Presentation
The objectives of the present review are to compare the clinical manifestations and analyze the mutational basis of these two AFP genetic disorders in accordance with presently accepted models of AFP gene regulation. [jps.dergipark.gov.tr]
Confirm each diagnosis by consulting a section, organized by symptoms, that presents the full range of differential diagnoses and treatment options for each specific condition. [books.google.com]
[FIGURE 1 OMITTED] We present a simple test based on restriction fragment length polymorphism (RFLP) analysis for screening of HPAFP mutations. [thefreelibrary.com]
In the present case, a very low percentage of AFP-L2 and L3 indicated no residual or recurrent tumor. [academic.oup.com]
Entire Body System
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Physician
We are grateful to the patients, to their families, and to the physicians, especially Dr. G. Perlemuter and Prof. C. Buffet. References (1.) Ferguson-Smith MA, May HM, O'Hare E, Aitken DA. [thefreelibrary.com]
Genes are large molecules More information Executive summary of recommendations MOH CLINICAL PRACTICE GUIDELINES 2/2011 Chronic Hepatitis B Infection College of Family Physicians, Singapore Academy of Medicine, Singapore Singapore Medical Association [docplayer.net]
*Medscape Business of Medicine Academy Survey, September 2015 Learn from Experienced Professionals Courses were developed especially for physicians by business health experts and experienced physicians. [medscape.org]
CONCLUSIONS: HPAFP could mislead the physician. Failure to recognize HPAFP can lead to unsuitable treatments. [ncbi.nlm.nih.gov]
Am Fam Physician. 2003, 68: 1075-1082. PubMed Google Scholar Babali A, Cakal E, Purnak T, Biyikoĝlu I, Cakal B, Yüksel O, Köklü S: Serum alpha-fetoprotein levels in liver steatosis. Hepatol Int. 2009, 10.1007/ s12072-009-9156-8. [wjso.biomedcentral.com]
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Accelerated Growth
The test was originally obtained as partof an extensive endocrine evaluation for accelerated growth andadvanced bone age (equivalent to 9 years and 6 months old). Aninitial AFP level was 55 ng/ml (normal disease. [documents.tips]
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Tall Stature
Both had stable persistently elevated AFP levels [12,19].Clinically our patient was healthy except tall stature and advancedbone age, likely secondary to constitutional advanced growth.The molecular mechanism underlying HPAFP has been studiedin seven [documents.tips]
Musculoskeletal
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Long Arm
Hereditary persistence of α-fetoprotein maps to the long arm of chromosome 4 (abstr) Cytogenet Cell Genet 1985; 40:623. [link.springer.com]
Psychiatrical
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Suggestibility
The mother delivered a live, healthy female at term and a repeat maternal serum AFP postpartum remained markedly elevated, suggestive of hereditary persistence of alpha-fetoprotein. [ncbi.nlm.nih.gov]
Failure of the AFP value to return to normal by approximately 1 month after surgery suggests the presence of residual tumor. [mayomedicallaboratories.com]
Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. Note For laboratory research only, not for drug, diagnostic or other use. [arigobio.com]
Workup
After radical orchiectomy and a negative workup for metastatic disease, his AFP level dropped, but remained mildly elevated over the normal range for six months. [thedoctorsdoctor.com]
Treatment
Review the latest developments in the field and get up-to-date clinical information on hot topics like polyps, capsule endoscopy, and pancreatic treatments. [books.google.com]
Unexplained persistent AFP should lead to family study and/or AFP gene promoter sequencing to avoid inappropriate explorations and treatment decisions. [ncbi.nlm.nih.gov]
Knowledge of AFP reference levels might serve to guide the clinician in avoiding: a) misguided diagnoses; b) unnecessary treatments and therapies; and c) undue anxieties and stress during pregnant and non-pregnant states. alpha-fetoprotein, genetic disorder [jps.dergipark.gov.tr]
Knowledge of AFP reference levels might serve to guide the clinician in avoiding: a) misguided diagnoses; b) unnecessary treatments and therapies; and c) undue anxieties and stress during pregnant and non-pregnant states. [pediatricsciences.com]
Prognosis
A nationwide study of granulosacell tumors in pre- and postpubertal girls: Missed diagnosis ofendocrine manifestations worsens prognosis. [documents.tips]
(REVIEW) PMID 21216289 Alpha-fetoprotein and prognosis in acute liver failure. Schiodt FV, Ostapowicz G, Murray N, Satyanarana R, Zaman A, Munoz S, Lee WM. Liver Transpl. 2006 Dec;12(12):1776-81. [atlasgeneticsoncology.org]
Extensive resection with a wide tumor margin is technically easier in HCC arising in a non-cirrhotic liver than a cirrhotic liver, resulting in a lower probability of recurrence and a better prognosis [ 23 – 26 ]. [wjso.biomedcentral.com]
Etiology
S.FLORET NEOPLASM OF LIVER PRIMARY 1)BENIGN 2)MALIGNANT METASTATIC/SECONDARY LIVER Primary Liver Cancer the Second Killer among tumors high morbidity and mortality(20.40/100,000) etiology More information LIVER CANCER AND TUMOURS LIVER CANCER AND TUMOURS [docplayer.net]
They are organised into groups, and further divided into clinical, etiological or histopathological sub-types. [orpha.net]
Three specific polymorphisms in the AFP promoter gene have been pointed out as etiologic explanations for HPAFP ( 6 ). Nevertheless, neither known nor any other mutations were detected in the present patient. [academic.oup.com]
Epidemiology
Relevant External Links for AFP Genetic Association Database (GAD) AFP Human Genome Epidemiology (HuGE) Navigator AFP Atlas of Genetics and Cytogenetics in Oncology and Haematology: AFP No data available for Genatlas for AFP Gene Alpha-fetoprotein gene [genecards.org]
Hepatocellular Carcinoma: Epidemiology, Risk Factors, and Screening. Medscape, from Semin Liver Dis. 2005;25(2):143-154 [On-line information]. Available online at . (2005 January 05). LBA AFP-L3. Wako [On-line package insert]. [labtestsonline.it]
PMID 14699509 Epidemiology of primary liver cancer. Bosch FX, Ribes J, Borras J. Semin Liver Dis. 1999;19(3):271-85. (REVIEW) PMID 10518307 Alpha-fetoprotein: from a diagnostic biomarker to a key role in female fertility. [atlasgeneticsoncology.org]
PubMed Central View Article PubMed Google Scholar Bosch FX, Ribes J, Borras J: Epidemiology of primary liver cancer. Semin Liver Dis. 1999, 19: 271-285. 10.1055/s-2007-1007117. [wjso.biomedcentral.com]
Pathophysiology
[…] helpful The follow-up management of patients undergoing cancer therapy, especially for testicular and ovarian tumors and for hepatocellular carcinoma Often used in conjunction with human chorionic gonadotropin(2) Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]
Prevention
Attention should therefore be paid to this benign condition to prevent misdiagnoses in those patients with elevated AFP levels. Three specific polymorphisms in the AFP promoter gene have been pointed out as etiologic explanations for HPAFP ( 6 ). [academic.oup.com]