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Hereditary Koilonychia


Presentation

  • More Idiopathic onycholysis A middle-aged lady presented with onycholysis involved all fingernails of one year duration.[dermatologyoasis.net]
  • […] pseudoainhum formation can be ruled out due to the presence of autoamputation of digits in the present case [Figure 3] .[jdrntruhs.org]
  • […] shift of water from interstitial fluid compartment to intra-vascular compartment A 5 year old patient presents w/ a fever and has a history of bleeding and fatigue.[quizlet.com]
  • […] p. 98 Y Hari Kishan Kumar, C Sujatha, Sushmitha Jayaprasad DOI :10.4103/2229-5178.153011 PMID :25821730 [ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [PubMed] [Sword Plugin for Repository] Beta Porokeratosis - Head to toe: An unusual presentation[idoj.in]
Nail Abnormality
  • Aging changes in hair and nails (Medical Encyclopedia) Fungal nail infection (Medical Encyclopedia) Ingrown toenail (Medical Encyclopedia) Ingrown toenail removal - discharge (Medical Encyclopedia) Nail abnormalities (Medical Encyclopedia) Nail injuries[icdlist.com]
  • "Nail Abnormalities: Clues to Systemic Disease." Am Family Physician 69.6 Mar. 15, 2004: 1417-1424. Medically Reviewed by a Doctor on 3/30/2017 Next Article[medicinenet.com]
  • Indian Dermatol Online J 2015;6:67-74 Subtle nail abnormalities can harbinger appalling systemic diseases.[idoj.in]
  • There is no other family history of hair or nail abnormalities. On physical examination, the well-developed and well-nourished boy has appropriate behavior for age.[pedsinreview.aappublications.org]
  • Brachydactyly with short cone-shaped fingers and nail abnormalities, such as koilonychia or pachyonychia, are frequently associated features.[jamanetwork.com]
Physician
  • This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment.[diseaseinfosearch.org]
  • *Medscape Business of Medicine Academy Survey, September 2015 Learn from Experienced Professionals Courses were developed especially for physicians by business health experts and experienced physicians.[medscape.com]
  • Seek a physicians diagnosis. Koilonychia Koilonychia is usually caused through iron deficiency anemia. these nails show raised ridges and are thin and concave. Seek a physicians advice and treatment.[hooked-on-nails.com]
  • Am Family Physician 69.6 Mar. 15, 2004: 1417-1424. Medically Reviewed by a Doctor on 3/30/2017 Next Article[medicinenet.com]
  • It is necessary for the person with this condition to approach a trusted and expert physician to allay worries and fear and also to be able to be well informed of why such thing is occuring.[healthzene.com]
Surgical Procedure
  • Pterygium Pterygium is the inward advance of skin over the nail plate, usually the result of trauma to the matrix due to a surgical procedure or by a deep cut to the nail plate.[hooked-on-nails.com]
  • Surgical procedures, including total or partial excision of the sterile matrix, 57, 58 phenolization, 59 and carbon dioxide laser matricectomy, 60 are commonly performed.[journals.lww.com]
Sneezing
  • […] reflex) (Szeezing from light expose) (Peroutka sneeze) 10 101000 Neurofibromatosis, type II (NF2) (Neurofibromatosis, central type) (Acoustic schwannoma, bilateral) (Bilateral acoustic neurofibromatosis; BANF) (Acoustic neurinoma, bilateral; ACN) 11[becomerich.lab.u-ryukyu.ac.jp]
Cyanosis
  • Seite xvi - The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. Acta Derm Venereol. ‎[books.google.de]
  • Pagina xvi - The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. Acta Derm Venereol. ‎[books.google.it]
  • The thyroid gland is not enlarged and the distal extremities are well perfused, with no clubbing or cyanosis. Several strands of hair from the affected area appear under microscopic examination in Figure 3. Figure 1.[pedsinreview.aappublications.org]
  • Pulmonary AVMs occur may present as dyspnoea, cyanosis, bruits, high-output heart failure, clubbing and paradoxical cerebral emboli that may cause stroke and cerebral abscess. They can also lead to haemoptysis and haemothorax.[medicaleducationleeds.com]
Koilonychia
  • Prognosis - Hereditary koilonychia Not supplied. Treatment - Hereditary koilonychia Not supplied. Resources - Hereditary koilonychia Not supplied.[checkorphan.org]
  • We describe a family with keratosis pilaris and hereditary koilonychia, with an autosomal dominant pattern of inheritance. These two findings have only been previously found in the context of monilethrix.[ncbi.nlm.nih.gov]
  • TY - JOUR T1 - Keratosis pilaris and hereditary koilonychia without monilethrix.[unboundmedicine.com]
  • Get Update Overview Koilonychia, or 'spoon nails,' is a relatively uncommon disorder in which the nails are abnormally thin and concave from side to side, with the edges turned up.[diseaseinfosearch.org]
  • Familial koilonychia with superimposed myxoid cyst. Indian J Dermatol Venereol Leprol 1995;61:63-4 How to cite this URL: Mittal R R, Dhaliwal M S. Familial koilonychia with superimposed myxoid cyst.[ijdvl.com]
Dermatitis
  • Clinical evaluation of atopic hand-foot dermatitis. Pediatr Dermatol 2001; 18: 102-6 Mevorah B, Orion E, de Viragh P, et al. Peeling skin syndrome with hair changes. Dermatology 1998; 197: 373-6 Tastan HB, Akar A, Gur AR, Deveci S. ‎[books.google.de]
  • 692.83 ) Dermatitis , due to metals ( 692.9 ) Contact dermatitis NOS ( 693 ) Dermatitis due to substances taken internally ( 693.0 ) Dermatitis due to drugs and medicines taken internally ( 693.1 ) Dermatitis due to food taken internally ( 694 ) Bullous[en.wikipedia.org]
  • […] and Eczema 316 Dermatitis and Eczema 318 Seborrheic Eczema 340 Atopy and Atopic Eczema 346 Dermatitis and Eczema of Various 357 Dermatitis and Eczema 362 Skin Diseases Due To Physical and Chemical 367 Skin Disorders Due to Heat and Cold 370 Skin Damage[books.google.it]
  • Am J Contact Dermat . 1997; 8(3):177-8. 11. Pancar GS, Kalkan G. Irritant nail dermatitis of chemical depilatory product presenting with koilonychia. Cutan Ocul Toxicol. 2014; 33(1):87-9.[podiatrytoday.com]
Hyperkeratosis
  • Splice site and deletion mutations in keratin (KRT1 and KRT10) genes: unusual phenotypic alterations in Scandinavian patients with epidermolytic hyperkeratosis. J Invest Dermatol 2003; 121: 1013-20... ‎[books.google.de]
  • Nail anomalies are the most common associated feature in the form of subungual hyperkeratosis, Beau’s lines, onycholysis, hyperconvexity, and koilonychias [ 1 , 2 ].[odermatol.com]
  • Other cutaneous manifestations include acanthosis nigricans, xerosis, follicular hyperkeratosis over the zygoma, and hyperhidrosis. Histologic findings include hyperkeratosis, hypergranulosis, and acanthosis.[emedicine.medscape.com]
  • A, Pronounced, transparent, yellowish hyperkeratosis with red border of desquamation delimiting the hyperkeratotic region in a 7-year-old girl with mal de Meleda. B, Less pronounced hyperkeratosis in a 2-year-old girl. Figure 4.[jamanetwork.com]
  • On histopathological examination with hematoxylin and eosin stain hyperkeratosis with parakeratosis, hypergranulosis, and papillamatous acanthosis were noted [Figure 8] .[jdrntruhs.org]
Eczema
  • , atopic dermatitis ( 692 ) Contact dermatitis and other eczema ( 692.0 ) Contact dermatitis and other eczema due to detergents ( 692.1 ) Contact dermatitis and other eczema due to oils and greases ( 692.2 ) Contact dermatitis and other eczema due to[en.wikipedia.org]
  • 316 Dermatitis and Eczema 318 Seborrheic Eczema 340 Atopy and Atopic Eczema 346 Dermatitis and Eczema of Various 357 Dermatitis and Eczema 362 Skin Diseases Due To Physical and Chemical 367 Skin Disorders Due to Heat and Cold 370 Skin Damage from Electricity[books.google.it]
  • History and examination excluded any underlying cause (psoriasis, eczema, lichen planus and drugs) and family history was negative. More Idiopathic Koilonychia All fingernails are spoon-shaped, t he shown index finger is an example.[dermatologyoasis.net]
  • Mal de Meleda syndrome, characterized by progressive PPK with eczema, hyperhidrosis, perioral erythema, nail thickening, and koilonychias has been ruled out due to their absence in the present case. [1] , [2] Pachyonychia congenita, a focal PPK with digital[jdrntruhs.org]
Keratosis Blennorrhagica
  • , blennorrhagica see Keratoderma blenorrhagica Keratotorus see Pellucid marginal degeneration Kerion Kernicterus Kernig sign positive Keshan disease see Selenium deficiency Ketamine Ketanserin Ketazolam Ketoacidosis Ketobemidone Ketoconazole Ketohexokinase[diseasesdatabase.com]
Suggestibility
  • The coexistence of the two disorders suggests a close association of their genetic pathogenesis.[ncbi.nlm.nih.gov]
  • It has been suggested that FIGURE 2.44 Subungual myxoid pseudocyst. FIGURE 2.45 Koilonychia.[pocayo.com]
  • The familial distribution of the process in this report suggests an autosomal dominant transmission with high degree of penetrance. 1981 S.[karger.com]
  • .: p63 gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split handfoot malformation suggest a genotype-phenotype correlation. ‎[books.google.it]

Workup

  • The presence of koilonychia should prompt further workup for an underlying systemic or environmental cause. References 1. Barnett JM, Scher RK, Taylor SC. Nail cosmetics. Dermatol Clin. 1991; 9(1):9-17. 2. Lembach L. Pediatric nail disorders.[podiatrytoday.com]

Treatment

  • CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes.[diseaseinfosearch.org]
  • Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color.[books.google.de]
  • Treatment - Hereditary koilonychia Not supplied. Resources - Hereditary koilonychia Not supplied.[checkorphan.org]
  • […] photographs of normal and abnormal skin conditions including images of rare conditions, this easily accessible resource is essential for pediatricians, neonatologists, and dermatologists as well as other healthcare professionals involved in the diagnosis and treatment[books.google.de]
  • Once a periungual wart diagnosis is made, the podiatrist may recommend one of several treatment options. Those options include laser treatments, salicylic treatments, topical creams and cryotherapy.[boyntonfeet.com]

Prognosis

  • Prognosis - Hereditary koilonychia Not supplied. Treatment - Hereditary koilonychia Not supplied. Resources - Hereditary koilonychia Not supplied.[checkorphan.org]
  • Prognosis The prognosis of mixed connective tissue disease is in most cases worse than that of systemic lupus erythematosus (SLE) in spite of prednisone treatment as this disease is progressive and may in many cases evolve into a progressive systemic[findzebra.com]
  • Phenotype and prognosis in monilethrix due to mutations of hair keratins hHb 1 and hHb 6. Br J Dermatol 1999; 141 Suppl. 55: 102–7 Google Scholar 6. Zlotogorski A, Christiano AM. Mapping of monilethrix and papular atrichia [letter].[link.springer.com]
  • Congestive heart failure can develop rapidly, but prognosis improves drastically if iron is removed before concentrations reach critical levels.[clinicaladvisor.com]
  • […] palmoplantar keratodermas (PPKs) are a group of heterogeneous skin disorders classified based upon their mode of inheritance, age of onset, morphology and distribution of palmoplantar thickening, presence of skin lesions elsewhere, histopathology, and prognosis[jdrntruhs.org]

Etiology

  • […] trichothiodystrophy, LEOPARD syndrome, Darier’s disease and nail-patella syndrome. 2 Familial koilonychias is a rare genetic disease that is not associated with other ectodermal, systemic or orthopedic defects. 3 There are several theories regarding the etiology[podiatrytoday.com]
  • There are different ways to classify nail disorders and a compromise between a scientifically based etiologic classification and a more clinico-morphologically based one appears to be a practical approach to nail disorders.[accessmedicine.mhmedical.com]
  • Koilonychia Causes Persons with this kind of condition, specifically koilonychia, have acquired the condition because of the following associated causes or etiological factors: Chronic iron deficiency anemia Hereditary forms such as: Adenoma sebaceum[healthzene.com]
  • The etiology of ASM is not well understood but there is evidence of an activating mutation of KIT, usually D816V, in the mast cells of the vast majority of patients with ASM.[findzebra.com]
  • It is known that its etiology is often associated with thinning and softening of the nails. 21 Supporting this is several studies that suggest that thin and/or fragile nails readily adopt a concave shape when they are subjected to mechanical force. 38[journals.lww.com]

Epidemiology

  • We sought to describe the epidemiology, clinical and dermoscopic features, and natural history of genital nevi in pediatric patients. We reviewed charts of 1159 children given the diagnosis of melanocytic nevi over 11 years.[allmedx.com]
  • […] age in developing countries. [ 2 ] The World Health Organization defines anaemia as: [ 1 ] Haemoglobin (Hb) Hb Hb Failure to investigate IDA appropriately in primary care can cause significant delay in final diagnosis, with associated morbidity. [ 3 ] Epidemiology[patient.info]
  • The Food and Nutrition Policy General Committee of the Ministry of Health addressed the epidemiological relevance of this issue and reported that, despite of not having complete national figures, studies show that approximately half of Brazilian preschool[scielo.br]
Sex distribution
Age distribution

Pathophysiology

  • The Physiology and Pathophysiology of the Skin, Vol. 2. The Nerves and Blood Vessels. London: Academic Press, 1973: 429-573. ‎ Página 24 - Physiology and Pathophysiology of the Skin Vol 3 The Dermis and the Dendrocytes. ‎ Página 30 - Irritantes.[books.google.es]
  • Pathophysiologically, when the SLURP-1 protein is non-functional, hyperkeratosis results due to improperly regulated keratinocyte apoptosis and the macrophage and keratinocyte release of tumor necrosis factor (TNF)-a is inhibited producing generalized[odermatol.com]
  • Although the pathophysiology of the cellular and tissue responses of the nail to mechanical force remains unknown, our hypothesis is a new concept that could lead to innovative methods that prevent and treat nail deformities. REFERENCES 1.[journals.lww.com]
  • The book explains disease processes according to presenting symptoms, treatment options and tiers, and pathophysiology sections. The final updates for the 17th edition are dated October 2, 2007. So, this is a relatively current resource.[clinicaladvisor.com]

Prevention

  • Causes - Hereditary koilonychia * Concave nails * Thin nails Prevention - Hereditary koilonychia Not supplied.[checkorphan.org]
  • There are many ways that this condition can be prevented.[toenailfungi.org]
  • Methods for treating or preventing Koilonychia include: For abnormalities because of toenails that are ingrown, wear types of shoes that do not crowd together the toes as well as always cut the toenails straight across the top.[symptomscausestreatmentprevention.blogspot.com]
  • The only thing that one should bear in mind is that when koilonychia is occuring or is manifested in a person, he or she should undergo treatment as soon as it is recognized to be present to prevent further problems.[healthzene.com]
  • It is essential to detect haemochromatosis as early as possible so that venesection can be instituted to prevent the build-up of iron and potential complications.[dermnetnz.org]

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