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Hepatitis B Virus


Presentation

  • The following is a case report detailing a patient presenting with all three of the above presentations who is cytoplasmic antineutrophil cytoplasmic antibody-positive and a chronic carrier of hepatitis B.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Testing indicated that both HBsAb and HBsAb were present.[ncbi.nlm.nih.gov]
  • -Oct-2005 Present study KP659221 B5 A1896 Full Alaska 25-Jan-2005 Present study KP659222 B5 A1896 Partial 153–881; 1839–3215 Alaska 12-May-2003 Present study KP659223 B5 A1896 Full Alaska 15-Sep-2003 Present study KP659224 B5 A1896 Full Alaska 10-Dec-[doi.org]
  • In the present study, RNA-binding motif protein 24 (RBM24) is shown to be involved in the modulation of HBV replication by targeting the TR of HBV RNA.[ncbi.nlm.nih.gov]
  • Here, we present a 34-year-old male patient with acute de novo hepatitis B virus that developed 7 months after successful liver transplant.[ncbi.nlm.nih.gov]
Splenectomy
  • KEYWORDS: cytokine; liver cirrhosis; portal hypertension; protein antibody array; splenectomy[ncbi.nlm.nih.gov]
Proximal Muscle Weakness
  • A 55-year-old male was confirmed to have HCC and dermatomyositis based on proximal muscle weakness, typical skin manifestations, elevated muscle enzyme levels, and muscle biopsy findings.[ncbi.nlm.nih.gov]
Blister
  • Histopathological examination showed the typical features of LP with subepidermal blisters, and with linear deposits of IgG along the basement membrane zone on direct immunofluorescence.[ncbi.nlm.nih.gov]
Quadriplegia
  • After 8 months, quadriplegia and hypesthesia recurred. Immunoglobulin therapy at this time had no effect, but steroid therapy had some effect. A diagnosis of CIDP was made.[ncbi.nlm.nih.gov]
Tonic-Clonic Seizure
  • She presented with a history of recurrent tonic-clonic seizures. Magnetic resonance imaging (MRI) showed progressive atrophy and multiple white matter lesions in the left side of the brain.[ncbi.nlm.nih.gov]
Microscopic Hematuria
  • All 5 children presented with different levels of proteinuria and microscopic hematuria. Renal biopsies showed membranous nephropathy accompanied by HBsAg and/or HBcAg deposits in glomeruli in all of the children.[ncbi.nlm.nih.gov]
Oliguria
  • A 59-year-old man with a 3-year history of liver cirrhosis was introduced to our department because of oliguria, proteinuria and microscopic haematuria. He, with negative serum HBV surface antigen, was not detected HBV DNA in his serum.[ncbi.nlm.nih.gov]

Workup

Microcytic Anemia
  • RESULTS: Patients with macrocytic anemia had evidently higher MELD scores (10.8   6.6) than those with normocytic anemia (8.0   5.5) or microcytic anemia (6.3   5.1).[ncbi.nlm.nih.gov]
Normocytic Anemia
  • RESULTS: Patients with macrocytic anemia had evidently higher MELD scores (10.8   6.6) than those with normocytic anemia (8.0   5.5) or microcytic anemia (6.3   5.1).[ncbi.nlm.nih.gov]
White Matter Lesions
  • Magnetic resonance imaging (MRI) showed progressive atrophy and multiple white matter lesions in the left side of the brain.[ncbi.nlm.nih.gov]

Treatment

  • Estimated glomerular filtration rate (eGFR) was calculated at baseline, 24 weeks, 52 weeks, and 104 weeks of treatment, respectively.[ncbi.nlm.nih.gov]
  • Treatment with the nucleoside analog lamivudine was started to reduce serum HBV-DNA levels, but lamivudine was discontinued and treatment with entecavir was started at a dosage of 0.5 mg/day after 6 weeks because of possible adverse effects.[ncbi.nlm.nih.gov]
  • The patient (caucasian race, 66-year-old) was diagnosed with RA in Novembre 2010 and in December 2010 he started a treatment with prednisone plus subcutaneous methotrexate.[ncbi.nlm.nih.gov]
  • Use of direct-acting antiviral drugs (DAAs) greatly improves management of adults infected with hepatitis C virus (HCV) whether patients are treatment-naive or unsuccessfully pre-treated.[ncbi.nlm.nih.gov]
  • Treatment of HBsAg-negative HBV-GN patients with immunosuppressants alone could not achieve satisfactory effects. Antiviral treatment is effective and may be necessary in this type of patient.[ncbi.nlm.nih.gov]

Prognosis

  • Approximately 9% of Taiwanese RA patients with HBsAg-/HBcAb serostatus had HBV reactivation around 2 years after starting regular rituximab therapy; they all had a relatively good prognosis.[ncbi.nlm.nih.gov]
  • Statistical analyses were conducted to assess the ability of differentially expressed miRNAs and other prognostic factors in identifying ACLF prognosis and to develop a new predictive model.[ncbi.nlm.nih.gov]
  • Acute Hepatitis B Infection , 4.1 What happens when Initially infected. 4.2 Symptoms. 4.3 Treatment 4.4 Prognosis 5. Chronic Hepatitis B infection. 5.1 How does chronic Hepatitis B Develop. 5.2 Symptoms 5.3 Treatment 5.4 Prognosis 6.[hon.ch]
  • The prognosis of the inactive carrier is generally good and well supported by long-term follow-up studies [ 20 , 21 , 22 ].[medsci.org]
  • Long-term prognosis is not predictable, although chronic HBV infection early in life increases the risk of subsequent liver disease including chronic hepatitis, cirrhosis, end-stage liver disease, and hepatocellular carcinoma.[msdmanuals.com]

Etiology

  • There is no any study to report that HBV infection is associated with the etiology of MCD. Herein, we report four MCD patients with HBV infection and speculate that there is an association of HBV infection with the pathological type of MCD.[ncbi.nlm.nih.gov]
  • Various theories have been given for explanation of the disease entity; however, the etiology remains elusive. This report describes a case of an 18-year-old man with idiopathic cervical resorption that progressed aggressively and involved 20 teeth.[ncbi.nlm.nih.gov]
  • Should such findings be confirmed by other studies, it may offer important insights into the etiology of pancreatic cancer and may suggest the need to consider prevention of HBV reactivation among patients with HBV-related pancreatic cancer during chemotherapy[ncbi.nlm.nih.gov]
  • Several long non-coding RNAs (lncRNAs) have been shown to be involved in the etiology of HBV-related HCC. AX800134 is one recently identified lncRNA associated with HCC.[ncbi.nlm.nih.gov]
  • The involvement of these lesions in the etiology of human diseases and aging was also investigated in the past several decades, suggesting that the oxidatively induced DNA adducts, especially bulky DNA lesions, may serve as biomarkers for exploring the[doi.org]

Epidemiology

  • Author information 1 Department of Epidemiology and Biostatistics, Key Laboratory of Environment and Health of Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.[ncbi.nlm.nih.gov]
  • Thomas London, Global Epidemiology of Hepatocellular Carcinoma, Clinics in Liver Disease, 10.1016/j.cld.2015.01.001, 19, 2, (223-238), (2015).[doi.org]
  • This study aimed to determine the sero-epidemiology of HIV, HBV and HCV infections in a rural setting of the West region of Cameroon, a SSA country.[ncbi.nlm.nih.gov]
  • When the worldwide molecular epidemiology of HBV based on the variability of the S-gene was defined, the E and F strains seemed to originate in aboriginal populations of Africa and the New World, respectively.[ncbi.nlm.nih.gov]
  • McMahon, Epidemiology and Prevention, Viral Hepatitis, (81-95), (2013).[dx.doi.org]
Sex distribution
Age distribution

Pathophysiology

  • BACKGROUND: Hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) is a life-threatening condition and its exact pathophysiology and progression remain unclear.[ncbi.nlm.nih.gov]
  • Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China 3.[jcancer.org]
  • The difference between intensity and duration of immunosuppression may be the basis of the differences in the pathophysiology of HBV reactivation.[ard.bmj.com]
  • […] countries) Membership in a high-risk group Infants of HBV-infected mothers Alaskan native and Pacific Islander children Men who have sex with men Children residing in households of first-generation immigrants from countries where HBV infection is endemic Pathophysiology[arupconsult.com]

Prevention

  • Antiviral therapy using lamivudine and tenofovir during the second pregnancy successfully prevented mother-to-child transmission of the HBV for high-risk mothers.[ncbi.nlm.nih.gov]
  • Medicine, School of Medicine, Ningbo University, Ningbo, 315211, China. 3 Institute of Infectious Disease Control and Prevention, Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China. 4 Department of Epidemiology and Biostatistics[ncbi.nlm.nih.gov]
  • Shenzhen, China. 8 NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China liujun@ivdc.chinacdc.cn mengsd@im.ac.cn. 9 CAS[ncbi.nlm.nih.gov]
  • CONCLUSIONS: In a setting where there exists a subtype mismatch between vaccine and circulating genotype, the vaccine was largely effective in preventing chronic infection but sub-optimal against any infection.[ncbi.nlm.nih.gov]
  • This report may alert the clinicians to take the measure to prevent an upcoming outbreak of recombinant HBV.[ncbi.nlm.nih.gov]

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