Presentation
We present a patient with Wegener's granulomatosis on azathioprine and prednisone medication, who developed a life-threatening hemophagocytic syndrome. [ncbi.nlm.nih.gov]
Respiratoric
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Rhinitis
RESULTS: After 2 days of rhinitis, a 6-month-old infant was intubated in the emergency room for sudden-onset respiratory failure. [ncbi.nlm.nih.gov]
Cardiovascular
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Vascular Disease
Circulation 103 : 45 –51, 2001 Luscher TF, Creager MA, Beckman JA, Cosentino F: Diabetes and vascular disease. Pathophysiology, clinical consequences, and medical therapy: part II. [care.diabetesjournals.org]
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Heart Disease
Diabetes Care 27 : 1171 –1175, 2004 Roivainen M, Viik-Kajander M, Palosuo T, Toivanen P, Leinonen M, Saikku P, Tenkanen L, Manninen V, Hovi T, Manttari M: Infections, inflammation, and the risk of coronary heart disease. [care.diabetesjournals.org]
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Hypertension
In patients aged 65 years, hypertension and coronary artery disease were more frequently found in the patients with diabetes than control subjects (all P 0.05). [care.diabetesjournals.org]
Neurologic
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Flaccid Paralysis
Neurological examination showed generalized areflexic flaccid paralysis with no detectable interaction, which resembled a coma. Brain MRI was normal. [ncbi.nlm.nih.gov]
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Cerebral Calcification
In the first patient, an intrauterine infection was suspected as the underlying basis for the seizure disorder and the extensive cerebral calcification and gliosis. [ncbi.nlm.nih.gov]
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Guillain-Barré Syndrome
INTRODUCTION: Guillain-Barré syndrome (GBS) may rarely manifest as a peripheral locked-in syndrome. METHODS: Clinical and instrumental features of a fulminant form of infantile GBS were assessed. [ncbi.nlm.nih.gov]
Workup
Previous workup of these episodes included a negative electroencephalogram and CT scan and negative cerebrospinal fluid, serologic, and skin tests for relevant microbial pathogens. [nejm.org]
Serum
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Dyslipidemia
The following potential risk factors for diabetes were analyzed in this study: age, cigarette smoking, physical inactivity, BMI, hypertension, dyslipidemia, coronary artery disease, and immunoglobulin G (IgG) seropositive status to HSV-1. [care.diabetesjournals.org]
Other Pathologies
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Gliosis
In the first patient, an intrauterine infection was suspected as the underlying basis for the seizure disorder and the extensive cerebral calcification and gliosis. [ncbi.nlm.nih.gov]
Treatment
[…] therapy who developed both Herpes simplex virus 1 (HSV) and Mycobacterium tuberculosis pneumonia; we conclude from clinical and histological data that HSV 1 played a major role in the fatal outcome of this immunocompromised patient, in spite of acyclovir treatment [ncbi.nlm.nih.gov]
Prognosis
Outcomes and prognosis The reduction in HSE mortality has led to a paradoxical situation. There are without doubt more survivors, but many may suffer from permanent neurological and/or psychological deficits, for example amnesia (memory loss). [encephalitis.info]
What should you tell the family about the patient's prognosis? Complications of severe oral herpes include dysphagia, severe pain, and inability to take oral medications. [infectiousdiseaseadvisor.com]
Etiology
Thus our cases represent two examples of chronic encephalitis associated with a seizure disorder, where a definitive viral etiology was documented by PCR. [ncbi.nlm.nih.gov]
PCR for the existence of both bacterial and viral etiological agent should be performed along with routine CSF detailed report test to confirm the etiology. [oatext.com]
Herpetic whitlow Pathogen : HSV-1 in 60% of cases; HSV-2 in 40% of cases (in the adult population) Etiology Direct contact with infected secretions through a break in the skin, e.g., torn cuticle Main groups: Children ; (via sucking of thumb/fingers [amboss.com]
Epidemiology
Modern Epidemiology, 323 -325, Little, Brown, and Company Boston 1986. Hosmer D. W., Lemeshow S. Confidence interval estimation of interaction. Epidemiology, 3 : 452 -456, 1992. Shillitoe E. J., Silverman S., Jr. [cancerres.aacrjournals.org]
A systematic review of the epidemiology and interaction of herpes simplex virus types 1 and 2 K J Looker, G P Garnett Department of Infectious Disease Epidemiology, Imperial College London, UK Correspondence to: K J Looker Department of Infectious Disease [sti.bmj.com]
Both are closely related but differ in epidemiology. HSV-1 is traditionally associated with orofacial disease (see the image below), while HSV-2 is traditionally associated with genital disease. [emedicine.medscape.com]
After the data became available, the Epidemiology and Surveillance Branch analyzed the data and developed the manuscript. [jamanetwork.com]
Pathophysiology
Abstract Controversy still surrounds both the etiology and pathophysiology of vestibular neuritis (VN). [ncbi.nlm.nih.gov]
Pathophysiology, clinical consequences, and medical therapy: part II. [care.diabetesjournals.org]
Prevention
Although Us3 did not detectably prevent energy stress-induced AMPK activation, it enforced mTORC1 activation despite the presence of activated AMPK. [ncbi.nlm.nih.gov]