis Hereditary disease/disorder Wilson disease Hemochromatosis Alpha-1-antitrypsin deficiency Ischemia Parasitic infection Liver [arupconsult.com]

Estimated glomerular filtration rate (eGFR) was calculated at baseline, 24 weeks, 52 weeks, and 104 weeks of treatment, respectively. [ncbi.nlm.nih.gov]

Statistical analyses were conducted to assess the ability of differentially expressed miRNAs and other prognostic factors in identifying ACLF prognosis and to develop a new predictive model. [ncbi.nlm.nih.gov]

Acute Hepatitis B Infection, 4.1 What happens when Initially infected. 4.2 Symptoms. 4.3 Treatment 4.4 Prognosis 5. Chronic Hepatitis B infection. 5.1 How does chronic Hepatitis B Develop. 5.2 Symptoms 5.3 Treatment 5.4 Prognosis 6. [hon.ch]

The prognosis of the inactive carrier is generally good and well supported by long-term follow-up studies [ 20, 21, 22 ]. [medsci.org]

Long-term prognosis is not predictable, although chronic HBV infection early in life increases the risk of subsequent liver disease including chronic hepatitis, cirrhosis, end-stage liver disease, and hepatocellular carcinoma. [msdmanuals.com]

Various theories have been given for explanation of the disease entity; however, the etiology remains elusive. This report describes a case of an 18-year-old man with idiopathic cervical resorption that progressed aggressively and involved 20 teeth. [ncbi.nlm.nih.gov]

The involvement of these lesions in the etiology of human diseases and aging was also investigated in the past several decades, suggesting that the oxidatively induced DNA adducts, especially bulky DNA lesions, may serve as biomarkers for exploring the [doi.org]

Author information 1 Department of Epidemiology and Biostatistics, Key Laboratory of Environment and Health of Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. [ncbi.nlm.nih.gov]

Thomas London, Global Epidemiology of Hepatocellular Carcinoma, Clinics in Liver Disease, 10.1016/j.cld.2015.01.001, 19, 2, (223-238), (2015). [doi.org]

McMahon, Epidemiology and Prevention, Viral Hepatitis, (81-95), (2013). [dx.doi.org]

BACKGROUND: Hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) is a life-threatening condition and its exact pathophysiology and progression remain unclear. [ncbi.nlm.nih.gov]

Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China 3. [jcancer.org]

The difference between intensity and duration of immunosuppression may be the basis of the differences in the pathophysiology of HBV reactivation. [ard.bmj.com]

[…] countries) Membership in a high-risk group Infants of HBV-infected mothers Alaskan native and Pacific Islander children Men who have sex with men Children residing in households of first-generation immigrants from countries where HBV infection is endemic Pathophysiology [arupconsult.com]

Antiviral therapy using lamivudine and tenofovir during the second pregnancy successfully prevented mother-to-child transmission of the HBV for high-risk mothers. [ncbi.nlm.nih.gov]

Prevention of Hepatitis Transmission One of the most important strategies of prevention is management of anemia in hemodialysis patient. Anemia is common in patients with chronic kidney disease. [omicsonline.org]