The following case study describes the assessment process for a less common genetic disorder known as Cowden syndrome, or multiple hamartoma syndrome, a hereditary cancer syndrome associated with early-onset breast cancer, thyroid cancer, goiters, enlarged [ncbi.nlm.nih.gov]

A family is presented in whom hereditary angioedema (HAE) and hereditary breast cancer were coexistent, an association not previously reported. A potential for genetic and treatment-related interactions between the two conditions exists. [ncbi.nlm.nih.gov]

Duponchel C, Di RC, Cicardi M, Tosi M : Rapid detection by fluorescent multiplex PCR of exon deletions and duplications in the C1 inhibitor gene of hereditary angioedema patients. Hum Mutat 2001; 17 : 61–70. 9. [nature.com]

Analysis revealed that women describe their own identity based on their family story and grieve over actual and potential familial loss. [ncbi.nlm.nih.gov]

The lymphocytic infiltrate was predominantly T-cell type. [ncbi.nlm.nih.gov]

Multivariate analysis has shown that features predictive of BRCA1 phenotype include pushing margins, lymphocytic infiltrate and high mitotic counts, but not the medullary phenotype per se ; hence BRCA1 tumours are high-grade, medullary-like cancers. [nature.com]

noninfiltrating, smooth edges), and a lymphocytic infiltrate, whereas tumors with BRCA2 mutations are heterogeneous, are often relatively high grade, and display substantially less tubule formation. [nejm.org]

Pathology Initial reports of BRCA1 -linked cases confirmed an excess of cancers with medullary features, lymphocytic infiltration, 31 and syncytial growth patterns. [jco.ascopubs.org]

When only IDC cases are compared, after excluding medullary carcinomas, BRCA1 tumours have more frequently a prominent lymphocytic infiltrate and pushing margins [ 11 ], some of the features that define the medullary histotype. [hccpjournal.biomedcentral.com]