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Hepatitis G

GBV


Presentation

  • In mononuclear cell samples (n 15) 100% presented the genomic chain of HCV and 60% presented that of HGV (p 0.05). Antigenomic chains were detected in 13 and 33%, respectively (ns).[ncbi.nlm.nih.gov]
  • The aim of the present investigation was to assess the prevalence of HGV by antibody testing and HGV-RNA determination by PCR.[ncbi.nlm.nih.gov]
  • In patients presenting with pancytopenia after an episode of acute hepatitis, the definitive diagnosis should be considered and confirmed by RT-PCR and if possible by bone marrow biopsy.[ncbi.nlm.nih.gov]
  • T virus-DNA was present in serum in 3 subjects, 1 with cryptogenic and 2 with hepatitis C virus-related chronic liver disease.[ncbi.nlm.nih.gov]
  • Hepatitis G virus (HGV) or GB-virus type C (GBV-C) is distributed globally and is present in the volunteer blood donor population.[ncbi.nlm.nih.gov]
Asymptomatic
  • Hepatitis G virus antibody was more frequent in patients with chronic liver disease (36.4%-43.9%) than in asymptomatic persons (23.1%).[ncbi.nlm.nih.gov]
  • Among asymptomatic HCV-carriers, the prevalence of HGV RNA was 9.09% and TTV DNA 75.7%. Neither HGV RNA nor TTV DNA had apparent effect on the HCV infection.[ncbi.nlm.nih.gov]
  • There was no significant increase in the prevalence of hepatitis GB virus-C viremia in asymptomatic hepatitis B virus- and hepatitis C virus-infected patients compared to that of controls (1.56% and 7.14%, respectively, vs 3.85%, both P NS).[ncbi.nlm.nih.gov]
  • Overall our findings seem to indicate that HGV infections generally are asymptomatic, transient and self-limiting and the virus does not seem to show a very high prevalence among the Indian population.[ncbi.nlm.nih.gov]
  • Most victims of this virus are asymptomatic, meaning showing no symptoms. Long term this virus can cause chronic infection but there is no evidence that HGV causes liver disease.[prezi.com]
Fever
  • The physical examination presents fever, pallor whereas bleeding, hepatomegaly, Splenomegaly and bruising were absent, abdominal ultrasonography confirmed the absence of hepatomegaly, Splenomegaly and lymphodenopathy.[ncbi.nlm.nih.gov]
  • At a Glance Hepatitis G virus, more properly known as GB virus type C (GBV-C), is a flavivirus; the same class of viruses as hepatitis C and yellow fever virus.[oncologynurseadvisor.com]
Malaise
  • Hepatitis may occur with limited or no symptoms, but often leads to yellow discoloration of the skin, mucus membranes, and conjunctivae, poor appetite and malaise.[disabled-world.com]
  • ., anorexia, nausea, malaise, vomiting, dark urine, clay colored or light stools, and abdominal pain). Appropriate diagnostic testing of such patients is crucial to ensure complete case ascertainment.[cdc.gov]
Loss of Appetite
  • Others may have; Diarrhea Stomach pain Loss of appetite Nausea and vomiting Jaundice, yellowing of skin and eyes Dark-colored urine and pale bowel movements Statistics: Hepatitis Viral hepatitis is the most common cause of hepatitis worldwide.[disabled-world.com]
  • For those who do develop symptoms of viral hepatitis, the most common are flu- like symptoms including: Loss of appetite Nausea Vomiting Fever Weakness Tiredness Aching in the abdomen Less common symptoms include: Dark urine Light-colored stools Fever[medicinenet.com]
  • DISEASE-SPECIFIC SURVEILLANCE GUIDELINES Acute Hepatitis A Case Definition (*) Clinical criteria An acute illness with discrete onset of symptoms (e.g. fatigue, abdominal pain, loss of appetite, intermittent nausea, vomiting), and jaundice or elevated[cdc.gov]
Jaundice
  • History In 1964 a surgeon whose initials are G.B. contracted a hepatitis with jaundice. His serum was saved frozen by Isa K. Mushahwar at Abbott laboratories near Chicago. In 1995 the serum produced hepatitis in tamarins.[meddean.luc.edu]
  • Typically, these patients do not have jaundice until the liver damage is far advanced. Therefore, these patients can remain undiagnosed for years to decades.[medicinenet.com]
  • None of the 10 patients had jaundice.[nejm.org]
  • Determine date of illness onset, whether jaundice was present and results of testing for aminotransferase levels. Serologic test results.[cdc.gov]
Liver Dysfunction
  • A 68-year-old man with moderate liver dysfunction diagnosed with atypical pneumonia showed serum alanine aminotransferase and gamma-glutamyltranspeptidase levels which revealed a sustained abnormality over six months.[ncbi.nlm.nih.gov]
  • Long-term liver dysfunction, mainly due to chronic graft-versus-host disease or hepatitis C virus infection, is a well-known complication.[ncbi.nlm.nih.gov]
  • . - Hepatitis C and G virus infection and liver dysfunction after allogeneic bone marrow transplantation: results from a prospective study. Blood, 9 0: 1326-1331, 1997. [ Links ] 23.[scielo.br]
Suggestibility
  • Two patients with acute hepatitis B with suggested sexual transmission of hepatitis G virus (HGV) are reported. A total of 18 patients with community acquired acute hepatitis B were analyzed in this study.[ncbi.nlm.nih.gov]
  • We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s, has been rather well studied.[ncbi.nlm.nih.gov]
  • Our study suggests that there may be an impact on HIV viral load in GBV-C/HGV-coinfected patients.[ncbi.nlm.nih.gov]
  • In vitro studies suggest that GBV-C inhibits HIV replication and alters cytokine, chemokine and chemokine receptor expression. Thus, GBV-C may be a major factor influencing the natural history of HIV disease.[ncbi.nlm.nih.gov]
  • This case suggests that hepatitis GB virus type C/hepatitis G virus may induce chronic hepatitis and that there may be cases with chronic hepatitis induced by this virus in patients who have been diagnosed with alcoholic liver disease, even in cases with[ncbi.nlm.nih.gov]
Excitement
  • It represents an exciting new technology that could have therapeutic applications for the treatment of viral infections.[ncbi.nlm.nih.gov]

Treatment

  • At the end of treatment, all of the 5 patients had undetectable hepatitis G virus RNA in sera. Early loss of hepatitis G virus RNA at week 4 of treatment was observed in the 2 patients on combination therapy.[ncbi.nlm.nih.gov]
  • ., subjects who were currently seeking treatment for an STD) compared with the group who never had received treatment for an STD.[ncbi.nlm.nih.gov]
  • Viral inactivation techniques that did not uniformly remove GBV-C included vapour heat treatment and dry heat treatments for less than 144 h.[ncbi.nlm.nih.gov]
  • , and 12 who received kidney transplantation were interviewed in one unit of dialysis treatment in Goiania city.[ncbi.nlm.nih.gov]
  • Hepatitis C Community A Bulletin Board for discussions on hepatitis, treatments, etc.[hepatitiscentral.com]

Prognosis

  • HGV or GBV-C has been ascertained to influence course and prognosis in the HIV-infected patient.[ncbi.nlm.nih.gov]
  • Although not linked to a disease, GB virus-C viraemia has been associated with an improved prognosis in HIV-1-co-infected individuals.[ncbi.nlm.nih.gov]
  • Prognosis What little is known about the course of hepatitis G suggests that illness is mild and does not last long. When more patients have been followed up after the acute phase, it will become clear whether HGV can cause severe liver damage.[medical-dictionary.thefreedictionary.com]
  • What is the prognosis of viral hepatitis? The prognosis of viral hepatitis for most patients is good; however, this prognosis varies somewhat depending on the infecting virus.[medicinenet.com]

Etiology

  • The role of this novel virus in the pathogenesis of chronic liver injury of unknown etiology appears insignificant in our geographic area.[ncbi.nlm.nih.gov]
  • Our results confirm the limited role of HGV as the etiological agent of non A-E acute hepatitis.[ncbi.nlm.nih.gov]
  • Sixty patients with chronic liver diseases, 11 with hepatitis B virus, 44 with hepatitis C virus and 5 patients with hepatitis of unknown etiology and 60 healthy blood donors as the control were included in the study.[ncbi.nlm.nih.gov]
  • The findings suggest that, despite the frequent detection of HGV markers in patients with HCC, isolated infection with this agent does not seem to be a relevant factor in the etiology of this carcinoma.[ncbi.nlm.nih.gov]
  • TTV and GBV-C/HGV infection does not appear to have a role in the etiology of acute hepatitis.[repositorio.ufba.br]

Epidemiology

  • A review of literature was performed in 2009 to summarize scientific reports on epidemiology and pathogenesis of the HGV infection and its exposure through hemodialysis.[ncbi.nlm.nih.gov]
  • Thus, for epidemiological reasons, HGV is of interest in haemodialysis patients, who are at risk of parenterally transmitted infections.[ncbi.nlm.nih.gov]
  • A cross-sectional epidemiology study evaluated the role of sexual activity and sexually transmitted diseases (STDs) in the transmission of hepatitis G virus (HGV/GBV-C) and other hepatitis virus infections in 944 subjects.[ncbi.nlm.nih.gov]
  • During the last decade an epidemiological association between hepatitis C virus (HCV) and B-cell lymphoproliferative disorders (B-LPD) has been reported; the same association has not been observed for Hodgkin's disease (HD).[ncbi.nlm.nih.gov]
  • Epidemiological data indicate that the virus is transmitted via blood/blood products, sexually and vertically from infected mothers to children. There are some previous reports on the prevalence of HGV infection among the blood/blood products.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Prevention

  • Ribavirin Combination of interferon and ribavirin Treatment Prevention: Absence of vaccine or any other specific prevention method. Non-specific prevention is used. Prevent sharing of personal items that might contain contaminated blood. Prevention[authorstream.com]
  • Assessing missed opportunities for prevention.[cdc.gov]
  • Prevention Since hepatitis G is a blood-borne infection, prevention relies on avoiding any possible contact with contaminated blood. Drug users should not share needles, syringes, or other equipment.[medical-dictionary.thefreedictionary.com]
  • How is viral hepatitis prevented? Prevention of hepatitis involves measures to avoid exposure to the viruses, using immunoglobulin in the event of exposure, and vaccines.[medicinenet.com]

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