• Pain and swelling: Patients with herpetic whitlow have swollen fingers with extreme pain. Common digits involved in this disease are thumb and the index finger. 
• Fever and malaise.
• The involved digit appears tender, and edematous.
• Vesicular lesions or ulcers, which are grouped together, with surrounding erythema, are seen. The fluid in these vesicles is often clear.
• In some cases, adenopathy of the axillary nodes may be seen. 
• There may be herpetic lesions in the oral or genital areas [6][7] [8].

• Axillary Lymphadenopathy

  Physical examination revealed an area of erythematous, confluent vesicles on the middle phalanx of the finger and associated axillary lymphadenopathy. [nejm.org]

  Lymphangitis and epitrochlear and axillary lymphadenopathy are not uncommon. After 10-14 days, symptoms usually improve significantly and lesions crust over and heal. Viral shedding is believed to resolve at this point. [emedicine.medscape.com]

  Fever, lymphadenitis, and epitrochlear and axillary lymphadenopathy may be present. Small, clear vesicles initially are present. These may eventually coalesce and, as the fluid becomes cloudier, mimic a pyogenic bacterial infection. [aafp.org]

• Swelling of the Finger

  Initial symptoms of herpetic whitlow may include: a tingling feeling in the affected area pain and swelling of a finger fever and discomfort (in some cases) These symptoms are usually followed by: sudden pain around the nail redness (erythema), swelling [health24.com]

  Find a 5-Star Infectious Disease Specialist A whitlow can cause pain, itching, redness or swelling on your fingers. Your fingers may also develop small blisters. [healthgrades.com]

  There is considerable pain, swelling of the fingers or thumb. Persons working in an atmosphere prone to bodily secretions (saliva, genital secretions), waste materials or poor toilet hygiene are prone to this infection. [dentalhygienefitness.com]

  […] of the finger Tenderness along the tendon sheath Limited movement with the finger held slightly bent Pain with attempted movement of the finger treatment of flexor tendon sheat infection early treatment is essential to avoid adhesions within flexor tendon [quizlet.com]

• Finger Pain

  Herpetic Whitlow Symptoms Symptoms include: Swelling Finger pain Tenderness Inflammation Blisters or ulcers Swollen lymph nodes This infection normally starts with swelling and inflammation that is painful on one or even more fingers. [byebyedoctor.com]

• Arm Pain

  Dermatopathology 5,170 satisfied customers Can HERPETIC WHITLOW in right index finger cause arm pain. hi can HERPETIC WHITLOW in right index finger cause arm pain. [justanswer.com]

• Fever of Unknown Origin

  Related Cases Disease: Hand Injuries and Disorders Herpes Simplex Symptom/Presentation: Extremity Problems Fever and Fever of Unknown Origin Vesiculobullous Lesions Specialty: Dermatology Infectious Diseases Age: Preschooler To Learn More To view pediatric [pediatriceducation.org]

• Coarctation of the Aorta

  […] of the Aorta 412 Tetralogy of Fallot 415 Total Anomalous Pulmonary Venous Connection 417 Transposition of the Great Arteries 419 Tricuspid Atresia 421 Truncus Arteriosus 423 Congenital Mitral Valve Disease 425 Mitral Valve Prolapse 427 Anomalous Origin [books.google.com]

• Mitral Valve Prolapse

  Valve Prolapse 427 Anomalous Origin of the Left Coronary Artery 429 Cardiomyopathy 433 Infective Endocarditis 439 Myocarditis 444 Rheumatic Heart Disease 447 Aortic Arch and Pulmonary Artery Abnormalities Vascular Rings and Slings 452 Diseases of the [books.google.com]

• Myopathy

  Connective Tissue 595 Lysosomal Storage Disorders 597 Nervous System 601 Developmental Defects 605 Epilepsy 608 Disorders of the Anterior Horn Cell 621 Basal Ganglia and Neurotransmitter Disorders 623 Leukodystrophies 632 Hereditary and Acquired Types of Myopathy [books.google.com]

• Cutaneous Manifestation

  Herpetic whitlow is a cutaneous manifestation of a herpetic infection. The source of the infection for many medical and dental professionals is the oral cavity. [ncbi.nlm.nih.gov]

  Acyclovir for herpetic whitlow Herpetic whitlow is a cutaneous manifestation of a herpes simplex infection and its treatment with acyclovir therapy is a widely used chemotherapeutic alternative. [drugsdetails.com]

Diagnosis of herpetic whitlow is clinical. The digit affected by herpetic whitlow can be identified by the characteristic lesions. In children, concurrent gingivostomatitis, and among adults, presence of occupational risk factors or concurrent genital infection suggests strong diagnosis.

Tzanck test, viral cultures, DNA hybridization and antibody testing are some of the known tests. Cost-effective and popular diagnostic tools for herpetic whitlow are polymerase chain reaction (PCR) and immune-fluorescent microscopy. Recurrent infections of herpetic whitlow, unusual locations or/and atypical presentation suggests an immunedeficient condition. HIV testing is therefore recommended in such patients [9].

Though herpetic whitlow is a self-limiting condition, treatment is aimed to relieve the patient from the symptoms. Topical acyclovir or penciclover shortens the duration of symptoms, while oral acyclovir prevents recurrence. For acute occurrence, famciclover and valacyclovir are also beneficial. Antibiotic treatment is prescribed in cases of bacterial superinfection [10] [11].

Since herpetic whitlow is a self-limiting condition, the prognosis is good. Unless complicated, the disease can be contained by clinical course with proven drug therapy. Spontaneous resolution within 3-4 weeks is observed in patient with herpetic whitlow [4] [5].

Complications

HSV infection can spread throughout the body. Weakened immune system makes the HSV infection severe, causing complications [1].

Two most important viruses that can cause this disease are herpes simplex virus 1 (HSV-1) and herpes simplex virus-2 (HSV-2). 60% and 40% of all the herpetic whitlow infections are caused by HSV-1 and HSV-2 respectively. Immunocompromised patients, health-care professionals and patients with herpetic lesions (due to autoinoculation) are at a higher risk of infections with these viruses [3].

Approximately 2.4 to 5 cases every 100,000 population have been reported for herpetic whitlow in USA. Though mortality with this disease is almost negligible, morbidity is attributed to the bacterial superinfection as well as iatrogenic complications.

Both male and female are equally affected by this condition. Toddlers and children are more likely to be affected by HSV-1 and HSV-2 viruses, as they are engaged in thumb or finger sucking.

Herpetic whitlow is caused by inoculation of the virus. Once the virus enters and invades the cells of the dermis, clinical infection ensues.

• In children, as the infection involves finger sucking, the autoinoculation by HSV-1 from oropharyngeal lesion is common. 
• In health care workers, inoculation with HSV-1 occurs secondary to the unprotected exposure. Prevention of such infections is possible with the use of gloves. 
• In adults, the source of autoinoculation is genital herpes, and thus the common cause of infection is HSV-2. 

The incubation period of the disease is 2 to 20 days. Initial symptom of the disease is pain and burning or tingling of the infected digit, followed by erythema, and edema. It leads to the formation of 1-3 mm grouped vesicle, which may ulcerate or rupture and contain clear fluid, (which may be cloudy or bloody).

After 10 to 14 days, there may be improvement in the symptoms of the condition. Viral shedding and complete resolution generally occur after 5 to 7 days. Herpetic whitlow is characterized by a primary infection followed by a latent period and subsequent recurrence (in 20-50% of cases) [1] [2].

Avoiding the exposure to HSV can prevent herpetic whitlow. Having no contact with patients with known infections is important. Health care workers must wear gloves, and wash his hands regularly and thoroughly. Infection by the HSV-1 and HSV-2 can spread to different parts of the body by touching the infected area, sharing towels, contact lenses or flannels. Children must be discouraged to suck the infected finger/thumb.

The painful infection of the hand (distal phalanx), that involves one or more fingers is known as herpetic whitlow. Adamson was the first person to describe the condition in 1909.

In 1959, occupational risk among the health care workers was also included as an important risk factor for this condition. Health care workers and immunocompromised patients are at a higher risk, as they are often exposed to the virus-containing secretions from the patients [1] [2].

Definition

Infection of the digit (thumb and index fingers are common), which appears as a whitlow or infection by the herpes virus is known as herpetic whitlow. Patients with this condition are often presented with severe pain, and swelling. 

Causes

Herpetic whitlow is caused by the two different types of herpes virus namely HSV-1 or HSV-2. Six in every 10 and four in every 10 patients with herpetic whitlow is caused by HSV-1 and HSV-2 respectively.

Symptoms

After approximately 20 days after exposure to the virus, the infected area starts burning, with a tingling sensation and pain. The finger may become red, with appearance of fluid-filled blisters. Complete healing of the condition within 2 weeks is common. Some of the other common symptoms of the condition are fever, swollen lymph nodes and red streaks on the finger. Recurrent infection lasts for 7-10 days. Triggers of the recurrent herpetic whitlow are fever, stress, surgery, exposure to sun or hormonal changes.

Diagnosis

HSV infection can be diagnosed by the serological tests, direct fluorescent antibody test from the cells from the lesion and viral culture. 

Treatment

Usually herpetic whitlow is a self-limiting condition, which resolves within 2-4 weeks. The treatment of herpetic whitlow is aimed at managing the symptoms and recurrence of the disease. Antiviral drugs such as acyclovir are beneficial in such patients. If the patient feels the constant, severe pain, analgesics can also be prescribed.

1. Wu IB, Schwartz RA. Herpetic whitlow. Cutis. Mar 2007;79(3):193-6. 
2. Klotz RW. Herpetic whitlow: an occupational hazard. AANA J. Feb 1990;58(1):8-13. 
3. American Academy of Pediatrics. Herpes simplex. In: Pickering LK, ed. 2003 Red Book: Report of the Committee on Infectious Diseases. 26th ed. Elk Grove Village, IL: American Academy of Pediatrics, 2003:344-353.
4. LaRossa D, Hamilton R. Herpes simplex infections of the digits. Archives of Surger. 1971; 102:600-603.
5. Polayes IM, Arons MS. The treatment of herpetic whitlow-A new surgical concept. Plastic and Reconstructive Surgery. 1980;65(6):811-817. 
6. Stern H. et al. Herpetic whitlow: A form of cross-infection in hospitals. Lancet, 1959; 2:871-874.
7. Lucey J, Baroni M. Herpetic whitlow. AJN. 1984; 84(1):60-61.
8. Eiferman RA. 1982. Herpetic whitlow and ocular infection. Annals of Ophthalmology, 1982; 14(5):453-455.
9. Aberle SW, Puchhammer-Stockl E. Diagnosis of herpesvirus infections of the central nervous system. J Clin Virol. 2002;25:S79-S85
10. Alexander L, Naisbett B. Patient and physician partnerships in managing genital herpes. J Infect Dis. 2002;186:S57-65.
11. Nikkels AF, Pierard GE. Treatment of mucocutaneous presentations of herpes simplex virus infections. Am J Clin Dermatol. 2002;3(7):475-87.