Presentation
The histologic findings of HSV, when present, are pathognomonic. [archivesofpathology.org]
We are currently sequencing the full genome of HHV-4 present in human saliva using both Roche 454 and Illumina sequencing technology. [sanger.ac.uk]
METHODS: Aqueous humor samples were collected from 42 patients suspected of having AU of infectious origin at presentation. [ncbi.nlm.nih.gov]
Diagnostic probability increased to >20% if at least three of these predictors were present. [doi.org]
Entire Body System
- Asymptomatic
It is not known why some individuals remain asymptomatic while others have outbreaks, but both asymptomatic and symptomatic patients are able to infect others (Centoufi 2012). [lifeextension.com]
Epidemiology Type 1 – contact with saliva of carriers, infection of hands of health care personnel; Type 2 – usually by sexual contact; infected secretions from symptomatic or asymptomatic individuals. [ehs.stanford.edu]
Asymptomatic human infection with B virus appears exceedingly rare if it occurs at all. [doi.org]
It is now known that some infants with HVH infections in neonatal life may be asymptomatic or have localized forms of the disease with late central nervous system (CNS) sequelae. [jamanetwork.com]
In people with latent infection, the virus can reactivate without causing symptoms; in such cases, asymptomatic shedding occurs and people can transmit infection. [msdmanuals.com]
- Pain
and American Society of Regional Anesthesia and Pain Medicine Disclosure: Nothing to disclose. [medscape.com]
These include: 1. vesicular (small blister) skin lesions at or near the site of injury. 2. localized neurological symptoms such as pain, numbness or itching near the wound site. 3. flu-like aches and pains 4. fever and chills 5. headaches lasting more [web.archive.org]
HHV-1 Herpes simplex 1 HSV-1 Herpes, cold sores, fever blisters Painful groups of vesicles Yes Yes HHV-2 Herpes simplex 2 HSV-2 Herpes, cold sores, fever blisters Painful groups of vesicles Yes Yes HHV-3 Varicella-Zoster VZV Varicella, Chicken pox Scattered [ojcpcd.com]
Shingles is the manifestation of VZV reactivation and although rarely a life-threatening disease, it is perhaps of more concern communitywide because of the pain, not only of the acute lesion but also of the frequent post-herpetic neuralgia, which can [creative-biolabs.com]
The pain and cutaneous signs generally resolve 7 to 10 days after the initial symptoms; however, postherpetic neuralgia is a common complication. [archivesofpathology.org]
- Varicella-Zoster Virus Infection
Complement-fixing reactivity of Varicella-Zoster virus subunit antigens with sera from homotypic infections and heterotypic Herpes simplex virus infections. Infect Immun. 1977 Mar;15(3):850–854. [ncbi.nlm.nih.gov]
Virus et peau. Paris: Esterm; 1994: 17–20. Google Scholar Straus SE, Ostrove JM, Inchauspe G et al. NIH conference. Varicella-zoster virus infections. Biology, natural history, treatment, and prevention. Ann Intern Med 1988; 108:221–237. [link.springer.com]
Science. (1990) [ Pubmed ] Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread. Li, Q., Ali, M.A., Cohen, J.I. [wikigenes.org]
- Hodgkin Lymphoma
It is also associated with particular forms of cancer, such as Hodgkin's lymphoma, Burkitt's lymphoma, gastric cancer, nasopharyngeal carcinoma and conditions associated with human immunodeficiency virus (HIV), such as hairy leukoplakia and central nervous [creative-biolabs.com]
Type 1 latency is seen in Burkitt lymphoma tissue with expression of EBNA1, while type 2 latency is observed in nasopharyngeal carcinoma and Hodgkin lymphoma with expression of EBNA1, LMP1, and LMP2. [jci.org]
Respiratoric
- Pneumonia
Viral Pneumonia Drug: Aciclovir Drug: Ganciclovir Drug: Placebo Phase 4 Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 480 participants Allocation: Randomized Intervention Model: Parallel Assignment [clinicaltrials.gov]
Reactivation or primary infection in immunosuppressed: pneumonia, hepatitis (chemical), retinitis, encephalitis, colitis, esophagitis, adrenalitis. [link.springer.com]
Varicella zoster virus pneumonia, chickenpox complication, 3D illustration Destruction of Epstein-Barr virus, 3D illustration. [shutterstock.com]
Gastrointestinal
- Diarrhea
Pestiviruses Pestiviruses account for important diseases in animals such as Classical swine fever (CSF) and Bovine viral diarrhea / Mucosal disease (BVD/MD). [horizonpress.com]
Uncommon symptoms (cough, diarrhea) were also present, but in most patients, it related to concomitant infections. Lymphomonocytosis ≥50% of the WBC was the only IM laboratory feature frequently observed. [doi.org]
- Abdominal Pain
Other variable symptoms include lymphadenitis and lymphangitis, nausea and vomiting, abdominal pain, and hiccups ( 12, 14 ). [doi.org]
Eyes
- Anterior Uveitis
[…] with HLA B-27 positive anterior uveitis (n=8), Behçet disease (n=6), Fuchs' heterochromic cyclitis (FHC) (n=4), sarcoidosis anterior uveitis (n=1) and multiple sclerosis (MS) related uveitis (n=1). [iovs.arvojournals.org]
PURPOSE: To target the use of two biologic tests in the diagnostic of viral Herpesviridae anterior uveitis (AC) by the consideration of clinical behavior and delay of intraocular sampling. [ncbi.nlm.nih.gov]
Not only anterior uveitis but one related study also revealed a high frequency of positive results without complications from aqueous analysis among patients with posterior uveitis. [dovepress.com]
Skin
- Skin Rash
Pityriasis rosea is a common skin disease. It appears as a rash that can last from several weeks to several months. The way the rash looks may differ from person to person. [aocd.org]
rash 19 11 25 20 60 Splenomegaly 15 11 19 27 0 Pharyngitis 12 9 0 25 40 Laboratory findings Elevated LDH ≥650 IU/L (66 tested) 65 72 62.5 60 40 Lymphomonocytosis ≥50% of WBC 64 81 29 79 0 Elevated ALT ≥70 IU/L 46 53 31.5 53 20 Lymphocytosis ≥40% of WBC [doi.org]
The rash lasts for 1 to 2 days before resolution.11 These viruses remain latent in mononuclear cells.16,17 Human herpesvirus 6 has been implicated in acute graft versus host disease with simultaneous skin rash. [archivesofpathology.org]
Infection with HHV-6B occurs within the first 2 years of life and is the primary cause of Roseola infantum, a febrile illness with a skin rash that can be accompanied by seizures, meningoencephalitis, and encephalopathy (Yamanishi et al., 1988; De Bolle [frontiersin.org]
- Pruritus
A single patient had systemic symptoms including fever, pruritus, and rash (patient 7 in table 3). [nn.neurology.org]
Neurologic
- Headache
These include: 1. vesicular (small blister) skin lesions at or near the site of injury. 2. localized neurological symptoms such as pain, numbness or itching near the wound site. 3. flu-like aches and pains 4. fever and chills 5. headaches lasting more [web.archive.org]
[…] and Pain Management, Jersey Institute of Neuroscience Manish K Singh, MD is a member of the following medical societies: American Academy of Neurology, American Academy of Pain Medicine, American Association of Physicians of Indian Origin, American Headache [medscape.com]
= 72) and per disease * All IM‐like syndromes ( n = 72) Primary CMV infections ( n = 36) Primary Toxoplasma gondii infections ( n = 16) Primary EBV infections ( n = 15) Primary HIV infections ( n = 5) Symptoms and signs Fever >7 days 72 74 69 80 60 Headache [doi.org]
Case presentation A 26-year-old immunocompetent male presented with dizziness, blurred vision, a 3-day history of fever, frontal headache, cervical and lumbar pain, and vomiting during the last 24 h. [virologyj.biomedcentral.com]
Inclusion criteria CSF samples were included in the study based on the clinical criteria of meningitis: acute onset (<3 weeks), presence of fever (>38ºC), meningo-radicular signs and headache. [scielo.br]
- Dizziness
Case presentation A 26-year-old immunocompetent male presented with dizziness, blurred vision, a 3-day history of fever, frontal headache, cervical and lumbar pain, and vomiting during the last 24 h. [virologyj.biomedcentral.com]
Workup
Therefore, combination of classic predictors is necessary to increase substantially the posttest probability of a first‐line workup. Precise etiologic diagnosis requires serological testing against all four commonly associated pathogens. [doi.org]
Microbiology
- Human Herpesvirus 8
Epstein-Barr virus (EBV), cytomegalovirus, human herpesvirus 6 (HHV-6), human herpesvirus 7 (HHV-7), and human herpesvirus 8 (HHV-8). [archivesofpathology.org]
Kaposi’s Sarcoma-associated Herpesvirus Vaccines The Human herpesvirus 8 (HHV-8) is associated with three forms of human neoplasia. [creative-biolabs.com]
6A (HHV-6A) Human betaherpesvirus 6B Human herpesvirus 6B (HHV-6B) Human betaherpesvirus 7 Human herpesvirus 7 (HHV-7) Human gammaherpesvirus 8 Human herpesvirus 8 (HHV-8) Kaposi syndrome herpesvirus (KSHV) Matching UniProtKB/Swiss-Prot entries 2055 [expasy.org]
4 Bovine herpesvirus 4 [AF318573=NC_002665] (BoHV-4) (Movar virus) Human herpesvirus 8 Human herpesvirus 8 [AF148805=NC_009333] (HHV-8) (Kaposi’s sarcoma-associated herpesvirus) Macacine herpesvirus 5 Macacine herpesvirus 5 [AF083501=NC_003401] (McHV- [talk.ictvonline.org]
- Toxoplasma Gondii
“While previous studies have focused on the effect of individual infectious exposure, namely, Herpesviridae viruses or Toxoplasma gondii (T gondii), on cognitive functioning, the objective of the present study was to examine the effect of multiple infections [psychcongress.com]
While previous studies have focused on the effect of individual infectious exposure, namely, Herpesviridae viruses or Toxoplasma gondii (T gondii), on cognitive functioning, the objective of the present study was to examine the effect of multiple infections [ncbi.nlm.nih.gov]
Abstract Background Infectious mononucleosis (IM), resulting from Epstein–Barr virus (EBV) infection, and IM‐like syndromes, mainly due to cytomegalovirus (CMV), Toxoplasma gondii, or human immunodeficiency virus (HIV), have been occasionally reported [doi.org]
Treatment
Treatment with cmvIL-10 reduced TNF-α levels by 86%. Unexpectedly, treatment with JAK1 inhibitor did not cause TNF-α levels to rise significantly. [doi.org]
Treatment: DHPG [9-(l,3-dihydroxy-2-propoxymethy)guanine] is an effective antiviral agent that suppresses CMV during treatment, but does not eradicate it. [link.springer.com]
For mild cases, no treatment is required as this disease is not a dangerous skin condition. [aocd.org]
HSV as a Treatment Vector for Cancer HSV has been an object of interest into research and development as a treatment vector for cancer. [microbewiki.kenyon.edu]
Prognosis
Advances in the technology available for the diagnosis of B virus infection and in the agents for its treatment are improving the prognosis for cases in human beings. [doi.org]
In these patients, prognosis is probably driven more by the underlying condition (namely, ARDS and other organ failures) than by HSV or CMV reactivation. [annalsofintensivecare.springeropen.com]
The tortoises died either during the spring (April-June: n = 8) or the fall (October-December: n = 4) including also Z02/1970 that was euthanized because of very poor prognosis. [dx.plos.org]
Etiology
CONCLUSIONS: While the GWC is progressively less often performed, these findings suggest that it still has a role in AU suspected of herpesvirus etiology. [ncbi.nlm.nih.gov]
There is little information on the etiology of viral meningitis in Brazil especially in the Southern region. [scielo.br]
Consequently, a single herpesvirus species can be attributed to a wide range of diseases as etiological agents or cofactors. [intechopen.com]
Clinical recognition of symptoms and appropriate advanced testing are necessary to correctly identify the infectious etiology. [journals.lww.com]
Epidemiology
Unfortunately, the epidemiology of B virus in group-housed macaques is poorly understood. [doi.org]
For each viral pathogen, we will describe the epidemiology, natural history, screening and diagnosis modalities, treatments, and implications for antepartum care. [journals.lww.com]
The findings of the present study have contributed to a better understanding of the epidemiology of these viruses in this region. [scielo.br]
Pathophysiology
The pathophysiology, epidemiology, clinical presentations of disease, diagnostic investigations, imaging characteristics, and treatment for each infectious etiology are discussed in detail. Author Information Address correspondence to Dr Kelly J. [journals.lww.com]
Biology and Pathophysiology The Herpesviridae family includes viruses that infect animals and humans (Siakallis 2009). Among these viruses, eight members are known to infect humans and are clinically important (Siakallis 2009). [lifeextension.com]
The current hypothesis concerning pathophysiology is that chronic alveolar epithelial cell injury leads to an aberrant reparative response resulting in chronic architecture remodelling of the lung. [openres.ersjournals.com]
HSV infection is mediated through attachment via ubiquitous receptors to cells, including sensory neurons, leading to establishment of latency. [1] Pathophysiology HSV-1 and HSV-2 are characterized by the following unique biological properties: [1] Neurovirulence [emedicine.medscape.com]
Prevention
Article Navigation 1 Department of Epidemiology, Emory University, and Centers for Disease Control and Prevention, Atlanta, Georgia 2 Centers for Disease Control and Prevention, Atlanta, Georgia Reprints or correspondence: Stephanie A. S. [doi.org]
Alternatively, vaccine in those with latent HSV could prevent reactivation, recurrent disease, and transmission. Clinical HSV vaccine trials should define clearly the types of protection being measured. [creative-biolabs.com]
Concept for Epstein-Barr virus infection treatment and prevention Cytomegalovirus CMV, a DNA virus from Herpesviridae family. 3D illustration. [shutterstock.com]
Prevention and Control: Infection can be prevented by avoiding close personal contact (including sexual) with an actively infected individual. [link.springer.com]