Edit concept Question Editor Create issue ticket

Hepatosplenomegaly

Enlarged Liver and Spleen


Presentation

  • Anemia, bone pains, renal failure are the most common symptoms at presentation. Though extra-medullary extra-osseous disease is well known in the course of the disease, initial presentation with extramedullary disease alone is rare.[ncbi.nlm.nih.gov]
  • Abstract This case report highlights the presentation of syphilis in a small-for-gestational age (SGA) female infant who was born to a mother with no prenatal care.[ncbi.nlm.nih.gov]
  • We present a case of an adult-onset type of Niemann-Pick disease in a 33-year-old woman who initially presented with dysarthria. At first, laboratory findings suggested Wilson's disease.[ncbi.nlm.nih.gov]
  • Massive hepatosplenomegaly as a presentation of ALL has not been described previously in any patient population.[ncbi.nlm.nih.gov]
  • Abstract A 24 year old woman living in the Mediterranean region of Turkey present with a three-month history of weight loss and irregular fever that was peaking at 40 degrees C with shivering.[ncbi.nlm.nih.gov]
Shivering
  • Abstract A 24 year old woman living in the Mediterranean region of Turkey present with a three-month history of weight loss and irregular fever that was peaking at 40 degrees C with shivering.[ncbi.nlm.nih.gov]
Dark Urine
  • Abstract A 42-year-old white man had headache, fever, chills, abdominal pain, nausea and vomiting, night sweats, and dark urine for 3 days before admission; he had history of a tick bite 6 weeks earlier.[ncbi.nlm.nih.gov]
  • Other symptoms of Hepatitis C include yellowish discoloration of skin and eyes, dark urine, fever and abdominal pain. Cirrhosis of Liver – Cirrhosis of liver causes enlarged liver and spleen.[primehealthchannel.com]

Workup

  • Workup for malaria, kala-azar and thalessemia were negative. Bone marrow studies revealed Gaucher cells [ Figure 2 ]. Skeletal survey revealed generalized osteopenia skull and typical Ehrlenmeyer flask deformity [ Figure 3 ].[ncbi.nlm.nih.gov]
Uric Acid Increased
  • From 6 months of age he has had lymphadenopathy, low levels of serum uric acid, increased levels of serum lactate dehydrogenase and hyper gamma-globulinemia.[ncbi.nlm.nih.gov]
Left Ventricular Hypertrophy
  • Fabry's disease, the most prevalent lysosomal storage disease, does usually not affect the liver, but causes painful episodes of hands' or feet pain (acroparesthesias), left ventricular hypertrophy, renal failure, early stroke and decreased life expectancy[ncbi.nlm.nih.gov]
Ventricular Hypertrophy
  • Fabry's disease, the most prevalent lysosomal storage disease, does usually not affect the liver, but causes painful episodes of hands' or feet pain (acroparesthesias), left ventricular hypertrophy, renal failure, early stroke and decreased life expectancy[ncbi.nlm.nih.gov]

Treatment

  • In the second case, the hepatomegaly was moderate, and with conservative treatment in the neonatal period the outcome was good.[ncbi.nlm.nih.gov]
  • These results demonstrate that praziquantel treatment reduces hepatosplenomegaly in the absence of exposure to S. mansoni, even with continuing exposure to malaria.[ncbi.nlm.nih.gov]
  • The constellation of symptoms is not compatible with any known disease, and we had difficulty in diagnosis and treatment. The age distribution was from 47 to 56 years, and two men and three women were affected.[ncbi.nlm.nih.gov]
  • Early diagnosis and treatment may improve outcomes. We herewith report the case of a 43 year old lady who presented with hepatosplenomegaly, without any classical manifestations of multiple myeloma and discuss the relevant literature.[ncbi.nlm.nih.gov]
  • Treatment The treatment for hepatosplenomegaly depends primarily on the underlying cause that has led to such changes in the first place.[healthh.com]

Prognosis

  • In these hydropic fetuses the prognosis seems to be poor.[ncbi.nlm.nih.gov]
  • Prognosis Prognosis is dominated by the risk of recurrence, which is high. Physical systemic evaluation is essential. The syndrome is not life-threatening. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • The presence of CD1a and S-100 surface markers, and characteristic racquet-shaped bodies in the cytoplasm (Birbeck granules) is confirmatory. 2 Prognosis for patients with single-system disease is generally excellent, with treatment consisting of observation[aafp.org]
  • Lymphoma Scoring systems in acute alcoholic hepatitis Maddrey's discriminant function test was described by Maddrey and colleagues in 1978 to predict prognosis in alcoholic hepatitis: It is calculated by: 4.6 x [PT:control value (sec)] serum bilirubin[quizlet.com]
  • From What is the prognosis for an enlarged spleen? Can you live without it? Often, the prognosis for an enlarged spleen depends entirely upon the underlying illness.[medicinenet.com]

Etiology

  • We present a previously healthy 5-year-old boy who was referred to the Hematology-Oncology Clinic to consider a bone marrow etiologic process after his pediatrician discovered progressive neutropenia, anemia, thrombocytopenia, and hepatosplenomegaly accompanied[ncbi.nlm.nih.gov]
  • CONCLUSION: Fetal hydrops and/or hepatosplenomegaly in the second half of pregnancy, although suggestive of infectious etiology, may be a sign of myeloproliferative disorder in fetuses with trisomy 21 or mosaic trisomy 21.[ncbi.nlm.nih.gov]
  • Because all the above tests do not reveal the etiology for this patient's severe disease, a tissue biopsy is needed.[journals.plos.org]
  • With meningitis one would consider Tuberculosis as an etiology. Hepatosplenomegaly would be seen with TB, and sarcoidosis or histiocytosis.[pediatriconcall.com]
  • Etiology The genetic basis is unknown.[orpha.net]

Epidemiology

  • The introduction of ultrasound examinations into epidemiology studies, used in tandem with clinical examination, showed a dissociation within endemic communities between presentation with hepatosplenomegaly and ultrasound periportal fibrosis, while immuno-epidemiological[ncbi.nlm.nih.gov]
  • He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education.[lifeinthefastlane.com]
  • Epidemiology of visceral leishmaniasis in India. Natl Med J India 1999 ; 12 : 62 –8. Agostoni C , Dorigoni N, Malfitano L, et al . Mediterranean leishmaniasis in HIV infected patients: epidemiological, clinical and diagnostic features of 22 cases.[pmj.bmj.com]
Sex distribution
Age distribution

Pathophysiology

  • Identification of hepatic enzyme levels – these indicate the good or bad functioning of the liver Blood clotting tests MRI scan Most faithful investigation Recommended for the confirmation of the diagnosis (suspected after the physical examination) Pathophysiology[healthh.com]
  • All support the hypothetical role of T cells as a key element in the pathophysiology of HLH.[journals.plos.org]

Prevention

  • The study is aimed to find out the common causes of hepatosplenomegaly in hospitalized patients so as to give emphasis on necessary preventive and therapeutic measures.[orion-group.net]
  • […] confusion Sponsored link • Fever of higher degree, over 101 Fahrenheit • Serious stomach ache • Paled skin and eye which is also known jaundiced These are some of the symptoms that should not be overlooked and immediate treatment should be obtained to prevent[symptomstreatment.org]
  • PREVENTION Food and Water Safe food and water precautions and frequent handwashing (especially before meals) are important in preventing typhoid and paratyphoid fever (see Chapter 2, Food & Water Precautions ).[wwwnc.cdc.gov]
  • Because the causes of hepatosplenomegaly are so diverse, it can’t always be prevented. However, a healthy lifestyle can only help. Avoid alcohol, get plenty of exercise, and consume a healthy diet to help minimize most of the common risk factors.[healthline.com]
  • Can an enlarged spleen be prevented? An enlarged spleen is the consequence of an underlying illnesses, many of which may not be anticipated or prevented.[medicinenet.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!