Oct-2005 Present study KP659221 B5 A1896 Full Alaska 25-Jan-2005 Present study KP659222 B5 A1896 Partial 153–881; 1839–3215 Alaska 12-May-2003 Present study KP659223 B5 A1896 Full Alaska 15-Sep-2003 Present study KP659224 B5 A1896 Full Alaska 10-Dec- [doi.org]

ReleaseID=847055" type=" "] Read the press release[/spotlight-link] [spotlight-link icon="presentation" href="https://www.alnylam.com/web/assets/ALNY-Conjugates-HBVprogram-TIDES-May2014.pdf" type="(1.8 MB PDF)"] View our presentation [/spotlight-link] [alnylam.com]

The following is a case report detailing a patient presenting with all three of the above presentations who is cytoplasmic antineutrophil cytoplasmic antibody-positive and a chronic carrier of hepatitis B. [ncbi.nlm.nih.gov]

• Chronic Infection

  CONCLUSIONS: In a setting where there exists a subtype mismatch between vaccine and circulating genotype, the vaccine was largely effective in preventing chronic infection but sub-optimal against any infection. [ncbi.nlm.nih.gov]

  […] the tremendous ability of HBV to thwart the human immune system and establish chronic infection. [gut.bmj.com]

  There are approximately 350 million people with chronic (lifelong) HBV infection. About 78% (275 million) of chronically infected individuals reside in Asia or the Pacific Islands. [web.archive.org]

  Chronic HBV infection can be classified into five phases: (I) HBeAg-positive chronic infection, (II) HBeAg-positive chronic hepatitis, (III) HBeAg-negative chronic infection, (IV) HBeAg-negative chronic hepatitis and (V) HBsAg-negative phase. [easl.eu]

• Fatigue

  In this article, a 51-year-old Chinese woman with severe hepatitis B virus infection complicated with alcoholic liver cirrhosis was admitted with a 3-month history of fatigue, jaundice, and edema of lower extremity, as well as presenting a high fever. [ncbi.nlm.nih.gov]

  Many people with chronic hepatitis B have no symptoms, or they have vague symptoms such as fatigue. As of 2012, around 1 in 3 people in Australia with chronic hepatitis B have not been diagnosed. [hepvic.org.au]

  Over time, as the virus causes increasing damage to the liver, the following symptoms may appear: fatigue nausea dark urine muscle soreness vomiting loss of appetite stomach pain jaundice [childrenshospital.org]

  Not all people newly infected with HBV have symptoms, but for those that do, symptoms can include fatigue, poor appetite, stomach pain, nausea, and jaundice. For many people, hepatitis B is a short-term illness. [cdc.gov]

• Asymptomatic

  METHODS: Serum was collected from 41 chronic hepatitis B and 55 HBV-ACLF patients in addition to 30 chronic asymptomatic HBV carriers as controls. The miRNAs expressions were measured by real-time quantitative PCR (q-PCR). [ncbi.nlm.nih.gov]

  It is usually asymptomatic but can cause chronic subclinical disease in later childhood or adulthood. Symptomatic infection causes jaundice, lethargy, failure to thrive, abdominal distention, and clay-colored stools. Diagnosis is by serology. [msdmanuals.com]

• Weakness

  Guidelines recommend considering antiviral therapy in both situations, although evidence supporting this recommendation is weak. [ncbi.nlm.nih.gov]

  Treatment may be considered for adults > 40 years old with viral load ≥1,000,000 IU/ml and liver biopsy showing moderate to severe fibrosis or inflammation (evidence regarding this is weak). [hepmag.com]

• Surgical Procedure

  A biopsy is a surgical procedure that involves taking a small sample of liver tissue for laboratory analysis. [southerncross.co.nz]

  HBV infection routes were clearly identified for 43 patients: sexual for 15 (10 heterosexual and 5 homosexual), intravenous drug abuse for 16, transfusions for 12 (during surgical procedures for 6). [journals.lww.com]

• Pertussis

  For more information, see HealthLinkBC File #105 Diphtheria, Tetanus, Pertussis, Hepatitis B, … tiny amounts of blood on them, such as razors, toothbrushes or nail files Keep all open cuts and sores bandaged until healed Put articles … HealthLinkBC Files [healthlinkbc.ca]

  Category Blood Culture (BCID) Critical ID Gastrointestinal (GI) Healthcare Associated Infections Respiratory Tropical Disease Women's Health & STIs Organism Acinetobacter Actinomyces Adenovirus Aspergillus B. parapertussis B. pertussis Bacillus Bacteroides [zeptometrix.com]

  […] options is considered appropriate: a 3-dose schedule of hepatitis B vaccine, with the first dose (monovalent) being given at birth and the second and third (monovalent or combined vaccine) given at the same time as the first and third doses of diphtheria, pertussis [who.int]

• Dyspnea

  After 2 months, severe extremity pain and dyspnea developed again, and steroid pulse therapy was initiated. Besides GBS, acute-onset CIDP can occur with hantavirus and HBV coinfection. [ncbi.nlm.nih.gov]

• Nausea

  A 58-year-old female lymphoma patient was admitted to our hospital for asthenia, nausea, vomiting, and abnormal liver function lasting over 1 week and diagnosed as acute hepatitis B. [ncbi.nlm.nih.gov]

  Over time, as the virus causes increasing damage to the liver, the following symptoms may appear: fatigue nausea dark urine muscle soreness vomiting loss of appetite stomach pain jaundice [childrenshospital.org]

  When they occur, symptoms can be mistaken for the flu (nausea and vomiting, malaise, loss of appetite and abdominal pain). Some people with hepatitis B also experience jaundice, a yellowing of the eyes or skin. [ashasexualhealth.org]

  A safe and effective vaccine… Read More vaccine In infectious disease: Hepatitis B vaccine Hepatitis B virus (HBV) produces an illness characterized by jaundice, poor appetite, malaise, and nausea. Chronic liver disease may follow the infection. [britannica.com]

  Not all people newly infected with HBV have symptoms, but for those that do, symptoms can include fatigue, poor appetite, stomach pain, nausea, and jaundice. For many people, hepatitis B is a short-term illness. [cdc.gov]

• Hypotension

  Complication of Dialysis Complications that occur during a hemodialysis sessions are Hypotension (20-30% of dialysis), Muscle cramps (5-20%), Nausea and vomiting (5-15%), Headache (5%), Chest and back pain (2-5%), Itching (5%), Fever and chills ( sterilization [omicsonline.org]

• Skin Lesion

  Bullous pemphigoid is a type of acute or chronic autoimmune disease that involves subepidermal skin lesions with bulla formation. [ncbi.nlm.nih.gov]

  Postnatal transmission HBV is only detectable in breast milk by PCR and therefore makes of breastfeeding a theoretical method of transmission, either by ingestion of the virus or by contact with skin lesions on the mother’s breast. [em-consulte.com]

• Irritability

  Hepatitis B is irritation and swelling (inflammation) of the liver due to infection with the hepatitis B virus (HBV). Other types of viral hepatitis include hepatitis A, hepatitis C, and hepatitis D. Hepatitis B infection is caused by the HBV. [medlineplus.gov]

  Individuals with dehydration may notice these symptoms: Extreme weakness Confusion or trouble concentrating Headache Lack of urination Irritability Symptoms of liver damage may include the following: Fluid retention causing swelling of the belly ( ascites [emedicinehealth.com]

• Asthenia

  A 58-year-old female lymphoma patient was admitted to our hospital for asthenia, nausea, vomiting, and abnormal liver function lasting over 1 week and diagnosed as acute hepatitis B. [ncbi.nlm.nih.gov]

  In the 28 other patients, hepatitis was clinically asymptomatic or limited to asthenia. Only 1 patient had jaundice. [journals.lww.com]

• Hepatocellular Carcinoma

  AIMS AND OBJECTIVES: To investigate hepatocellular carcinoma screening utilisation and factors associated with utilisation among patients prescribed hepatitis B virus anti-viral therapy and at risk of hepatocellular carcinoma. [ncbi.nlm.nih.gov]

  Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nat. Genet. 44, 1117–1121 (2012). 28. Cleary, S. P. et al. Identification of driver genes in hepatocellular carcinoma by exome sequencing. [doi.org]

Estimated glomerular filtration rate (eGFR) was calculated at baseline, 24 weeks, 52 weeks, and 104 weeks of treatment, respectively. [ncbi.nlm.nih.gov]

Statistical analyses were conducted to assess the ability of differentially expressed miRNAs and other prognostic factors in identifying ACLF prognosis and to develop a new predictive model. [ncbi.nlm.nih.gov]

Acute Hepatitis B Infection, 4.1 What happens when Initially infected. 4.2 Symptoms. 4.3 Treatment 4.4 Prognosis 5. Chronic Hepatitis B infection. 5.1 How does chronic Hepatitis B Develop. 5.2 Symptoms 5.3 Treatment 5.4 Prognosis 6. [hon.ch]

The prognosis of the inactive carrier is generally good and well supported by long-term follow-up studies [ 20, 21, 22 ]. [medsci.org]

Long-term prognosis is not predictable, although chronic HBV infection early in life increases the risk of subsequent liver disease including chronic hepatitis, cirrhosis, end-stage liver disease, and hepatocellular carcinoma. [msdmanuals.com]

Various theories have been given for explanation of the disease entity; however, the etiology remains elusive. This report describes a case of an 18-year-old man with idiopathic cervical resorption that progressed aggressively and involved 20 teeth. [ncbi.nlm.nih.gov]

The involvement of these lesions in the etiology of human diseases and aging was also investigated in the past several decades, suggesting that the oxidatively induced DNA adducts, especially bulky DNA lesions, may serve as biomarkers for exploring the [doi.org]

Author information 1 Department of Epidemiology and Biostatistics, Key Laboratory of Environment and Health of Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. [ncbi.nlm.nih.gov]

Thomas London, Global Epidemiology of Hepatocellular Carcinoma, Clinics in Liver Disease, 10.1016/j.cld.2015.01.001, 19, 2, (223-238), (2015). [doi.org]

McMahon, Epidemiology and Prevention, Viral Hepatitis, (81-95), (2013). [dx.doi.org]

BACKGROUND: Hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) is a life-threatening condition and its exact pathophysiology and progression remain unclear. [ncbi.nlm.nih.gov]

Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China 3. [jcancer.org]

The difference between intensity and duration of immunosuppression may be the basis of the differences in the pathophysiology of HBV reactivation. [ard.bmj.com]

[…] countries) Membership in a high-risk group Infants of HBV-infected mothers Alaskan native and Pacific Islander children Men who have sex with men Children residing in households of first-generation immigrants from countries where HBV infection is endemic Pathophysiology [arupconsult.com]

Antiviral therapy using lamivudine and tenofovir during the second pregnancy successfully prevented mother-to-child transmission of the HBV for high-risk mothers. [ncbi.nlm.nih.gov]

Prevention of Hepatitis Transmission One of the most important strategies of prevention is management of anemia in hemodialysis patient. Anemia is common in patients with chronic kidney disease. [omicsonline.org]