Herpes simplex virus 1 infection (although unusual) should be considered in patients with systemic lupus erythematosus with an atypical clinical presentation. [ncbi.nlm.nih.gov]

• Rhinitis

  RESULTS: After 2 days of rhinitis, a 6-month-old infant was intubated in the emergency room for sudden-onset respiratory failure. [ncbi.nlm.nih.gov]

• Vascular Disease

  Circulation 103 : 45 –51, 2001 ↵ Luscher TF, Creager MA, Beckman JA, Cosentino F: Diabetes and vascular disease. Pathophysiology, clinical consequences, and medical therapy: part II. [care.diabetesjournals.org]

• Thrombosis

  A 43-year-old man, admitted with a swollen right thigh, was diagnosed with a deep vein thrombosis. On day 6 he became septic. A CT scan demonstrated a right-sided hydronephrosis and a large retroperitoneal collection. [ncbi.nlm.nih.gov]

• Flaccid Paralysis

  Neurological examination showed generalized areflexic flaccid paralysis with no detectable interaction, which resembled a coma. Brain MRI was normal. [ncbi.nlm.nih.gov]

Previous workup of these episodes included a negative electroencephalogram and CT scan and negative cerebrospinal fluid, serologic, and skin tests for relevant microbial pathogens. [nejm.org]

• Dyslipidemia

  The following potential risk factors for diabetes were analyzed in this study: age, cigarette smoking, physical inactivity, BMI, hypertension, dyslipidemia, coronary artery disease, and immunoglobulin G (IgG) seropositive status to HSV-1. [care.diabetesjournals.org]

• Gliosis

  In the first patient, an intrauterine infection was suspected as the underlying basis for the seizure disorder and the extensive cerebral calcification and gliosis. [ncbi.nlm.nih.gov]

Prompt recognition and treatment can be life-saving in the care of patients with herpes simplex-1 virus encephalitis, the most commonly identified cause of sporadic encephalitis worldwide. [ncbi.nlm.nih.gov]

See “Diagnostics” and "Treatment" below. [amboss.com]

If the PCR no longer detects HSV the treatment can be stopped; if HSV is identified, the treatment should continue with repeat lumbar punctures at 7-day intervals until the absence of HSV is confirmed. [encephalitis.info]

Outcomes and prognosis The reduction in HSE mortality has led to a paradoxical situation. There are without doubt more survivors, but many may suffer from permanent neurological and/or psychological deficits, for example amnesia (memory loss). [encephalitis.info]

What should you tell the family about the patient's prognosis? Complications of severe oral herpes include dysphagia, severe pain, and inability to take oral medications. [infectiousdiseaseadvisor.com]

Thus our cases represent two examples of chronic encephalitis associated with a seizure disorder, where a definitive viral etiology was documented by PCR. [ncbi.nlm.nih.gov]

PCR for the existence of both bacterial and viral etiological agent should be performed along with routine CSF detailed report test to confirm the etiology. [oatext.com]

For genital herpes during pregnancy, see congenital herpes simplex virus infection Herpetic gingivostomatitis Etiology : severe manifestation of an (often primary) HSV-1 infection Mainly in children (∼ 1–6 years), but also immunocompromised patients [amboss.com]

A systematic review of the epidemiology and interaction of herpes simplex virus types 1 and 2 K J Looker, G P Garnett Department of Infectious Disease Epidemiology, Imperial College London, UK Correspondence to: K J Looker Department of Infectious Disease [sti.bmj.com]

Modern Epidemiology, 323 -325, Little, Brown, and Company Boston 1986. ↵ Hosmer D. W., Lemeshow S. Confidence interval estimation of interaction. Epidemiology, 3 : 452 -456, 1992. ↵ Shillitoe E. J., Silverman S., Jr. [cancerres.aacrjournals.org]

Both are closely related but differ in epidemiology. HSV-1 is traditionally associated with orofacial disease (see the image below), while HSV-2 is traditionally associated with genital disease. [emedicine.medscape.com]

After the data became available, the Epidemiology and Surveillance Branch analyzed the data and developed the manuscript. [jamanetwork.com]

Abstract Controversy still surrounds both the etiology and pathophysiology of vestibular neuritis (VN). [ncbi.nlm.nih.gov]

Pathophysiology, clinical consequences, and medical therapy: part II. [care.diabetesjournals.org]

Although Us3 did not detectably prevent energy stress-induced AMPK activation, it enforced mTORC1 activation despite the presence of activated AMPK. [ncbi.nlm.nih.gov]

Image courtesy Public Health Image Library (PHIL), Department of Health and Human Services, Centers for Disease Control and Prevention (CDC-USA) Dr Herrmann. [sahealth.sa.gov.au]

Centers for Disease Control and Prevention. [On-line information]. Available online at http://www.cdc.gov/std/tg2015/herpes.htm. Accessed October 2016. Ural, S. (2015 April 16 Updated). Genital Herpes in Pregnancy. [labtestsonline.it]