Case report 2 A 9-year-old boy had a progressive splenomegaly, mild hepatomegaly and thrombocytopenia. The bone marrow biopsy showed hypercellular marrow without atypical lymphoid cells. Splenectomy was performed due to progressive splenomegaly. [adc.bmj.com]

He underwent surgical resection for splenomegaly. The spleen weighed 983 g and measured 21 14.5 7 cm, with no identifiable gross lesions. The cut surface was homogeneous and red-purple (panel A). [bloodjournal.org]

Most patients had massive splenomegaly, and bone marrow showed sinusoidal involvement by lymphoma. The HSTCL cells expressed γδ T-cell receptor (TCR) in 20 (74%), αβ TCR in 5 (19%), and neither in 2 (7%) patients (1 case not assessed). [mdanderson.elsevierpure.com]

On ultrasound of abdomen: Hepatomegaly Splenomegaly CT scan Tumor mass can be seen in liver or spleen or both. MRI Tumor mass can be seen in liver or spleen or both. [wikidoc.org]

Hepatosplenic T-cell lymphoma (effective October 01, 2015) Signs and Symptoms Anemia Drenching night sweats Fatigue Fever (for no known reason) Hepatomegaly Leukopenia Pain in the chest, abdomen, or bone s (for no known reason) Skin rash or itchy skin Splenomegaly [seer.cancer.gov]

Most patients had massive splenomegaly, and bone marrow showed sinusoidal involvement by lymphoma. The HSTCL cells expressed γδ T-cell receptor (TCR) in 20 (74%), αβ TCR in 5 (19%), and neither in 2 (7%) patients (1 case not assessed). [mdanderson.elsevierpure.com]

A CT scan revealed a liver with cirrhotic changes without focal lesions and massive splenomegaly with axillary, retroperitoneal and inguinal lymphadenopathy ( Figure 1 ). Bone marrow and lymph node biopsies were performed. [jgo.amegroups.com]

An acute form of T γ lymphoproliferative disease presenting with massive splenomegaly – importance of immunophenotyping for diagnosis Clin Immunol Immunopathol 1993 67 : 100–108 35. Lei KI-K, Chow JH-S, Johnson PJ. [nature.com]

Most patients had massive splenomegaly, and bone marrow showed sinusoidal involvement by lymphoma. The HSTCL cells expressed γδ T-cell receptor (TCR) in 20 (74%), αβ TCR in 5 (19%), and neither in 2 (7%) patients (1 case not assessed). [mdanderson.elsevierpure.com]

A CT scan revealed a liver with cirrhotic changes without focal lesions and massive splenomegaly with axillary, retroperitoneal and inguinal lymphadenopathy ( Figure 1 ). Bone marrow and lymph node biopsies were performed. [jgo.amegroups.com]

An acute form of T γ lymphoproliferative disease presenting with massive splenomegaly – importance of immunophenotyping for diagnosis Clin Immunol Immunopathol 1993 67 : 100–108 35. Lei KI-K, Chow JH-S, Johnson PJ. [nature.com]

(Pentostatin, ICE) auto-SCT 7 Humphreys et al [ 19 ] 2008 27, F 5 (AZT) Fever, nights sweats, pancytopenia, HSM Interferon-α 31 Zeidan et al [ 20 ] 2007 31, M 6 (6MP) 1 Chills, SM, fever, pancytopenia Ch. [wjgnet.com]

Blood 2014 124:677; doi: A 30-year-old man with an unremarkable medical history presented with fever, anemia, and thrombocytopenia, along with hepatosplenomegaly, for 1 month. Laboratory findings for infectious etiology were nondiagnostic. [bloodjournal.org]

His clinical course involved multiple hospitalizations complicated by hyponatremia, neutropenic fevers and pulmonary emboli. [jgo.amegroups.com]

VL is a systemic disease with gradual onset of fever, pancytopenia, hepatosplenomegaly, and weight loss. The incubation period can range from weeks to a year. VL is fatal if left untreated [ 6 ]. [jmedicalcasereports.biomedcentral.com]

loss (for no known reason) Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Splenectomy Progression and Transformation Relapses seen in vast majority of patients who respond initially to chemotherapy Epidemiology and Mortality Age [seer.cancer.gov]

Patients with HSTCL frequently have generalized symptoms, such as fatigue, significant night sweats, weight loss and unexplained fevers. [tcllfoundation.org]

(Pentostatin, ICE) auto-SCT 7 Humphreys et al [ 19 ] 2008 27, F 5 (AZT) Fever, nights sweats, pancytopenia, HSM Interferon-α 31 Zeidan et al [ 20 ] 2007 31, M 6 (6MP) 1 Chills, SM, fever, pancytopenia Ch. [wjgnet.com]

Patients with Sézary syndrome may also exhibit general, nonspecific symptoms including fevers, unintended weight loss, chills, fatigue, and malaise. [rarediseases.org]

Supportive treatment: Steroids, blood transfusions, anti-nausea medications, and antibiotics, may also be used. In combination with other treatment measures, these can help combat the symptoms of immune deficiency. [dovemed.com]

This called for a celebration even the oncologist announced this as Very Good news to us, so now she is on MTX ( methetraxte) once a week 12,5mg, but the three days following the dose she is wipped, she has unbearable nausea, cannot eat, and sleeps all [cancerresearchuk.org]

Acupuncture has been helpful in relieving musculoskeletal symptoms, as well as in controlling nausea and vomiting associated with chemotherapy. [emedicinehealth.com]

History of present illness was notable for a 6-month history of nausea, emesis, early satiety, and severe left upper quadrant abdominal pain that radiated to her shoulder. [hematologyandoncology.net]

It is most commonly used in combination with chemotherapy The radiation may be administered by a machine placed outside the body, or by putting a radioactive material inside the body The side effects of radiation therapy include nausea, vomiting, fatigue [dovemed.com]

The patient had no history of fever, vomiting, night sweats, chest pain, icterus, diarrhea or stool blood loss. [spandidos-publications.com]

Acupuncture has been helpful in relieving musculoskeletal symptoms, as well as in controlling nausea and vomiting associated with chemotherapy. [emedicinehealth.com]

[…] of appetite and weight loss Fatigue High temperatures and excessive night sweats ‘Non-painful’ swelling of lymph nodes in the neck, armpits, or groin, may be present; though, this is an uncommon finding Abnormal liver function tests, irregular lymphocytes [dovemed.com]

Depending on how and where the radiation is administered, it may cause certain side effects such as fatigue, loss of appetite, nausea, diarrhea, and skin problems. [emedicinehealth.com]

Review of systems was positive for jaundice, mild abdominal pain, diarrhea, loss of appetite and subjective weight loss since one month. [ispub.com]

upper quadrant pain and early satiety, peripheral blood cytopenias, and systemic symptoms. [hematologyandoncology.net]

It occurs mainly in young adults presenting with splenomegaly and most often with hepatomegaly but without lymphadenopathy. The lymphoma cells are usually CD3 , CD2 , CD5 , CD7 / , CD4 , CD8 / , and CD56 / . [bloodjournal.org]

Case report 2 A 9-year-old boy had a progressive splenomegaly, mild hepatomegaly and thrombocytopenia. The bone marrow biopsy showed hypercellular marrow without atypical lymphoid cells. Splenectomy was performed due to progressive splenomegaly. [adc.bmj.com]

On ultrasound of abdomen: Hepatomegaly Splenomegaly CT scan Tumor mass can be seen in liver or spleen or both. MRI Tumor mass can be seen in liver or spleen or both. [wikidoc.org]

ICD-10 Codes C84.5 Other and unspecified T-cell lymphoma s Corresponding ICD-10-CM Codes (U.S. only) C86.1 Hepatosplenic T-cell lymphoma (effective October 01, 2015) Signs and Symptoms Anemia Drenching night sweats Fatigue Fever (for no known reason) Hepatomegaly [seer.cancer.gov]

Alcohol intake, drug abuse, sexual risk behavior, insect bites, and close contact to animals were denied. Except for low doses of ibuprofen and acetylsalicylic acid she denied any regular medication or allergies. Medical history was otherwise empty. [ghrnet.org]

(f) These CD2, CD7, CD56 positive events are negative for alpha-beta/gamma-delta T-cell receptors Click here to view X-ray chest-posteroanterior showed massive left pleural effusion with mediastinal shift to the right. [ijpmonline.org]

Other clinical features such as fatigue, jaundice due to hepatic involvement and Coombs negative hemolytic anemia, and purpura may occur. [nature.com]

It can be easily misdiagnosed as acute leukemia on morphology as well as flow-cytometry, though massive hepatosplenomegaly with bicytopenia and no lymphadenopathy is highly suspicious of a diagnosis of HSTCL, especially in young individuals. [ijpmonline.org]