Presentation
This study presents clinical scenarios of HCV-infected patients with hematologic malignancies, focusing on diagnosis, clinical and laboratory presentations, complications, and DAA therapy. An up-to-date treatment algorithm is presented. [ncbi.nlm.nih.gov]
Entire Body System
Neurologic
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Excitement
Exciting progress has recently been made in understanding the replication of hepatitis C virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma worldwide. [ncbi.nlm.nih.gov]
An exciting area of progress has been the delineation of cis -acting RNA elements that guide viral replication. [nature.com]
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Rabies
Hepatitis C virus genotype 1, complete genome Hepatitis C virus genotype 1, complete genome gi 22129792 ref NC_004102.1 Nucleotide Figure 61-4, Life cycle of rabies - Medical Microbiology Figure 61-4, Life cycle of rabies - Medical Microbiology Micrococcus [ncbi.nlm.nih.gov]
Photolabeling identifies a putative fusion domain in the envelope glycoprotein of rabies and vesicular stomatitis viruses. J. Biol. Chem. 270 : 17575 -17581. Farci, P., A. Shimoda, D. Wong, T. Cabezon, D. DeGioannis, A. Strazzera, Y. Shimizu, M. [doi.org]
Workup
See Workup for more detail. Management Treatment of acute hepatitis C has rapidly evolved and continues to evolve. HCV infection has become a curable disease, although a vaccine does not yet exist. See Treatment and Medication for more detail. [emedicine.medscape.com]
Treatment
AIM: To determine risk factors associated with hepatitis C virus (HCV) treatment failure after direct acting antivirals in patients with complex treatment histories. [ncbi.nlm.nih.gov]
Prognosis
Genotypes HCV-1: most common overall HCV-2: HCV-3: HCV-4: more common in Africa HCV-5: HCV-6: Treatment and prognosis Vaccination has not been developed for the virus. [radiopaedia.org]
Links: epidemiology transmission clinical features diagnosis and further investigation treatment prognosis practical suggestions to help prevention in primary care predictors of disease progression hepatitis C virus testing in primary care hepatitis C [gpnotebook.co.uk]
Prognosis of Hepatitis C virus (HCV) The probable outcome of a viral infection depends a lot of what type of the hepatitis C virus you are infected with. [myvmc.com]
With early diagnosis and treatment, the current prognosis is excellent for those who are chronically infected. [emedicinehealth.com]
Etiology
Abstract Scleromyxedema (SM) is a chronic and progressive fibromucinous disease with no known etiology. We report a patient with scleromyxedema associated with hepatitis C virus, successfully treated with interferon and ribavirin therapy. [ncbi.nlm.nih.gov]
Abstract Hepatitis C virus (HCV) is the major etiologic agent of non-A, non-B hepatitis. HCV infection frequently causes chronic hepatitis, which progresses to liver cirrhosis and hepatocellular carcinoma. [doi.org]
Epidemiology
Information on their past transmission and epidemiology might be obtained by estimation of the time of divergence of the different genotypes of HCV, HBV and HGV/GBV–C using knowledge of their rates of sequence change. [doi.org]
In this paper, we study the molecular epidemiology of HCV genotype 2 in its region of endemic origin, west and central Africa. Our analysis includes 56 new and highly diverse HCV isolates sampled from infected individuals in Guinea-Bissau. [ncbi.nlm.nih.gov]
Pathophysiology
Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009; 65 (9) 732-741 33 Raison C L, Capuron L, Miller A H. [doi.org]
Pathophysiology of hepatitis C virus infection and related liver disease. Trends Microbiol. 2004;12(2):96-102. [ Links ] 65. Blackard JT, Shata MT, Shire NJ, Sherman KE. Acute hepatitis C virus infection: a chronic problem. [scielo.org.co]
Pathophysiology of hepatitis C virus infection and related liver disease. Trends Microbiol. 12 : 96-102. [ PubMed ] [ Google Scholar ] 28. Phan, T., R. K. Beran, C. Peters, I. C. Lorenz, and B. D. Lindenbach. 2009. [ncbi.nlm.nih.gov]
Pathophysiology of hepatitis C virus infection and related liver disease. Trends Microbiol. 12 : 96 -102. 28. Phan, T., R. K. Beran, C. Peters, I. C. Lorenz, and B. D. Lindenbach. 2009. [dx.doi.org]
Pathophysiology Hepatitis C virus (HCV) is a spherical, enveloped, single-stranded RNA virus belonging to the family Flaviviridae, genus Flavivirus. [emedicine.medscape.com]
Prevention
Because there is no vaccine and no post-exposure prophylaxis for HCV, the focus of primary prevention efforts should be safer blood supply in the developing world, safe injection practices in health care and other settings, and decreasing the number of [ncbi.nlm.nih.gov]