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Hepatitis D

Delta Hepatitis


Presentation

  • Cirrhosis was present in 28 (44%). IFNλ3, rs12979860 genotype CC, was present in 41 (64.1%), CT in 21 (32.8%) and TT in 2 (3.1%).[ncbi.nlm.nih.gov]
  • HBV markers were present in 25 of the former and 40 of the latter. Of the 65 patients with HBV infection, 12 were not available for delta antibody screening.[ncbi.nlm.nih.gov]
  • INTERPRETATION & CONCLUSIONS: Acute infection by HDV (IgM detection) was not present in HBsAg positive cancer patients. Further studies on a large number of patients in different regions are required to confirm our preliminary findings.[ncbi.nlm.nih.gov]
  • The aim of this study was to assess the clinical presentation of hepatitis D virus (HDV) infection in Pakistani children.[ncbi.nlm.nih.gov]
  • The designations employed and the presentation of the information in this manual do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory[web.archive.org]
Vietnamese
  • The prevalence of HDV in Vietnamese HBsAg-positive patients is speculative. Therefore, we assessed the prevalence of HDV in Vietnamese patients, determined the HDV-genotype distribution and compared the findings with the clinical outcome.[ncbi.nlm.nih.gov]
Loss of Hair
  • Arthralgias Hair loss Headache Itching 56 50 47 47 41 38 38 12 Gaudin 1995 Flu‐like symptoms Leukopoenia Thrombocytopoenia Hyperthyroidism Death (by suicide) 100 100 100 10 10 Figures and Tables - Table 2.[doi.org]
Noncompliance
  • Eight untreated patients were withdrawn from the control group for noncompliance. In Farci 1994 , one patient was lost to follow‐up in the control group.[doi.org]
Agitation
  • The cell lysates were clarified by centrifugation at 12,000 rpm for 10 min, and then 1 μg of monoclonal antibody against HDAg was added to 200 μg of cell lysates in a total volume of 500 μl, which was incubated at 4 C for 18 h with agitation.[doi.org]

Workup

Amino Acids Increased
  • In contrast, removal of the next six adjacent amino acids increased the IC 50 by an extra factor of 100 to 400 nM.[doi.org]

Treatment

  • […] the end of treatment.[ncbi.nlm.nih.gov]
  • End of treatment biological response, that is, normal ALT at the end of treatment was also a predictor of ETR and SVR (P 0.004 and P 0.041, respectively). CONCLUSIONS: Treatment with PEG-IFN for hepatitis D is of limited efficacy.[ncbi.nlm.nih.gov]
  • Five trials compared interferon alpha with no treatment in the control group. One of these trials had two treatment arms with a higher dose and lower dose of interferon alpha and a no-treatment control group.[ncbi.nlm.nih.gov]
  • No evidence-based rules for treating CDH exist, and treatment duration needs to be individualized based on virologic response at end of treatment or end of follow-up.[ncbi.nlm.nih.gov]

Prognosis

  • Despite the success of the national vaccination program, delta hepatitis is not a vanishing disease and it has a grave prognosis due to development of early cirrhosis.[ncbi.nlm.nih.gov]
  • […] hepatitis D HDV antigens and HDV RNA levels Initial management of Hepatitis D See management of HBV Peg-interferon is the only treatment for chronic hepatitis delta Complications of hepatitis D Chronic liver disease with all its associated complications Prognosis[oxfordmedicaleducation.com]
  • Hepatitis D Prognosis Your health outlook depends on whether you were coinfected or superinfected with hepatitis D; the prognosis is better for people who were co-infected.[everydayhealth.com]
  • HDV more severe than HBV alone HDV increases risk for progression to cirrhosis and for hepatocellular carcinoma Hepatitis D genotypes 2 and 3 seem to have a worse prognosis (Romeo, 2015) Clinical course of hepatitis D genotypes 5-8 still unclear (Romeo[arupconsult.com]
  • The prognosis in cirrhosis varies widely according to patient characteristics.[doi.org]

Etiology

  • In fulminant hepatitis cases, delta virus superinfection of hepatitis B virus carriers was the most common serological pattern; histopathologic examination showed features identical to those described in fulminant hepatitis cases of similar etiology in[ncbi.nlm.nih.gov]
  • Abstract The hepatitis D virus (HDV) was first detected in Italy in 1977 and is the etiologic agent of type D hepatitis. A defective RNA virus, HDV depends completely on the hepatitis B virus for its expression and replication.[ncbi.nlm.nih.gov]
  • Paul, MN 55164-0975 Etiology Hepatitis D virus (HDV) is a defective, single-stranded RNA virus that requires the helper function of the hepatitis B virus (HBV) to replicate.[health.state.mn.us]
  • (Etiology) Hepatitis D Infections is caused by the hepatitis D virus. However, the hepatitis D virus alone cannot cause an infection.[dovemed.com]

Epidemiology

  • To define more exactly the epidemiology of delta virus infection and confirm its role in causing fulminant Labrea hepatitis in the Amazon Basin, we studied the prevalence of delta virus infection among persons with acute and chronic hepatitis B virus[ncbi.nlm.nih.gov]
  • Wedemeyer H, Manns MP (2010) Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead. Nat Rev Gastroenterol Hepatol 7:31–40 PubMed CrossRef Google Scholar 12.[doi.org]
  • The clinical picture of HDV disease is evolving as a consequence of a significant change in the epidemiology of HDV infection, which has led to a significant decline in incidence in Western countries, mainly as a result of universal HBV vaccination programs[ncbi.nlm.nih.gov]
  • OBJECTIVE: Inrtroduction: The epidemiological situation for hepatitis D has changed significantly.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • […] infection in patients with acute hepatitis B virus (HBV) infection (acute coinfection), chronic HBV infection (chronic coinfection), or acute exacerbation of known chronic HBV infection (HDV superinfection) Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]
  • Back to Top Pathophysiology Patients may be infected with HDV at the same time that they acquire the hepatitis B virus (acute coinfection) or they can acquire the virus after infection with hepatitis B (superinfection).[clevelandclinicmeded.com]
  • Grazia Anna Niro and Antonina Smedile, Current Concept in the Pathophysiology of Hepatitis Delta Infection, Current Infectious Disease Reports, 10.1007/s11908-011-0233-5, 14, 1, (9-14), (2011). M.[doi.org]
  • Grazia Anna Niro and Antonina Smedile, Current Concept in the Pathophysiology of Hepatitis Delta Infection, Current Infectious Disease Reports, 10.1007/s11908-011-0233-5, 14, 1, (9-14), (2011).[doi.org]
  • Google Scholar 39 40 41 42 43 44 The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation B Stieger (2011) Handb Exp Pharmacol pp. 205–259.[doi.org]

Prevention

  • […] and Prevention, Changping District, Beijing 102206, China.[ncbi.nlm.nih.gov]
  • “Epidemiology and Prevention of Vaccine-Preventable Diseases, 7th ed.” Jan 2002, DHHS-CDC.[health.state.mn.us]
  • […] options are; 1) The inhibition of the farnesylation of the large HD-protein permissive of virion assembly with Lonafarnib, 2) The blocking of HBsAg entry into cells with Myrcludex B via the inhibition of the Sodium Taurocholate Cotransporting Receptor, to prevent[ncbi.nlm.nih.gov]
  • As with most forms of hepatitis, prevention is the best strategy.[everydayhealth.com]
  • […] in preventing HDV transmission.[who.int]

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