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Herbicide Poisoning

Glyphosphate Herbicide Ingestion


Presentation

  • CONCLUSION: Age, ingested amount, delayed presentation, and reason for exposure were likely to be determinants of the severity of GlySH exposure.[ncbi.nlm.nih.gov]
  • Three cases presented with delayed-onset neurotoxicity including stupor, delirium, seizures, coma, and amnesia after ingesting large amount of Basta.[ncbi.nlm.nih.gov]
  • These findings suggest that the present case involved aseptic meningitis in association with GlySH poisoning. CNS signs and symptoms induced by aseptic meningitis should be considered in cases of glyphosate-surfactant herbicide poisoning.[ncbi.nlm.nih.gov]
  • SELECTION CRITERIA: Randomised controlled trials of urinary alkalinisation in patients ingesting a chlorophenoxy herbicide and presenting within 24 to 48 hours of poisoning were sought.[ncbi.nlm.nih.gov]
  • However, due to the poor outcomes in patients who present with severe toxicity it may have a role in addition to standard intensive care support. More research should be conducted.[cochrane.org]
Asymptomatic
  • Twenty-eight out of 102 patients with oral exposure were asymptomatic, while the others developed vomiting, central nervous system depression, and other outcomes.[ncbi.nlm.nih.gov]
  • Among patients with oral exposure, 25 were asymptomatic, while the others developed gastrointestinal, neurological, cardiovascular, and/or respiratory manifestations. Seven patients (6.1%) died following deliberate glufosinate ingestion.[ncbi.nlm.nih.gov]
  • Though it is less toxic to humans, it produces a wide range of symptoms ranging from asymptomatic to death.[mjdrdypu.org]
Fatigue
  • , vomiting, skin/airway/mucous membrane irritation, renal dysfunction, coma O, R, D Coumarins (rodenticide) Brodifacoum, warfarin, pindone Echymoses, epistaxis, excessive bleeding, haematuria, prolonged prothrombin time, intracranial bleed, anaemia, fatigue[who.int]
  • Headache, fatigue, soreness in joints, irritation of nose and throat. Yes. Fever, intense thirst, vomiting, muscle twitches, pinpoint pupils, unconsciousness. Yes.[articles.extension.org]
Hypoventilation
  • Hypoventilation occurred not infrequently, usually in association with central nervous system depression, but respiratory muscle weakness was a factor in the development of respiratory failure in some patients.[ncbi.nlm.nih.gov]
Rales
  • Systemic examination was normal except for fine basal rales and altered mental status. His glucometer random blood sugar was 128 mg%, urea was 52 mg%, and serum creatinine was 1.8 mg%.[mjdrdypu.org]
Aspiration
  • Patients' airway should also be secured to avoid aspiration and subsequent respiratory failure.[ncbi.nlm.nih.gov]
Muscle Rigidity
  • […] fever, tremor O, R, D Pyrethrins, Pyrethroids Allethrin, cyfluthrin, permethrin Allergic reactions, anaphylaxis, dermatitis, paresthesias, wheezing, seizures, coma, pulmonary oedema, diarrhoea, abdominal pain R, D Strychnine (rodenticide) Strychnine Muscle[who.int]
Blurred Vision
  • The victims, whose symptoms included headache, weight loss, blurred vision and loss of consciousness, died within a day of falling ill in the town of Ode-Irele, in south-western Ondo state.[abc.net.au]
  • Those who died in Ondo state suffered from blurred vision and headaches, and then lost consciousness before dying within 24 hours. The specific cause of the strange disease has not been identified.[thecable.ng]
  • Moderate Poisoning or Early Symptoms of Acute Poisoning nausea, diarrhea, excessive saliva, stomach cramps, excessive perspiration, trembling, no muscle coordination, muscle twitches, extreme weakness, mental confusion, blurred vision, difficulty in breathing[articles.extension.org]
Suggestibility
  • All signs and symptoms suggesting meningitis resolved as the concentration of glyphosate in CSF decreased. She was discharged on day 39 of hospitalization.[ncbi.nlm.nih.gov]
  • These data strongly suggest that the female orally ingested the herbicide. From these toxicological data together with autopsy findings, the cause of her death was determined to be an acute herbicide poisoning.[ncbi.nlm.nih.gov]
  • Conclusion: This case report suggests that the use of ILE may be an additional option for the treatment of cardiocirculatory disturbances caused by commercial products of glyphosate herbicide.[ncbi.nlm.nih.gov]
  • Some case reports of human exposure have suggested benefit from urinary alkalinisation also.[ncbi.nlm.nih.gov]
  • CONCLUSION: This study suggests that the paraquat ban decreased intentional herbicide ingestion and contributed to lowering herbicide poisoning-associated mortality.[ncbi.nlm.nih.gov]
Paresthesia
  • , renal dysfunction O, R, D Metal phosphides(rodenticide, fumigant) Zinc-, aluminium-, magnesium- phosphide Abdominal pain, diarrhoea, acidosis, shock, jaundice, paresthesias, ataxia, tremors, coma, pulmonary oedema, tetany, dermal irritation O, R, D[who.int]
Neck Stiffness
  • Meningitis was also suspected as she demonstrated Kernig's sign and significant neck stiffness with rigidity of the extremities as well as consciousness disturbance and fever (38.4 C).[ncbi.nlm.nih.gov]
Kernig's Sign
  • Meningitis was also suspected as she demonstrated Kernig's sign and significant neck stiffness with rigidity of the extremities as well as consciousness disturbance and fever (38.4 C).[ncbi.nlm.nih.gov]
Meningism
  • These findings suggest that the present case involved aseptic meningitis in association with GlySH poisoning. CNS signs and symptoms induced by aseptic meningitis should be considered in cases of glyphosate-surfactant herbicide poisoning.[ncbi.nlm.nih.gov]
Neglect
  • This case report also emphasis that one should not neglect this nonorgan phosphorous compound poisoning and observation of the patient for complications if neglected it can take the lives. References 1.[mjdrdypu.org]

Treatment

  • In recent times, the efficacy of intravenous lipid emulsion (ILE) administration for the treatment of acute poisoning caused by Gly- SH has been investigated.[ncbi.nlm.nih.gov]
  • A well conducted randomised controlled trial is urgently required to determine whether the efficacy and indications of this treatment.[ncbi.nlm.nih.gov]
  • This review looked for studies where this treatment had been given to poisoned patients. No studies of sufficient quality were identified and therefore routine use of this approach to treatment cannot be recommended.[cochrane.org]
  • This case report emphasizes on timely systemic supportive measure as a sole method of treatment since this poison has no known specific antidote and the use of IV lipid emulsion for a successful outcome.[ncbi.nlm.nih.gov]
  • This case report emphasizes on timely systemic supportive measure as the sole method of treatment since this poison has no specific antidote.[mjdrdypu.org]

Prognosis

  • Early renal replacement therapy may improve prognosis, but there is no evidence to support this and requires identification of those at risk. [5] Intravenous fat emulsion (IFE) has been used in the management of severe local anesthetic toxicity, calcium[mjdrdypu.org]

Epidemiology

  • We evaluated the effect of the paraquat ban on the epidemiology and mortality of herbicide-induced poisoning.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Prevention

  • There is no clear evidence that, it will prevent further absorption of the poison.[mjdrdypu.org]
  • A water-based layer prevents oily substances from being absorbed and a fatty layer of the skin prevents water soluble substances from being absorbed.[theguardian.com]
  • Cut Stump Treatment Prevents regrowth of trees following mechanical control. Crops See full label for details.[dowagro.com]
  • You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week. Take the container with you to the hospital, if possible.[medlineplus.gov]
  • Mulch or sheet mulching: Heavy mulching prevents weeds from reseeding and also keeps roots from sending up shoots. Sheet mulching can also be done to smother existing weeds.[sustainablebabysteps.com]

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