Presentation
Outline Of Cases : We present two patients with discrepancy between the results of thyroid function tests and clinical status. The first case presents a 62-year-old patient with a nodular goiter and Hashimoto thyroiditis. [pubfacts.com]
Presentation of observed values related to reference values. J. Clin. Chem. Clin. Biochem. Página 836 - Wilson JD. Braunwald E. Isselbacher KJ. Petersdorf RG, Martin JB. Fauci AS, Root RK (eds): Harrison's Principles of Internal Medicine. [books.google.es]
The genes involved in CH etiopathogenesis are presented in Figure 1. Figure 1 Genetic background of congenital hypothyroidism. [thyroidresearchjournal.biomedcentral.com]
The disorder presents no clinical symptoms and causes no discernible ill-effects. The low concentration of protein-bound iodine is accompanied by an accelerated turnover of thyroxine,. .. [nejm.org]
Similar laboratory findings were also present in 16 mothers and 1 father. © 1993 S. [karger.com]
Treatment
Make informed clinical choices for each patient, from diagnosis and treatment selection through post-treatment strategies and management of complications, with new evidence-based criteria throughout. [books.google.com]
Normally there are no side effects from the treatment, but some people might find the treatment area is a little red post treatment but this usually resolves after 30 mins post treatment. 3. [lybrate.com]
It is also used as a platelet count stimulator in the treatment of idiopathic thrombocytopenic purpura. serum g's all plasma proteins except albumin, which is not a globulin, and fibrinogen, which is not in the serum. [medical-dictionary.thefreedictionary.com]
The risks you experience will likely be minor and resolve without treatment. [healthline.com]
Prognosis
[…] but not in human immunodeficiency virus/acquired immunodeficiency syndrome [HIV/AIDS] or acute intermittent porphyria) [3] Malnutrition Acromegaly (in very rare cases only) [4, 5] Cushing syndrome Drugs (eg, androgens, glucocorticoids, L-asparaginase) Prognosis [thehealthscience.com]
Etiology
Etiology of euthyroid hyperthyroxinemia Euthyroid hyperthyroxinemia follows abnormalities of the binding proteins and is usually a result of an increase in the binding proteins. [lecturio.com]
The etiologic basis for this association remains unclear. [thehealthscience.com]
The general prevalence of CH, regardless of its etiology, is 1:2,000 to 1:4,000 of neonates (primary CH - 1:4,000, secondary CH – 1:66,000) with a female-to-male ratio of 2:1. [thyroidresearchjournal.biomedcentral.com]
Epidemiology
Epidemiology The prevalence of inherited complete thyroxine-binding globulin (TBG) deficiency is approximately 1 case per 15,000 male births, while the prevalence of inherited partial TBG deficiency is 1 case per 4000 newborns. [thehealthscience.com]
So far, there are no broad studies of association between thyroid function and TBG deficiency including clinical research and epidemiological research. [e-sciencecentral.org]
Rare diseases epidemiology research. In: Posada de la Paz M, Groft SC, editors. Rare diseases epidemiology. London, New York: Springer Dordrecht Heidelberg; 2010. p. 17–40. View Article Google Scholar Hennekam RC. [thyroidresearchjournal.biomedcentral.com]
Pathophysiology
Interpretation Provides information to assist in interpretation of the test results A change in thyroxine-binding globulin (TBG) concentration may be of hereditary, pathophysiologic, or pharmacologic origin. [mayomedicallaboratories.com]
Reference Range Information Males: 12-26 mcg/mL Females: 11-27 mcg/mL Interpretation A change in thyroxine-binding globulin (TBG) concentration may be of hereditary, pathophysiologic, or pharmacologic origin. [marshfieldlabs.org]
Pathophysiology Thyroglobulin is non-iodine containing glycoprotein found in the colloid of thyroid follicle. Thyroglobulin is the protein produced in the thyroid follicles and take part in the thyroxine formation. [labpedia.net]
Tyrosine kinase inhibitors induced thyroid dysfunction: a review of its incidence, pathophysiology, clinical relevance, and treatment. Biomed Res Int. 2013;2013:725410. Burra P. Liver abnormalities and endocrine diseases. [sapd.es]
Prevention
Treat your inpatient and ambulatory patients more effectively with the absolute latest on new topics such as quality improvement and patient care safety *school violence and bullying * preventive measures * vitamin deficiencies * adolescent rape * effect [books.google.com]
Rh 0 (D) immune globulin a specific immune globulin derived from human blood plasma containing antibody to the erythrocyte factor Rh 0 (D); used to prevent Rh-sensitization of Rh-negative females and thus prevent erythroblastosis fetalis in subsequent [medical-dictionary.thefreedictionary.com]
Some mutations in the SERPINA7 gene prevent the production of a functional protein, causing TBG-CD. Other mutations reduce the amount of this protein or alter its structure, resulting in TBG-PD. [ghr.nlm.nih.gov]
Funding and Disclosures * From the departments of Medicine and Preventive Medicine, Western Reserve University School of Medicine. [nejm.org]